261 research outputs found
funcX: A Federated Function Serving Fabric for Science
Exploding data volumes and velocities, new computational methods and
platforms, and ubiquitous connectivity demand new approaches to computation in
the sciences. These new approaches must enable computation to be mobile, so
that, for example, it can occur near data, be triggered by events (e.g.,
arrival of new data), be offloaded to specialized accelerators, or run remotely
where resources are available. They also require new design approaches in which
monolithic applications can be decomposed into smaller components, that may in
turn be executed separately and on the most suitable resources. To address
these needs we present funcX---a distributed function as a service (FaaS)
platform that enables flexible, scalable, and high performance remote function
execution. funcX's endpoint software can transform existing clouds, clusters,
and supercomputers into function serving systems, while funcX's cloud-hosted
service provides transparent, secure, and reliable function execution across a
federated ecosystem of endpoints. We motivate the need for funcX with several
scientific case studies, present our prototype design and implementation, show
optimizations that deliver throughput in excess of 1 million functions per
second, and demonstrate, via experiments on two supercomputers, that funcX can
scale to more than more than 130000 concurrent workers.Comment: Accepted to ACM Symposium on High-Performance Parallel and
Distributed Computing (HPDC 2020). arXiv admin note: substantial text overlap
with arXiv:1908.0490
Mineral maturity and crystallinity index are distinct characteristics of bone mineral
The purpose of this study was to test the hypothesis that mineral maturity and crystallinity index are two different characteristics of bone mineral. To this end, Fourier transform infrared microspectroscopy (FTIRM) was used. To test our hypothesis, synthetic apatites and human bone samples were used for the validation of the two parameters using FTIRM. Iliac crest samples from seven human controls and two with skeletal fluorosis were analyzed at the bone structural unit (BSU) level by FTIRM on sections 2–4 lm thick. Mineral maturity and crystallinity index were highly correlated in synthetic apatites but poorly correlated in normal human bone. In skeletal fluorosis, crystallinity index was increased and maturity decreased, supporting the fact of separate measurement of these two parameters. Moreover, results obtained in fluorosis suggested that mineral characteristics can be modified independently of bone remodeling. In conclusion, mineral maturity and crystallinity index are two different parameters measured separately by FTIRM and offering new perspectives to assess bone mineral traits in osteoporosis
Penis deformity after intra-urethral liquid paraffin administration in a young male: a case report
This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens
Triaxial Deformation and Nuclear Shape Transition in \u3csup\u3e192\u3c/sup\u3eAu
Background: Nuclei in the A≈190 mass region show gradual shape changes from prolate through nonaxial deformed shapes and ultimately towards spherical shapes as the Pb region is approached. Exploring how this shape evolution occurs will help us understand the evolution of collectivity in this region.
Purpose: The level scheme of the 192Au nucleus in A ≈ 190 region was studied in order to deduce its deformations.
Methods: High-spin states of 192Au have been populated in the 186W(11B, 5n) reaction at a beam energy of 68 MeV and their γ decay was studied using the YRAST Ball detector array at the Wright Nuclear Structure Laboratory (WNSL), Yale University.
Results: Based on double and triple γ-ray coincidence data the level scheme of 192Au has been extended up to Iπ = 32+ at an excitation energy of ∼6 MeV.
Conclusion: The results are discussed in the framework of pairing and deformation self-consistent total Routhian surface (TRS) and cranked shell model (CSM) calculations. The comparison of the experimental observations with the calculations indicates that this nucleus takes a nonaxial shape similar to other Au nuclei in this region
Gastrointestinal stromal tumour of the duodenum in childhood: a rare case report
<p>Abstract</p> <p>Background</p> <p>Gastrointestinal stromal tumours (GISTs) are uncommon primary mesenchymal tumours of the gastrointestinal tract mostly observed in the adults. Duodenal GISTs are relatively rare in adults and it should be regarded as exceptional in childhood. In young patients duodenal GISTs may be a source of potentially lethal haemorrhage and this adds diagnostic and therapeutic dilemmas to the concern about the long-term outcome.</p> <p>Case presentation</p> <p>A 14-year-old boy was referred to our hospital with severe anaemia due to recurrent episodes of upper gastrointestinal haemorrhage. Endoscopy, small bowel series, scintigraphy and video capsule endoscopy previously done elsewhere were negative. Shortly after the admission, the patient underwent emergency surgery for severe recurrence of the bleeding. At surgery, a 4 cm solid mass arising from the wall of the fourth portion of the duodenum was identified. The invasion and the erosion of the duodenal mucosa was confirmed by intra-operative pushed duodenoscopy. The mass was resected by a full-thickness duodenal wall excision with adequate grossly free margins. Immunohistochemical analysis of the specimen revealed to be positive for CD117 (c-KIT protein) consistent with a diagnosis of GIST. The number of mitoses was < 5/50 HPF. Mutational analysis for c-KIT/PDGFRA tyrosine kinase receptor genes resulted in a wildtype pattern. The patient had an uneventful course and he has remained disease-free during two years of follow-up.</p> <p>Conclusion</p> <p>Duodenal GISTs in children are very rare and may present with massive bleeding. Cure can be achieved by complete surgical resection, but even in the low-aggressive tumours the long-term outcome may be unpredictable.</p
Determination of composition and structure of spongy bone tissue in human head of femur by Raman spectral mapping
Biomechanical properties of bone depend on the composition and organization of collagen fibers. In this study, Raman microspectroscopy was employed to determine the content of mineral and organic constituents and orientation of collagen fibers in spongy bone in the human head of femur at the microstructural level. Changes in composition and structure of trabecula were illustrated using Raman spectral mapping. The polarized Raman spectra permit separate analysis of local variations in orientation and composition. The ratios of ν2PO43−/Amide III, ν4PO43−/Amide III and ν1CO32−/ν2PO43− are used to describe relative amounts of spongy bone components. The ν1PO43−/Amide I ratio is quite susceptible to orientation effect and brings information on collagen fibers orientation. The results presented illustrate the versatility of the Raman method in the study of bone tissue. The study permits better understanding of bone physiology and evaluation of the biomechanical properties of bone
Experimental search for muonic photons
We report new limits on the production of muonic photons in the CERN neutrino beam. The results are based on the analysis of neutrino production of dimuons in the CHARM II detector. A CL limit on the coupling constant of muonic photons, is derived for a muon neutrino mass in the range eV. This improves the limit obtained from a precision measurement of the anomalous magnetic moment of the muon by a factor from 8 to 4
Acoustic and mechanical properties of luffa fiber-reinforced biocomposites
This chapter presents an overview of acoustic and mechanical behaviors of luffa fiber reinforced biocomposites. A growing number of studies are examining the composites of biodegradable fibers such as flax, hemp, kenaf and luffa due to the adverse effects of chemical materials on nature. The low cost and superior acoustic and acceptable mechanical properties of biocomposites make them very attractive for practical applications such as sound and vibration isolation. However, the acoustic and mechanical characteristics of biocomposites and their dynamic behaviors should be fully determined before considering them for practical applications. In this chapter, acoustic properties, such as sound absorption and transmission loss, and mechanical properties, such as damping and elasticity of luffa fiber reinforced composites, are presented. The variations in acoustic and mechanical properties due to different samples and manufacturing process are explored.WOS:000532438200017Scopus - Affiliation ID: 60105072Book Citation Index- ScienceArticle; Book ChapterOcak2019YÖK - 2018-1
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