User Experiences When Testing a Messaging App for Communication Between Individuals who are Hearing and Deaf or Hard of Hearing

This study investigated user experiences of participants testing a prototype messaging app with automatic speech recognition (ASR). Twelve pairs of participants, where one individual was deaf or hard-of-hearing (DHH), and the other one was hearing used the app, with the hearing individual using speech and ASR and the DHH one using typing. Participants completed a standardized decision making task to test the app. Regardless of hearing status of the participants or the type of device used, participants were generally satisfied with the app. These findings indicate that ASR has potential to facilitate communication between DHH and hearing individuals in small groups and that the technology merits further investigation

Deaf STEM Community Alliance: Establishing a model virtual academic community

Abstract - This presentation describes the incremental and iterative development of the Deaf STEM Community Alliance’s virtual academic community, the Deaf and Hard of Hearing Virtual Academic Community (DHHVAC). The DHHVAC components address three critical barriers to the success of students who are deaf or hard-of-hearing: student preparation, socialization, and access to media

How To Use C-Print Mobile

This poster shows how to download and use C-Print Mobil

Deaf and Hard of Hearing Individuals\u27 Perceptions of Communication with Hearing Colleagues in Small Groups

This survey-based study investigated the the perception of deaf and hard of hearing (DHH) individuals’ perceived need for technologies that may facilitate communication when meeting in small groups with hearing colleagues. Participants were 108 DHH postsecondary students who participated in co-op (internship) and capstone experiences at workplaces with hearing employees within the past two years. Participants’ responses to a survey indicated that they were generally not satisfied with their current strategies and technologies for communicating with hearing persons in small groups

Get Mobile Captioning Anywhere

Abstract - This paper describes the C-Print technology and highlights a recent development, C-Print Mobile, which is currently being evaluated with National Science Foundation funding. The C-Print captioning technology is used to produce a text display of spoken information for individuals who are deaf or hard of hearing (or other individuals who may have difficulty understanding speech). The C-Print service has most often been provided in educational settings, primarily to provide communication access for a deaf student enrolled in a class with primarily hearing students. C-Print may also be used in business and community meetings, presentations, and many other situations. The new C-Print Mobile app allows users to view captioning in a variety of settings: for example, in traditional classrooms, labs, and meetings. Users can also use the Mobile app to view captioning in remote settings, such as a classroom field trip. In July 2013 the app for viewing C-Print real-time captions on mobile devices was released to the general public as a free download from the Apple iTunes and Google Play stores

Creating an Online Community of Practice: The Deaf and Hard of Hearing Virtual Academic Community

This presentation describes the activities of the Deaf STEM Community Alliance project using the social media platform Google+ private community. The private community provides socialization opportunities and shares accessible STEM media with community participants. A pilot study was conducted on a segment of the community’s activity. Posting frequency was analyzed for the highest impact day, posting times, and types of posts that received the most activity. Tuesdays were the most active, and the best times to post were during the afternoon hours. Posts having content related to community members received the most responses. These findings were compared to research on posting frequency in open social media platforms. Future research should investigate in greater detail the uses of social media for education and for other groups with disabilities

Mucosal Immunization with the Moraxella Catarrhalis Porin M35 Induces Enhanced Bacterial Clearance from the Lung: A Possible Role for Opsonophagocytosis

