Non-genomic effects of nuclear receptors: insights from the anucleate platelet

Nuclear receptors have the ability to elicit two different kinds of responses, genomic and non-genomic. While genomic responses control gene expression by influencing the rate of transcription, non-genomic effects occur rapidly and independently of transcriptional regulation. Due to their anucleate nature and mechanistically well-characterised and rapid responses, platelets provide a model system for the study of any non-genomic effects of the nuclear receptors. Several nuclear receptors have been found to be expressed in human platelets, and multiple nuclear receptor agonists have been shown to elicit anti-platelet effects by a variety of mechanisms. The non-genomic functions of NRs vary, including the regulation of kinase and phosphatase activity, ion channel function, intracellular calcium levels and production of second messengers. Recently, the characterisation of mechanisms and identification of novel binding partners of nuclear receptors have further strengthened the prospects of developing their ligands into potential therapeutics that offer cardio-protective properties in addition to their other defined genomic effects

Cohomologie de Hochschild et espaces projectifs tronquds

In this paper, we outline the construction of obstructions to k-formality where k is a field of arbitrary characteristic. We show that the obstructions to intrinsic k-formality of a graded algebra H* lie in the Hochschild cohomology HH'~'I(H*/k, H*). We calculate explicitly the Hochschild cohomology of the algebra H*((~P~ k) and deduce that the stunted complex projective space (I;P~176 n is intrinsically k-formal for any field k

Parcel delivery by vehicle and drone

We investigate a single-vehicle parcel delivery problem in which customers may be served either by the vehicle or by a portable companion drone launched from the vehicle. The problem may be viewed as a Traveling Salesman Problem with Drone (TSP-D), and is modelled as a 0-1 mixed-integer program (MIP) that synchronizes vehicle and drone operations with the objective of minimizing the duration of the joint tour. Using a combination of valid inequalities, pre-processing, and other bound tightening strategies, we enhance the tractability of the proposed MIP formulation. - 2019, - 2019 Operational Research Society.Scopu

Green hydrogen for industrial sector decarbonization: Costs and impacts on hydrogen economy in qatar

This study focuses on the development of a strategic framework for the design of a hydrogen supply chain network (HSCN) mainly investigating the potential of industrial decarbonization and multi-sectors integration (i.e., transportation, energy, shipping) via green hydrogen economy. The problem was formulated as a mixed integer linear programming (MILP) and solved in GAMS/ IBM ILOG CPLEX 30.3.0 solver. The applicability of the developed model was demonstrated using a base case Eco-industrial city consisting of 10 diverse industrial portfolios targeting decarbonization by 5%. The solution was able to find the optimal HSCN from the probable superstructure along with the optimal sizing of green hydrogen production (453.03 MM kg/y), optimal water sources, optimal sinks and the optimal amount of byproducts generation. Furthermore, the multi-purpose model can accomplish detailed techno-economic-environmental analysis for variable scenarios (e.g., variation in decarbonization target, liquid hydrogen demand, hydrogen production cost, earnings from byproducts) based on net present value. 2020 Elsevier LtdThis paper was made possible by NPRP grant No 10-0205-170347 from the Qatar National Research Fund (a member of Qatar Foundation). The statements made herein are solely the responsibility of the author[s].Scopu

Optical Absorption Coefficient on-center donor impurity in a spherical core/shell quantum dots

The polaronic effect on the linear, third-order nonlinear and total optical absorption coefficients have been calculated in the case of GaAs/AlAs core/shell quantum dot, with the impurity is positioned at the central radial position of the GaAs shell. The calculations are realized in the framework of the effective mass approximation and the numerical results are obtained by using a variational method and an infinite confining potential. The results show that the polaronic effect has a great influence on optical properties of core/ shell quantum dot, he causes a red-shift of the nonlinear optical coefficients associated to light absorption. Also, the polaronic effect is enhanced with the decreasing of quantum dot radius