QUALIDADE DE VIDA E RISCO CARDIOVASCULAR EM CRIANÇAS QUE PRATICAM NATAÇÃO

Objetivo: Identificar os efeitos de uma intervenção com natação sobre a Qualidade de Vida (QV) e o Risco Cardiovascular (RC) em crianças na cidade de Anápolis- Goiás, bem como, correlacionar a QV com o RC. Métodos: Estudo observacional experimental, incluindo 41 crianças, com média de idade (9,88±1,452). Foi utilizado um questionário de Qualidade de Vida - PedsQL e mensuradas circunferência de cintura (CC), massa corporal, estatura e pressão arterial (PA). Para a análise estatística foi utilizado um Teste “t” pareado, o teste de Wilcoxon e uma correlação de Pearson. Resultados: Para QV as médias foram de 69,8 a 84,1 de scores nos dois momentos. Para variáveis de risco cardiovascular apenas o IMC obteve melhoras, diminuindo o número de obesos/sobrepesos de 39% para 31,7%. O Domínio Ambiente teve correlação com a PAS de -0,339*, CC -0,429*e IMC -0,527. Já no domínio social houve correlação com CC -0,323*, IMC -0,314* e IC -0,339*. No domínio psicológico houve correlação com o IMC -0,371*. Já no domínio saúde a correlação foi com a PAD de 0,495*. Conclusões: O estudo concluiu que, dois meses de prática de natação não houve diferença significativa quanto a QV e quanto aos RC apenas uma melhora na classificação do IMC. E houve uma correlação moderada da QV com RC, percebeu-se que quanto menor a QV das crianças, maiores foram as variáveis que indicam o Risco Cardiovascular

Antimicrobial consumption in pediatric intensive care units during the first year of COVID-19 pandemic / Consumo antimicrobiano em unidades de cuidados intensivos pediátricos durante o primeiro ano da pandemia de COVID-19

Introduction: The absence of standardized treatment for critical children admitted in pediatric intensive care units (PICUs) with COVID could lead to an increase in antimicrobial consumption, as indirect effect. Aim: To describe trends of antimicrobial consumption in two PICUs before and during the COVID pandemic year.Methods: We did a retrospective study in children admitted in two PICUs of Rio de Janeiro city, between March 2019 and March 2021. The first year represented the pre-pandemic period and the last one the pandemic period. Trends of antimicrobial consumption were measured by days of therapy (DOT/1000 patient-days) and analyzed by linear regression for antibiotics, antivirals and antifungals Results: Number of patients-days in the PICU 1 was 3495 in the pre-pandemic period and 3600 in the pandemic period. The overall DOT/1000 PD of antibiotics, antivirals and antifungal was 15,308.1, 942.8 and 1,691.1, respectively in the pre-pandemic period and 13,481.5, 1,335.4 and 1,243.7, respectively in pandemic period. It was verified trend of reduction of antibiotic and antifungals and increase in antivirals consumption. Number of patients-days in the PICU 2 was 5029 in the pre-pandemic period and 4557 in the pandemic period and the overall DOT/1000 PD of antibiotics, antivirals and antifungal was 16,668.5, 1,385 and 1,966.7, respectively in the pre-pandemic period and 10,896.5, 830.7 and 677.3 in pandemic period. It was verified trend of reduction of antibiotic, antivirals and antifungals consumption. Conclusion: Trends of antimicrobial consumption reduction were verified for antibiotics and antifungals in two PICUs and reduction for antiviral in one of them

MALE URINARY INCONTINENCE AND THE DIGITAL TECHNOLOGY: EVALUATION OF MOBILE APPLICATIONS AVAILABLE FOR DOWNLOAD

Objective: to evaluate the suitability and usefulness of mobile apps aimed at urinary incontinence rehabilitation in the male population.  Method: descriptive study, carried out with apps directed to the rehabilitation of male urinary incontinence. The apps were obtained from the Play Store and App Store. The search was conducted between May 3 and 10, 2021, in Minas Gerais, Brazil. The terms "urinary incontinence", "incontinencia urinaria", "urinary incontinence", and "Kegel" were used for selection. The applications were described and evaluated as established in the Applications Scoring System items. Results: Twenty-two apps were selected. Three were specific for men; three addressed exercises for pelvic muscle strengthening and voiding diary simultaneously; and five were compatible with both online stores. Conclusion: most of the available apps have limited functionality and information about male urinary incontinence. This study is expected to contribute to the development of more comprehensive and appropriate software for the male urinary incontinent population

