OTURMA MOBİLYASI TASARIMINDA BİLGİSAYAR DESTEKLİ ERGONOMİK ANALİZ

Çalışmada, insanların birebir ilişkide olduğu oturma mobilyalarının tasarımında, ergonomik kriterlerin belirlenmesi amacıyla bir “insan odaklı ürün geliştirme” yazılımının (Anybody Technology) kullanılabilirliği araştırılmıştır. Yapılan örnek uygulamada, oturma derinliği, oturma yüksekliği ve arkalık eğim açısı farklı olan 2 adet sandalyede oturan insanın kas–iskelet sisteminde oluşan yükler niceliksel olarak analiz edilmiştir. Ayrıca, 10 erkek deneğin katılımıyla uygulanan bir anket yardımı ile de bu iki farklı sandalyede oturan bireylerin çeşitli vücut bölgelerinde hissettikleri duygular niteliksel olarak belirlenmiştir. Çalışma sonucunda, ürün geliştirme yazılımından alınan veriler, anketlerden alınan veriler ile tutarlı olup, insan odaklı ürün geliştirme yazılımının tasarlanacak mobilyaların ergonomik kriterlerinin belirlenmesinde kullanılabilir olduğunu doğrulamaktadır

The contraception methods preferred bywomen who demand legal abortion and their attitude about contraception methods following ınduced abortion ın Aydın.

Amaç : Aydın'da yasal tahliye amacıyla başvuran kadınların kontraseptif kullanım özelliklerini ve tahliye sonrasında kullanmayı düşündükleri kontraseptif yöntem hakkındaki fikirlerini öğrenmek için yapılan tanımlayıcı bir anket çalışması. Yöntem : Adnan Menderes Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı ve Aydın Doğum ve Çocuk Bakımevi Hastanesi Aile Planlaması Polikliniği`nde rastgele günlerde yasal gebelik tahliyesi amacıyla başvuran 107 kadın ile tahliye öncesinde yüz yüze görüşme yapıldı. Tanımlayıcı bulgular aritmetik ortalama ± standart sapma ve yüzde değerleri ile verildi. Bulgular : Çalışmaya alınan kadınların gebe kaldıklarında kullandıkları yöntemler: 21'i (%20) korunmamış, 71'i (%66) geri çekme, 11'i (%10) takvim yöntemi, 3'ü (%3) kılıf ve 1'i (%1) rahim içi araç (RıA). Bundan sonra nasıl korunmayı düşündükleri sorulduğunda, 48'i (%44) RıA, 22'si (%20) hap, 8'i (%8) tüp bağlatma, 8'i (%8) kılıf, 2'si (%2) enjeksiyon, 2'si (%2) geri çekme yöntemini tercih edeceklerini ve 17'si (%16) ise henüz bir tercihi olmadığını ifade etmiştir. Sonuç : Yasal tahliye sonrası danışmanlık çok büyük önem kazanmaktadır. Evlilik öncesinde rutine girecek bir danışmanlık hizmetine gereksinim vardır. Yasal tahliye için başvuran kadınlar yasal tahliyeyi halen bir aile planlaması yöntemi olarak görmektedir. Temel çözüm etkili alternatif yöntemler önermek ve kullandıkları yöntemlerle ilgili karşılaşılan sorunlara yönelik bilgilendirmede bulunmaktır. Aile Planlaması hizmetlerinin organizasyonunda hizmet sonrası danışmanlık gerekli ve zorunlu bir örgütlenmedir.Objective: This descriptive study was designedto determine the contraception method preferred by womenwho demand legal abortion and their attitude about contraception methods following legal abortion inAydın. Methods: Hundred and seven women admitted to Adnan Menderes University Faculty of Medicine, Department of Obstetrics and Gynecology and Aydın Maternity and Childcare Hospital for legal abortion participated in this questionnaire on random days. The questionnaire was filled out by interview. The descriptive results were analyzed and obtained in the format of average ± standard deviation and a percent ratio. Results: The methods used by women at the time they got pregnant were as follows; 21 (20%) no method, 71 (66%)coitus interruptus, 11 (10%) calendarmethod, 3 (3%)condomand 1 (1%) intrauterine device (IUD).Atthe time of procedure, the contraception methods they would prefer following induced abortion were as follows, 48 (44%) iUD, 22 (20%) oral contraceptive steroid pills, 8 (8%) surgical sterilization, 8 (8%) condom, 2 (2%) oral contraceptive steroid injections, 2 (2%) coitus interruptus and 17(16%) no decision. Conclusion: Counseling for family planning is gaining more importance following legal abortion. Routine pre-marriage counseling for family planning is necessary. Women participated in this study still think that legal abortion is a family planning method. A major solution would be advising alternative effective methods and informing women about the pitfalls of the methods they were using. Follow-up counseling for family planning services is amandatory component ofthe organization

