Nutritional supplements for muscle building and fat loss

Adquirir una buena forma física es el objetivo de la mayoría de las personas que asisten a un centro de acondicionamiento físico; sin embargo, este proceso requiere de una individualización en la programación del entrenamiento y en la estrategia de alimentación, razón por la cual muchas personas no alcanzan sus metas y resultan adoptando prácticas innecesarias y peligrosas de suplementación. De acuerdo a la evidencia científica actual cuando el objetivo es incrementar la masa muscular, y solo de recomendarse por un profesional, se podría hacer uso de la suplementación con proteína de suero de leche o Whey Protein (0.4 - 0.5 g / kg / post-ejercicio), caseína (≈30 g antes de dormir) y monohidrato de creatina (0.3 g / kg / día durante 5-7 días seguido de 0.075 g / kg / post-entrenamiento durante 4-6 semanas). Se requiere más investigación respecto al consumo de Ashwagandha - Withania somnifera (300 mg dos veces al día) durante el mesociclo de entrenamiento de la fuerza. Por otro lado, durante una estrategia de reducción de grasa corporal para sujetos con sobrepeso u obesidad, los profesionales de la salud que realizan el seguimiento del caso pueden valorar el consumo de un reemplazo de comida en polvo (Meal Replacement Powder), como una alternativa para incrementar el aporte diario de proteína si se requiere, además de contemplar el consumo de Isomaltulosa (Palatinosa®) o amilopectinas modificadas en algunas comidas o 1-2 horas antes del ejercicio, sobre todo para controlar la hiperinsulinemia postprandial. La ingesta de un suplemento de cafeína anhidra (2-4 mg·kg-1·día-1) y algunos compuestos termogénicos; tales como, capsaicina (capsicum), té verde (Camelia sinensis), pimienta negra (Piper nigrum) y jengibre (Ginger officinale) pueden ser una alternativa para mejorar la adherencia a la dieta y aprovechar su potencial para reducir el porcentaje de grasa corporal, aunque se necesita más investigación a largo plazo para respaldar un efecto con significancia clínica

Palladium-catalyzed domino carbopalladation/5-exo-allylic amination of \u3b1-amino allenamides: an efficient entry to enantiopure imidazolidinones

Allenamides of alpha-amino acids were converted into enantiopure 2-vinylimidazolidin-4-ones by a carbopalladation/exo-cyclization process. The products were obtained in 2.5:1-5.5:1 dr, with 94-99% ee. The palladium-catalyzed carbonylative cyclization of the same substrates afforded enone structures. Starting from properly substituted allenamides, an intramolecular carbopalladation followed by intramolecular amination gave rise to tricyclic fused-ring imidazolidinones

Convergent evolution of pregnancy-specific glycoproteins in human and horse

Pregnancy-specific glycoproteins (PSGs) are members of the carcinoembryonic antigen cell adhesion molecule (CEACAM) family that are secreted by trophoblast cells. PSGs may modulate immune, angiogenic and platelet responses during pregnancy. Until now, PSGs are only found in species that have a highly invasive (hemochorial) placentation including humans, mice and rats. Surprisingly, analyzing the CEACAM gene family of the horse, which has a non-invasive epitheliochorial placenta, with the exception of the transient endometrial cups, we identified equine CEACAM family members that seem to be related to PSGs of rodents and primates. We identified seven genes that encode secreted PSG-like CEACAMs. Phylogenetic analyses indicate that they evolved independently from an equine CEACAM1-like ancestor rather than from a common PSG-like ancestor with rodents and primates. Significantly, expression of PSG-like genes (CEACAM44, CEACAM48, CEACAM49 and CEACAM55) was found in non-invasive as well as invasive trophoblast cells such as purified chorionic girdle cells and endometrial cup cells. Chorionic girdle cells are highly invasive trophoblast cells that invade the endometrium of the mare where they form endometrial cups and are in close contact with maternal immune cells. Therefore, the microenvironment of invasive equine trophoblast cells has striking similarities to the microenvironment of trophoblast cells in hemochorial placentas, suggesting that equine PSG-like CEACAMs and rodent and primate PSGs have undergone convergent evolution. This is supported by our finding that equine PSG-like CEACAM49 exhibits similar activity to certain rodent and human PSGs in a functional assay of platelet–fibrinogen binding. Our results have implications for understanding the evolution of PSGs and their functions in maternal–fetal interactions

