A Study of Aspects on Gender and Prognosis in Synchronous Colorectal Cancer

Abstract Aim To assess differences in demography, pathology and prognosis with tumor multiplicity in colorectal cancer. Method A retrospective single centre study of all patients surgically treated for a colorectal cancer during 1999–2008 (n = 2524). Patient characteristics, pathology and follow-up data were retrieved. Survival was assessed by overall and cancer specific survival. Results 60 (2.4%) patients had a synchronous cancer (SC), associated with right colon, higher age, more assessed lymph nodes but a lower frequency of stage III/IV disease (42% vs. 52%). There was no overall prognostic difference between single or multiple cancer patients but females with SC had better survival than corresponding males ( P < 0.046). Conclusion The incidence of synchronous cancers was 2.4% with the second cancer often located in right colon. The SC patients were older than single tumor patients, had a lower frequency of stage III/IV disease and the females with SC had a better survival prognosis than corresponding males

Improved dietary guidelines for vitamin D: application of individual participant data (IPD)-level meta-regression analyses

Dietary Reference Values (DRVs) for vitamin D have a key role in the prevention of vitamin D deficiency. However, despite adopting similar risk assessment protocols, estimates from authoritative agencies over the last 6 years have been diverse. This may have arisen from diverse approaches to data analysis. Modelling strategies for pooling of individual subject data from cognate vitamin D randomized controlled trials (RCTs) are likely to provide the most appropriate DRV estimates. Thus, the objective of the present work was to undertake the first-ever individual participant data (IPD)-level meta-regression, which is increasingly recognized as best practice, from seven winter-based RCTs (with 882 participants ranging in age from 4 to 90 years) of the vitamin D intake–serum 25-hydroxyvitamin D (25(OH)D) dose-response. Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of 25(OH)D concentrations >25, 30, and 50 nmol/L across the population are 10, 13, and 26 µg/day, respectively. In contrast, standard meta-regression analyses with aggregate data (as used by several agencies in recent years) from the same RCTs estimated that a vitamin D intake requirement of 14 µg/day would maintain 97.5% of 25(OH)D >50 nmol/L. These first IPD-derived estimates offer improved dietary recommendations for vitamin D because the underpinning modeling captures the between-person variability in response of serum 25(OH)D to vitamin D intake

DESARROLLO DE UNA CÁMARA DE IMPLANTACIÓN IÓNICA PARA LA GENERACIÓN DE DEFECTOS ESTRUCTURALES EN SISTEMAS NO MAGNÉTICOS

Durante las últimas dos décadas varios trabajos han reportado la aparición de ordenamiento magnético a temperatura ambiente en óxidos semiconductores dopados con iones magnéticos. Sin embargo, ahora se acepta que el origen del estado magnéticamente ordenado en óxidos semiconductores diluidos está relacionado con la formación de defectos estructurales y/o agregados iónicos, que no son necesariamente magnéticos, fenómeno llamado magnetismo inducido por defectos (DIM). Se ha demostrado teóricamente que es posible el orden magnético en sólidos intrínsecamente no magnéticos debido a la influencia del hidrógeno,&nbsp; y se ha observado experimentalmente en grafito así como en muestras de ZnO no dopado y dopado. Trabajos publicados recientemente demostraron que el tratamiento con plasma de hidrógeno a bajas energías de implantación (300 eV) y temperaturas relativamente bajas (T 700 K) puede desencadenar el orden magnético a temperatura ambiente en monocristales de ZnO después de la implantación de H atómico a bajas concentraciones. En este trabajo presentamos el desarrollo de una cámara de implantación de iones de Ar+H2 producidos en un plasma remoto de corriente directa (DC). Fueron implantadas capas delgadas de ZnO obtenidas por RF-Magnetron Sputtering. Analizamos la relación existente entre la formación de defectos estructurales, condiciones de depósito de las películas delgadas y propiedades magnéticas

Scientific and Regulatory Policy Committee (SRPC) Review*: Interpretation and Use of Cell Proliferation Data in Cancer Risk Assessment

Increased cell proliferation is a central key event in the mode of action for many non-genotoxic carcinogens, and quantitative cell proliferation data play an important role in the cancer risk assessment of many pharmaceutical and environmental compounds. Currently, there is limited unified information on assay standards, reference values, targeted applications, study design issues, and quality control considerations for proliferation data. Here, we review issues in measuring cell proliferation indices, considerations for targeted studies, and applications within current risk assessment frameworks. As the regulatory environment moves toward more prospective evaluations based on quantitative pathway-based models, standardiza- tion of proliferation assays will become an increasingly important part of cancer risk assessment. To help address this development, we also discuss the potential role for proliferation data as a component of alternative carcinogenicity testing models. This information should improve consistency of cell proliferation methods and increase efficiency of targeted testing strategies

Observation of water vapor in the stratosphere of Jupiter with the Odin Space Telescope.

