689 research outputs found
Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury
Context: Military recruits and elite athletes are susceptible to stress fracture injuries. Genetic predisposition has been postulated to have a role in their development. The P2X7 receptor (P2X7R) gene, a key regulator of bone remodelling, is a genetic candidate that may contribute to stress fracture predisposition.
Objective: To evaluate the putative contribution of P2X7R to stress fracture injury in two separate cohorts, military personnel and elite athletes.
Methods: In 210 Israeli Defence Forces (IDF) military conscripts, stress fracture injury was diagnosed (n=43) based on symptoms and a positive bone scan. In a separate cohort of 518 elite athletes, self-reported medical imaging scan-certified stress fracture injuries were recorded (n=125). Non-stress fracture controls were identified from these cohorts who had a normal bone scan or no history or symptoms of stress fracture injury. Study participants were genotyped for functional SNPs within the P2X7R gene using proprietary fluorescence-based competitive allele-specific PCR assay. Pearson Chi-square (χ2) tests, corrected for multiple comparisons, were used to assess associations in genotype frequencies.
Results: The variant allele of P2X7R SNP rs3751143 (Glu496Ala- loss of function) was associated with stress fracture injury, while the variant allele of rs1718119 (Ala348Thr- gain of function) was associated with a reduced occurrence of stress fracture injury in military conscripts (P<0.05). The association of the variant allele of rs3751143 with stress fractures was replicated in elite athletes (P<0.05), whereas the variant allele of rs1718119 was also associated with reduced multiple stress fracture cases in elite athletes (P<0.05).
Conclusions: The association between independent P2X7R polymorphisms with stress fracture prevalence supports the role of a genetic predisposition in the development of stress fracture injury
Performances and stability of a 2.4 ton Gd organic liquid scintillator target for antineutrino detection
In this work we report the performances and the chemical and physical
properties of a (2 x 1.2) ton organic liquid scintillator target doped with Gd
up to ~0.1%, and the results of a 2 year long stability survey. In particular
we have monitored the amount of both Gd and primary fluor actually in solution,
the optical and fluorescent properties of the Gd-doped liquid scintillator
(GdLS) and its performances as a neutron detector, namely neutron capture
efficiency and average capture time. The experimental survey is ongoing, the
target being continuously monitored. After two years from the doping time the
performances of the Gd-doped liquid scintillator do not show any hint of
degradation and instability; this conclusion comes both from the laboratory
measurements and from the "in-tank" measurements. This is the largest stable
Gd-doped organic liquid scintillator target ever produced and continuously
operated for a long period
The research of the maximum wind speed in Tomsk and calculations of dynamic load on antenna systems
The work is concerned with calculations and analysis of the maximum wind speed in Tomsk city. The data for analysis were taken from the TOR-station located in the north-eastern part of the city. The TOR-station sensors to measure a speed and a direction of wind are installed on the 10-meter meteorological mast. Wind is measured by M-63, which uses the standard approach and the program with one-minute averaging for wind gusts recording as well. According to the measured results in the research performed, the estimation of the dynamic and wind load on different types of antenna systems was performed. The work shows the calculations of wind load on ten types of antenna systems, distinguished by their different constructions and antenna areas. For implementation of calculations, we used methods developed in the Central Research and Development Institute of Building Constructions named after V.A. Kucherenko. The research results could be used for design engineering of the static antenna systems and mobile tracking systems for the distant objects
A New 76Ge Double Beta Decay Experiment at LNGS
This Letter of Intent has been submitted to the Scientific Committee of the
INFN Laboratori Nazionali del Gran Sasso (LNGS) in March 2004. It describes a
novel facility at the LNGS to study the double beta decay of 76Ge using an
(optionally active) cryogenic fluid shield. The setup will allow to scrutinize
with high significance on a short time scale the current evidence for
neutrinoless double beta decay of 76Ge using the existing 76Ge diodes from the
previous Heidelberg-Moscow and IGEX experiments. An increase in the lifetime
