11 research outputs found
Behavioral profiling of multiple pairs of rats selectively bred for high and low alcohol intake using the MCSF test
Genetic aspects of alcoholism have been modeled using rats selectively bred for extremes of alcohol preference and voluntary alcohol intake. These lines show similar alcohol drinking phenotypes but have different genetic and environmental backgrounds and may therefore display diverse behavioral traits as seen in human alcoholics. The multivariate concentric square field™ (MCSF) test is designed to provoke exploration and behaviors associated with risk assessment, risk taking and shelter seeking in a novel environment. The aim was to use the MCSF to characterize behavioral profiles in rat lines from selective breeding programs in the United States (P/NP, HAD1/LAD1, HAD2/LAD2), Italy (sP/sNP) and Finland (AA/ANA). The open field and elevated plus maze tests were used as reference tests. There were substantial differences within some of the pairs of selectively bred rat lines as well as between all alcohol-preferring rats. The most pronounced differences within the pairs of lines were between AA and ANA rats and between sP and sNP rats followed by intermediate differences between P and NP rats and minor differences comparing HAD and LAD rats. Among all preferring lines, P, HAD1 and HAD2 rats shared similar behavioral profiles, while AA and sP rats were quite different from each other and the others. No single trait appeared to form a common 'pathway' associated with a high alcohol drinking phenotype among all of the alcohol-preferring lines of rats. The marked behavioral differences found in the different alcohol-preferring lines may mimic the heterogeneity observed among human alcoholic subtypes
J. NORMAN LOCKYER. — On the evidence of variation in molecular structure (Sur la preuve d'une variation dans la structure moléculaire); Proceedings of the Royal Society, t. XXII, p. 372; 1874
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J. NORMAN LOCKYER. — On a new class of absorption phenomena (Sur une nouvelle classe de phénomènes d'absorption); Proceedings of the royal Society, t. XXII, p. 378, juin 1874
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JOHN TYNDALL. — Further experiments on the transmission of sound (Nouvelles expériences sur la transmission du son); Proceedings of the royal Society, p. 359, juin 1874
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J. TYKDALL. — The acoustic transparency and opacity of the atmosphere (La transparence et l'opacité acoustique); Nature, Journal of Science, janvier et février 1874, p. 251 et 267
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Note sur les spectres d'absorption du potassium et du sodium à de basses températures
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