Faılure mode and effect analysıs: An applıcatıon ın jeans productıon process

Na kvalitetu proizvodnje odjeće utječu stroj, poslužitelj, materijal i proces. Proizvodnja bez grešaka u stvarnosti nije moguća. Svrha je spriječiti moguće greške tako da se poduzimaju određene mjere ili da se greške minimaliziraju. Da bi se odredile i odstranile moguće greške tijekom proizvodnih faza, koriste se različite tehničke mjere. Jedna od njih je metoda analize mogućih grešaka i njihovih posljedica (FMEA – Failure Mode and Effects Analysis). U radu se opisuju greške koje se pronalaze kontrolom kvalitete u proizvodnji džins odjeće prema metodi FMEA i predlažu preventivne i korektivne mjere za njihovo otklanjanje.Apparel production quality is influenced depending upon machine, operator, material and process. Therefore, production is not possible with zero defect. The purpose is to prevent the possible defects by taking measures or to minimize them. In order to determine and remove the these possible defects during production stages, various engineering applications are used for this purpose. One of them is “Failure Mode and Effects Analysis (FMEA)” technique. In this study, defects encountered at the quality control department of jean production in apparel firm were observed and analyzed according to FMEA method

A research regardıng the ımprovement of some operatıons that cause defects related to the suıt productıon

U današnjem konkurentskom poslovnom okruženju tvrtke se moraju razlikovati u odnosu na svoje konkurente te predstaviti fenomen kvalitete na temelju zadovoljstva kupaca i osigurati da kontrola kvalitete postoji u svim fazama proizvodnje proizvoda. U proizvodnji odijela potrebni su stručno izvođenje procesa proizvodnje i njegovo nadziranje. Klasično muško odijelo ima više od 200 faza u proizvodnoj liniji dok ne dobije svoj konačni oblik. S obzirom na radno intenzivan rad i aktualne tehnike proizvodnje može doći do raznih grešaka. Radni postupci se definiraju tako da se analiziraju proizvodni procesi te se preporučuju prikladna poboljšanja kako bi se spriječile greške koje su uočene pregledom rezultata u odjelu tvrtke koja je odabrana za ovo proučavanje.In today competitive business environment companies are forced to make a difference with respect to their competitors, to bring the quality phenomenon forward based on customer satisfaction and to provide taking part of the quality control applications on all production processes of the product. On looking at suit production, it is seen that it is necessary to have professional production process and supervision. A classical men’s suit has more than 200 processes on the production line until it gets final shape. In consideration of involving labor intensive work and current production techniques, many and various manufacturing defects are developed. Work definitions are defined by analyzing the production processes and some suitable improvements are recommended in order to prevent defects by the review of the results obtained in the company selected for this study

Genotoxicity and antioxidant enzyme activities induced by the captan fungicide in the root of bell pepper (capsicum annuum L. var. grossum L. cv. kandil)

In this study, we investigated the toxic effects of the captan fungicide by using morphological, physiological and cytological parameters in bell pepper (Capsicum annuum L. var. grossum L. cv. Kandil) root tissue. The seeds of bell pepper were germinated in Petri dishes including different concentrations (0, 25 μM, 50 μM, 100 μM, 150 μM) of captan fungicide for 7 days. The germination rates and root lengths were significantly reduced in captan-treated seeds. All concentrations caused a significant decrease in mitotic index and increase in different types of chromosomal abnormalities such as c-mitosis and chromosome stickness in meristematic cells of bell pepper root. Captan treatment also induced oxidative stress by leading to membrane damage with an increase in root electrolyte leakage in 7 days-old bell pepper root. Catalase, glutathione reductase and total peroxidase activities increased under different concentrations as a response to oxidative stress. Our results showed that captan fungicide had negative effects on germination and growth in bell pepper seed.Bu çalışmada, dolmalık biberde (Capsicum annuum L. var. grossum L. cv. Kandil) kök dokusunda morfolojik, fizyolojik ve sitolojik parametreler kullanarak captan fungisitinin toksik etkisi araştırıldı. Dolmalık biber tohumları 7 gün boyunca farklı konsantrasyonlarda (0,25 μM, 50 μM, 100 μM, 150 μM) captan fungisit içeren petri kabında çimlenmiştir. Elde edilen sonuçlar, captanla muamele edilmiş tohumlarda çimlenme oranının ve kök uzunluğunun düştüğünü göstermiştir. Ayrıca, captan fungisitinin tüm konsantrasyonları, mitotik indekste önemli bir azalmaya ve biber kökünün meristematik hücrelerinde c-mitoz ve kromozom yapışkanlığı gibi farklı tipte kromozomal anormalliklerin artmasına neden olmuştur. Ayrıca, captan muamelesi, 7 günlük dolmalık biber kökündeki kök elektrolit sızıntısında bir artış ile membran hasarına yol açarak oksidatif stresi tetiklemiştir. Oksidatif stres ile başa çıkmak için katalaz, glutatyon redüktaz ve toplam peroksidaz aktivitelerinin dolmalık biber köklerinde farklı captan fungisit konsantrasyonu altında arttığı belirlenmiştir. Elde ettiğimiz sonuçlar captan fungisitinin dolmalık biber tohumundaki çimlenme ve büyümeyi olumsuz yönde etkilediğini göstermiştir