limit can be achieved by adding more enriched detectors, remaining thereby
background-free up to a few 100 kg-years of exposure.Comment: 67 pages, 19 eps figures, 17 tables, gzipped tar fil
The background in the neutrinoless double beta decay experiment GERDA
The GERmanium Detector Array (GERDA) experiment at the Gran Sasso underground
laboratory (LNGS) of INFN is searching for neutrinoless double beta decay of
76Ge. The signature of the signal is a monoenergetic peak at 2039 keV, the
Q-value of the decay, Q_bb. To avoid bias in the signal search, the present
analysis does not consider all those events, that fall in a 40 keV wide region
centered around Q_bb. The main parameters needed for the neutrinoless double
beta decay analysis are described. A background model was developed to describe
the observed energy spectrum. The model contains several contributions, that
are expected on the basis of material screening or that are established by the
observation of characteristic structures in the energy spectrum. The model
predicts a flat energy spectrum for the blinding window around Q_bb with a
background index ranging from 17.6 to 23.8*10^{-3} counts/(keV kg yr). A part
of the data not considered before has been used to test if the predictions of
the background model are consistent. The observed number of events in this
energy region is consistent with the background model. The background at Q-bb
is dominated by close sources, mainly due to 42K, 214Bi, 228Th, 60Co and alpha
emitting isotopes from the 226Ra decay chain. The individual fractions depend
on the assumed locations of the contaminants. It is shown, that after removal
of the known gamma peaks, the energy spectrum can be fitted in an energy range
of 200 kev around Q_bb with a constant background. This gives a background
index consistent with the full model and uncertainties of the same size
Characterization of 30 Ge enriched Broad Energy Ge detectors for GERDA Phase II
The GERmanium Detector Array (GERDA) is a low background experiment located
at the Laboratori Nazionali del Gran Sasso in Italy, which searches for
neutrinoless double beta decay of Ge into Se+2e. GERDA has
been conceived in two phases. Phase II, which started in December 2015,
features several novelties including 30 new Ge detectors. These were
manufactured according to the Broad Energy Germanium (BEGe) detector design
that has a better background discrimination capability and energy resolution
compared to formerly widely-used types. Prior to their installation, the new
BEGe detectors were mounted in vacuum cryostats and characterized in detail in
the HADES underground laboratory in Belgium. This paper describes the
properties and the overall performance of these detectors during operation in
vacuum. The characterization campaign provided not only direct input for GERDA
Phase II data collection and analyses, but also allowed to study detector
phenomena, detector correlations as well as to test the strength of pulse shape
simulation codes.Comment: 29 pages, 18 figure
Background free search for neutrinoless double beta decay with GERDA Phase II
The Standard Model of particle physics cannot explain the dominance of matter
over anti-matter in our Universe. In many model extensions this is a very
natural consequence of neutrinos being their own anti-particles (Majorana
particles) which implies that a lepton number violating radioactive decay named
neutrinoless double beta () decay should exist. The detection
of this extremely rare hypothetical process requires utmost suppression of any
kind of backgrounds.
The GERDA collaboration searches for decay of Ge
(^{76}\rm{Ge} \rightarrow\,^{76}\rm{Se} + 2e^-) by operating bare detectors
made from germanium with enriched Ge fraction in liquid argon. Here, we
report on first data of GERDA Phase II. A background level of
cts/(keVkgyr) has been achieved which is the world-best if
weighted by the narrow energy-signal region of germanium detectors. Combining
Phase I and II data we find no signal and deduce a new lower limit for the
half-life of yr at 90 % C.L. Our sensitivity of
yr is competitive with the one of experiments with
significantly larger isotope mass.
GERDA is the first experiment that will be background-free
up to its design exposure. This progress relies on a novel active veto system,
the superior germanium detector energy resolution and the improved background
recognition of our new detectors. The unique discovery potential of an
essentially background-free search for decay motivates a
larger germanium experiment with higher sensitivity.Comment: 14 pages, 9 figures, 1 table; ; data, figures and images available at
http://www.mpi-hd.mpg/gerda/publi
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