237 research outputs found
Linear feedback control of transient energy growth and control performance limitations in subcritical plane Poiseuille flow
Suppression of the transient energy growth in subcritical plane Poiseuille
flow via feedback control is addressed. It is assumed that the time derivative
of any of the velocity components can be imposed at the walls as control input,
and that full-state information is available. We show that it is impossible to
design a linear state-feedback controller that leads to a closed-loop flow
system without transient energy growth.
In a subsequent step, full-state feedback controllers -- directly targeting
the transient growth mechanism -- are designed, using a procedure based on a
Linear Matrix Inequalities approach. The performance of such controllers is
analyzed first in the linear case, where comparison to previously proposed
linear-quadratic optimal controllers is made; further, transition thresholds
are evaluated via Direct Numerical Simulations of the controlled
three-dimensional Poiseuille flow against different initial conditions of
physical interest, employing different velocity components as wall actuation.
The present controllers are effective in increasing the transition thresholds
in closed loop, with varying degree of performance depending on the initial
condition and the actuation component employed
Model-based Aeroservoelastic Design and Load Alleviation of Large Wind Turbine Blades
This paper presents an aeroservoelastic modeling approach for dynamic load alleviation
in large wind turbines with trailing-edge aerodynamic surfaces. The tower, potentially on a
moving base, and the rotating blades are modeled using geometrically non-linear composite
beams, which are linearized around reference conditions with arbitrarily-large structural
displacements. Time-domain aerodynamics are given by a linearized 3-D unsteady vortexlattice
method and the resulting dynamic aeroelastic model is written in a state-space
formulation suitable for model reductions and control synthesis. A linear model of a single
blade is used to design a Linear-Quadratic-Gaussian regulator on its root-bending moments,
which is finally shown to provide load reductions of about 20% in closed-loop on the full
wind turbine non-linear aeroelastic model
Modelling for Robust Feedback Control of Fluid Flows
This paper addresses the problem of obtaining low-order models of fluid flows for the purpose of designing robust feedback controllers. This is challenging since whilst many flows are governed by a set of nonlinear, partial differential-algebraic equations (the Navier-Stokes equations), the majority of established control theory assumes models of much greater simplicity, in that they are firstly: linear, secondly: described by ordinary differential equations, and thirdly: finite-dimensional. Linearisation, where appropriate, overcomes the first disparity, but attempts to reconcile the remaining two have proved difficult. This paper addresses these two problems as follows. Firstly, a numerical approach is used to project the governing equations onto a divergence-free basis, thus converting a system of differential-algebraic equations into one of ordinary differential equations. This dispenses with the need for analytical velocity-vorticity transformations, and thus simplifies the modelling of boundary sensing and actuation. Secondly, this paper presents a novel and straightforward approach for obtaining suitable low-order models of fluid flows, from which robust feedback controllers can be synthesised that provide~\emph{a~priori} guarantees of robust performance when connected to the (infinite-dimensional) linearised flow system. This approach overcomes many of the problems inherent in approaches that rely upon model-reduction. To illustrate these methods, a perturbation shear stress controller is designed and applied to plane channel flow, assuming arrays of wall mounted shear-stress sensors and transpiration actuators. DNS results demonstrate robust attenuation of the perturbation shear-stresses across a wide range of Reynolds numbers with a single, linear controller
The Quantum Theory of MIMO Markovian Feedback with Diffusive Measurements
Feedback control engineers have been interested in MIMO (multiple-input
multiple-output) extensions of SISO (single-input single-output) results of
various kinds due to its rich mathematical structure and practical
applications. An outstanding problem in quantum feedback control is the
extension of the SISO theory of Markovian feedback by Wiseman and Milburn
[Phys. Rev. Lett. {\bf 70}, 548 (1993)] to multiple inputs and multiple
outputs. Here we generalize the SISO homodyne-mediated feedback theory to allow
for multiple inputs, multiple outputs, and \emph{arbitrary} diffusive quantum
measurements. We thus obtain a MIMO framework which resembles the SISO theory
and whose additional mathematical structure is highlighted by the extensive use
of vector-operator algebra.Comment: 17 pages, 2 figure
Network modeling of the transcriptional effects of copy number aberrations in glioblastoma
DNA copy number aberrations (CNAs) are a characteristic feature of cancer genomes. In this work, Rebecka Jörnsten, Sven Nelander and colleagues combine network modeling and experimental methods to analyze the systems-level effects of CNAs in glioblastoma
Concept of a Maneuvering Load Control System and Effect on the Fatigue Life Extension
