Memoria y violencia en el cine colombiano

El presente artículo es resultado del trabajo investigativo de un grupo de estudiantes del Semillero de investigación en Comunicación y Derechos Humanos, de la Facultad de Comunicación Social - Periodismo de la Universidad Externado de Colombia, quienes hicieron un ejercicio investigativo alrededor del tema Cine, memoria y violencia en el cine colombiano, para el cual analizaron dos películas nacionales: Cóndores no entierran todos los días y La pasión de Gabriel.

Facilitation of Relational Learning in Schizophrenia

behavioral sciences ISSN 2076-328X www.mdpi.com/journal/behavsc

Memoria y violencia en el cine colombiano

El presente artículo es resultado del trabajo investigativo de un grupo de estudiantes del Semillero de investigación en Comunicación y Derechos Humanos, de la Facultad de Comunicación Social - Periodismo de la Universidad Externado de Colombia, quienes hicieron un ejercicio investigativo alrededor del tema Cine, memoria y violencia en el cine colombiano, para el cual analizaron dos películas nacionales: Cóndores no entierran todos los días y La pasión de Gabriel.

Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections

Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of M. tuberculosis (Mtb) have developed resistance against most of the established anti-TB drugs, new therapeutic options are urgently needed. An attractive target for the development of new anti-TB agents is the salicylate synthase MbtI, the first enzyme of the mycobacterial siderophore biochemical machinery, absent in human cells. In this work, a set of analogues of 5-(3-cyanophenyl)furan-2-carboxylic acid (I), the most potent MbtI inhibitor identified to date, was synthesized, characterized, and tested to further elucidate the structural requirements for achieving an efficient MbtI inhibition and potent antitubercular activity. The structure–activity relationships (SAR) discussed herein evidenced the importance of the side chain linked to the phenyl moiety to improve the in vitro antimycobacterial activity. In detail, 1f emerged as the most effective analogue against the pathogen, acting without cytotoxicity issues. To deepen the understanding of its mechanism of action, we established a fluorescence-based screening test to quantify the pathogen infectivity within host cells, using MPI-2 murine cells, a robust surrogate for alveolar macrophages. The set-up of the new assay demonstrates significant potential to accelerate the discovery of new anti-TB drugs