Antigonos Gonatas : coinage, money and the economy

'Antigonos Gonatas: Coinage, Money and the Economy' is a presentation and systematic analysis of the precious metal coinages in the name of `king Antigonos'. Most of these issues, including (a) gold staters and silver tetradrachms with the types of Alexander III and (b) silver with individual Antigonid types (tetradrachms, `Pans' and 'Poseidons'; a few drachmae, `Pans' and 'Zeus'; pentobols, `Zeus'), are traditionally assigned to the Makedonian king Antigonos Gonatas (r. 283/277-239 BC). However, their relative chronology and their respective presence in hoards allow for their wider distribution from Gonatas to his later homonym, Antigonos Doson, and for their production at a single mint, demonstrating thus a strong sense of dynastic continuity among Gonatas' successors(chapter 2). It is argued that the numismatic iconography aligns itself with the main threads of the Antigonid international policy established by Gonatas: the Antigonids, following the example of the Temenids, deliberately emphasised their Hellenic identity and piety, in order to become assimilated to the military and political `debates' both in mainland Greece and on an international level. The introduction, in particular, of the second Antigonid tetradrachm type, the Poseidon-head, meant the resumption of the naval claims of Monophthalmos and Poliorketes in the Aegean concomitantly to Gonatas' victorious naval battle against the Ptolemaic fleet at Andros (chapters 2.1,2.4). The analysis of the numismatic material (chapters 3-6) is a prerequisite for a tentative estimation of its approximate quantity and for a better assessment of its distribution pattern. The disproportion between the low annual production rate of these issues and the Antigonid financial requirements may be explained by the use of other precious metal coinages following the Attic weight standard (chapter 7). It is therefore argued that the exercise by the Antigonids of pro-active economic and administrative control was limited and that the introduction of the Antigonid individual issues was inspired by political alongside economic forces

Magnetostratigraphic and chronostratigraphic constraints on the Marathousa 1 Lower Palaeolithic site and the Middle Pleistocene deposits of the Megalopolis basin, Greece

We investigated the magnetostratigraphy of the Megalopolis basin in central Peloponnese, Greece, which encompasses a record of Pleistocene lacustrine and lignite-bearing sedimentation, where lithic tools stratigraphically associated with remnants of an almost complete skeleton of Palaeoloxodon antiquus were recently found at the Marathousa 1 site. A magnetic polarity reversal was observed within a 3c10 m-thick lignite seam at the base of the (exposed) stratigraphic sequence, and it was interpreted as a record of the Brunhes/Matuyama boundary (0.78 Ma). Assuming that lignite seams were deposited generally under warm and humid climate conditions, this finding is in agreement with data from the literature indicating that the Brunhes/Matuyama boundary occurs within warm Marine Isotope Stage (MIS) 19. We then attempted to correlate the remainder of the lacustrine and lignite-bearing intervals above the Brunhes/Matuyama boundary to a standard oxygen isotope record of Pleistocene climate variability. Two age models of sedimentation were generated: according to preferred option #1, the artifact-bearing stratigraphic units of the Marathousa 1 site should have an age between 3c0.48 Ma and 3c0.42 Ma, while according to alternative option #2, the archaeological layers would have an age between 3c0.56 Ma and 3c0.54 Ma. Option #1 is at present considered the preferred option as it is in closer agreement with preliminary post-IR IRSL and ESR dates from the Marathousa 1 site. This age model has been exported to other areas of the Megalopolis basin, where additional archaeological and/or palaeontological sites could be present, by means of correlations to lithostratigraphic logs derived from commercial drill cores taken in the 1960s and 1970s for lignite exploitation

Overcoming job demands to deliver high quality of care in the hospital setting across Europe: the role of teamwork and positivity

