11 research outputs found
Disinterested Malevolence as an Actionable Wrong
- Author
- Publication venue
- FLASH: The Fordham Law Archive of Scholarship and History
- Publication date
- 01/01/1953
- Field of study
Disinterested Malevolence as an Actionable Wrong
- Author
- Publication venue
- FLASH: The Fordham Law Archive of Scholarship and History
- Publication date
- 01/01/1953
- Field of study
Radiation therapy in the management of low-grade supratentorial astrocytomas
- Author
- Publication venue
- 'Journal of Neurosurgery Publishing Group (JNSPG)'
- Publication date
- Field of study
Effects of Surface Composition on the Aerosolisation and Dissolution of Inhaled Antibiotic Combination Powders Consisting of Colistin and Rifampicin
- Author
- AS Melani
- BY Shekunov
- D Heng
- F Depreter
- F Lavorini
- F Wan
- G Beamson
- G Döring
- G Pilcer
- H Adi
- H Piao
- Hak-Kim Chan
- J Li
- J Li
- JGY Chan
- Jian Li
- John A. Denman
- JY Song
- KR Morris
- L Asking
- Mingshi Yang
- MS Coates
- Nicolas Barraud
- NM Davies
- P Duport
- P O’Hara
- P York
- PCL Kwok
- Q Zhou
- Q Zhou
- Qi Tony Zhou
- QT Zhou
- QT Zhou
- QT Zhou
- QT Zhou
- QT Zhou
- RJ White
- RO Salama
- S May
- S Rennard
- Scott A. Rice
- SH Lee
- Si-Ping Sun
- SM Garonzik
- SQ Henwood
- SWS Yapa
- T Riley
- T Sou
- T Sou
- T Velkov
- Thomas R. Gengenbach
- Wenbo Wang
- Publication venue
- 'American Association of Pharmaceutical Scientists (AAPS)'
- Publication date
- Field of study
Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology
- Author
- Amar Gajjar
- AP Becker
- Arie Perry
- AS Prabowo
- BC Mobley
- Bo Tang
- BR Driver
- BS Paugh
- C Chappé
- C Daumas-Duport
- C Dunham
- Chandanamali Punchihewa
- CL Lannon
- CW Brennan
- Daniel Brat
- David George
- David W. Ellison
- DJ Brat
- DN Louis
- DT Jones
- DW Ellison
- DW Parsons
- E Clappier
- E Raabe
- Elaine R. Mardis
- F Andre
- Fredrick A. Boop
- G Bird-Lieberman
- G Schindler
- G Stenman
- G Wu
- G Wu
- Gang Wu
- GR Cruz
- H Yan
- Heather Mulder
- Hilary Nickols
- I Blumcke
- I Lahortiga
- Ibrahim Qaddoumi
- J Schwartzentruber
- J Zhang
- J Zhang
- J Zhang
- James D. Dalton
- James R. Downing
- Jared Becksfort
- JE Eckel-Passow
- Ji Wen
- Jinghui Zhang
- JJ Roth
- JL Anderson
- John Easton
- JR Ow
- JS Reis-Filho
- JT Huse
- Kathreena M. Kurian
- Kathryn McFadden
- Kelly Haupfear
- Kirti Gupta
- Kristy Boggs
- LA Ramkissoon
- Luciano Neder Serafini
- M Parker
- M Peifer
- M Persson
- M Preusser
- M Thom
- M Wang
- Michael Rusch
- MJ Alvarez-Cubero
- MJ Dougherty
- N Keskin
- N Nguyen
- N Thon
- P Bandopadhayay
- P Kauraniemi
- Pankaj Gupta
- Paul D. Klimo
- R McKean-Cowdin
- RG Ramsay
- RG Tatevossian
- Richard K. Wilson
- Ruth G. Tatevossian
- RW Dudley
- Ryan P. Lee
- S Sankar
- Sheila Shurtleff
- Shuoguo Wang
- Sonika Dahiya
- Suzanne J. Baker
- T Forshew
- T Mastrangelo
- T Stokland
- Teresa Santiago
- TJ Cummings
- V Frattini
- V Rand
- V Sorensen
- V. Peter Collins
- Wilda Orisme
- William Konomos
- WM Lin
- Y Feng
- Ying Shao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The Impact of Family History of Breast Cancer on Knowledge, Attitudes, and Early Detection Practices of Mexican Women Along the Mexico-US Border
- Author
- AD Weinberg
- AF Abraido-Lanza
- AG Ramirez
- AP Hubbell
- AP Polednak
- AS O’Malley
- B Theis
- BA Husaini
- Beti Thompson
- C Lerman
- C Lerman
- CC Drossaert
- CD O’Malley
- Collaborative Group on Hormonal Factors in Breast Cancer
- D Ortega-Altamirano
- DS West
- E Selvin
- EC Chan
- ED Paskett
- F Aparicio-Ting
- FM Knaul
- FM Knaul
- G Olaiz
- G Olaiz-Fernández
- JB Hunter
- JD Allen
- JG Zapka
- JL Valdespino
- John Moraros
- JS Mandelblatt
- KD McCaul
- KD McCaul
- KM Egan
- KM Kaplan
- KM Wall
- L Lopez-Carrillo
- LJ Finney
- LM Tumiel-Berhalter
- M Cohen
- M Qureshi
- M Salazar
- M Shah
- Matthew P. Banegas
- ME Costanza
- ME Parent
- MT Lippert
- N Duport
- N Mavaddat
- R Shyyan
- RG Roetzheim
- RR Luquis
- RS Foster Jr
- S Garbers
- S Rodriguez-Cuevas
- S Rodriguez-Cuevas
- S Rodriguez-Cuevas
- S Rodriguez-Cuevas
- S Taplin
- Sasha King
- Secretaría de Salud
- SL McFall
- Surasri Prapasiri
- T Estape
- United States-Mexico Border Health Commission USMBHC
- V Tovar-Guzmán
- VA Lawrence
- World Cancer Research Fund/American Institute for Cancer Research
- Yelena Bird
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
On glioblastoma and the search for a cure: where do we stand?
