Оценка экономической эффективности проекта разработки и эксплуатации нефтегазового месторождения

Целью работы является технико-экономическое обоснование разработки обустройства Восточно-Таркосалинского месторождения, расположенного на контрактной территории РФ. Актуальность выбранной темы тем, что большинство нефтяных и газонефтяных месторождений на территории России находятся в стадии эксплуатации, характеризующейся падающей добычей углеводородов в связи с постепенным истощением их запасов. Такая сложившаяся ситуация приводит к необходимости составления новых проектных документов для дальнейшей разработки (доразработки) месторождений.Materials of such calculations are usually drawn up in the form of special documents: technical and economic calculations (TER), technical and economic considerations (TES), technical and economic reports (TED) or feasibility studies of proposed solutions. Depending on the conclusions of such calculations, the company decides to proceed to the next stage of geological exploration, to switch to exploration with the subsequent development of the field, or refuses to continue works because of the high risk of non-return of investments or the unacceptably low profitability of future productio

EMQN best practice guidelines for the molecular genetic testing and reporting of chromosome 11p15 imprinting disorders: Silver–Russell and Beckwith–Wiedemann syndrome

Molecular genetic testing for the 11p15-associated imprinting disorders Silver–Russell and Beckwith–Wiedemann syndrome (SRS, BWS) is challenging because of the molecular heterogeneity and complexity of the affected imprinted regions. With the growing knowledge on the molecular basis of these disorders and the demand for molecular testing, it turned out that there is an urgent need for a standardized molecular diagnostic testing and reporting strategy. Based on the results from the first external pilot quality assessment schemes organized by the European Molecular Quality Network (EMQN) in 2014 and in context with activities of the European Network of Imprinting Disorders (EUCID.net) towards a consensus in diagnostics and management of SRS and BWS, best practice guidelines have now been developed. Members of institutions working in the field of SRS and BWS diagnostics were invited to comment, and in the light of their feedback amendments were made. The final document was ratified in the course of an EMQN best practice guideline meeting and is in accordance with the general SRS and BWS consensus guidelines, which are in preparation. These guidelines are based on the knowledge acquired from peer-reviewed and published data, as well as observations of the authors in their practice. However, these guidelines can only provide a snapshot of current knowledge at the time of manuscript submission and readers are advised to keep up with the literature

Recent Advances in Imprinting Disorders.

Imprinting disorders (ImpDis) are a group of currently 12 congenital diseases with common underlying (epi)genetic etiologies and overlapping clinical features affecting growth, development and metabolism. In the last years it has emerged that ImpDis are characterized by the same types of mutations and epimutations, i.e. uniparental disomies, copy number variations, epimutations, and point mutations. Each ImpDis is associated with a specific imprinted locus, but the same imprinted region can be involved in different ImpDis. Additionally, even the same aberrant methylation patterns are observed in different phenotypes. As some ImpDis share clinical features, clinical diagnosis is difficult in some cases. The advances in molecular and clinical diagnosis of ImpDis help to circumvent these issues, and they are accompanied by an increasing understanding of the pathomechanism behind them. As these mechanisms have important roles for the etiology of other common conditions, the results in ImpDis research have a wider effect beyond the borders of ImpDis. For patients and their families, the growing knowledge contributes to a more directed genetic counseling of the families and personalized therapeutic approaches.COST (BM1208), Bundesministerium für Bildung und Forschung (Network ‘Imprinting Diseases’, 01GM1513B), German Ministry of research and education (01GM1513B)This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1111/cge.1282

ГЛАГОЛЫ ДВИЖЕНИЯ РУССКОГО ЯЗЫКА (сборник таблиц и упражнений слушателям подготовительного отделения для иностранных граждан)

Представлены русские глаголы, обозначающие способы передвижения в пространстве, формы и случаи употребления глаголов движения в языке для изучения иностранными студентами подготовительного отделения (сборник таблиц и упражнений)

Muallime

Emine Semiye'nin Hanımlara Mahsus Gazete'de tefrika edilen Muallime adlı roman

Recommendations for a nomenclature system for reporting methylation aberrations in imprinted domains

The analysis of DNA methylation has become routine in the pipeline for diagnosis of imprinting disorders, with many publications reporting aberrant methylation associated with imprinted differentially methylated regions (DMRs). However, comparisons between these studies are routinely hampered by the lack of consistency in reporting sites of methylation evaluated. To avoid confusion surrounding nomenclature, special care is needed to communicate results accurately, especially between scientists and other health care professionals. Within the European Network for Human Congenital Imprinting Disorders we have discussed these issues and designed a nomenclature for naming imprinted DMRs as well as for reporting methylation values. We apply these recommendations for imprinted DMRs that are commonly assayed in clinical laboratories and show how they support standardized database submission. The recommendations are in line with existing recommendations, most importantly the Human Genome Variation Society nomenclature, and should facilitate accurate reporting and data exchange among laboratories and thereby help to avoid future confusion

Проектирование автоматизированной системы управления установки предварительного сбора воды

Объектом исследования является УПСВ. Цель работы – разработка автоматизированной системы управления УПСВ с использованием ПЛК, на основе выбранной SCADA-системы. В данном проекте была разработана система контроля и управления технологическим процессом на базе промышленных контроллеров Siemens SIMATIC S7-300 с применением SCADA-системы SIMATIC WinCC. Разработанная система может быть применена в системах контроля, управления и сбора данных на различных промышленных предприятиях.The object of the study is the UWWR. The aim of the work is the development of an automated control system for the UPSV using PLC, based on the selected SCADA system. In this project, a system for monitoring and controlling the process was developed on the basis of Siemens SIMATIC S7-300 industrial controllers using the SIMATIC WinCC SCADA system. The developed system can be applied in the systems of control, management and data collection at various industrial enterprises

Diagnosis and management of Silver–Russell syndrome: first international consensus statement

This Consensus Statement summarizes recommendations for clinical diagnosis, investigation and management of patients with Silver–Russell syndrome (SRS), an imprinting disorder that causes prenatal and postnatal growth retardation. Considerable overlap exists between the care of individuals born small for gestational age and those with SRS. However, many specific management issues exist and evidence from controlled trials remains limited. SRS is primarily a clinical diagnosis; however, molecular testing enables confirmation of the clinical diagnosis and defines the subtype. A 'normal' result from a molecular test does not exclude the diagnosis of SRS. The management of children with SRS requires an experienced, multidisciplinary approach. Specific issues include growth failure, severe feeding difficulties, gastrointestinal problems, hypoglycaemia, body asymmetry, scoliosis, motor and speech delay and psychosocial challenges. An early emphasis on adequate nutritional status is important, with awareness that rapid postnatal weight gain might lead to subsequent increased risk of metabolic disorders. The benefits of treating patients with SRS with growth hormone include improved body composition, motor development and appetite, reduced risk of hypoglycaemia and increased height. Clinicians should be aware of possible premature adrenarche, fairly early and rapid central puberty and insulin resistance. Treatment with gonadotropin-releasing hormone analogues can delay progression of central puberty and preserve adult height potential. Long-term follow up is essential to determine the natural history and optimal management in adulthood