Multilevel Noncontiguous Spinal Fractures: Surgical Approach towards Clinical Characteristics

Study DesignThe study retrospectively investigated 15 cases with multilevel noncontiguous spinal fractures (MNSF).PurposeTo clarify the evaluation of true diagnosis and to plane the surgical treatment.Overview of LiteratureMNSF are defined as fractures of the vertebral column at more than one level. High-energy injuries caused MNSF, with an incidence ranging from 1.6% to 16.7%. MNSF may be misdiagnosed due to lack of detailed neurological and radiological examinations.MethodsPatients with metabolic, rheumatologic diseases and neoplasms were excluded. Despite the presence of a spinal fracture associated clearly with the clinical picture, all patients were scanned within spinal column by direct X-rays, computed tomography and magnetic resonance imaging. When there were ≥5 intact vertebrae between two fractured vertebral segments, each fracture region was managed with a separated stabilization. In cases with ≤4 intact segments between two fractured levels, both fractures were fixed with the same rod and screw system.ResultsThere were 32 vertebra fractures in 15 patients. Eleven (73.3%) patients were male and age ranged from 20 to 64 years (35.9±13.7 years). Eleven cases were the American Spinal Injury Association (ASIA) E, 3 were ASIA A, and one was ASIA D. Ten of the 15 (66.7%) patients returned to previous social status without additional deficit or morbidity. The remaining 5 (33.3%) patients had mild or moderate improvement after surgery.ConclusionsThe spinal column should always be scanned to rule out a secondary or tertiary vertebra fracture in vertebral fractures associated with high-energy trauma. In MNSF, each fracture should be separately evaluated for decision of surgery and planned approach needs particular care. In MNSF with ≤4 intact vertebra in between, stabilization of one segment should prompt the involvement of the secondary fracture into the system

The real-life efficacy of the second line treatment strategy in advanced pancreas cancer

ABS TRACT Objective: Pancreatic cancer is one of the leading causes of cancer-related death. Despite the introduction of new therapeutic agents, survival rates remain low. Furthermore, few trials have evaluated the options for second-line therapy and the prognostic variables. In this study, we aimed to determine the real-world efficacy and prognostic parameters of second-line treatment for advanced pancreatic cancer. Material and Methods: Patients with advanced pancreatic cancer from different centers who received second-line treatment were enrolled in the study. The patients’ demographic, clinical, and pathological characteristics were retrieved retrospectively. Results: A total of 161 patients were enrolled in the study. The majority of the patients (50.3%) received oxaliplatin plus fluoropyrimidine as second-line treatment. The median progression-free survival and overall survival for the entire cohort were 2.5 months and 4.5 months, respectively. In univariate anal-yses, an Eastern Cooperative Oncology Group performance status ≥2, age ≥65 years, hypoalbuminemia, thrombocytosis, presence of metastatic peritoneal disease, elevated alkaline phosphatase and carcinoembryonic antigen levels, and a neutrophil-lymphocyte ratio (NLR) ≥3 were identified as poor prognostic factors. In multivariable analyses, low albumin level (p=0.031) and high NLR (p=0.05) were found to be independent prognostic factors for overall survival. Conclusion: Pancreatic cancer is a unique malignancy, and advanced disease has a dismal prog-nosis. In univariate analyses, we identified multiple factors that were poor prognostic variables. In particular, the albumin level and NLR were independent prognostic factors for overall survival, and these parameters might be useful in selecting the second-line treatment and pre-dicting the survival of these patients

Unpublished Mediterranean records of marine alien and cryptogenic species

Good datasets of geo-referenced records of alien species are a prerequisite for assessing the spatio-temporal dynamics of biological invasions, their invasive potential, and the magnitude of their impacts. However, with the exception of first records on a country level or wider regions, observations of species presence tend to remain unpublished, buried in scattered repositories or in the personal databases of experts. Through an initiative to collect, harmonize and make such unpublished data for marine alien and cryptogenic species in the Mediterranean Sea available, a large dataset comprising 5376 records was created. It includes records of 239 alien or cryptogenic taxa (192 Animalia, 24 Plantae, 23 Chromista) from 19 countries surrounding the Mediterranean Sea. In terms of records, the most reported Phyla in descending order were Chordata, Mollusca, Chlorophyta, Arthropoda, and Rhodophyta. The most recorded species was Caulerpa cylindracea, followed by Siganus luridus, Magallana sp. (cf. gigas or angulata) and Pterois miles. The dataset includes records from 1972 to 2020, with the highest number of records observed in 2018. Among the records of the dataset, Dictyota acutiloba is a first record for the Mediterranean Sea. Nine first country records are also included: the alga Caulerpa taxifolia var. distichophylla, the cube boxfish Ostracion cubicus, and the cleaner shrimp Urocaridella pulchella from Israel; the sponge Paraleucilla magna from Libya and Slovenia; the lumpfish Cyclopterus lumpus from Cyprus; the bryozoan Celleporaria vermiformis and the polychaetes Prionospio depauperata and Notomastus aberans from Malta