- Author
- A Bennet
- A Calzolari
- A Davies
- A Desjardins
- A Gutkin
- A Tosoni
- A Vellimana
- A Yin
- Aleksander Jankovski
- Anne des Rieux
- B Campos
- B Kaina
- B Kovic
- B Scheithauer
- Baker Fn
- C Bastiancich
- C Bastiancich
- C Corso
- C Daumas-Duport
- C Lindquist
- C Powell
- C Scaringi
- Chiara Bastiancich
- D Beier
- D Bonnet
- D Canale
- D Kirkpatrick
- D Patel
- D Peer
- DS K Hoare T
- E Bolderson
- E Domingo-Musibay
- E Jones
- E Krumbhaar
- E Krumbhaar
- E Spiegel
- F Danhier
- F Marchesi
- Fabienne Danhier
- G Bradač
- G Hounsfield
- G Liu
- G Perazzoli
- G Sarkar
- H Ardon
- H Bock
- H Brem
- H Bryant
- H Farmer
- H Liu
- H Ohgaki
- H Scherer
- H Scherer
- H Sun
- I Camby
- J Buckner
- J Choi
- J Deeken
- J Fenn
- J Lathia
- J Lister
- J Peiffer
- J Reijneveld
- J Rich
- J Roth
- J Sampson
- J Scott
- J Senra
- J Silber
- J Voorhees
- J Wright
- John Bianco
- K Hynynen
- K Lee
- K Messaoudi
- K Uluç
- K Zülch
- K Zülch
- K Zülch
- L Ashby
- L DeAngelis
- L Muldoon
- L Qin
- L Tavano
- L Toledo-Pereyra
- M Borner
- M Brada
- M Cohen
- M Gilbert
- M Hegi
- M Le Mercier
- M McGee
- M Mut
- M Neagu
- M Netsky
- M Prados
- M Rouleau
- M Vogelbaum
- M Weller
- M Westphal
- N Parker
- O Bailey
- O Bock
- O Chinot
- O Chinot
- P Bailey
- P Bailey
- P Bailey
- P Bailey
- P Delgado-López
- P Ehrlich
- P Gupta
- P Kerr
- P Lauterbur
- P Rubin
- R Galli
- R Mirimanoff
- R Stupp
- R Stupp
- R Stupp
- R Thomas
- R Yong
- R Young
- S Agnihotri
- S Ferguson
- S Greenblatt
- S Greenblatt
- S Greenblatt
- S Hervey-Jumper
- S Kim
- S Rose
- S Sachs
- S Taillibert
- T Allen
- T Connors
- T Fourniols
- T Smets
- T Tan
- T Verschuere
- T Yanagihara
- V Gupta
- V Horsley
- V Horsley
- V Schijns
- Véronique Préat
- W Dandy
- W Dandy
- W Macewen
- W Macewen
- W Pardridge
- W Penfield
- W Wick
- W Wick
- Y Ramirez
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Molecular Genetics of the Genus Paracoccus
- Author
- Alberti M.
- Anthony C.
- Arigoni F.
- Baker S. C.
- Bartosik D.
- Bartosik D.
- Bauer C. E.
- Bedzyk L. A.
- Beijerinck M.
- Bell L. C.
- Bell L. C.
- Bell L. C.
- Bell L. C.
- Bennett B.
- Benning M. M.
- Berks B. C.
- Berks B. C.
- Berks B. C.
- Berks B. C.
- Berks B. C.
- Berks B. C.
- Berry E. A.
- Blackall L. L.
- Bonin P.
- Boogerd F. C.
- Bosma G.
- Breton J.
- Burns H. D.
- Cannon W.