Determinação do volume de madeira em povoamento de eucalipto por escâner a laser aerotransportado

The objective of this work was to evaluate the possibility of estimating the diameter at breast height (DBH) with tree height and number data derived from airborne laser scanning (LiDAR, light detection and ranging) dataset, and to determine the timber volume of an Eucalyptus sp. stand from these variables. The total number of detected trees was obtained using a local maxima filtering. Plant height estimated by LiDAR showed a nonsignificant tendency to underestimation. The estimate for DBH was coherent with the results found in the forest inventory; however, it also showed a tendency towards underestimation due to the observed behavior for height. The variable number of stems showed values close to the ones observed in the inventory plots. LiDAR underestimated the total timber volume in the stand in 11.4%, compared to the total volume delivered to the industry. The underestimation tendency of tree height (5% mean value) impacted the individual tree volume estimate and, consequently, the stand volume estimate. However, it is possible to obtain regression equations that estimate DBH with good precision, from the LiDAR plant height derived data. The parabolic model is the one that provides the best estimates for timber volumetric yield of eucalyptus stands.O objetivo deste trabalho foi avaliar a possibilidade de se estimar o diâmetro à altura do peito (DAP) com os dados de altura e de número de árvores derivados do escâner a laser aerotransportado (LiDAR, “light detection and ranging”), e determinar o volume de madeira de talhão de Eucalyptus sp. a partir dessas variáveis. O número total de árvores detectadas foi obtido com uso da filtragem de máxima local. A altura de plantas estimada pelo LiDAR apresentou tendência não significativa à subestimativa. A estimativa do DAP foi coerente com os valores encontrados no inventário florestal; porém, também mostrou tendência à subestimativa, em razão do comportamento observado quanto à altura. A variável número de fustes apresentou valores próximos aos observados nas parcelas do inventário. O LiDAR subestimou o volume total de madeira do talhão em 11,4%, em comparação ao volume posto na fábrica. A tendência de subestimação da altura das árvores (em média, cerca de 5%) impactou a estimativa do volume individual de árvores e, consequentemente, a do volume do talhão. No entanto, é possível gerar equações de regressão que estimam o DAP com boa precisão, a partir de dados de altura de plantas obtidos pelo LiDAR. O modelo parabólico é o que possibilita as melhores estimativas da produção volumétrica dos talhões de eucalipto

Collagen-induced arthritis as an animal model of rheumatoid cachexia

Background Rheumatoid arthritis is characterized by chronic polyarticular synovitis and presents systemic changes that impact quality of life, such as impaired muscle function, seen in up to 66% of the patients. This can progress to severely debilitating state known as rheumatoid cachexia—without loss of fat mass and body weight—for which there is little consensus in terms of diagnosis or treatment. This study aims to evaluate whether the collagen-induced arthritis (CIA) animal model also develops clinical and functional features characteristic of rheumatoid cachexia. Methods Male DBA1/J mice were randomly divided into 2 groups: healthy animals (CO, n = 11) and CIA animals (n = 13). The clinical score and edema size, animal weight and food intake, free exploratory locomotion, grip strength, and endurance exercise performance were tested 0, 18, 35, 45, 55, and 65 days after disease induction. After euthanasia, several organs, visceral and brown fat, and muscles were dissected and weighed. Muscles were used to assess myofiber diameter. Ankle joint was used to assess arthritis severity by histological score. Statistical analysis were performed using one-way and two-way analyses of variance followed by Tukey’s and Bonferroni’s test or t-test of Pearson and statistical difference were assumed for a P value under 0.05. Background Rheumatoid arthritis is characterized by chronic polyarticular synovitis and presents systemic changes that impact quality of life, such as impaired muscle function, seen in up to 66% of the patients. This can progress to severely debilitating state known as rheumatoid cachexia—without loss of fat mass and body weight—for which there is little consensus in terms of diagnosis or treatment. This study aims to evaluate whether the collagen-induced arthritis (CIA) animal model also develops clinical and functional features characteristic of rheumatoid cachexia. Methods Male DBA1/J mice were randomly divided into 2 groups: healthy animals (CO, n = 11) and CIA animals (n = 13). The clinical score and edema size, animal weight and food intake, free exploratory locomotion, grip strength, and endurance exercise performance were tested 0, 18, 35, 45, 55, and 65 days after disease induction. After euthanasia, several organs, visceral and brown fat, and muscles were dissected and weighed. Muscles were used to assess myofiber diameter. Ankle joint was used to assess arthritis severity by histological score. Statistical analysis were performed using one-way and two-way analyses of variance followed by Tukey’s and Bonferroni’s test or t-test of Pearson and statistical difference were assumed for a P value under 0.0