Gender and Perception of Profession

There are negative impacts of gender stereotypes particularly on the education of girls and women. The purpose of this study is to examine pre-service teachers’ profession perceptions within the context of gender using word association test technique and to identify the definition of the concept of “profession” depending on sex. This study is designed as a qualitative research and involves 250 pre-service teachers. In analysing the data, descriptive analysis method is used. Findings are presented in frequency tables and concept networks. The results show that the first profession pre-service teachers mention in their sentences about the concepts of “women and profession” is “teacher”, whereas it is “worker” for the concept of “men and profession”. In the light of the findings, suggestions are made to overcome gender stereotypes and to help individuals to become aware of the acts and talks that reproduce gender inequality

Investigation of interventional studies on COVID-19 in Turkey: a systematic review

Bu çalışmada, COVID-19'un tedavisi ve yönetimi için yürütülmüş ulusal ve uluslararası veri tabanlarında yayınlanmış Türkiye adresli girişimsel araştırmaların sistematik olarak incelenmesi amaçlanmıştır. Gereç ve Yöntem: Ocak 2020-Ağustos 2021 tarihlerinde yapılan araştırmalar; PubMed, Cochrane, CINAHL, EBSCHO, Web of Science, Google Akademik/Scholar, Türkiye Atıf Dizini, ULAKBİM ve COVID-19 Türkiye Web Portalını içeren veri tabanları üzerinden taranmıştır. Kriterleri karşılayan on dört çalışma dahil edilmiştir. Bulgular: Çalışmalar randomize kontrollü (n=6), klinik çalışma (n=1), girişimsel çift kontrollü çalışma (n=1) ve yarı deneysel çalışma tasarımı (n=5) ile yürütülmüştür. Bir çalışma randomize, prospektif çapraz, manken simülasyon çalışmasıdır. Araştırmaların sekizi non-farmakolojik, altısı ise farmakolojik içerikli araştırmalardır. Non-farmakolojik çalışmaların içeriklerinin tümünde tele-rehabilitasyon veya online yöntemlerin kullanıldığı görülmüştür. Altı çalışmada bireylerin stres, depresyon ve anksiyete düzeyini azaltmaya yönelik girişimler uygulanmıştır. Farmakolojik çalışmaların içeriklerinin ise (n=6) farklı tedavi yöntemlerinin etkinliğini değerlendirmeye yönelik olduğu belirlenmiştir. Non-farmakolojik çalışmalarda uygulanan girişimlerin büyük oranda etkili olduğu, farmakolojik çalışmalarda uygulanan tedavi yöntemlerinin ise olumlu etkiye sahip olduğu sonucuna varılmıştır. Sonuç: Bu derleme çalışmasının ileride yapılacak araştırmalara ışık tutması açısından literatüre önemli bir katkı sağlayacağı düşünülmektedir. Ayrıca, çocuklar veThis study aims to systematically review the interventional studies from Turkey published in national and international databases for the treatment and management of COVID-19. Material and Methods: The studies conducted between January-2020 and August-2021 were searched through PubMed, Cochrane, CINAHL, EBSCHO, Web of Science, Google Scholar, Turkey Citation Index, ULAKBİM, and COVID-19 Turkey Web Portal. Fourteen studies meeting the criteria were included. Results: The studies were conducted with randomized controlled (n=6), clinical trial (n=1), interventional double-controlled trial (n=1), and quasi-experimental study design (n=5). One is a randomized, prospective crossover, model simulation study. The evaluated studies include non-pharmacological (n=8) and pharmacological (n=6) approaches. Tele-rehabilitation or online methods were used in all non-pharmacological studies. Six studies aimed at reducing the stress, depression, and anxiety levels of individuals. Pharmacological studies were (n=6) aimed at evaluating the effectiveness of different treatment modalities. The result shows that interventions in non-pharmacological studies are highly effective, and treatment methods applied in pharmacological studies also have a positive effect. Conclusion: This review will contribute to the literature by shedding light on future research. Moreover, there is a need for more comprehensive studies on the diagnosis, treatment, symptoms, effects, and management of COVID-19, including children and older people at risk

