533 research outputs found
Vibration stimuli and the differentiation of musculoskeletal progenitor cells: Review of results in vitro and in vivo
Due to the increasing burden on healthcare budgets of musculoskeletal system disease and injury, there is a growing need for safe, effective and simple therapies. Conditions such as osteoporosis severely impact on quality of life and result in hundreds of hours of hospital time and resources. There is growing interest in the use of low magnitude, high frequency vibration (LMHFV) to improve bone structure and muscle performance in a variety of different patient groups. The technique has shown promise in a number of different diseases, but is poorly understood in terms of the mechanism of action. Scientific papers concerning both the in vivo and in vitro use of LMHFV are growing fast, but they cover a wide range of study types, outcomes measured and regimens tested. This paper aims to provide an overview of some effects of LMHFV found during in vivo studies. Furthermore we will review research concerning the effects of vibration on the cellular responses, in particular for cells within the musculoskeletal system. This includes both osteogenesis and adipogenesis, as well as the interaction between MSCs and other cell types within bone tissue
The Problem on the Lattice
If the expression of the topological charge density operator, suggested by
fermions obeying the Ginsparg--Wilson relation, is employed, it is possible to
prove on the lattice the validity of the Witten--Veneziano formula for the
mass. Recent numerical results from simulations with overlap fermions
in 2 (abelian Schwinger model) and 4 (QCD) dimensions give values for the mass
of the lightest pseudo-scalar flavour-singlet state that agree with theoretical
expectations and/or experimental data.Comment: 3 pages, talk presented by G.C. Rossi at Lattice2001(theorydevelop
The pharmacokinetics of medetomidine administered subcutaneously during Isoflurane anaesthesia in Sprague-Dawley rats
Anaesthetic protocols involving the combined use of a sedative agent, medetomidine, and an anaesthetic agent, isoflurane, are increasingly being used in functional magnetic resonance imaging (fMRI) studies of the rodent brain. Despite the popularity of this combination, a standardised protocol for the combined use of medetomidine and isoflurane has not been established, resulting in inconsistencies in the reported use of these drugs. This study investigated the pharmacokinetic detail required to standardise the use of medetomidine and isoflurane in rat brain fMRI studies. Using mass spectrometry, serum concentrations of medetomidine were determined in Sprague-Dawley rats during medetomidine and isoflurane anaesthesia. The serum concentration of medetomidine for administration with 0.5% (vapouriser setting) isoflurane was found to be 14.4 ng/mL (±3.0 ng/mL). The data suggests that a steady state serum concentration of medetomidine when administered with 0.5% (vapouriser setting) isoflurane can be achieved with an initial subcutaneous (SC) dose of 0.12 mg/kg of medetomidine followed by a 0.08 mg/kg/h SC infusion of medetomidine. Consideration of these results for future studies will facilitate standardisation of medetomidine and isoflurane anaesthetic protocols during fMRI data acquisition
Phenomenological glass model for vibratory granular compaction
A model for weakly excited granular media is derived by combining the free
volume argument of Nowak et al. [Phys. Rev. E 57, 1971 (1998)] and the
phenomenological model for supercooled liquids of Adam and Gibbs [J. Chem.
Phys. 43, 139 (1965)]. This is made possible by relating the granular
excitation parameter \Gamma, defined as the peak acceleration of the driving
pulse scaled by gravity, to a temperature-like parameter \eta(\Gamma). The
resulting master equation is formally identical to that of Bouchaud's trap
model for glasses [J. Phys. I 2, 1705 (1992)]. Analytic and simulation results
are shown to compare favourably with a range of known experimental behaviour.
