Mid-term Fixation Stability of the EndoVascular Technologies Endograft

AbstractAim of the study to determine the positional stability of the EndoVascular Technologies (EVT) endograft after endovascular aneurysm repair during morphologic changes of the abdominal aorta during follow-up. Patients and methods all patients treated worldwide with an EVT endograft with an adequate postoperative and at least 12 months postoperative CT scan were included (n=125). Endograft migration was investigated by recording the position of the endograft attachment systems relative to the renal arteries and the aortic or iliac bifurcations. The vertical body axis served as a scale to quantify migration. Aortic cross-sectional areas were measured in the suprarenal aorta and in the proximal and distal aneurysm necks. Length changes of the infrarenal aorta during follow-up were measured, comparing the distance between the left renal artery and the aortic bifurcation. Results the median follow-up was 24 months (range 12–48 months). Graft migration was identified in 4 out of 125 patients (3%). Significant infrarenal aortic dilation was observed at the proximal and distal aneurysm neck during follow-up. However, aortic neck dilation was not associated with endograft migration. The length of the infrarenal aorta did not change significantly after endovascular repair. Conclusion fixation by stents containing hooks of the EVT design appear to be effective in preventing migration of endografts with an unsupported trunk for up to four years. A stable position was maintained in spite of changes in cross-sectional areas of the aneurysm neck

Computed tomographic angiographic imaging of abdominal aortic aneurysms: implications for transfemoral endovascular aneurysm management

PURPOSE: To describe anatomic features pertinent to patient selection and graft design for transfemoral endovascular aneurysm management (TEAM) of the infrarenal aorta using computed tomographic (CT) angiography. METHODS: A prospective noncomparative analysis of 102 spiral CT scans of the abdominal aorta of patients with abdominal aortic aneurysms was performed. From the original CT data set, slices were reconstructed perpendicular to the vessel axis (central lumen line) at a 10 mm interval. In these reconstructed slices, diameter measurements were performed. Vessel length was measured along the central lumen line. In each patient possibilities for TEAM were analyzed. RESULTS: Because of technical reasons, 36 scans were excluded from the analysis. Of the remaining 66 patients, 18 could potentially be treated with a bifurcated endovascular device. The infrarenal aortic diameter-to-iliac artery diameter ratio was less than 2 in most patients. The vessel segments judged to be adequate for endovascular graft anchoring had a noncylindrical shape in the majority of cases. CONCLUSION: Only a minority of patients with abdominal aortic aneurysms can at this stage be treated with an endovascular graft. The ideal endovascular graft should be a combination of rigid and flexible components. The proximal and distal attachment systems should have some flexibility with an intrinsic maximum diameter while the midsection of the graft can be relatively rigi

Cerebral Blood Flow in Relation to Contralateral Carotid Disease an MRA and TCD Study

AbstractObjective: to describe redistribution of cerebral blood flow in patients with severe internal carotid artery (ICA) stenoses in relation to contralateral ICA disease. Methods: sixty-six patients scheduled for carotid endarterectomy (CEA) were grouped according to severity of contralateral stenosis (<30% [group I]; 30–69% [group II]; 70–99% [group III]; occlusion [group IV]. Transcranial Doppler (TCD) and magnetic resonance angiography (MRA) investigations were performed preoperatively. Results: TCD demonstrated a reversed flow in the contralateral anterior cerebral artery (A1segment) and ophthalmic artery in three-quarters of group IV patients (p <0.0001). Group IV patients also exhibited decreased blood flow velocity in the contralateral middle cerebral artery (p =0.001). MRA showed increased ipsilateral ICA and basilar artery (BA) blood flow volumes (Q-flows) in group IV patients when compared to the other groups (p <0.001). No changes in total Q-flow (ICAs+BA) were found. Conclusions: in patients considered for CEA, the severity of the contralateral ICA disease is an important determinant of the pattern of blood flow redistribution through the anterior communicating pathway and ophthalmic artery. Significant flow redistribution through the posterior communicating pathway occurs especially in patients with contralateral ICA occlusion

