Paroxysmal eye–head movements in Glut1 deficiency syndrome

Objective:To describe a characteristic paroxysmal eye–head movement disorder that occurs in infants with Glut1 deficiency syndrome (Glut1 DS).Methods:We retrospectively reviewed the medical charts of 101 patients with Glut1 DS to obtain clinical data about episodic abnormal eye movements and analyzed video recordings of 18 eye movement episodes from 10 patients.Results:A documented history of paroxysmal abnormal eye movements was found in 32/101 patients (32%), and a detailed description was available in 18 patients, presented here. Episodes started before age 6 months in 15/18 patients (83%), and preceded the onset of seizures in 10/16 patients (63%) who experienced both types of episodes. Eye movement episodes resolved, with or without treatment, by 6 years of age in 7/8 patients with documented long-term course. Episodes were brief (usually &lt;5 minutes). Video analysis revealed that the eye movements were rapid, multidirectional, and often accompanied by a head movement in the same direction. Eye movements were separated by clear intervals of fixation, usually ranging from 200 to 800 ms. The movements were consistent with eye–head gaze saccades. These movements can be distinguished from opsoclonus by the presence of a clear intermovement fixation interval and the association of a same-direction head movement.Conclusions:Paroxysmal eye–head movements, for which we suggest the term aberrant gaze saccades, are an early symptom of Glut1 DS in infancy. Recognition of the episodes will facilitate prompt diagnosis of this treatable neurodevelopmental disorder.</jats:sec

Super Cracks in Your Fields?

Super cracks are being found in farm fields in a number of Iowa counties following the recent dry seasons. And they\u27re hazardous-to you, your machinery and livestock. Here\u27s what we can tell you about them

A Unified Graph Formulation for Spatio-Temporal Wind Forecasting

publishedVersio

Foreword

Little information exists about the loss of all one’s teeth (edentulism) among older adults in low- and middle-income countries. This study examines the prevalence of edentulism and associated factors among older adults in a cross-sectional study across six such countries. Data from the World Health Organization (WHO’s) Study on global AGEing and adult health (SAGE) Wave 1 was used for this study with adults aged 50-plus from China (N = 13,367), Ghana (N = 4724), India (N = 7150), Mexico (N = 2315), Russian Federation (N = 3938) and South Africa (N = 3840). Multivariate regression was used to assess predictors of edentulism. The overall prevalence of edentulism was 11.7% in the six countries, with India, Mexico, and Russia has higher prevalence rates (16.3%–21.7%) than China, Ghana, and South Africa (3.0%–9.0%). In multivariate logistic analysis sociodemographic factors (older age, lower education), chronic conditions (arthritis, asthma), health risk behaviour (former daily tobacco use, inadequate fruits and vegetable consumption) and other health related variables (functional disability and low social cohesion) were associated with edentulism. The national estimates and identified factors associated with edentulism among older adults across the six countries helps to identify areas for further exploration and targets for intervention

An analytical model of the virtual collision handler of 802.11e

A number of analytical models have been proposed to describe the priority schemes of the Enhanced Distributed Channel Access (EDCA) mechanism of the IEEE 802.11e standard. EDCA provides a class-based differentiated Quality of Service (QoS) to IEEE 802.11 WLANs. Many have used a multiple number of nodes to study the differentiation behaviour of the model. However, in many real-life usage scenarios Internet traffic is often asymmetric with much downlink traffic from the access point to the stations and little traffic in the reverse direction. Hence, most of the overall traffic differentiation will happen in the Virtual Collision Handler (VCH) of the access point. If the access point uses EDCA, it should know the characteristics of the VCH to be able to control the differentiation of the downlink traffic. The main contribution of this paper opposed to other works is that it demonstrates how a generic channel model of 802.11e can be modified to predict the behaviour of the VCH with a remarkably good accuracy. In doing so, we first introduce virtual collision handling into the generic model. We observe good match between the analytical model and simulations

Towards Using Reinforcement Learning for Autonomous Docking of Unmanned Surface Vehicles

Author's accepted manuscriptProviding full autonomy to Unmanned Surface Vehicles (USV) is a challenging goal to achieve. Autonomous docking is a subtask that is particularly difficult. The vessel has to distinguish between obstacles and the dock, and the obstacles can be either static or moving. This paper developed a simulator using Reinforcement Learning (RL) to approach the problem. We studied several scenarios for the task of docking a USV in a simulator environment. The scenarios were defined with different sensor inputs and start-stop procedures but a simple shared reward function. The results show that the system solved the task when the IMU (Inertial Measurement Unit) and GNSS (Global Navigation Satellite System) sensors were used to estimate the state, despite the simplicity of the reward function.acceptedVersio

Improving Classification of Tweets Using Linguistic Information from a Large External Corpus

The bag of words representation of documents is often unsat- isfactory as it ignores relationships between important terms that do not co-occur literally. Improvements might be achieved by expanding the vocabulary with other relevant word, like synonyms. In this paper we use word-word co-occurence information from a large corpus to expand the vocabulary of another corpus consisting of tweets. Several different methods on how to include the co-occurence information are constructed and tested out on the classification of real twitter data. Our results show that we are able to reduce the number of erroneous classifications by 14% using co-occurence information

Guidelines for VCCT-Based Interlaminar Fatigue and Progressive Failure Finite Element Analysis

This document is intended to detail the theoretical basis, equations, references and data that are necessary to enhance the functionality of commercially available Finite Element codes, with the objective of having functionality better suited for the aerospace industry in the area of composite structural analysis. The specific area of focus will be improvements to composite interlaminar fatigue and progressive interlaminar failure. Suggestions are biased towards codes that perform interlaminar Linear Elastic Fracture Mechanics (LEFM) using Virtual Crack Closure Technique (VCCT)-based algorithms [1,2]. All aspects of the science associated with composite interlaminar crack growth are not fully developed and the codes developed to predict this mode of failure must be programmed with sufficient flexibility to accommodate new functional relationships as the science matures

The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility

Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs). Here, we uncover a previously unappreciated role for the formin FHOD1 and the small GTPase Rac1 in vaccinia actin tail formation. FHOD1 depletion decreased the number of CEVs forming actin tails and impaired the elongation rate of the formed actin tails. Recruitment of FHOD1 to actin tails relied on its GTPase binding domain in addition to its FH2 domain. In agreement with previous studies showing that FHOD1 is activated by the small GTPase Rac1, Rac1 was enriched and activated at the membrane surrounding actin tails. Rac1 depletion or expression of dominant-negative Rac1 phenocopied the effects of FHOD1 depletion and impaired the recruitment of FHOD1 to actin tails. FHOD1 overexpression rescued the actin tail formation defects observed in cells overexpressing dominant-negative Rac1. Altogether, our results indicate that, to display robust actin-based motility, vaccinia virus integrates the activity of the N-WASP– ARP2/3 and Rac1–FHOD1 pathways.Fil: Alvarez, Diego Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Yale. School of Medicine; Estados UnidosFil: Agaisse, Herve. University of Yale. School of Medicine; Estados Unido