International audienceThe water vapor line at 557 GHz has been observed with the Odin space telescope with a high signal-to-noise ratio and a high spectral resolution on November 8, 2002. The analysis of this observation as well as a re-analysis of previously published observations obtained with the SubmillimeterWavelength Astronomy Satellite seem to favor a cometary origin (Shoemaker-Levy 9) for water in the stratosphere of Jupiter, in agreement with the ISO observation results. Our model predicts that the water line should become fainter and broader from 2007. The observation of such a temporal variablity would be contradictory with an IDP steady flux, thussupporting the SL9 source hypothesis

Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program

Navigate PD was an educational program established to supplement existing guidelines and provide recommendations on the management of Parkinson's disease (PD) refractory to oral/transdermal therapies. It involved 103 experts from 13 countries overseen by an International Steering Committee (ISC) of 13 movement disorder specialists. The ISC identified 71 clinical questions important for device-aided management of PD. Fifty-six experts responded to a web-based survey, rating 15 questions as ‘critically important;’ these were refined to 10 questions by the ISC to be addressed through available evidence and expert opinion. Draft guidance was presented at international/national meetings and revised based on feedback. Key take-home points are: • Patients requiring levodopa &gt;5 times daily who have severe, troublesome ‘off’ periods (&gt;1–2 h/day) despite optimal oral/transdermal levodopa or non-levodopa-based therapies should be referred for specialist assessment even if disease duration is &lt;4 years. • Cognitive decline related to non-motor fluctuations is an indication for device-aided therapies. If cognitive impairment is mild, use deep brain stimulation (DBS) with caution. For patients who have cognitive impairment or dementia, intrajejunal levodopa infusion is considered as both therapeutic and palliative in some countries. Falls are linked to cognitive decline and are likely to become more frequent with device-aided therapies. • Insufficient control of motor complications (or drug-resistant tremor in the case of DBS) are indications for device-aided therapies. Levodopa-carbidopa intestinal gel infusions or subcutaneous apomorphine pump may be considered for patients aged &gt;70 years who have mild or moderate cognitive impairment, severe depression or other contraindications to DBS

A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease

BACKGROUND: The relationships between primary sclerosing cholangitis (PSC) and the environment are largely unknown. AIM: To validate associations reported in previous studies and to identify novel environmental exposures among PSC patients. METHODS: We performed a multicenter, case-control analysis utilising self-administered questionnaires. Responses between cases (n = 1000) and controls (n = 663) were compared using multivariable logistic regression adjusted for age and gender. The model was further stratified based on inflammatory bowel disease (IBD) status (with IBD n = 741 without IBD n = 259). RESULTS: Smoking was associated with PSC only when IBD was present (OR, 0.5; 95% CI 0.4-0.7) but not among those PSC patients without IBD (OR, 0.9; 95% CI 0.7-1.2). Compared to controls, women with PSC (irrespective of the presence of IBD) were less likely to have received hormone replacement therapy (HRT; OR, 0.5; 95% CI 0.4-0.7) and were more likely to have recurrent urinary tract infections (OR, 1.6; 95% CI 1.2-2.3). PSC patients regardless of gender or IBD status were less likely to eat fish (OR, 0.4; 95% CI 0.3-0.6) and grilled/barbecued meat (OR, 0.8; 95% CI 0.7-0.9). In contrast, PSC patients with and without IBD were more likely to consume steak/burgers that were more well done (OR, 1.3; 95% CI 1.2-1.5). CONCLUSIONS: IBD (rather than PSC) is associated with smoking. Women with PSC are more likely to have recurrent urinary tract infections and less likely to receive HRT. Dietary intake and methods of food preparation differ in PSC patients when compared to controls

Specific heat of classical disordered elastic systems

We study the thermodynamics of disordered elastic systems, applied to vortex lattices in the Bragg glass phase. Using the replica variational method we compute the specific heat of pinned vortons in the classical limit. We find that the contribution of disorder is positive, linear at low temperature, and exhibits a maximum. It is found to be important compared to other contributions, e.g. core electrons, mean field and non linear elasticity that we evaluate. The contribution of droplets is subdominant at weak disorder in $d=3$.Comment: 4 pages, RevTe