3,480 research outputs found
Martian atmospheric compositional analysis- its biological significance first quarterly progress report, 15 may - 15 aug. 1965
Biological significance of Martian atmospheric compositional analysis, and life detection studies of chemical free energy in surface matte
Progranulin regulates neurogenesis in the developing vertebrate retina
We evaluated the expression and function of the microgliaâspecific growth factor, Progranulinâa (Pgrnâa) during developmental neurogenesis in the embryonic retina of zebrafish. At 24 hpf pgrnâa is expressed throughout the forebrain, but by 48 hpf pgrnâa is exclusively expressed by microglia and/or microglial precursors within the brain and retina. Knockdown of Pgrnâa does not alter the onset of neurogenic programs or increase cell death, however, in its absence, neurogenesis is significantly delayedâretinal progenitors fail to exit the cell cycle at the appropriate developmental time and postmitotic cells do not acquire markers of terminal differentiation, and microglial precursors do not colonize the retina. Given the link between Progranulin and cell cycle regulation in peripheral tissues and transformed cells, we analyzed cell cycle kinetics among retinal progenitors following Pgrnâa knockdown. Depleting Pgrnâa results in a significant lengthening of the cell cycle. These data suggest that Pgrnâa plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina. Collectively, these data show that Pgrnâa governs neurogenesis by regulating cell cycle kinetics and the transition from proliferation to cell cycle exit and differentiation. © 2017 The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 77: 1114â1129, 2017Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138360/1/dneu22499.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138360/2/dneu22499_am.pd
Materiales y tecnologĂas en la Arquitectura Modernista: casos de estudio de decoraciĂłn de fachadas en Italia, Portugal y Polonia persiguiendo una restauraciĂłn racional
The results of a diagnostic survey on the materials of representative Art Nouveau buildings in Italy, Portugal and Poland are here presented and compared, as a contribution to their understanding and, hence, to support compatible restoration. In particular, the facade decorations were investigated for the appraisal of their materials and technologies, often neglected in current maintenance/restoration works and so cancelled, leading to a severe loss in architectural image. The ongoing diagnostic campaign, in collaboration among different universities, is aimed to set up a database on materials and technologies of Art Nouveau facade decorations at a European scale, as a technical-scientific background for the highlighting of preservation guidelines
Current Status of Copyright Protection in the Digital Age and Related Topics
This Article provides a basic overview of the recent amendments to the copyright law, including the DMCA and recent developments generally, in relation to the protection of digital works. While portions of the discussion are directed to general copyright law, the primary discussion is directed specifically to legal theories used to protect or defend digital works. Interestingly, the DMCA amendments affect only slightly the rights incident to a copyrighted work, but provide significant protection against unauthorized access to copyrighted works
Effect of cycloheximide and actinomycin D on germinating conidia
Effect of cycloheximide and actinomycin D on germinating conidi
What other STI testing should we do for a patient with chlamydia?
Testing for gonorrhea is recommended for a patient with genital chlamydia; also test for gonorrhea and chlamydia in their sexual partner because of the high prevalence of coinfection, particularly among younger patients (strength of recommendation [SOR]: C, based on expert opinion and observational studies). Testing for syphilis and HIV is also recommended for the patient and their partner (SOR: C, based on expert opinion)
How should you evaluate elevated calcium in an asymptomatic patient?
Patients with unexplained asymptomatic true hypercalcemia should be screened for primary hyperparathyroidism (PHPT) and malignancy using an intact parathyroid hormone (PTH) level by immunoradioassay (SOR: C, expert opinion). Other recommended tests that can distinguish PHPT from malignancy and familial hypocalciuric hypercalcemia, as well as help manage patients with PHPT include urinary 24-hour calcium and creatinine levels, parathyroid hormone related peptide (PTHrP), alkaline phosphatase, calcitriol, and bone densitometry (SOR: C, expert opinion)
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