The cellular prion protein increases the uptake and toxicity of tdp-43 fibrils

Cytoplasmic aggregation of the primarily nuclear TAR DNA-binding protein 43 (TDP-43) affects neurons in most amyotrophic lateral sclerosis (ALS) and approximately half of frontotemporal lobar degeneration (FTLD) cases. The cellular prion protein, PrPC, has been recognized as a common receptor and downstream effector of circulating neurotoxic species of several proteins involved in neurodegeneration. Here, capitalizing on our recently adapted TDP-43 real time quaking induced reaction, we set reproducible protocols to obtain standardized preparations of recombinant TDP-43 fibrils. We then exploited two different cellular systems (human SH-SY5Y and mouse N2a neuroblastoma cells) engineered to express low or high PrPC levels to investigate the link between PrPC expression on the cell surface and the internalization of TDP-43 fibrils. Fibril uptake was increased in cells overexpressing either human or mouse prion protein. Increased internalization was associated with detrimental consequences in all PrP-overexpressing cell lines but was milder in cells expressing the human form of the prion protein. As described for other amyloids, treatment with TDP-43 fibrils induced a reduction in the accumulation of the misfolded form of PrPC, PrPSc, in cells chronically infected with prions. Our results expand the list of misfolded proteins whose uptake and detrimental effects are mediated by PrPC, which encompass almost all pathological amyloids involved in neurodegeneration

Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men.

In contrast to conventional dual-energy X-ray absorptiometry, quantitative computed tomography separately measures trabecular and cortical volumetric bone mineral density (vBMD). Little is known about the genetic variants associated with trabecular and cortical vBMD in humans, although both may be important for determining bone strength and osteoporotic risk. In the current analysis, we tested the hypothesis that there are genetic variants associated with trabecular and cortical vBMD at the femoral neck by genotyping 4608 tagging and potentially functional single-nucleotide polymorphisms (SNPs) in 383 bone metabolism candidate genes in 822 Caucasian men aged 65 years or older from the Osteoporotic Fractures in Men Study (MrOS). Promising SNP associations then were tested for replication in an additional 1155 men from the same study. We identified SNPs in five genes (IFNAR2, NFATC1, SMAD1, HOXA, and KLF10) that were robustly associated with cortical vBMD and SNPs in nine genes (APC, ATF2, BMP3, BMP7, FGF18, FLT1, TGFB3, THRB, and RUNX1) that were robustly associated with trabecular vBMD. There was no overlap between genes associated with cortical vBMD and trabecular vBMD. These findings identify novel genetic variants for cortical and trabecular vBMD and raise the possibility that some genetic loci may be unique for each bone compartment

Unconventional motional narrowing in the optical spectrum of a semiconductor quantum dot

Motional narrowing refers to the striking phenomenon where the resonance line of a system coupled to a reservoir becomes narrower when increasing the reservoir fluctuation. A textbook example is found in nuclear magnetic resonance, where the fluctuating local magnetic fields created by randomly oriented nuclear spins are averaged when the motion of the nuclei is thermally activated. The existence of a motional narrowing effect in the optical response of semiconductor quantum dots remains so far unexplored. This effect may be important in this instance since the decoherence dynamics is a central issue for the implementation of quantum information processing based on quantum dots. Here we report on the experimental evidence of motional narrowing in the optical spectrum of a semiconductor quantum dot broadened by the spectral diffusion phenomenon. Surprisingly, motional narrowing is achieved when decreasing incident power or temperature, in contrast with the standard phenomenology observed for nuclear magnetic resonance

Recent Advances in Soil Liquefaction Engineering and Seismic Site Response Evaluation

Over the past decade, major advances have occurred in both understanding and practice with regard to engineering treatment of seismic soil liquefaction and assessment of seismic site response. Seismic soil liquefaction engineering has evolved into a sub-field in its own right, and assessment and treatment of site effects affecting seismic site response has gone from a topic of controversy to a mainstream issue addressed in most modem building codes and addressed in both research and practice. This rapid evolution in the treatment of both liquefaction and site response issues has been pushed by a confluence of lessons and data provided by a series of earthquakes over the past eleven years, as well as by the research and professional/political will engendered by these major seismic events. Although the rate of progress has been laudable, further advances are occurring, and more remains to be done. As we enter a “new millenium”, engineers are increasingly well able to deal with important aspects of these two seismic problem areas. This paper will highlight a few major recent and ongoing developments in each of these two important areas of seismic practice, and will offer insights regarding work/research in progress, as well as suggestions regarding further advances needed. The first part of the paper will address soil liquefaction, and the second portion will (briefly) address engineering assessment of seismic site response

