6,145 research outputs found
Two-photon absorption and broadband optical limiting with bis-donor stilbenes
Large two-photon absorptivities are reported for symmetrical bis-donor stilbene derivatives with dialkylamino or diphenylamino groups. These molecules exhibit strong optical limiting of nanosecond pulses over a broad spectral range in the visible. Relative to bis(di-n-butylamino)stilbene, bis(diphenylamino)stilbene exhibits a 90-nm red shift of its optical limiting band but only a minimal shift of ~13 nm of its lowest one-photon electronic absorption band. Mixtures of these compounds offer an unprecedented combination of broad optical limiting bandwidth and high linear transparency
Numerical test of the damping time of layer-by-layer growth on stochastic models
We perform Monte Carlo simulations on stochastic models such as the
Wolf-Villain (WV) model and the Family model in a modified version to measure
mean separation between islands in submonolayer regime and damping time
of layer-by-layer growth oscillations on one dimension. The
stochastic models are modified, allowing diffusion within interval upon
deposited. It is found numerically that the mean separation and the damping
time depend on the diffusion interval , leading to that the damping time is
related to the mean separation as for the WV model
and for the Family model. The numerical results are in
excellent agreement with recent theoretical predictions.Comment: 4 pages, source LaTeX file and 5 PS figure
Modulation of Neuronal Signal Transduction Systems by Extracellular ATP
The secretion of ATP by stimulated nerves is well documented. Following repetitive stimulation, extracellular ATP at the synapse can accumulate to levels estimated to be well over 100 Μ M. The present study examined the effects of extracellular ATP in the concentration range of 0.1–1.0 m M on second-messenger-generating systems in cultured neural cells of the clones NG108-15 and NIE-115. Cells in a medium mimicking the physiological extracellular environment were used to measure 45 Ca 2+ uptake, changes in free intracellular Ca 2+ levels by the probes aequorin and Quin-2, de novo generation of cyclic GMP and cyclic AMP from intracellular GTP and ATP pools prelabeled with [ 3 H]guanosine and [ 3 H]adenine, respectively, and phosphoinositide metabolism in cells preloaded with [ 3 H]inositol and assayed in the presence of LiCI. Extracelluar ATP induced a concentration-dependent increase of 45 Ca 2+ uptake by intact cells, which was additive with the uptake induced by K + depolarization. The increased uptake involved elevation of intracellular free Ca 2+ ions, evidenced by measuring aequorin and Quin-2 signals. At the same concentration range (0.1–1.0 m M ), extracellular ATP induced an increase in [ 3 H]cyclic GMP formation, and a decrease in prostaglandin E 1 -stimulated [ 3 H]cyclic AMP generation. In addition, extracellular ATP (1 m M ) caused a large (15-fold) increase in [ 3 H]inositol phosphates accumulation, and this effect was blocked by including La 3+ ions in the assay medium. In parallel experiments, we found in NG 108–15 cells surface protein phosphorylation activity that had an apparent K m for extracellular ATP at the same concentration required to produce half-maximal effects on Ca 2+ uptake. Extracellular ATP at concentrations that can be produced in the synaptic cleft by repetitive stimulation but not during routine transmission can thus initiate a unique chain of events, which may play a role in the induction of long-term adaptive changes in neuronal function.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65952/1/j.1471-4159.1988.tb13263.x.pd
Unrestricted CTL recognition of HFE, an empty-peptide-groove MHC class I molecule controlling iron metabolism highlights its potential role as a major histocompatibility antigen in unrelated bone marrow tranplantation
What is in a pebble shape?
We propose to characterize the shapes of flat pebbles in terms of the
statistical distribution of curvatures measured along the pebble contour. This
is demonstrated for the erosion of clay pebbles in a controlled laboratory
apparatus. Photographs at various stages of erosion are analyzed, and compared
with two models. We find that the curvature distribution complements the usual
measurement of aspect ratio, and connects naturally to erosion processes that
are typically faster at protruding regions of high curvature.Comment: Phys. Rev. Lett. (to appear
The shape and erosion of pebbles
The shapes of flat pebbles may be characterized in terms of the statistical
distribution of curvatures measured along their contours. We illustrate this
new method for clay pebbles eroded in a controlled laboratory apparatus, and
also for naturally-occurring rip-up clasts formed and eroded in the Mont
St.-Michel bay. We find that the curvature distribution allows finer
discrimination than traditional measures of aspect ratios. Furthermore, it
connects to the microscopic action of erosion processes that are typically
faster at protruding regions of high curvature. We discuss in detail how the
curvature may be reliable deduced from digital photographs.Comment: 10 pages, 11 figure
Molecular Dynamics Simulation of Semiflexible Polyampholyte Brushes - The Effect of Charged Monomers Sequence
Planar brushes formed by end-grafted semiflexible polyampholyte chains, each
chain containing equal number of positively and negatively charged monomers is
studied using molecular dynamics simulations. Keeping the length of the chains
fixed, dependence of the average brush thickness and equilibrium statistics of
the brush conformations on the grafting density and the salt concentration are
obtained with various sequences of charged monomers. When similarly charged
monomers of the chains are arranged in longer blocks, the average brush
thickness is smaller and dependence of brush properties on the grafting density
and the salt concentration is stronger. With such long blocks of similarly
charged monomers, the anchored chains bond to each other in the vicinity of the
grafting surface at low grafting densities and buckle toward the grafting
surface at high grafting densities.Comment: 8 pages,7 figure
Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2
Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo. We report that the Ca2+ channel Polycystin-2 (Pkd2) is required specifically in the perinodal crown cells for sensing the nodal flow. Examination of mutant forms of Pkd2 shows that the ciliary localization of Pkd2 is essential for correct L-R patterning. Whereas Kif3a mutant embryos, which lack all cilia, failed to respond to an artificial flow, restoration of primary cilia in crown cells rescued the response to the flow. Our results thus suggest that nodal flow is sensed in a manner dependent on Pkd2 by the cilia of crown cells located at the edge of the node.CREST of the Japan Science and Technology Corporation; NIH [P30 DK090744]; Human Frontier Science Program [ST00246/2003C]; Deutsche Forschungsgemeinschaft [PE 853/2]; Japan Society for the Promotion of Science; American Heart Association [R10682]info:eu-repo/semantics/publishedVersio
Rigid Singularity Theorem in Globally Hyperbolic Spacetimes
We show the rigid singularity theorem, that is, a globally hyperbolic
spacetime satisfying the strong energy condition and containing past trapped
sets, either is timelike geodesically incomplete or splits isometrically as
space time. This result is related to Yau's Lorentzian splitting
conjecture.Comment: 3 pages, uses revtex.sty, to appear in Physical Review
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