Organic bulk heterojunction solar cells based on benzodithiophene and benzothiadiazole containing conjugated polymers

Organic photovoltaics (OPVs) or so-called organic solar cells particularly hold promise for manufacturing solar energy due to their advantages in low cost and production processes. In order to understand and improve the performance of OPVs, intense efforts have been dedicated around the world [1]. In particular, conjugated polymers are attractive for OPVs due to the π-conjugated systems in the polymer backbone which generates and transport the charge carriers [2]. Therefore, the design and synthesis of novel conjugated organic polymers play important role to obtain higher photovoltaic properties and improve the power conversion efficiencies (PCEs) of the OPVs. For this purpose, benzodithiophene and benzothiadiazole containing monomers were independently synthesized, then polymerized via Stille cross-coupling reaction to obtain P1 and P2 polymers. Oxidation and reduction behavior of the polymers were studied by cyclic voltammetry. Measurements indicated that the highest occupied molecular orbital (HOMO) levels were -5.25 eV for P1 and -5.38 eV for P2. The optical band gaps of P1 and P2 were calculated via UV-VIS-NIR spectroscopy as 1.54 eV and 1.64 eV, respectively. Bulk heterojunction solar cells were constructed with these polymers as the donor moieties together with PC71BM as the acceptor in the active layer. The current/voltage measurements showed that the highest PCEs of these photovoltaic devices were recorded as 2.52% for P1: PC71BM (1:4, w/w) in 2% DIO and 1.67% for P2: PC71BM (1:3, w/w) in 3% DIO solution

Growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) gene polymorphisms in Turkish native cattle breeds

The aim of this study was to determine the genetic diversity of 4 native Turkish cattle breeds, based on the growth hormone (GH), prolactin (PRL), and diacylglycerol acyltransferase (DGAT1) genes. In order to study the polymorphisms in these genes, the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method was performed. A 329-bp fragment and a 223-bp fragment of GH, a 156-bp fragment of PRL, and a 411-bp fragment of DGAT1, thus 4 loci of 3 genes, were amplified via PCR. These fragments were then restricted with the enzymes MspI, Alu1, RsaI, and CfrI, respectively. In this study, 2 types of alleles, (+) and (-) for the GH-MspI, L and V for the GH-Alu1, A and B for the PRL, and K and A for the DGAT1 loci, were observed. The results of the present study will contribute to the polymorphism data on the world's cattle breeds. Furthermore, the above-mentioned allele frequencies of Turkish native breeds are evaluated in relation to their genetic relatedness, and to infer their milk production properties on the basis of the available literature. In turn, these results can be utilized for future breeding programs of dairy cattle in Turkey

Investigation effect of origanum bilgeri on the bioactivity and microbiological profile of kombucha tea

Kombu çayı, insan sağlığı üzerindeki olumlu etkileri nedeniyle dünya çapında sıklıkla tercih edilen geleneksel fermente bir içecektir. Kombu çayı fermentasyonunda genellikle siyah çay kullanılıyor olsa da günümüzde farklı bitkisel materyaller eklenerek bu fermente ürünün antioksidan özelliklerinin arttırılması amaçlanmaktadır. Bu çalışmada, Antalya iline endemik ve tıbbi öneme sahip Origanum bilgeri P.H. Davis (Tüylü mercan) ile fermente edilen kombu çayının 0., 7. ve 14. fermentasyon günlerindeki mikrobiyal profili, antibakteriyel etkisi, serbest radikal yakalama kapasitesi, toplam flavonoid ve fenolik madde miktarları incelenmiş ayrıca duyusal analizi yapılarak geleneksel kombu çayı ile karşılaştırılmıştır. Sonuç olarak, O. bilgeri katkılı kombu çayının antioksidan aktivitesinin geleneksel kombu çayı ile yakın sonuç gösterdiği, toplam flavonoid ve fenolik madde miktarının ise geleneksel kombu çayından daha yüksek olduğu bulunmuştur. Ayrıca fermentasyonun 7. ve 14. gününde O. bilgeri katkılı kombu çayının, geleneksel kombu çayının etkili olamadığı bakteri suşlarına karşı antibakteriyel etkiye sahip olduğu ve duyusal analizlerdeki genel değerlendirmelere göre daha hoş karşılandığı görülmüştür.Kombucha is a traditional fermented beverage that is preferred world-wide due to its positive effects on human health. Although black tea is generally used in the fermentation of kombucha, nowadays it is aimed to increase the beneficial health effects of the product by fermenting it with different herbal materials. Origanum bilgeri, is endemic to Antalya and used generally in traditional medicine. In this study, traditional kombucha fermented with Origanum bilgeri, and the microbial profile, antimicrobial effect, free radical scavenging ability, total flavonoid content, total phenolic content, and sensory analysis of the analogue drink was investigated and compared with traditional kombucha on fermentation days 0, 7 and 14. As a result, it was found that the antioxidant activity of O. bilgeri added kombucha was similar to traditional kombucha, and the total amount of flavonoid and phenolic content was higher than that of traditional kombucha. In addition, on the 7th and 14th days of fermentation, O. bilgeri added kombucha had an antibacterial effect against bacterial strains that traditional kombucha tea could not be effective on and was more welcomed in the sensory analysis

