Short stature diagnosis and referral

The "360° GH in Europe" meeting, which examined various aspects of GH diseases, was held in Lisbon, Portugal, in June 2016. The Merck KGaA (Germany) funded meeting comprised three sessions entitled "Short Stature Diagnosis and Referral, " "Optimizing Patient Management, " and "Managing Transition." Each session had three speaker presentations, followed by a discussion period, and is reported as a manuscript, authored by the speakers. The first session examined current processes of diagnosis and referral by endocrine specialists for pediatric patients with short stature. Requirements for referral vary widely, by country and by patient characteristics such as age. A balance must be made to ensure eligible patients get referred while healthcare systems are not over-burdened by excessive referrals. Late referral and diagnosis of non-GH deficiency conditions can result in increased morbidity and mortality. The consequent delays in making a diagnosis may compromise the effectiveness of GH treatment. Algorithms for growth monitoring and evaluation of skeletal disproportions can improve identification of non-GH deficiency conditions. Performance and validation of guidelines for diagnosis of GH deficiency have not been sufficiently tested. Provocative tests for investigation of GH deficiency remain equivocal, with insufficient information on variations due to patient characteristics, and cutoff values for definition differ not only by country but also by the assay used. When referring and diagnosing causes of short stature in pediatric patients, clinicians need to rely on many factors, but the most essential is clinical experience

Roadmap for investment in the seed potato value chain in Eastern Africa

This roadmap describes the five-year strategy in five african countries (Ethiopia, Kenya, Rwanda, Tanzania and Uganda) to target business investments in key areas along the seed potato value chain to increase the availability of high-quality seed potatoes and promote improved seed management. The approaches presented in the rRoadmap are consistent with those laid out in USAID’s comprehensive Feed the Future initiative and are supportive of development themes and programs of other multilateral donors

Energy balance of mussels Mytilus galloprovincialis: the effect of length and age

Clearance and ingestion rates, absorption efficiencies and respiration rates were measured in mussels Mytilus galloprovincialis Lmk of different lengths (53 to 89 mm) and age (10 to 24 mo) from cultivation rafts in the Ría de Arosa (Galicia, Spain). The experiments were carried out either in the laboratory, using monoalgal food (Isochrysis galbana) with an organic content of 91%, or under natural conditions of food availability in cultivation rafts with seston, the organic content of which ranged from 33 to 69%. Food concentrations ranged from 0.57 to 1.00 mg l-1 of total particulate matter (TPM), a load which is below the threshold for the production of pseudofaeces in Mytilus. These experiments proved that the ingestion rate (IR = mg TPM h-1) of food increases with the size of the mussel (measured as g of soft-tissue dry weight [DW]) according to the power equation IR = 12.661DW0.619, this model accounting for over 90% of the variance of the IR. Behavioural patterns that tended to maintain constant IR regardless of the density of the food were observed. Absorption efficiency (AE) is positively related to the organic content (OC) of the food according to the following hyperbolic equation: AE = 1.015 - 0.163(1/OC) (r = 0.940). AE is independent of mussel size for most of the size range used in this study, but there is a critical length around 85 mm, above which there is a noticeable decrease of AE. Metabolic expenditure, measured in terms of oxygen consumption standarized per unit of dry weight of flesh, tends to increase with the age of the mussel. The results obtained led to the conclusion that physiological traits such as the regulation of ingestion or differences in AE between groups do not explain the differences in growth between mussels of the same age. These differences must therefore be due to the limited food and space available as a result of the large numbers of mussels on the cultivation rafts and the agglomeration of mussels on the cultivation ropes.Versión de editor

Temperature dependence of the magnetization processes in Co/Al oxide/Permalloy trilayers

The magnetization process of Co/Al oxide/Py trilayers and its evolution with the temperature have been analyzed. The particular behavior of the Co layers, including the shift of the hysteresis loops and a coercivity increase with the decrease of temperature, is related with the apparition of a CoO layer at the Co/Al-oxide interface

Synthesis of graphenic nanomaterials by decomposition of methane on a Ni-Cu/biomorphic carbon catalyst. Kinetic and characterization results

