Donor genetic determinant of thymopoiesis, rs2204985, and stem cell transplantation outcome in a multipopulation cohort

\ua9 2024 The Author(s)Background: A genetic polymorphism, rs2204985, has been reported to be associated with the diversity of T-cell antigen receptor repertoire and TREC levels, reflecting the function of the thymus. As the thymus function can be assumed to be an important factor regulating the outcome of stem cell transplantation (SCT), it was of great interest that rs2204985 showed a genetic association to disease-free and overall survival in a German SCT donor cohort. Tools to predict the outcome of SCT more accurately would help in risk assessment and patient safety. Objective: To evaluate the general validity of the original genetic association found in the German cohort, we determined genetic associations between rs2204985 and the outcome of SCT in 1,473 SCT donors from four different populations. Study design: Genetic associations between rs2204985 genotype AA versus AG/GG and overall survival (OS) and disease-free survival (DFS) in 1,473 adult, allogeneic SCT from Finland, the United Kingdom, Spain, and Poland were performed using the Kaplan-Meier analysis and log-rank tests. We adjusted the survival models with covariates using Cox regression. Results: In unrelated SCT donors (N = 425), the OS of genotype AA versus AG/GG had a trend for a similar association (p = 0.049, log-rank test) as previously reported in the German cohort. The trend did not remain significant in the Cox regression analysis with covariates. No other associations were found. Conclusion: Weak support for the genetic association between rs2204985, previously also associated with thymus function, and the outcome of SCT could be found in a cohort from four populations

Dementia as a determinant of social and health service use in the last two years of life 1996-2003

<p>Abstract</p> <p>Background</p> <p>Dementia is one of the most common causes of death among old people in Finland and other countries with high life expectancies. Dementing illnesses are the most important disease group behind the need for long-term care and therefore place a considerable burden on the health and social care system. The aim of this study was to assess the effects of dementia and year of death (1998-2003) on health and social service use in the last two years of life among old people.</p> <p>Methods</p> <p>The data were derived from multiple national registers in Finland and comprise all those who died in 1998, 2002 or 2003 and 40% of those who died in 1999-2001 at the age of 70 or over (n = 145 944). We studied the use of hospitals, long-term care and home care in the last two years of life. Statistics were performed using binary logistic regression analyses and negative binomial regression analyses, adjusting for age, gender and comorbidity.</p> <p>Results</p> <p>The proportion of study participants with a dementia diagnosis was 23.5%. People with dementia diagnosis used long-term care more often (OR 9.30, 95% CI 8.60, 10.06) but hospital (OR 0.33, 95% CI 0.31, 0.35) and home care (OR 0.50, 95% CI 0.46, 0.54) less often than people without dementia. The likelihood of using university hospital and long-term care increased during the eight-year study period, while the number of days spent in university and general hospital among the users decreased. Differences in service use between people with and without dementia decreased during the study period.</p> <p>Conclusions</p> <p>Old people with dementia used long-term care to a much greater extent and hospital and home care to a lesser extent than those without dementia. This difference persisted even when controlling for age, gender and comorbidity. It is important that greater attention is paid to ensuring that old people with dementia have equitable access to care.</p

Rigid and Non-rigid Shape Matching for Mechanical Components Retrieval

Reducing the setup time for a new production line is critical to the success of a manufacturer within the current competitive and cost-conscious market. To this end, being able to reuse already available machines, toolings and parts is paramount. However, matching a large warehouse of previously engineered parts to a new component to produce, is often more a matter of art and personal expertise rather than predictable science. In order to ease this process we developed a database retrieval approach for mechanical components that is able to deal with both rigid matching and deformable shapes. The intended use for the system is to match parts acquired with a 3D scanning system to a large database of components and to supply a list of results sorted according with a metric that expresses a structural distance. © 2012 IFIP International Federation for Information Processing

Life expectancy in long-term institutional care by marital status: multistate life table estimates for older Finnish men and women

Objectives.We estimate (a) probabilities of moving to and from long-Term institutional care and probabilities of death and (b) life expectancy in the community and in care by gender and marital status.Method.A 40% random sample of Finns aged 65+ at the end of 1997 (n = 301,263) drawn from the population register was linked with register-based information on sociodemographic characteristics, entry and exit dates for long-Term institutional care, and dates of death in 1998-2003. Probabilities and life expectancies were estimated using multistate life tables.Results.At age 65, women are expected to spend more of their remaining lifetime in institutions than men (1.6 and 0.7 years, respectively). These care expectancies remain similar even for survivors to very advanced ages. Gender differences are driven by women's higher chances of entering institutions at ages above 80 years and lower chances of exit. At age 65, 59% of women and 36% of men will ever enter long-Term institutions. The married spend less of their longer life expectancy in institutions than the non-married. The large gender difference in care use exists within each marital status group.Discussion.The resources that are needed to provide long-Term care services will increase as age of death increases. We demonstrate significantly longer care expectancy among women and among the unmarried

Gender, living arrangements and social circumstances as determinants of entry into and exit from long-term institutional care at older ages: a six-year follow-up study of older Finns

Purpose: Due to population ageing, the need for long-term institutional care is increasing. We study the potentially modifiable sociodemographic factors that affect the rate of entry into and exit from long-term care. Design and Methods: A 40% sample from the population registration data of Finns aged 65 and older living in private households at the end of 1997 (n = 280,722) was followed for first entry into (n = 35,926) and subsequent exit—due to death or return to the community—from long-term institutional care until the end of 2003. Results: Being female, old, living alone, and of low socioeconomic status increased the risk for entering long-term care. Exit was affected by the same factors, but the associations were weaker and, with the exception of age, in the opposite direction. Women's higher risk for entry was due to older age and greater likelihood of living alone. The effects of living arrangements and socioeconomic factors on entry were stronger among men and were attenuated after adjustment for each other and for health status. The mean duration of care was 1,064 days among women and 686 among men. Implications: Gender, age, living arrangements, and socioeconomic status are major determinants of institutional residence. Women and certain other population groups, e.g., those living alone, are likely to spend a longer time in institutional care because of higher rates of entry and lower rates of exit. These results have implications for the financing of long-term care and for targeting of interventions aimed at delaying it