Health care professionals deal on a daily basis with several job demands – emotional, cognitive, organizational and physical. They must also ensure high quality care to their patients. The aim of this study is to analyse the impact of job demands on quality of care and to investigate team (backup behaviors) and individual (positivity ratio) processes that help to shield that impact. Data was collected from 2,890 doctors and nurses in 9 European countries by means of questionnaires. Job demands have a negative impact on the quality of care delivered by health professionals. Backup behaviors had a mediating effect between job demands and quality of care. Also, the positivity ratio of professionals (ratio of positive and negative emotions experienced) was also found as a significant mediator between most job demands and quality of care dimensions. Finally, we found a double mediation between most job demands and quality of care, where backup behaviors influenced the positivity ratio. Quality of care in hospitals is closely related to job demands. Hospital managers should consider the importance of cooperation within health care professionals’ teams and ought to find ways to develop teamwork in order to promote patients’ safety

Thorough investigation of the phenolic profile of reputable Greek honey varieties:varietal discrimination and floral markers identification using liquid chromatography–high-resolution mass spectrometry

Honey is a highly consumed commodity due to its potential health benefits upon certain consumption, resulting in a high market price. This fact indicates the need to protect honey from fraudulent acts by delivering comprehensive analytical methodologies. In this study, targeted, suspect and non-targeted metabolomic workflows were applied to identify botanical origin markers of Greek honey. Blossom honey samples (n = 62) and the unifloral fir (n = 10), oak (n = 24), pine (n = 39) and thyme (n = 34) honeys were analyzed using an ultra-high-performance liquid chromatography hybrid quadrupole time-of-flight mass spectrometry (UHPLC-q-TOF-MS) system. Several potential authenticity markers were revealed from the application of different metabolomic workflows. In detail, based on quantitative targeted analysis, three blossom honey markers were found, namely, galangin, pinocembrin and chrysin, while gallic acid concentration was found to be significantly higher in oak honey. Using suspect screening workflow, 12 additional bioactive compounds were identified and semi-quantified, achieving comprehensive metabolomic honey characterization. Lastly, by combining non-targeted screening with advanced chemometrics, it was possible to discriminate thyme from blossom honey and develop binary discriminatory models with high predictive power. In conclusion, a holistic approach to assessing the botanical origin of Greek honey is presented, highlighting the complementarity of the three applied metabolomic approaches

A palaeoenvironmental reconstruction (based on palaeobotanical data and diatoms) of the Middle Pleistocene elephant (Palaeoloxodon antiquus) butchery site at Marathousa, Megalopolis, Greece

Bioarchaeolog

Effect of synbiotic supplementation in children and adolescents with cystic fibrosis: a randomized controlled clinical trial

BACKGROUND/OBJECTIVES:Cystic fibrosis (CF) is characterized by excessive activation of immune processes. The aim of this study was to evaluate the effect of synbiotic supplementation on the inflammatory response in children/adolescents with CF. SUBJECTS/METHODS:A randomized, placebo-controlled, double-blind, clinical-trial was conducted with control group (CG, n = 17), placebo-CF-group (PCFG, n = 19), synbiotic CF-group (SCFG, n = 22), PCFG negative (n = 8) and positive (n = 11) bacteriology, and SCFG negative (n = 12) and positive (n = 10) bacteriology. Markers of lung function (FEV1), nutritional status [body mass index-for age (BMI/A), height-for-age (H/A), weight-for-age (W/A), upper-arm fat area (UFA), upper-arm muscle area (UMA), body fat (%BF)], and inflammation [interleukin (IL)-12, tumor necrosis factor-alpha (TNF-α), IL-10, IL-6, IL-1β, IL-8, myeloperoxidase (MPO), nitric oxide metabolites (NOx)] were evaluated before and after 90-day of supplementation with a synbiotic. RESULTS:No significance difference was found between the baseline and end evaluations of FEV1 and nutricional status markers. A significant interaction (time vs. group) was found for IL-12 (p = 0.010) and myeloperoxidase (p = 0.036) between PCFG and SCFG, however, the difference was not maintained after assessing the groups individually. NOx diminished significantly after supplementation in the SCFG (p = 0.030). In the SCFG with positive bacteriology, reductions were found in IL-6 (p = 0.033) and IL-8 (p = 0.009) after supplementation. CONCLUSIONS: Synbiotic supplementation shown promise at diminishing the pro-inflammatory markers IL-6, IL-8 in the SCFG with positive bacteriology and NOx in the SCFG in children/adolescents with CF