This work addresses the preparation and application of the synthesis of graphene in Ni-Cu catalysts supported on carbonaceous materials. The catalysts have been prepared by a biomorphic mineralization technique which involves the thermal decomposition, under reductive atmosphere, of commercial cellulose previously impregnated with the metallic precursors. The characterization results indicate that the preparation method leads to the formation of carbonaceous supports with a moderate microporosity (ca. 33% pore volume) and adequate surface area (343 m2/g), maintaining the original external texture. The catalytic performance of these materials was previously tested in liquid phase reactions (Zampieri et al., 2007 [7]). In order to extend the use of these catalysts, in this work we present a study corresponding to a gas phase reaction: the synthesis of graphenic nanomaterials by catalytic decomposition of methane (CDM). The influence of the reaction temperature and of the feed composition (i.e.%CH4 and%H2) has been studied. The graphenic nanomaterials obtained after reaction were characterized by nitrogen adsorption-desorption isotherms, Raman spectroscopy and transmission electron microscopy (TEM). The results indicate that the carbonaceous nanomaterial with the highest quality is obtained operating at 950 °C and feeding 28.6% of CH4 and 14.3% of H2. The evolution of the carbon mass during the reaction time was analysed using a phenomenological kinetic model that takes into account the main stages involved during the formation of carbonaceous nanomaterials (NCMs). The results obtained from the kinetic model along with the characterization results enable the influence of the operating variables on each stage of the carbonaceous nanomaterial formation to be discerned

Normalization factors for magnetic relaxation of small particle systems in non-zero magnetic field

We critically discuss relaxation experiments in magnetic systems that can be characterized in terms of an energy barrier distribution, showing that proper normalization of the relaxation data is needed whenever curves corresponding to different temperatures are to be compared. We show how these normalization factors can be obtained from experimental data by using the $T \ln(t/\tau_0)$ scaling method without making any assumptions about the nature of the energy barrier distribution. The validity of the procedure is tested using a ferrofluid of Fe_3O_4 particles.Comment: 5 pages, 6 eps figures added in April 22, to be published in Phys. Rev. B 55 (1 April 1997

Shifted loops and coercivity from field imprinted high energy barriers in ferritin and ferrihydrite nanoparticles

We show that the coercive field in ferritin and ferrihydrite depends on the maximum magnetic field in a hysteresis loop and that coercivity and loop shifts depend both on the maximum and cooling fields. In the case of ferritin we show that the time dependence of the magnetization also depends on the maximum and previous cooling fields. This behavior is associated to changes in the intra-particle energy barriers imprinted by these fields. Accordingly, the dependence of the coercive and loop shift fields with the maximum field in ferritin and ferrihydrite can be described within the frame of a uniform-rotation model considering a dependence of the energy barrier with the maximum and the cooling fields.Comment: 8 pages, 5 figures. Accepted for publication in Phys. Rev. B. Final version with improved writing and figure

Environmental and Economic Water Management in Shale Gas Extraction

This paper introduces a comprehensive study of the Life Cycle Impact Assessment (LCIA) of water management in shale gas exploitation. First, we present a comprehensive study of wastewater treatment in the shale gas extraction, including the most common technologies for the pretreatment and three different desalination technologies of recent interest: Single and Multiple-Effect Evaporation with Mechanical Vapor Recompression and Membrane Distillation. The analysis has been carried out through a generic Life Cycle Assessment (LCA) and the ReCiPe metric (at midpoint and endpoint levels), considering a wide range of environmental impacts. The results show that among these technologies Multiple-Effect Evaporation with Mechanical Vapor Recompression (MEE-MVR) is the most suitable technology for the wastewater treatment in shale gas extraction, taking into account its reduced environmental impact, the high water recovery compared to other alternatives as well as the lower cost of this technology. We also use a comprehensive water management model that includes previous results that takes the form of a new Mixed-Integer Linear Programming (MILP) bi-criterion optimization model to address the profit maximization and the minimization Life Cycle Impact Assessment (LCIA), based on its results we discuss the main tradeoffs between optimal operation from the economic and environmental points of view.This project has received funding from the Spanish «Ministerio de Economía, Industria y Competitividad» under the projects CTQ2016-77968-C3-1-P and CTQ2016-77968-C3-2-P (FEDER, UE)