Outcome After Occlusion of Infrainguinal Bypasses in the Dutch BOA Study: Comparison of Amputation Rate in Venous and Prosthetic Grafts

AbstractObjectiveTo compare the consequences of occlusion of infrainguinal venous and prosthetic grafts.MethodsIn total, 2690 patients were included in the Dutch BOA study, a multicenter randomised trial that compared the effectiveness of oral anticoagulants with aspirin in the prevention of infrainguinal bypass graft occlusion. Two thousand four hundred and four patients received a femoropopliteal or femorodistal bypass with a venous (64%) or prosthetic (36%) graft. The incidence of occlusion and amputation was calculated according to graft material and the incidence of amputation after occlusion was compared with Cox regression to adjust for differences in prognostic factors.ResultsThe indication for operation was claudication in 51%, rest pain in 20% and tissue loss in 28% of patients. The mean follow up was 21 months.After venous bypass grafting 171 (15%) femoropopliteal and 96 (24%) femorodistal grafts occluded. After prosthetic bypass grafting 234 (30%) femoropopliteal and 25 (38%) femorodistal grafts occluded. Patients with occlusions in the venous group had more severe ischemia, less runoff vessels and were older than the patients with prosthetic grafts. In the venous occlusion group 54 (20%) amputations were performed compared to 42 (16%) in the prosthetic occlusion group; crude hazard ratio 1.17 (95% CI 0.78–1.75). After adjustment for above mentioned differences in patient characteristics the hazard ratio was 0.86 (95% CI 0.56–1.32).ConclusionThe need for amputation after occlusion is not influenced by graft material in infrainguinal bypass surgery

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

The role of infrarenal aortic side branches in the pathogenesis of endoleaks after endovascular aneurysm repair

Aim:to investigate the relation between the number of preoperative patent side branches and the presence or absence of postoperative endoleaks, and to study the fate of patent branches after operation.Patients and Methods:thirty consecutive patients were included. Cine mode viewing of axial CT angiography images was applied to detect infrarenal aortic side branches. The position of side branches relative to the renal arteries, branch patency and run-off pathways were studied.Results:a total of 160 patent side branches were found. All patients had two or more patent side branches. A patent inferior mesenteric artery was found in 22/30 patients (73%). Postoperative CT scans revealed major endoleaks in five patients (16%) and minor endoleaks in eight (27%). There was no significant difference in the number of preoperative patent side branches in patients with a completely thrombosed aneurysm sac (five; range 2–8) compared to patients with postoperative endoleaks (six; range 3–9; p = 0.12). Backbleeding from patent side branches as the sole cause of endoleak was seen in one patient only (3.3%).Conclusion:postoperative endoleaks are not related to the number of preoperative patent side branches. In patients without endoleaks, contrast enhancement of side branches was repeatedly seen in the vicinity of the aneurysm wall. Although close follow-up of these branches is warranted, they did not affect the outcome of endovascular aneurysm repair

Recognising stroke prone patients with a poor collateral circulation

The prognosis in carotid disease is extremely variable and is influenced by the availability of collateral circulation. This study investigates the possibility of recognising patients with a poor collateral potential by using non-invasive tests. Preoperative OPG and EEG were compared with intraoperative EEG during test clamping in 208 carotid endarterectomies. Clamping ischaemia occurred in 29 patients (14%). Preoperative EEG had a sensitivity of 62% and a specificity of 82%. OPG showed a sensitivity of 96% and a specificity of 54%. Combined OPG and EEG resulted in a sensitivity of 93% and a specificity of 73%. Both tests are safe and easy to perform and interpret. These techniques can be used to identify those patients with carotid stenosis who have an increased risk of stroke due to a poor collateral circulation and may help to refine the indications for carotid endarterectomy