Encontros com mulheres em situação de vulnerabilidade social: relato de experiência em extensão

O presente artigo visa apresentar os resultados do projeto de extensão nomeado “Ser Mulher” desenvolvido em Faculdade Privada de Medicina. As atividades foram desenvolvidas no segundo semestre de 2022, com três encontros presenciais prévios à extensão para discussão da temática e organização das atividades extensionistas. Em sequência foram realizados três encontros em Instituição Não Governamental que recebe mulheres em situação de vulnerabilidade. Os temas abordados pelo projeto envolveram além da questão do que é ser mulher, mas principalmente a violência de gênero e a pobreza menstrual

Metabolomic biomarker candidates for skeletal muscle loss in the collagen-induced arthritis (CIA) model

There is no consensus for diagnosis or treatment of RA muscle loss. We aimed to investigate metabolites in arthritic mice urine as biomarkers of muscle loss. DBA1/J mice comprised collagen-induced arthritis (CIA) and control (CO) groups. Urine samples were collected at 0, 18, 35, 45, 55, and 65 days of disease and subjected to nuclear magnetic resonance spectroscopy. Metabolites were identified using Chenomx and Birmingham Metabolite libraries. The statistical model used principal component analysis, partial least-squares discriminant analysis, and partial least-squares regression analysis. Linear regression and Fisher’s exact test via the MetaboAnalyst website were performed (VIP-score). Nearly 100 identified metabolites had CIA vs. CO and disease time-dependent differences (p < 0.05). Twenty-eight metabolites were muscle-associated: carnosine (VIPs 2.8 × 102) and succinyl acetone (VIPs 1.0 × 10) showed high importance in CIA vs. CO models at day 65; CIA pair analysis showed histidine (VIPs 1.2 × 102) days 55 vs. 65, histamine (VIPs 1.1 × 102) days 55 vs. 65, and L-methionine (VIPs 1.1 × 102) days 0 vs. 18. Carnosine was fatigue- (0.039) related, creatine was food intake- (−0.177) and body weight- (−0.039) related, and both metabolites were clinical score- (0.093; 0.050) and paw edema- (0.125; 0.026) related. Therefore, muscle metabolic alterations were detected in arthritic mice urine, enabling further validation in RA patient’s urine, targeting prognosis, diagnosis, and monitoring of RA-mediated muscle loss

C-glycosyl flavones in Passiflora incarnata: C-glicosil flavona em Passiflora incarnata

Brazil has a diversity of plant species and many of them are medicinal plants used in the production of herbal medicines. Passiflora incarnata is popularly known as passion fruit, its fruits and aerial parts have anxiolytic and sedative properties. Recent studies have shown that P. incarnata has several bioactive compounds such as indole alkaloids, cyanogenic glycosides, maltol and flavonoids. Among the substances identified in the species, vitexin has action on the Central Nervous System, interfering with the functioning of gamma-aminobutyric acid. Thus, the objective of the study was to identify and quantify the vitexin present in the ethyl acetate fraction of the aerial parts of the passion fruit. For this, the aerial parts of P. incarnata were submitted to extraction with ethanol, followed by fractionation in organic solvents, obtaining the hexane, dichloromethane and ethyl acetate fractions. The presence of vitexin in the ethyl acetate fraction was verified by Thin Layer Chromatography (TLC) and the total flavonoid content by colorimetric reaction in a spectrophotometer. The quantification of vitexin was performed by High Performance Liquid Chromatography (HPLC). The total flavonoid content was 5.34 mg/g and 960 µg/g of vitexin in the ethyl acetate fraction. Studies like this contribute to the development of new pharmaceutical formulations from the substance vitexin