Doença poliquística renal autossómica dominante : clínica, genética e epidemiologia

Tese de doutoramento, Medicina (Nefrologia), Universidade de Lisboa, Faculdade de Medicina, 2009Resumos em inglês e em português disponíveis no document

Jan Dejnozka, “The Concept of Relevance and the Logic Diagram Tradition”, Create Space Independent Publishing Platform, 2012

Jan Dejnozka, The Concept of Relevance and the Logic Diagram Tradition, Create Space Independent Publishing Platform, 2012, 170 pp., ISBN-10 1475071094, ISBN-13 978-1475071092

Trace Elements as Contaminants and Nutrients

Knowledge about trace elements has evolved remarkably in recent decades, both in terms of their metabolism and their functions. Acting mainly as cofactors of enzymatic systems, several trace elements play an essential role in numerous physiological processes in the human organism, from cell metabolism to the immune response and gene expression, among others. On the other hand, it is also well known that excessive exposure to trace elements can be highly harmful and even fatal.info:eu-repo/semantics/publishedVersio

Editorial: Iodine in health and disease

Iodine is an essential micronutrient, used by the thyroid gland to synthesize thyroid hormones that perform pleiotropic functions in the human organism. These roles include stimulating somatic growth and regulating metabolism, cardiac function, and neurodevelopment, the latter through the control of synapse formation, neuronal migration, and myelination.info:eu-repo/semantics/publishedVersio

Trace elements in ambient air at Porto metropolitan area: checking for compliance with new European Union (EU) air quality standards

Because of the scientific evidence showing that arsenic (As), cadmium (Cd), and nickel (Ni) are human genotoxic carcinogens, the European Union (EU) recently set target values for metal concentration in ambient air (As: 6 ng/m3, Cd: 5 ng/m3, Ni: 20 ng/m3). The aim of our study was to determine the concentration levels of these trace elements in Porto Metropolitan Area (PMA) in order to assess whether compliance was occurring with these new EU air quality standards. Fine (PM2.5) and inhalable (PM10) air particles were collected from October 2011 to July 2012 at two different (urban and suburban) locations in PMA. Samples were analyzed for trace elements content by inductively coupled plasma–mass spectrometry (ICP-MS). The study focused on determination of differences in trace elements concentration between the two sites, and between PM2.5 and PM10, in order to gather information regarding emission sources. Except for chromium (Cr), the concentration of all trace elements was higher at the urban site. However, results for As, Cd, Ni, and lead (Pb) were well below the EU limit/target values (As: 1.49 ± 0.71 ng/m3; Cd: 1.67 ± 0.92 ng/m3; Ni: 3.43 ± 3.23 ng/m3; Pb: 17.1 ± 10.1 ng/m3) in the worst-case scenario. Arsenic, Cd, Ni, Pb, antimony (Sb), selenium (Se), vanadium (V), and zinc (Zn) were predominantly associated to PM2.5, indicating that anthropogenic sources such as industry and road traffic are the main source of these elements. High enrichment factors (EF > 100) were obtained for As, Cd, Pb, Sb, Se, and Zn, further confirming their anthropogenic origin

O primeiro ano do resto da minha vida : relatório de Estágio realizado na Escola Secundária Fernando Namora

Este relatório tem como objetivo realizar uma análise, com recurso à reflexão, das tarefas desempenhadas enquanto professor estagiário de Educação Física, no ano letivo de 2021/2022, na Escola Secundária Fernando Namora. Ao longo do documento apresentarei os aspetos que considerei mais relevantes para a realização de cada uma das quatro áreas que compuseram o meu estágio pedagógico e possibilitaram a minha evolução pessoal e profissional. Desse modo, abordarei o contexto onde estava inserido e como foi feito o planeamento, condução de ensino e avaliação da turma do 9º1, o trabalho de investigação realizado sobre a avaliação inicial em Educação física, a minha participação enquanto professor coadjuvante do grupo-equipa de basquetebol masculino de desporto escolar e a coadjuvação a um diretor de turma.This report aims to carry out an analysis, using reflection, of the tasks performed as a trainee Physical Education teacher, in the 2021/2022 academic year at Escola Secundária Fernando Namora. Throughout the document I will present the aspects that I considered most relevant in the achievement of each of the four areas that made up my pedagogical internship and enabled my personal and professional evolution. In this way, I will address the context in which I was inserted and how the planning, teaching and evaluation of the 9th grade class was carried out, the research work carried out on the initial assessment in Physical Education, my participation as a supporting teacher in the group-team of school sport men's basketball and the assistance of a class director

Measuring Mental Health Literacy of Teacher: A Pilot Study

Almeida A, Pinheiro P, Okan O, Pereira A, Mesquita E. Measuring Mental Health Literacy of Teacher: A Pilot Study. International Journal of Case Studies. 2017;5(12):35-40

Trace elements in medicinal plants traditionally used in the treatment of diabetes—do they have a role in the claimed therapeutic effect?

Medicinal plants are often used in the treatment of diabetes mellitus, although knowledge about their mode of action and the substances responsible for their antidiabetic potential is limited. It is well known that some trace elements play a role in glucose metabolism and insulin action. Thus, a particular trace elements profile could be associated with the antidiabetic properties observed for some medicinal plants. Methods: Infusions (n = 102) prepared from commercial herbal products (n = 34) containing medicinal plants indicated for the treatment of diabetes (n = 16 different plant species) and infusions (n = 60) prepared from commercial herbal products (n = 20) containing medicinal plants without such an indication (n = 7 different plant species) were analyzed by ICP-MS for their trace elements content. In both groups, results varied significantly between different medicinal plants and also between different origins (brands) of the same medicinal plant. Significant differences (p < 0.05) between the two groups were found for nine elements, including four trace elements related to glucose metabolism (Mn, B, V, and Se), but with lower median contents in the group of medicinal plants for diabetes. Except for some particular species (e.g., Myrtilli folium) in which the trace element Mn may play a role in its antidiabetic effect, globally, a direct association between the claimed antidiabetic properties and a specific trace element profile of the studied medicinal plants was not evident.info:eu-repo/semantics/publishedVersio

Metals transfer from tobacco to cigarette smoke: Evidences in smokers’ lung tissue

Tobacco use kills millions of people every year around the world. The current level of 11 metals in tobacco was determined and their transfer rate to cigarette smoke was calculated as the difference between the total metal content in cigarettes and the amount present in its ashes. The metals content was also determined in the lung tissue of smokers and non-smokers in order to evaluate the marks that smoking leaves in this tissue. Metals content in tobacco ranged from less than 1μg/g (Co, Cd, Pb, As and Tl) to several hundreds of μg/g (Al, Mn and Ba). The highest transfer rate from tobacco to cigarette smoke was found for Tl (85-92%) and Cd (81-90%), followed by Pb (46-60%) and As (33-44%). Significantly higher levels of As, Cd and Pb were found in the lung tissue of smokers compared to non-smokers, showing that smoking results in an increase of these metals in the lungs and that they contribute to the carcinogenic potential of cigarette smoke. This study presents important data on current metals content in tobacco and its transference to cigarette smoke and provides evidence of their accumulation in smokers' lung tissue.info:eu-repo/semantics/publishedVersio