Moraxella catarrhalis is a significant cause of respiratory tract infection against which a vaccine is sought. Several outer membrane proteins are currently under investigation as potential vaccine antigens, including the porin M35. We have previously shown that the third external loop of M35 was immunodominant over the remainder of the protein for antibody produced in mice against the refolded recombinant protein. However, as this loop is predicted to fold inside the porin channel we also predicted that it would not be accessible to these antibodies when M35 is expressed on the surface of the bacteria in its native conformation. This study investigated the functional activity of antibodies against M35 and those specific for the loop 3 region of M35 in vitro and in vivo. Antisera from mice immunized with M35 or the loop 3-deletion, M35loop3−, recombinant proteins were not bactericidal but did have enhanced opsonic activity, whereas antibodies raised against the loop 3 peptide were not opsoniszing indicating that the immunodominant loop 3 of M35 was not accessible to antibody as we had previously predicted. Mucosal immunization with M35, M35 that had an antigenically altered loop 3 [M35(ID78)] and M35loop3− enhanced the clearance of M. catarrhalis from the lungs of mice challenged with live M. catarrhalis. The in vivo clearance of bacteria in the mice with the M35-derived protein constructs correlated significantly (p < 0.001) with the opsonic activity assessed an in vitro opsonophagocytosis assay. This study has demonstrated that the immunodominant B-cell epitope to loop 3 of the M. catarrhalis outer membrane protein M35 is not associated with immune protection and that M35-specific antibodies are not bactericidal but are opsoniszing. The opsoniszing activity correlated with in vivo clearance of the bacteria suggesting that opsoniszing antibody may be a good correlate of immune protection

Technical Consultation of the International Space Station (ISS) Internal Active Thermal Control System (IATCS) Cooling Water Chemistry

The Internal Active Thermal Control System (IATCS) coolant exhibited unexpected chemical changes during the first year of on-orbit operation following the launch and activation in February 2001. The coolant pH dropped from 9.3 to below the minimum specification limit of 9.0, and re-equilibrated between 8.3 and 8.5. This drop in coolant pH was shown to be the result of permeation of CO2 from the cabin into the coolant via Teflon flexible hoses which created carbonic acid in the fluid. This unexpected diffusion was the result of having a cabin CO2 partial pressure higher than the ground partial pressure (average 4.0 mmHg vs. less than 0.2 mmHg). This drop in pH was followed by a concurrent increasing coolant nickel concentration. No other metal ions were observed in the coolant and based on previous tests, the source of nickel ion was thought to be the boron nickel (BNi) braze intermetallics used in the construction of HXs and cold plates. Specifically, BNi2 braze alloy was used for the IATCS IFHX and BNi3 braze alloy was used for the IATCS Airlock Servicing and Performance Checkout Unit (SPCU) HX and cold plates. Given the failure criticality of the HXs, a Corrosion Team was established by the IATCS CWG to determine the impact of the nickel corrosion on hardware performance life

Identification of a BRCA2-Specific modifier locus at 6p24 related to breast cancer risk

Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS). To comprehensively identify breast cancer risk modifying loci for BRCA2 mutation carriers, we conducted a deep replication of an ongoing GWAS discovery study. Using the ranked P-values of the breast cancer associations with the imputed genotype of 1.4 M SNPs, 19,029 SNPs were selected and designed for inclusion on a custom Illumina array that included a total of 211,155 SNPs as part of a multi-consortial project. DNA samples from 3,881 breast cancer affected and 4,330 unaffected BRCA2 mutation carriers from 47 studies belonging to the Consortium of Investigators of Modifiers of BRCA1/2 were genotyped and available for analysis. We replicated previously reported breast cancer susceptibility alleles in these BRCA2 mutation carriers and for several regions (including FGFR2, MAP3K1, CDKN2A/B, and PTHLH) identified SNPs that have stronger evidence of association than those previously published. We also identified a novel susceptibility allele at 6p24 that was inversely associated with risk in BRCA2 mutation carriers (rs9348512; per allele HR = 0.85, 95% CI 0.80-0.90, P = 3.9×10−8). This SNP was not associated with breast cancer risk either in the general population or in BRCA1 mutation carriers. The locus lies within a region containing TFAP2A, which encodes a transcriptional activation protein that interacts with several tumor suppressor genes. This report identifies the first breast cancer risk locus specific to a BRCA2 mutation background. This comprehensive update of novel and previously reported breast cancer susceptibility loci contributes to the establishment of a panel of SNPs that modify breast cancer risk in BRCA2 mutation carriers. This panel may have clinical utility for women with BRCA2 mutations weighing options for medical prevention of breast cancer