The impact of inlet boundary layer thickness on the unsteady aerodynamics of S-duct intakes

The need to reduce aero-engine emissions and direct operating costsis driving the civil aerospace sectortowards considering more integrated propulsion systems. Many of the proposed novel aircraft architectures employ convoluted intakes for either the aero-engine or propulsion system. These intakes are characterized by unsteady distortion that can hinder the performance and operability of the propulsion system. This work assessesthe impact of the inlet boundary layer on the unsteady aerodynamics of an S-duct intake using time-resolved particle image velocimetry at the aerodynamic interface plane.An increase in the boundary layer thickness at the intake inlet increasesthe flow unsteadiness on the swirl angle by up to 40% relativeto the baseline case. The azimuthal orientation of the inlet boundary layer modifies the intensity and topology of the most frequent swirl distortion pattern. For a relatively thick inlet boundary layer, the reduction of the dominant frequencies associated withthe unsteady swirl angle is postulated to be beneficial for the engine stability. Overall, this works gives guidelines for the integration between the intake and the engine across the range of potential inlet operating conditions

Equilibration times in numerical simulation of structural glasses: Comparing parallel tempering and conventional molecular dynamics

Generation of equilibrium configurations is the major obstacle for numerical investigation of the slow dynamics in supercooled liquid states. The parallel tempering (PT) technique, originally proposed for the numerical equilibration of discrete spin-glass model configurations, has recently been applied in the study of supercooled structural glasses. We present an investigation of the ability of parallel tempering to properly sample the liquid configuration space at different temperatures, by mapping the PT dynamics into the dynamics of the closest local potential energy minima (inherent structures). Comparing the PT equilibration process with the standard molecular dynamics equilibration process we find that the PT does not increase the speed of equilibration of the (slow) configurational degrees of freedom.Comment: 5 pages, 3 figure

GRAVITY K-band spectroscopy of HD 206893 B

Context. Near-infrared interferometry has become a powerful tool for studying the orbital and atmospheric parameters of substellar companions. Aims. We aim to reveal the nature of the reddest known substellar companion HD 206893 B by studying its near-infrared colors and spectral morphology and by investigating its orbital motion. Methods. We fit atmospheric models for giant planets and brown dwarfs and perform spectral retrievals with petitRADTRANS and ATMO on the observed GRAVITY, SPHERE, and GPI spectra of HD 206893 B. To recover its unusual spectral features, first and foremost its extremely red near-infrared color, we include additional extinction by high-altitude dust clouds made of enstatite grains in the atmospheric model fits. However, forsterite, corundum, and iron grains predict similar extinction curves for the grain sizes considered here.We also infer the orbital parameters of HD 206893 B by combining the  100 μas precision astrometry from GRAVITY with data from the literature and constrain the mass and position of HD 206893 C based on the Gaia proper motion anomaly of the system. Results. The extremely red color and the very shallow 1:4 μm water absorption feature of HD 206893 B can be fit well with the adapted atmospheric models and spectral retrievals. By comparison with AMES-Cond evolutionary tracks, we find that only some atmospheric models predict physically plausible objects. Altogether, our analysis suggests an age of  3–300 Myr and a mass of  5–30 MJup for HD 206893 B, which is consistent with previous estimates but extends the parameter space to younger and lower-mass objects. The GRAVITY astrometry points to an eccentric orbit (e = 0:29+0:06 0:11) with a mutual inclination of \u3c34:4 deg with respect to the debris disk of the system. Conclusions. While HD 206893 B could in principle be a planetary-mass companion, this possibility hinges on the unknown influence of the inner companion on the mass estimate of 10+5 4 MJup from radial velocity and Gaia as well as a relatively small but significant Argus moving group membership probability of  61%. However, we find that if the mass of HD 206893 B is \u3c30 MJup, then the inner companion HD 206893 C should have a mass between  8–15 MJup. Finally, further spectroscopic or photometric observations at higher signal-to-noise and longer wavelengths are required to learn more about the composition and dust cloud properties of HD 206893 B