955 research outputs found
Characterization of the gene for the a subunit of human factor XIII (plasma transglutaminase), a blood coagulation factor.
Isolation, identification and characterisation of ballan wrasse Labrus bergylta plasma pigment
This work was supported by co-funding from Innovate U.K. (formerly Technology Strategy Board), Marine Harvest Scotland and Scottish Seafarms Ltd (project ref: 81199) as well as the University of Stirling, Impact studentship funding scheme. Mass spectrometry analysis was performed by the BSRC Mass Spectrometry Facility, University of St Andrews.This study confirmed that observations of blue-green colouration in plasma fractions of the ballan wrasse Labrus bergylta were caused by the linear tetra-pyrrole biliverdin and that the molecule was of the physiologically relevant IXÎą isomer. Accumulation appears driven by chromogenic association with an unknown protein moiety which precludes enzymatic reduction and would suggest active management. It was demonstrated that the pigment did not fluctuate relative to ontogeny, or indeed binary gender in the species of interest, but mobilisation and depletion in the subset of individuals undergoing sex change at the time of study supports a potential association with gender inversion processes. It is of note that although biliverdin does have some effect on external colouration, the evidence is indicative that crypsis is a supplementary function thus other factors must be considered.PostprintPeer reviewe
Numerical Schemes for Rough Parabolic Equations
This paper is devoted to the study of numerical approximation schemes for a
class of parabolic equations on (0, 1) perturbed by a non-linear rough signal.
It is the continuation of [8, 7], where the existence and uniqueness of a
solution has been established. The approach combines rough paths methods with
standard considerations on discretizing stochastic PDEs. The results apply to a
geometric 2-rough path, which covers the case of the multidimensional
fractional Brownian motion with Hurst index H \textgreater{} 1/3.Comment: Applied Mathematics and Optimization, 201
The Hidden Cost of Cancer: The Siblingsâ Story, A Motherâs Narrative on How Three of Her Children Journeyed Through Their 14-Year-Old Sisterâs 9-Month Journey From Ill Heath to Death and Beyond
The siblings of children diagnosed with cancer can get lost in the cancer journey. Through a motherâs eyes, this paper examines the issues faced by three siblings when their teenage sister is diagnosed with and dies of cancer. It focusses on the impact their sisterâs illness has on their educational, social, emotional and communication skills. Each sibling not only had their own unique set of needs but this paper argues that the term âcancer survivorâ should also be extended to the siblings as they comprise an intrinsic part of the familyâs cancer journey. The paper calls on professionals to adopt a holistic approach to reduce the impact that childhood cancer has on the siblings and it highlights the far-reaching consequences of not properly supporting the siblings during this time
The role of ongoing dendritic oscillations in single-neuron dynamics
The dendritic tree contributes significantly to the elementary computations a neuron performs while converting its synaptic inputs into action potential output. Traditionally, these computations have been characterized as temporally local, near-instantaneous mappings from the current input of the cell to its current output, brought about by somatic summation of dendritic contributions that are generated in spatially localized functional compartments. However, recent evidence about the presence of oscillations in dendrites suggests a qualitatively different mode of operation: the instantaneous phase of such oscillations can depend on a long history of inputs, and under appropriate conditions, even dendritic oscillators that are remote may interact through synchronization. Here, we develop a mathematical framework to analyze the interactions of local dendritic oscillations, and the way these interactions influence single cell computations. Combining weakly coupled oscillator methods with cable theoretic arguments, we derive phase-locking states for multiple oscillating dendritic compartments. We characterize how the phase-locking properties depend on key parameters of the oscillating dendrite: the electrotonic properties of the (active) dendritic segment, and the intrinsic properties of the dendritic oscillators. As a direct consequence, we show how input to the dendrites can modulate phase-locking behavior and hence global dendritic coherence. In turn, dendritic coherence is able to gate the integration and propagation of synaptic signals to the soma, ultimately leading to an effective control of somatic spike generation. Our results suggest that dendritic oscillations enable the dendritic tree to operate on more global temporal and spatial scales than previously thought
Theoretical studies of the historical development of the accounting discipline: a review and evidence
Many existing studies of the development of accounting thought have either been atheoretical or have adopted Kuhn's model of scientific growth. The limitations of this 35-year-old model are discussed. Four different general neo-Kuhnian models of scholarly knowledge development are reviewed and compared with reference to an analytical matrix. The models are found to be mutually consistent, with each focusing on a different aspect of development. A composite model is proposed. Based on a hand-crafted database, author co-citation analysis is used to map empirically the entire literature structure of the accounting discipline during two consecutive time periods, 1972â81 and 1982â90. The changing structure of the accounting literature is interpreted using the proposed composite model of scholarly knowledge development
Emotions in business-to-business service relationships
Emotion in business-to-business service relationships regarding cargo services is explored. The service relationship is characterised by mutual trust and cooperation. Contact is mainly via telephone or e-mail with some face-to-face interactions and participants providing a complex, multi-skilled seamless service. Experience rather than training plays a vital role with long-term service relationships built up and maintained. Emotional sensitivity is acquired partly by experience and a repeat customer base but mainly through a genuine desire to help and get to know others. In contrast to the view of emotional labour bringing managerial control or adverse affects to service staff, the emotion engendered by this work is authentic expression bringing personal satisfaction
Growing food on the green world: J. H. Prynneâs agro-chemical pastoral in the Vale of Tintern
This article reads the poetry of J. H. Prynne of the early- to mid-1970s through an ecocritical lens, arguing that this work responds to the language of a nascent environmentalism framed by the concerns of political ecology. It does so by drawing on Prynneâs archival correspondence with the American poet Edward Dorn in the mid-1970s, which demonstrates a private concern with agro-chemicals, colour and cultivation that served as an analogue for shifts in the politics of relating to the extra-human world. It argues that Prynneâs High Pink on Chrome (1975) is closely attuned to the suppressed human and extra-human costs of high-yield monocrop cultivation. In turn, the article sets these post-war practices in a longer continuum of pastoral suppression, linking such hidden violence with ecocritical and New Historicist arguments about the âgreenâ politics of William Wordsworthâs âTintern Abbeyâ, to which Prynne alluded when writing to Dorn in 1975
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