A polynomial regression model for stabilized turbulent confined jet diffusion flames using bluff body burners

AbstractThermal structure of stabilized confined jet diffusion flames in the presence of different geometries of bluff body burners has been mathematically modeled. Two stabilizer disc burners tapered at 30° and 60° and another frusted cone of 60°/30° inclination angle were employed all having the same diameter of 80(mm) acting as flame holders. The measured radial mean temperature profiles of the developing stabilizing flames at different normalized axial distances were considered as the model example of the physical process.A polynomial mathematical model of fourth degree has been investigated to study this phenomenon to find the best correlation representing the experimental data. Least Squares regression analysis has been employed to estimate the coefficients of the polynomial and investigate its adequacy. High values for R2>0.9 obtained for most of the investigated bluff burners at the various locations of x/dj prove the adequacy of the suggested polynomial for representing the experimental results. Very small values of significance F<(α=0.05) for all investigated cases indicate that there is a real relationship between the independent variable r and the dependant variable T. The low values of p<(α=0.05) obtained reveal that all the recorded parameters for all the investigated cases are significant

Role of N-terminal pro B-type natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease

AbstractObjectivesAcute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a major public health problem. Recognition of comorbid heart dysfunction in such patients is often difficult. The aim of this work is to evaluate the role of N-terminal pro B-type natriuretic peptide (Nt-pro BNP) in AECOPD with respiratory failure.Patients and methodsThis study was conducted on 20 patients with AECOPD and respiratory failure. All patients were subjected to history taking, clinical examination, routine laboratory investigations, arterial blood gases analysis, echocardiography and estimation of plasma level of NT-pro BNP.ResultsPatients were classified into 3 groups: Group I: those without heart dysfunction (40%), Group II: those with diastolic heart failure (40%), and Group III: those with systolic heart failure (20%). NT-pro BNP mean±SD in group I was 673.38±416.02, in group II 1962±847.88, and in group III 6776.75±1433.59pg/ml. There was a statistically significant difference between the three groups (p=0.001). NT-pro BNP showed a statistically significant inverse correlation with pH (p=0.005), ejection fraction (p=0.007) and a direct one with both left ventricular systolic (p=0.008) and diastolic (p=0.016) dimensions and E/A (p=0.016). The NT-pro BNP significantly decreased after recovery from AECOPD (p=0.030). The receiver operating characteristic curve demonstrated a ruling out of LV dysfunction in AECOPD of a sensitivity of 100% and a specificity of 60%; and a ruling in of a sensitivity of 48% and a specificity of 67%.ConclusionPlasma BNP is usually elevated in AECOPD and is related to right or left ventricular systolic or diastolic dysfunction

Tapping uncultured microorganisms through metagenomics for drug discovery

Natural products have been an important historical source of therapeutic agents. Microorganisms are major source of bioactive natural products, and several microbial products including antibiotics, anti-inflammatory, anti-tumour, immunosuppressants and others are currently used as therapeutic agents for human and  domestic animals. Most of these products were obtained from cultured environmental microorganisms. However, it is widely accepted that a very large majority of the microorganisms present in natural  environments are not readily cultured under laboratory conditions, and therefore are not accessible for drug  discovery. Metagenomics is a recent culture-independent approach that has been developed to access the  collective genomes of natural bacterial populations. It enables discovery of the diverse biosynthetic pathways encoded by diverse microbial assemblages that are known to be present in the environment but not-yet  cultured. Recently, several new bioactive molecules and proteins have been discovered using a metagenomic approach. This review highlights the recent methodologies, limitations, and applications of metagenomics for the discovery of new drugs. Moreover, it shows how a multidisciplinary approach combining metagenomics with other technologies can expedite and revolutionize drug discovery from diverse environmental microorganisms.Key words: Microbial diversity, metagenomics, natural products, drug discovery, microbial ecology

Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties

Abstract: A series of 1″-(alkylsulfonyl)-dispiro[indoline-3,2′-pyrrolidine-3′,3″-piperidine]-2,4″-diones 6a‒o has been synthesized through regioselective multi-component azomethine dipolar cycloaddition reaction of 1-(alkylsulfonyl)-3,5-bis(ylidene)-piperidin-4-ones 3a‒h. X-ray diffraction studies (6b‒d, h) confirmed the structures. The majority of the synthesized analogs reveal promising antiproliferation properties against a variety of human cancer cell lines (MCF7, HCT116, A431 and PaCa2) with good selectivity index towards normal cell (RPE1). Some of the synthesized agents exhibit potent inhibitory properties against the tested cell lines with higher efficacies than the standard references (sunitinib and 5-fluorouracil). Compound 6m is the most potent. Multi-targeted inhibitory properties against EGFR and VEGFR-2 have been observed for the synthesized agents. Flow cytometry supports the antiproliferation properties and shows the tested agents as apoptosis and necrosis forming. Vero cell viral infection model demonstrates the anti-SARS-CoV-2 properties of the synthesized agents. Compound 6f is the most promising (about 3.3 and 4.8 times the potency of the standard references, chloroquine and hydroxychloroquine). QSAR models explain and support the observed biological properties

Support for UNRWA's survival

The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) provides life-saving humanitarian aid for 5·4 million Palestine refugees now entering their eighth decade of statelessness and conflict. About a third of Palestine refugees still live in 58 recognised camps. UNRWA operates 702 schools and 144 health centres, some of which are affected by the ongoing humanitarian disasters in Syria and the Gaza Strip. It has dramatically reduced the prevalence of infectious diseases, mortality, and illiteracy. Its social services include rebuilding infrastructure and homes that have been destroyed by conflict and providing cash assistance and micro-finance loans for Palestinians whose rights are curtailed and who are denied the right of return to their homeland

Genome-wide association study for systemic lupus erythematosus in an egyptian population

Systemic lupus erythematosus (SLE) susceptibility has a strong genetic component. Genome-wide association studies (GWAS) across trans-ancestral populations show both common and distinct genetic variants of susceptibility across European and Asian ancestries, while many other ethnic populations remain underexplored. We conducted the first SLE GWAS on Egyptians–an admixed North African/Middle Eastern population–using 537 patients and 883 controls. To identify novel susceptibility loci and replicate previously known loci, we performed imputation-based association analysis with 6,382,276 SNPs while accounting for individual admixture. We validated the association analysis using adaptive permutation tests (n = 109). We identified a novel genome-wide significant locus near IRS1/miR-5702 (Pcorrected = 1.98 × 10−8) and eight novel suggestive loci (Pcorrected 0.8) with lead SNPs from four suggestive loci (ARMC9, DIAPH3, IFLDT1, and ENTPD3) were associated with differential gene expression (3.5 × 10−95 < p < 1.0 × 10−2) across diverse tissues. These loci are involved in cellular proliferation and invasion—pathways prominent in lupus and nephritis. Our study highlights the utility of GWAS in an admixed Egyptian population for delineating new genetic associations and for understanding SLE pathogenesis

حركة المياه والكتل المائية وتأثيرها على انتقال الملوثات في خليج أبو قير (مصر) خلال ( فترة الصيف )

