RRS James Cook cruise JC166-167, 19 June – 6 July 2018. CLASS – Climate-linked Atlantic System Science Haig Fras Marine Conservation Zone AUV habitat monitoring, Equipment trials and staff training

Expedition JC166-167 combined a number of science and technical objectives in order to deliver a comprehensive programme for the UK marine science sector. The expedition supported the NERC National Capability programme CLASS (Climate-Linked Atlantic Sector Science, grant no NE/R015953/1), which aims to increase our understanding of the Atlantic Ocean system, in order to support evidence-based ocean management. More specifically, JC166-167 was part of the Fixed Point Observations Underpinning Activity, where repeated observations and surveys of Marine Protected Areas (MPAs) and their surroundings provide insight into the development and recovery of benthic ecosystems following natural and/or anthropogenic impacts. The target location for JC166-167 was the Greater Haig Fras Marine Conservation Zone (MCZ), west of Cornwall, which was surveyed by NOC, using Autosub AUVs, in 2012 and 2015. The 2018 expedition continued that time series, and expanded the study by also looking at differences in benthic community observed between day and night. Haig Fras is the only rocky reef on the Celtic Shelf, and was protected in 2016. In parallel with these science objectives, JC166-167 included an extensive series of equipment trials, combined with training for staff members of the Marine Autonomous and Robotic Systems group at NOC. The robotic and autonomous systems tested included the Isis ROV, HyBIS vehicle, the Autosub6000 AUV, a deep glider, a wave glider, a C-worker 4 USV and a drone. Some of the trials were carried out in the shallow waters around Haig Fras, while others required greater depths, for which we visited the Whittard Canyon system along the Celtic Margin. Wherever possible, trials and training were carried out in a way that the resulting data would help address CLASS science objectives, including objectives related to the sustained observations in the Canyons MCZ

The influence of semantic and phonological factors on syntactic decisions: An event-related brain potential study

During language production and comprehension, information about a word's syntactic properties is sometimes needed. While the decision about the grammatical gender of a word requires access to syntactic knowledge, it has also been hypothesized that semantic (i.e., biological gender) or phonological information (i.e., sound regularities) may influence this decision. Event-related potentials (ERPs) were measured while native speakers of German processed written words that were or were not semantically and/or phonologically marked for gender. Behavioral and ERP results showed that participants were faster in making a gender decision when words were semantically and/or phonologically gender marked than when this was not the case, although the phonological effects were less clear. In conclusion, our data provide evidence that even though participants performed a grammatical gender decision, this task can be influenced by semantic and phonological factors

The assessment and management of chemotherapy-related toxicities in patients with breast cancer, colorectal cancer, and Hodgkin and non-Hodgkin lymphomas: A scoping review

Purpose: The purpose of the eSMART (Electronic Symptom Management using the Advanced Symptom Management System (ASyMS) Remote Technology) study is to evaluate the use of mobile phone technology to manage chemotherapy-related toxicities (CRTs) in people with breast cancer (BC), colorectal cancer (CRC), Hodgkin's lymphoma (HL), and non-Hodgkin lymphoma (NHL)) across multiple European sites. One key objective was to review the published and grey literature on assessment and management of CRTs among patients receiving primary chemotherapy for BC, CRC, HL, and NHL to ensure that ASyMS remained evidence-based and reflected current and local practice. Methods: Three electronic databases were searched for English papers, with abstracts available from 01/01/2004-05/04/2014. For the grey literature, relevant clinical practice guidelines (CPGs)/evidence-based resources (EBRs) from the main international cancer organisations were reviewed as were symptom management (SM) protocols from the sites. Results: After full-text screening, 27 publications were included. The majority (n = 14) addressed fatigue and focused on BC patients. Relevant CPGs/EBRs were found for fatigue (n = 4), nausea/vomiting (n = 5), mucositis (n = 4), peripheral neuropathy (n = 3), diarrhoea (n = 2), constipation (n = 2), febrile neutropenia/infection (n = 7), palmar plantar erythrodysesthesia (PPE) (n = 1), and pain (n = 4). SM protocols were provided by >40% of the clinical sites. Conclusions: A need exists for empirical research on SM for PPE, diarrhoea, and constipation. Research is needed on the efficacy of self-care strategies in patients with BC, CRC, HL, and NHL. In general, consistency exists across CPGs/EBRs and local guidelines on the assessment and management of common CRTs

The eSMART Project: real time symptom management in the oncology setting

In 2013 European Union funding was awarded for the eSMART (Electronic Symptom Management Using the ASyMS Remote Technology) study, to evaluate the use of mobile phone technology for management of chemotherapy symptoms in a two-part, pragmatic, RCT across fourteen European clinical sites, including four in the Republic of Ireland (ROI).European Commission - Seventh Framework Programme (FP7

Symptom phenotype during chemotherapy

Some oncology outpatients experience a higher number of and more severe symptoms during chemotherapy (CTX). However, little is known about whether this high risk phenotype persists over time. Latent transition analysis (LTA) was used to examine the probability that patients remained in the same symptom class when assessed prior to the administration of and following their next dose of CTX. For the patients whose class membership remained consistent, differences in demographic and clinical characteristics, and quality of life (QOL) were evaluated. The Memorial Symptom Assessment Scale (MSAS) was used to evaluate symptom burden. LTA was used to identify subgroups of patients with distinct symptom experiences based on the occurrence of the MSAS symptoms. Of the 906 patients evaluated, 83.9% were classified in the same symptom occurrence class at both assessments. Of these 760 patients, 25.0% were classified as Low-Low, 44.1% as Moderate-Moderate and 30.9% as High-High. Compared to the Low-Low class, the other two classes were younger, more likely to be women and to report child care responsibilities, and had a lower functional status and a higher comorbidity scores. The two higher classes reported lower QOL scores. The use of LTA could assist clinicians to identify higher risk patients and initiate more aggressive interventions.European Commission - Seventh Framework Programme (FP7)US National Cancer Institut