1,579 research outputs found
Novel Precursors for Boron Nanotubes: The Competition of Two-Center and Three-Center Bonding in Boron Sheets
We present a new class of boron sheets, composed of triangular and hexagonal
motifs, that are more stable than structures considered to date and thus are
likely to be the precursors of boron nanotubes. We describe a simple and clear
picture of electronic bonding in boron sheets and highlight the importance of
three-center bonding and its competition with two-center bonding, which can
also explain the stability of recently discovered boron fullerenes. Our
findings call for reconsideration of the literature on boron sheets, nanotubes,
and clusters.Comment: 4 pages, 4 figures, 1 tabl
Teaching for Life
The Teaching for Life project aimed to explore the needs of teachers in relation to children with life limiting or life threatening conditions. Teachers were well aware of the medical, emotional and social needs of both the child and the other children and adults that surround that child, as well as the importance of the physical atributes of the building and the culture of the school. They wanted more information, guidance and support. Teachers need emotional support for themselves if they are to be able to contain their own anxieties and to be able to support others. In turn they need to be supported by a whole school approach to emotional health and wellbeing, which includes addressing bullying and inclusion. Collaboration between themselves and inter-professional health and social care agencies needs to work more effectively
Attitudes and behaviours of maternal health care providers in interactions with clients: a systematic review
Background: High maternal mortality and morbidity persist, in large part due to inadequate access to timely and quality health care. Attitudes and behaviours of maternal health care providers (MHCPs) influence health care seeking and quality of care.
Methods: Five electronic databases were searched for studies from January 1990 to December 2014. Included studies report on types or impacts of MHCP attitudes and behaviours towards their clients, or the factors influencing these attitudes and behaviours. Attitudes and behaviours mentioned in relation to HIV infection, and studies of health providers outside the formal health system, such as traditional birth attendants, were excluded.
Findings: Of 967 titles and 412 abstracts screened, 125 full-text papers were reviewed and 81 included. Around two-thirds used qualitative methods and over half studied public-sector facilities. Most studies were in Africa (n = 55), followed by Asia and the Pacific (n = 17). Fifty-eight studies covered only negative attitudes or behaviours, with a minority describing positive provider behaviours, such as being caring, respectful, sympathetic and helpful. Negative attitudes and behaviours commonly entailed verbal abuse (n = 45), rudeness such as ignoring or ridiculing patients (n = 35), or neglect (n = 32). Studies also documented physical abuse towards women, absenteeism or unavailability of providers, corruption, lack of regard for privacy, poor communication, unwillingness to accommodate traditional practices, and authoritarian or frightening attitudes. These behaviours were influenced by provider workload, patients’ attitudes and behaviours, provider beliefs and prejudices, and feelings of superiority among MHCPs. Overall, negative attitudes and behaviours undermined health care seeking and affected patient well-being.
