Fluid inclusions in minerals and zonation of scapolite metasoms (Eastern Pamir).

In the article the questions of Geochemistry and Mineralogy scapolite Deposit of the East Pamirs. Scapolite mineralization is localized in metasomatity Alpine veins. Scapolite occurs in three generations. Early metamorphic scapolite. Milky-white coarse-grained scapolite. Jewelry clear crystals of scapolite from a later generation. Scapolite different generations differ on a number of indicators. The temperature and pressure of mineral formation, the concentration of the solutions and their composition scapolite different

Synthesis and Structure of Trinuclear W3S4 Clusters Bearing Aminophosphine Ligands and Their Reactivity toward Halides and Pseudohalides

The aminophosphine ligand (2-aminoethyl)- diphenylphosphine (edpp) has been coordinated to the W3(μ- S)(μ-S)3 cluster unit to afford trimetallic complex [W3S4Br3(edpp)3]+ (1+) in a one-step synthesis process with high yields. Related [W3S4X3(edpp)3]+ clusters (X = F−, Cl−, NCS−; 2+−4+) have been isolated by treating 1+ with the corresponding halide or pseudohalide salt. The structure of complexes 1+ to 4+ contains an incomplete W3S4 cubane-type cluster unit, and only one of the possible isomers is formed: the one with the phosphorus atoms trans to the capping sulfur and the amino groups trans to the bridging sulphurs. The remaining coordination position on each metal is occupied by X. Detailed studies using stopped-flow, 31P{1H} NMR, and ESI-MS have been carried out in order to understand the solution behavior and the kinetics of interconversion among species 1+, 2+, 3+, and 4+ in solution. Density functional theory (DFT) calculations have been also carried out on the reactions of cluster 1+ with the different anions. The whole set of experimental and theoretical data indicate that the actual mechanism of substitutions in these clusters is strongly dependent on the nature of the leaving and entering anions. The interaction between an entering F− and the amino group coordinated to the adjacent metal have also been found to be especially relevant to the kinetics of these reactions

Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the existing knowledge of CRC. We identify PRKCI, SPZ1, MUTYH, MAP2K4, FETUB, and TGFBR2 as additional genes significantly mutated in CRC. We find that among hypermutated tumors, an increased mutation burden is associated with improved CRC-specific survival (HR=0.42, 95% CI: 0.21-0.82). Mutations in TP53 are associated with poorer CRC-specific survival, which is most pronounced in cases carrying TP53 mutations with predicted 0% transcriptional activity (HR=1.53, 95% CI: 1.21-1.94). Furthermore, we observe differences in mutational frequency of several genes and pathways by tumor location, stage, and sex. Overall, this large study provides deep insights into somatic mutations in CRC, and their potential relationships with survival and tumor features. Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutational burden and specific mutations in TP53 are associated with survival odds

Inner/Outer Nuclear Membrane Fusion in Nuclear Pore Assembly: Biochemical Demonstration and Molecular Analysis

The nuclear pore complex (NPC) is characterized by a long-lived membrane-lined channel connecting the inner and outer nuclear membranes. This stabilized membrane channel, within which the nuclear pore is built, has little evolutionary precedent. In this report we demonstrate and map the inner/outer nuclear membrane fusion in NPC assembly

Fluid inclusions in minerals and zonation of scapolite metasoms (Eastern Pamir).

In the article the questions of Geochemistry and Mineralogy scapolite Deposit of the East Pamirs. Scapolite mineralization is localized in metasomatity Alpine veins. Scapolite occurs in three generations. Early metamorphic scapolite. Milky-white coarse-grained scapolite. Jewelry clear crystals of scapolite from a later generation. Scapolite different generations differ on a number of indicators. The temperature and pressure of mineral formation, the concentration of the solutions and their composition scapolite different

Fluid inclusions in minerals and zonation of scapolite metasoms (Eastern Pamir).

In the article the questions of Geochemistry and Mineralogy scapolite Deposit of the East Pamirs. Scapolite mineralization is localized in metasomatity Alpine veins. Scapolite occurs in three generations. Early metamorphic scapolite. Milky-white coarse-grained scapolite. Jewelry clear crystals of scapolite from a later generation. Scapolite different generations differ on a number of indicators. The temperature and pressure of mineral formation, the concentration of the solutions and their composition scapolite different

Fluid inclusions in minerals and zonation of scapolite metasoms (Eastern Pamir).

In the article the questions of Geochemistry and Mineralogy scapolite Deposit of the East Pamirs. Scapolite mineralization is localized in metasomatity Alpine veins. Scapolite occurs in three generations. Early metamorphic scapolite. Milky-white coarse-grained scapolite. Jewelry clear crystals of scapolite from a later generation. Scapolite different generations differ on a number of indicators. The temperature and pressure of mineral formation, the concentration of the solutions and their composition scapolite different

Data processing as a critical part of GIS based mapping of renewable energy perspectives

Estimation of optimal location for power plants using renewable energy sources requires big data processing and consideration lots of factors. It is suggested to use geographical information systems based approach to simplify workflow. The result of investigation is a series of maps divided into 2 groups: estimation of natural resources for renewable energy, and evaluation of limitations caused with socioeconomic policy. These maps help us to outline the most suitable as well as restricted places for perspective power plants

Data processing as a critical part of GIS based mapping of renewable energy perspectives

Estimation of optimal location for power plants using renewable energy sources requires big data processing and consideration lots of factors. It is suggested to use geographical information systems based approach to simplify workflow. The result of investigation is a series of maps divided into 2 groups: estimation of natural resources for renewable energy, and evaluation of limitations caused with socioeconomic policy. These maps help us to outline the most suitable as well as restricted places for perspective power plants