Unpublished Mediterranean and Black Sea records of marine alien, cryptogenic, and neonative species

To enrich spatio-temporal information on the distribution of alien, cryptogenic, and neonative species in the Mediterranean and the Black Sea, a collective effort by 173 marine scientists was made to provide unpublished records and make them open access to the scientific community. Through this effort, we collected and harmonized a dataset of 12,649 records. It includes 247 taxa, of which 217 are Animalia, 25 Plantae and 5 Chromista, from 23 countries surrounding the Mediterranean and the Black Sea. Chordata was the most abundant taxonomic group, followed by Arthropoda, Mollusca, and Annelida. In terms of species records, Siganus luridus, Siganus rivulatus, Saurida lessepsianus, Pterois miles, Upeneus moluccensis, Charybdis (Archias) longicollis, and Caulerpa cylindracea were the most numerous. The temporal distribution of the records ranges from 1973 to 2022, with 44% of the records in 2020–2021. Lethrinus borbonicus is reported for the first time in the Mediterranean Sea, while Pomatoschistus quagga, Caulerpa cylindracea, Grateloupia turuturu, and Misophria pallida are first records for the Black Sea; Kapraunia schneideri is recorded for the second time in the Mediterranean and for the first time in Israel; Prionospio depauperata and Pseudonereis anomala are reported for the first time from the Sea of Marmara. Many first country records are also included, namely: Amathia verticillata (Montenegro), Ampithoe valida (Italy), Antithamnion amphigeneum (Greece), Clavelina oblonga (Tunisia and Slovenia), Dendostrea cf. folium (Syria), Epinephelus fasciatus (Tunisia), Ganonema farinosum (Montenegro), Macrorhynchia philippina (Tunisia), Marenzelleria neglecta (Romania), Paratapes textilis (Tunisia), and Botrylloides diegensis (Tunisia).peer-reviewe

Preparation of Fe(III)-chelated poly (HEMA-MAH) cryogel for lysozyme adsorption

Odabaşı, Mehmet ( Aksaray, Yazar )Poly(2-hydroxyethyl methacrylate-N-methacryloyl-(L)-histidine methyl ester) [poly(HEMA-MAH)] cryogel was prepared by bulk polymerization which proceeds in an aqueous solution of monomers frozen inside a glass column (cryo-polymerization). After thawing, the monolithic cryogel contains a continuous polymeric matrix having interconnected pores of 10-50 μm size. Then the monolithic cryogel was loaded with Fe(III) ions to form the metal chelate with poly(HEMAMAH) cryogel. Poly(HEMA-MAH) cryogel was characterized by swelling studies, FTIR, scanning electron microscopy, and elemental analysis. The equilibrium swelling degree of the poly(HEMA-MAH) monolithic cryogel was 2.82 g H2O/g cryogel. Poly(HEMA-MAH) cryogel containing 36.4 μmol MAH/g was used in the adsorption/desorption of lysozyme from aqueous solutions. The nonspecific adsorption of lysozyme was very low (1.1 mg/g). The maximum amount of lysozyme adsorption from aqueous solution in phosphate buffer was 40.7 mg/g at pH 7.0. It was observed that lysozyme could be repeatedly adsorbed and desorbed with the poly(HEMA-MAH) cyogel without significant loss of adsorption capacit

National Undergraduate Medical Core Curriculum in Turkey: Evaluation of Residents

Background: There is very little information available on self-perceived competence levels of junior medical doctors with regard to definitions by the National Core Curriculum (NCC) for Undergraduate Medical Education. Aims: This study aims to determine the perceived level of competence of residents during undergraduate medical education within the context of the NCC. Study Design: Descriptive study. Methods: The survey was conducted between February 2010 and December 2011; the study population comprised 450 residents. Of this group, 318 (71%) participated in the study. Self-assessment questionnaires on competencies were distributed and residents were asked to assess their own competence in different domains by scoring them on a scale of 1 to 10. Results: Nearly half of the residents reported insufficient experience of putting clinical skills into practice when they graduated. In the theoretical part of NCC, the lowest competency score was reported for health-care administration, while the determination of level of chlorine in water, delivering babies, and conducting forensic examinations had the lowest perceived levels of competency in the clinical skills domain. Conclusion: Residents reported low levels of perceived competency in skills they rarely performed outside the university hospital. They were much more confident in skills they performed during their medical education