Variability of wavefront aberration measurements in small pupil sizes using a clinical Shack-Hartmann aberrometer

BACKGROUND: Recently, instruments for the measurement of wavefront aberration in the living human eye have been widely available for clinical applications. Despite the extensive background experience on wavefront sensing for research purposes, the information derived from such instrumentation in a clinical setting should not be considered a priori precise. We report on the variability of such an instrument at two different pupil sizes. METHODS: A clinical aberrometer (COAS Wavefront Scienses, Ltd) based on the Shack-Hartmann principle was employed in this study. Fifty consecutive measurements were perfomed on each right eye of four subjects. We compared the variance of individual Zernike expansion coefficients as determined by the aberrometer with the variance of coefficients calculated using a mathematical method for scaling the expansion coefficients to reconstruct wavefront aberration for a reduced-size pupil. RESULTS: Wavefront aberration exhibits a marked variance of the order of 0.45 microns near the edge of the pupil whereas the central part appears to be measured more consistently. Dispersion of Zernike expansion coefficients was lower when calculated by the scaling method for a pupil diameter of 3 mm as compared to the one introduced when only the central 3 mm of the Shack – Hartmann image was evaluated. Signal-to-noise ratio was lower for higher order aberrations than for low order coefficients corresponding to the sphero-cylindrical error. For each subject a number of Zernike expansion coefficients was below noise level and should not be considered trustworthy. CONCLUSION: Wavefront aberration data used in clinical care should not be extracted from a single measurement, which represents only a static snapshot of a dynamically changing aberration pattern. This observation must be taken into account in order to prevent ambiguous conclusions in clinical practice and especially in refractive surgery

Feasibility and acceptability of expressive writing with postpartum women: a randomised controlled trial

Abstract Background: Pregnancy, birth and adjusting to a new baby is a potentially stressful time that can negatively affect women’s mental and physical health. Expressive writing, where people write about a stressful event for at least 15 minutes on three consecutive days, has been associated with improved health in some groups but it is not clear whether it is feasible and acceptable for use with postpartum women. This study therefore examined the feasibility and acceptability of expressive writing for postpartum women as part of a randomised controlled trial (RCT). Methods: The Health After Birth Trial (HABiT) was an RCT evaluating expressive writing for postpartum women which included measures of feasibility and acceptability. At 6 to 12 weeks after birth 854 women were randomised to expressive writing, a control writing task or normal care, and outcome measures of health were measured at baseline, one month later and six months later. Feasibility was measured by recruitment, attrition, and adherence to the intervention. Quantitative and qualitative measures of acceptability of the materials and the task were completed six months after the intervention. Results: Recruitment was low (10.7% of those invited to participate) and the recruited sample was from a restricted sociodemographic range. Attrition was high, increased as the study progressed (35.8% at baseline, 57.5% at one month, and 68.1% at six months) and was higher in the writing groups than in the normal care group. Women complied with instructions to write expressively or not, but adherence to the instruction to write for 15 minutes per day for three days was low (Expressive writing: 29.3%; Control writing: 23.5%). Acceptability measures showed that women who wrote expressively rated the materials/task both more positively and more negatively than those in the control writing group, and qualitative comments revealed that women enjoyed the writing and/or found it helpful even when it was upsetting. Conclusions: The feasibility of offering expressive writing as a universal self-help intervention to all postpartum women 6 to 12 weeks after birth in the HABiT trial was low, but the expressive writing intervention was acceptable to the majority of women who completed it