This includes the logarithmic densification and power spectrum of fluctuations
under constant \eta, the annealing curve when \eta is varied cyclically in
time, and memory effects observed for a discontinuous shift in \eta. Finally,
we discuss the physical interpretation of the model parameters and suggest
further experiments for this class of systems.Comment: 2 references added; some figure labels tweaked. To appear in PR
Glassy dynamics in granular compaction: sand on random graphs
We discuss the use of a ferromagnetic spin model on a random graph to model
granular compaction. A multi-spin interaction is used to capture the
competition between local and global satisfaction of constraints characteristic
for geometric frustration. We define an athermal dynamics designed to model
repeated taps of a given strength. Amplitude cycling and the effect of
permanently constraining a subset of the spins at a given amplitude is
discussed. Finally we check the validity of Edwards' hypothesis for the
athermal tapping dynamics.Comment: 13 pages Revtex, minor changes, to appear in PR
Compaction of Rods: Relaxation and Ordering in Vibrated, Anisotropic Granular Material
We report on experiments to measure the temporal and spatial evolution of
packing arrangements of anisotropic, cylindrical granular material, using
high-resolution capacitive monitoring. In these experiments, the particle
configurations start from an initially disordered, low-packing-fraction state
and under vertical vibrations evolve to a dense, highly ordered, nematic state
in which the long particle axes align with the vertical tube walls. We find
that the orientational ordering process is reflected in a characteristic, steep
rise in the local packing fraction. At any given height inside the packing, the
ordering is initiated at the container walls and proceeds inward. We explore
the evolution of the local as well as the height-averaged packing fraction as a
function of vibration parameters and compare our results to relaxation
experiments conducted on spherically shaped granular materials.Comment: 9 pages incl. 7 figure
Effects of inhomogeneities on apparent cosmological observables: "fake" evolving dark energy
Using the exact Lemaitre-Bondi-Tolman solution with a non-vanishing
cosmological constant , we investigate how the presence of a local
spherically-symmetric inhomogeneity can affect apparent cosmological
observables, such as the deceleration parameter or the effective equation of
state of dark energy (DE), derived from the luminosity distance under the
assumption that the real space-time is exactly homogeneous and isotropic. The
presence of a local underdensity is found to produce apparent phantom behavior
of DE, while a locally overdense region leads to apparent quintessence
behavior. We consider relatively small large scale inhomogeneities which today
are not linear and could be seeded by primordial curvature perturbations
compatible with CMB bounds. Our study shows how observations in an
inhomogeneous CDM universe with initial conditions compatible with the
inflationary beginning, if interpreted under the wrong assumption of
homogeneity, can lead to the wrong conclusion about the presence of "fake"
evolving dark energy instead of .Comment: 22 pages, 19 figures,Final version to appear in European Physical
Journal
A two-species model of a two-dimensional sandpile surface: a case of asymptotic roughening
We present and analyze a model of an evolving sandpile surface in (2 + 1)
dimensions where the dynamics of mobile grains ({\rho}(x, t)) and immobile
clusters (h(x, t)) are coupled. Our coupling models the situation where the
sandpile is flat on average, so that there is no bias due to gravity. We find
anomalous scaling: the expected logarithmic smoothing at short length and time
scales gives way to roughening in the asymptotic limit, where novel and
non-trivial exponents are found.Comment: 7 Pages, 6 Figures; Granular Matter, 2012 (Online
Counter-propagating radiative shock experiments on the Orion laser and the formation of radiative precursors
We present results from new experiments to study the dynamics of radiative
shocks, reverse shocks and radiative precursors. Laser ablation of a solid
piston by the Orion high-power laser at AWE Aldermaston UK was used to drive
radiative shocks into a gas cell initially pressurised between and $1.0 \
bar with different noble gases. Shocks propagated at {80 \pm 10 \ km/s} and
experienced strong radiative cooling resulting in post-shock compressions of {
\times 25 \pm 2}. A combination of X-ray backlighting, optical self-emission
streak imaging and interferometry (multi-frame and streak imaging) were used to
simultaneously study both the shock front and the radiative precursor. These
experiments present a new configuration to produce counter-propagating
radiative shocks, allowing for the study of reverse shocks and providing a
unique platform for numerical validation. In addition, the radiative shocks
were able to expand freely into a large gas volume without being confined by
the walls of the gas cell. This allows for 3-D effects of the shocks to be
studied which, in principle, could lead to a more direct comparison to
astrophysical phenomena. By maintaining a constant mass density between
different gas fills the shocks evolved with similar hydrodynamics but the
radiative precursor was found to extend significantly further in higher atomic
number gases (\sim4$ times further in xenon than neon). Finally, 1-D and 2-D
radiative-hydrodynamic simulations are presented showing good agreement with
the experimental data.Comment: HEDLA 2016 conference proceeding
Region graph partition function expansion and approximate free energy landscapes: Theory and some numerical results
Graphical models for finite-dimensional spin glasses and real-world
combinatorial optimization and satisfaction problems usually have an abundant
number of short loops. The cluster variation method and its extension, the
region graph method, are theoretical approaches for treating the complicated
short-loop-induced local correlations. For graphical models represented by
non-redundant or redundant region graphs, approximate free energy landscapes
are constructed in this paper through the mathematical framework of region
graph partition function expansion. Several free energy functionals are
obtained, each of which use a set of probability distribution functions or
functionals as order parameters. These probability distribution
function/functionals are required to satisfy the region graph
belief-propagation equation or the region graph survey-propagation equation to
ensure vanishing correction contributions of region subgraphs with dangling
edges. As a simple application of the general theory, we perform region graph
belief-propagation simulations on the square-lattice ferromagnetic Ising model
and the Edwards-Anderson model. Considerable improvements over the conventional
Bethe-Peierls approximation are achieved. Collective domains of different sizes
in the disordered and frustrated square lattice are identified by the
message-passing procedure. Such collective domains and the frustrations among
them are responsible for the low-temperature glass-like dynamical behaviors of
the system.Comment: 30 pages, 11 figures. More discussion on redundant region graphs. To
be published by Journal of Statistical Physic
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