Conclusions: The review documented a broad range of negative MHCP attitudes and behaviours affecting patient well-being, satisfaction with care and care seeking. Reported negative patient interactions far outweigh positive ones. The nature of the factors which influence health worker attitudes and behaviours suggests that strengthening health systems, and workforce development, including in communication and counselling skills, are important. Greater attention is required to the attitudes and behaviours of MHCPs within efforts to improve maternal health, for the sake of both women and health care providers
Geographic variation in malarial parasite lineages in the Common Yellowthroat (Geothlypis trichas)
Our current understanding of migration routes of many birds is limited and researchers have employed various methods to determine migratory patterns. Recently, parasites have been used to track migratory birds. The objective of this study was to determine whether haemosporidian parasite lineages detect significant geographic structure in common yellowthroats (Geothlypis trichas). We examined liver tissue or blood from 552 birds sampled from multiple locations throughout the continental United States, southern Canada, and the Bahamas. We found a 52.7% overall prevalence of haematozoan infection. We identified 86.1% of these infections to genus: 81% were Plasmodium; 5% were Haemoproteus; and 0.1% were Leucocytozoon. There were significant differences in the prevalence of different parasite genera among regions (χ2 = 36.82, P \u3c 0.0001) and in the proportion of Plasmodium infections versus other parasites among regions (χ2 = 35.52, P \u3c 0.0001). Sequence information identified three Haemoproteus lineages, two Leucocytozoon lineages, and thirteen Plasmodium lineages. Due to the low number of Haemoproteus and Leucocytozoon, only Plasmodium lineages were used in the geographic comparison of lineages. Six Plasmodium lineages were found in eight or more birds and the prevalence of these varied significantly among regions (χ2 = 172.33, P \u3c 0.0001). Additionally, 45 juvenile birds were sampled to determine what parasites could be obtained in the breeding grounds and we found only one lineage. In conclusion, parasite lineages show some geographic structure, with some lineages being more geographically specific than others, but are not useful for determining migratory connectivity in this species
Inverse problem of photoelastic fringe mapping using neural networks
This paper presents an enhanced technique for inverse analysis of photoelastic fringes using neural networks to determine the applied load. The technique may be useful in whole-field analysis of photoelastic images obtained due to external loading, which may find application in a variety of specialized areas including robotics and biomedical engineering. The presented technique is easy to implement, does not require much computation and can cope well within slight experimental variations. The technique requires image acquisition, filtering and data extraction, which is then fed to the neural network to provide load as output. This technique can be efficiently implemented for determining the applied load in applications where repeated loading is one of the main considerations. The results presented in this paper demonstrate the novelty of this technique to solve the inverse problem from direct image data. It has been shown that the presented technique offers better result for the inverse photoelastic problems than previously published works
Living with multiple losses: Insights from patients living with pressure injury
© 2017 Australian College of Nursing Ltd Background: Pressure injury is a common problem. Its prevention and treatment is predominantly focussed on views, perceptions and knowledge of healthcare staff rather than on patient experience, particularly those patients living in their own homes. Aim: This paper reports findings on patients experiences and perceptions of loss associated with PI. These findings are drawn from a larger study of pressure injury patients living and receiving care in the community. Methods: Qualitative interviews with 12 participants with pressure injury and five carers. Data was audio recorded and thematically analysed. The study is reported in accordance with the COREQ guidelines. Findings: Having a pressure injury negatively affected many aspects of life for our participants resulting in multiple losses. These losses included loss of mobility and independence, privacy and dignity, and social engagement and ability to engage in preferred activities. Discussion: Although the effects of a pressure injury may be similar for many people, the most important issues will differ from person-to-person thus treatment and prevention of pressure injury requires a multidisciplinary team having a holistic care approach. Some patients’ pressure injury will never heal and it is increasingly important to involve the patient to find out what matters most to them and how their wound is impacting on them, to jointly develop a holistic, person-centred plan. Conclusion: Policy and practice should recognise and reflect that patients living with a pressure injury at home have different challenges and needs to those in acute or long term care. Pragmatic solutions in the delivery of pressure injury care are needed to compliment the drive to move healthcare from the hospital-to-home
Towards the development of novel Trypanosoma brucei RNA editing ligase 1 inhibitors