Abstract This paper presents a methodology for the conceptual design of a Maneuver Load Control system taking into account the airframe flexibility. The system, when switched on, is able to minimize the bending moment augmentation at a wing station near the wing root during an unsteady longitudinal maneuver. The reduction of the incremental wing bending moment due to maneuvers can lead to benefits such as improved pay-loads/gross weight capabilities and/or extended structural fatigue life. The maneuver is performed by following a desired vertical load factor law with elevators deflections, starting from the trim equilibrium in level flight. The system observes load factor and structural bending through accelerometers and calibrated strain sensors and then sends signals to a computer that symmetrically actuates ailerons for reducing the structural bending and elevators for compensating the perturbation to the longitudinal equilibrium. The major limit of this kind of systems appears when it has to be installed on commercial transport aircraft for reduced OEW or augmented wing aspect-ratio. In this case extensive RAMS analyses and high redundancy of the MLC related sub-systems are required by the Certification Authority. Otherwise the structural design must be performed at system off. Thus the unique actual benefit to be gained from the adoption of a MLC system on a commercial transport is the fatigue life extension. An application to a business aircraft responding to the EASA Certification Specifications, Part 25, has been performed. The aircraft used for the numerical application is considered only as a test case-study. Most of design and analysis considerations are applicable also to other aircraft, such as unmanned or military ones, although some design requirements can be clearly different. The estimation of the fatigue life extension of a structural joint (wing lower skin-stringer), located close to the wing root, has been estimated by showing the expected benefit to be gained from the adoption of such a maneuvering load control system
How Xenopus laevis embryos replicate reliably: investigating the random-completion problem
DNA synthesis in \textit{Xenopus} frog embryos initiates stochastically in
time at many sites (origins) along the chromosome. Stochastic initiation
implies fluctuations in the time to complete and may lead to cell death if
replication takes longer than the cell cycle time ( min).
Surprisingly, although the typical replication time is about 20 min, \textit{in
vivo} experiments show that replication fails to complete only about 1 in 300
times. How is replication timing accurately controlled despite the
stochasticity? Biologists have proposed two solutions to this
"random-completion problem." The first solution uses randomly located origins
but increases their rate of initiation as S phase proceeds, while the second
uses regularly spaced origins. In this paper, we investigate the
random-completion problem using a type of model first developed to describe the
kinetics of first-order phase transitions. Using methods from the field of
extreme-value statistics, we derive the distribution of replication-completion
times for a finite genome. We then argue that the biologists' first solution to
the problem is not only consistent with experiment but also nearly optimizes
the use of replicative proteins. We also show that spatial regularity in origin
placement does not alter significantly the distribution of replication times
and, thus, is not needed for the control of replication timing.Comment: 16 pages, 9 figures, submitted to Physical Review
A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
To identify the susceptibility gene in hand osteoarthritis (OA) the authors used a two-stage approach genome-wide association study using two discovery samples (the TwinsUK cohort and the Rotterdam discovery subset; a total of 1804 subjects) and four replication samples (the Chingford Study, the Chuvasha Skeletal Aging Study, the Rotterdam replication subset and the Genetics, Arthrosis, and Progression (GARP) Study; a total of 3266 people). Five single-nucleotide polymorphisms (SNPs) had a likelihood of association with hand OA in the discovery stage and one of them (rs716508), was successfully confirmed in the replication stage (meta-analysis p = 1.81×10−5). The C allele conferred a reduced risk of 33% to 41% using a case–control definition. The SNP is located in intron 1 of the A2BP1 gene. This study also found that the same allele of the SNP significantly reduced bone density at both the hip and spine (p<0.01), suggesting the potential mechanism of the gene in hand OA might be via effects on subchondral bone. The authors' findings provide a potential new insight into genetic mechanisms in the development of hand OA
Centralized Inverted Decoupling Control
This paper presents a new methodology of multivariable centralized control based on the structure of inverted decoupling. The method is presented for general n×n processes, obtaining very simple general expressions for the controller elements with a complexity independent of the system size. The possible configurations and realizability conditions are stated. Then, the specification of performance requirements is carried out from simple open loop transfer functions for three common cases. As a particular case, it is shown that the resulting controller elements have PI structure or filtered derivative action plus a time delay when the process elements are given by first order plus time delay systems. Comparisons with other works demonstrate the effectiveness of this methodology through the use of several simulation examples and an experimental lab process
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