Abuquir Bay is a shallow area with a mean depth of about 10 meters, and it is affected by significant sources of industrial and agricultural pollutants. Water masses, the distribution of dissolved oxygen and total suspended matter, as well as the water circulation in this area are discussed using hydrographic data collected in September, 1984, at 40 stations. In Summer, horizontal distributions of oxygen, salinity and currents showed a strong outflow from the Maadia outlet, which connects the bay with Idku Lake. Therefore, it is expected that agricultural pollutants from Lake Idku are dispersed in the above current direction. The density current plays an important role in the observed water movement in the bay. The high concentration of suspended matter was associated with lower oxygen values due to oxidation of organic matter. The currents are strong enough to initiate the sediment movement and to intensify the coastal processes. This sediment motion could also transport adsorbed pollutants to the offshore area.يتضمن هذا البحث ملخصا للدراسات السابقة في مجال التيارات البحرية والكتل المائية في منطقة خليج أبو قير ، كما يتضمن نتائج تحليل بيانات هيدروجرافية وبيانات عن التيارات البحرية مقاسه عند 40 محطة خلال شهري أغسطس وسبتمبر 1984 ، في نفس المنطقة . وقد أظهرت التوزيعات الأفقية لدرجة الحرارة والملوحة وتركيز الأكسوجين ومتجهات سرعة التيار وجود تيار مائي قوي متجه من بحيرة أدكو الي الخليج ، حاملا معه الملوثات الناتجة عن استخدام المبيدات الزراعية ، ومن المتوقع أن تنتشر هذه الملوثات في اتجاه هذه التيارات . وبدراسة بيانات سرعة الرياح ومقارنتها بتوزيع التيارات البحرية ، تبين أن انسياب المياه القليلة الملوحة من بحيرة أدكو ومن محطة ضخ المياه عن الطابية كان له دور هام في توليد التيارات البحرية في الخليج خلال فترة الدراسة

Metabolomics-based profiling for quality assessment and revealing the impact of drying of Turmeric (Curcuma longa L.)

Turmeric, the rhizomes of Curcuma longa L., is one of the top selling spices, food preservatives, and food colorants. In addition, it exhibits health promoting benefits owing to its unique phytochemical composition. Nevertheless, it is commonly subjected to heat drying, hence, the dried powder is the most used form and can easily be adulterated with allied species. Therefore, our research aimed to profile the phytochemical composition and investigate the impact of drying of turmeric. Extraction and fractionation followed by LC- and GC–MS analysis resulted in the identification of a total of 161 metabolites belonged to various phytochemical classes. Moreover, multivariate data analysis identified curcuminoids, terpecurcumins, and organic acids as potential markers for drying. Based on the applied analytical techniques in combination with chemometrics, these investigations have succeeded to provide good coverage of the metabolome of turmeric in both fresh and dried forms

Serum level of brain-derived neurotrophic factor in fibromyalgia

Introduction Fibromyalgia syndrome (FMS) is a complex clinical syndrome that primarily affects middle-aged women. Fibromyalgia (FM) is characterized by pain associated with sleep disturbances (nonrefreshing sleep, hypersomnolence), the presence of specific painful sites (tender points), and is often accompanied by fatigue and depression. It is believed to arise from the abnormal central sensory processing of pain signals, involving the interaction between neurotransmitters, external stressors, behavioral constructs, hormones, and the sympathetic nervous system. Brain-derived neurotrophic factor (BDNF), a member of neurotrophines, is the most prevalent growth factor in the central nervous system. It is essential for the development of the central nervous system and for neuronal plasticity. Because BDNF plays a crucial role in the development and plasticity of the brain, it is widely implicated in psychiatric diseases. Aim of the work This study aimed to evaluate serum level of BDNF in FM patients and its relation with depression. Patients and methods Thirty patients with primary fibromyalgia syndrome were enrolled into this study. These patients were subjected to clinical examination and assessment of depression using the Hamilton Rating Scale for depression. Serum BDNF levels were determined using an enzyme-linked-immunosorbent assay. Twenty age-matched and sex-matched healthy volunteers were included as controls. Results The mean serum BDNF level was age-dependent in healthy controls. FMS patients had higher level of serum BDNF compared with healthy controls. In addition, serum level of BDNF showed correlation with depression, but not with other disease manifestations. The mean serum level of BDNF increased with higher values of depression score in FM patients. Conclusion BDNF is involved in the pathophysiology of FMS. Moreover, it seems to be correlated with the intensity of depression symptoms in FMS patients