Abstract Background Trypanosoma brucei (T. brucei) is an infectious agent for which drug development has been largely neglected. We here use a recently developed computer program called AutoGrow to add interacting molecular fragments to S5, a known inhibitor of the validated T. brucei drug target RNA editing ligase 1, in order to improve its predicted binding affinity. Results The proposed binding modes of the resulting compounds mimic that of ATP, the native substrate, and provide insights into novel protein-ligand interactions that may be exploited in future drug-discovery projects. Conclusions We are hopeful that these new predicted inhibitors will aid medicinal chemists in developing novel therapeutics to fight human African trypanosomiasis
Healthcare professionals\u27 perspectives on working with patient-generated data for supporting person-centred HIV care
BACKGROUND We report on a UK study with Healthcare Professionals (HCPs) providing routine adult HIV care, to understand their experiences of working with Patient-generated Data (PGData) including Patient Reported Outcome Measures (PROMs), with the aim to inform the design of tools (e.g. electronic patient questionnaires) for supporting Person-centred Care. METHOD Semi-structured (individual and group) interviews were conducted (March 2020 to October 2022) with 15 HCPs (5 men, 10 women) from multi-disciplinary teams at: a large London HIV outpatient clinic (A); an Infectious Diseases service in Northern England (B). Due to COVID-19, all but one interview took place online. 90-minute interviews were supported by persona-based scenarios and infographics, prompting participants\u27 engagement with individual lived experiences. Transcribed audio-recordings were coded using Reflexive Thematic Analysis. Participants included: seven physicians; three psychologists; two nurses; health advisor; pharmacist; peer support worker. Two physicians, one nurse, and one psychologist at Clinic B participated in follow-up interviews focussing on PROMs. RESULTS Physicians needed to balance patient agendas with clinician agendas, highlighting the practical reality of time constraints for achieving this balance. Nurses and psychologists highlighted wider patient circumstances impacting personal information sharing, plus health inequities shaping access to internet-mediated tools. Post-pandemic, preference for in-person consultation was emphasised for good communication. The value of PROMs in HIV care was perceived in: facilitating face-to-face conversation with patients who struggle to articulate problems or discuss difficult topics; co-defining an agenda; helping both parties ask the right questions and acquire contextual information; tracking progress; helping meet BHIVA standards; capturing and evaluating experience of attending services; tailoring services. Differing use of PROMs at each clinic reflected geographical diversity and type of specialist providing the service. Perceived challenges of using PROMs for HIV care include: patients’ confidentiality concerns; questioning validity of PGData - honesty in self-reports, context of capture; time constraints for interpreting data; system interoperability for data processing and access by HCPs and patients. Design considerations include: visual presentation, for readability, discretion, accessibility; language formats; value of capturing information between consultations. CONCLUSION Interview findings evidence UK HIV Healthcare Professionals\u27 perspectives on how PGData including PROMs may support Person-centred Care, plus considerations for designing supportive data collection tools
Photocurrents from photosystem II in a metal oxide hybrid system: electron transfer pathways
We have investigated the nature of the photocurrent generated by Photosystem II (PSII), the water oxidizing enzyme, isolated from Thermosynechococcus elongatus, when immobilized on nanostructured titanium dioxide on an indium tin oxide electrode (TiO2/ITO). We investigated the properties of the photocurrent from PSII when immobilized as a monolayer versus multilayers, in the presence and absence of an inhibitor that binds to the site of the exchangeable quinone (QB) and in the presence and absence of exogenous mobile electron carriers (mediators). The findings indicate that electron transfer occurs from the first quinone (QA) directly to the electrode surface but that the electron transfer through the nanostructured metal oxide is the rate-limiting step. Redox mediators enhance the photocurrent by taking electrons from the nanostructured semiconductor surface to the ITO electrode surface not from PSII. This is demonstrated by photocurrent enhancement using a mediator incapable of accepting electrons from PSII. This model for electron transfer also explains anomalies reported in the literature using similar and related systems. The slow rate of the electron transfer step in the TiO2 is due to the energy level of electron injection into the semiconducting material being below the conduction band. This limits the usefulness of the present hybrid electrode. Strategies to overcome this kinetic limitation are discussed
Forest Focus Monitoring Database System - Executive Summary Report 2003 Level II Data
This Executive Report presents the results obtained from all processing stages (data reception, validation checks ¿ compliance, conformity, uniformity) for submitted data referring to the monitoring year 2003. This report presents the results at the end of the processing phase after data have been re-submitted in 2007. It presents in addition a brief comment on the data status for each NFC, for the reporting year, with respect to the parameter assessed and including analyses of spatial variability of data and temporal trends of parameters.JRC.H.7-Land management and natural hazard
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