Doublecortin-like kinase 1 levels and oxidant status in Alzheimer's disease

Purpose: Alzheimer disease (AD) is a progressive neurodegenerative disease that affects the neurons in various parts of the central nervous system. Recently discovered protein Doublecort like kinase-1 (DCLK-1) is one of the microtubule-associated protein. Our goal is to investigate the relationship of the role of the DCLK-1 in AD disease and oxidative stress. Material and Methods: The study included Alzheimerdisease- diagnosed 60 patients admitted to the clinic with memory disorders, and 30 healthy subjects. In the serum of patient and control group, DCLK-1, tau protein and zinc levels were measured. To assess the presence of oxidative stress, malondialdehyde (MDA), protein carbonyl group (PCG), protein thiol groups (PTG), glutathione (GSH) and catalase levels were detected. Dementia level was staged with Mini-Mental State Examination (MMSE) and Dementia Clinical Staging Scale (CDR). Results: Serum DCLK-1 and tau levels were determined significantly higher in AD compared to the control group). In the group with AD, levels of MDA, and PCG levels were significantly higher and GSH, catalase levels were determined significantly lower. DCLK-1 and MDA levels were determined significantly higher in the group with severe AD compared to the group with mild AD. In AD group, a positive correlation between DCLK-1 and, CDR and MDA; and negative correlation was found between MMSE and B12 vitamin Conclusions: The presence of a relation with increase in DCLK1 levels in AD and risk factors shows that it can be a new marker in assessing the disease

The frequency of Duchenne muscular dystrophy/Becker muscular dystrophy and Pompe disease in children with isolated transaminase elevation: results from the observational VICTORIA study

IntroductionElevated transaminases and/or creatine phosphokinase can indicate underlying muscle disease. Therefore, this study aims to determine the frequency of Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) in male children and Pompe disease (PD) in male and female children with isolated hypertransaminasemia.MethodsThis multi-center, prospective study enrolled patients aged 3–216 months with serum alanine transaminase (ALT) and/or aspartate transaminase (AST) levels >2× the upper limit of normal (ULN) for ≥3 months. Patients with a known history of liver or muscle disease or physical examination findings suggestive of liver disease were excluded. Patients were screened for creatinine phosphokinase (CPK) levels, and molecular genetic tests for DMD/BMD in male patients and enzyme analysis for PD in male and female patients with elevated CPK levels were performed. Genetic analyses confirmed PD. Demographic, clinical, and laboratory characteristics of the patients were analyzed.ResultsOverall, 589 patients [66.8% male, mean age of 63.4 months (standard deviation: 60.5)] were included. In total, 251 patients (188 male and 63 female) had CPK levels above the ULN. Of the patients assessed, 47% (85/182) of male patients were diagnosed with DMD/BMD and 1% (3/228) of male and female patients were diagnosed with PD. The median ALT, AST, and CPK levels were statistically significantly higher, and the questioned neurological symptoms and previously unnoticed examination findings were more common in DMD/BMD patients than those without DMD/BMD or PD (p < 0.001).DiscussionQuestioning neurological symptoms, conducting a complete physical examination, and testing for CPK levels in patients with isolated hypertransaminasemia will prevent costly and time-consuming investigations for liver diseases and will lead to the diagnosis of occult neuromuscular diseases. Trial RegistrationClinicaltrials.gov NCT04120168