- Capaldi R. A.
- Carr G. J.
- Carr G. J.
- Castresana J.
- Chen L.
- Chen L.
- Chepuri V.
- Chistoserdov A. Y.
- Coucheron D. H.
- Cox J. C.
- Cullen P. J.
- Davidson V. L.
- Davies K. J.
- de Boer A. P. N.
- de Boer A. P. N.
- de Gier J. W. L.
- de Gier J. W. L.
- de Gier J. W. L.
- de Miersman C.
- de Vries G. E.
- Deligiannakis Y.
- Delorme C.
- Duport C.
- Durley R.
- Ferguson S. J.
- Ferguson S. J.
- Fernandez de Henestrosa A. R.
- Fernandez de Henestrosa A. R.
- Ferrante A. A.
- Feurst J. A.
- Flory J. E.
- Forkl H.
- Frey J.
- Friedrich C. G.
- Fülöp V.
- Gabellini N.
- Garcià-Horsman J. A.
- Gibson L. C.
- Gicquel-Sanzey B.
- Girsch P.
- Glockner A. B.
- Gohlke U.
- Goodhew C. F.
- Goretski J.
- Green J.
- Gregory S.
- Gunsalus R. P.
- Haltia T.
- Haltia T.
- Haltia T.
- Harker M.
- Harms N.
- Harms N.
- Hawley D. K.
- Heck C.
- Hill B. C.
- Hirsch A.
- Hoeren F. U.
- Hofhaus G.
- Hornberger U.
- Hosler P.
- Husain I.
- Husain M.
- Husain M.
- Iwata S.
- John P.
- John P.
- Jordan S. L.
- Jungst A.
- Jungst A.
- Katayama Y.
- Kawasaki H.
- Kawasaki H.
- Kelly D. P.
- Kelly D. P.
- Khoroshilova N.
- Kitts P. A.
- Kleymann G.
- Klug G.
- Knaff D. B.
- Knight A. I.
- Kobayashi M.
- Kostler M.
- Kucera I.
- Kucera I.
- Kurowski B.
- Kwiatkowski A. V.
- Lazazzera B. A.
- Leimkuhler S.
- Leung Y. C.
- Lidstrom M. E.
- Lipski A.
- Lloyd D.
- Lommen A.
- Lu W. P.
- Lu W. P.
- Ludwig B.
- Ludwig B.
- Ludwig B.
- Ludwig W.
- Ludwig W.
- MacKay R. M.
- Mariani F.
- Maszenan A. M.
- Mat’chova I.
- Moir J. W. B.
- Moir J. W. B.
- Moir J. W. B.
- Moir J. W. B.
- Nakai Y.
- Newton N.
- Nickel C. M.
- Nokhal T. H.
- Nowicka B.
- Oda K.
- Ohara M.
- Ostermeier C.
- Ostermeier C.
- Oue S.
- Paetow B.
- Page M. D.
- Page M. D.
- Page M. D.
- Page M. D.
- Page M. D.
- Page M. D.
- Page M. D.
- Page M. D.
- Papa S.
- Parkinson J. S.
- Parsek M. R.
- Pasternak C.
- Pasternak C.
- Paulus F.
- Pearce D. A.
- Pennoyer J. D.
- Pittard J.
- Preisig O.
- Puustinen A.
- Raitio M.
- Raitio M.
- Raitio M.
- Ras J.
- Reyes F.
- Richter O.-M. H.
- Roberts D. L.
- Robertson L. A.
- Robertson L. A.
- Saraste M.
- Saraste M.
- Saraste M.
- Savioz A.
- Saxena K.
- Scala D. J.
- Schulte U.
- Sears H. J.
- Sears H. J.
- Shaw D. J.
- Shiota S.
- Siller H.
- Six S.
- Spiro S.
- Spiro S.
- Spiro S.
- Spurgin P.
- Steenkamp D. J.
- Steinbüchel A.
- Steinrücke P.
- Steinrücke P.
- Steinrücke P.
- Steinrücke P.
- Stoll R.
- Stouthamer A. H.
- Stouthamer A. H.
- Tagaki T.
- Thöny-Meyer L.
- Toussaint B.
- Trieschmann M. D. A.
- Trumpower B. L.
- Turba A.
- Ubbink M.
- Ubbink M.
- Ubbink M.
- Unden G.
- Urakami T.
- Urakami T.
- van der Oost J.
- van der Palen C. J. N. M.
- van der Palen C. J. N. M.
- van Ophem P. W.
- van Spanning R. J. M.
- van Spanning R. J. M.
- van Spanning R. J. M.
- van Spanning R. J. M.
- van Spanning R. J. M.
- van Spanning R. J. M.
- van Verseveld H. W.
- Verhoeven W.
- Wiese A.
- Williams P. A.
- Williams R.
- Winterstein C.
- Winterstein C.
- Witt H.
- Xu H. H.
- Xu X. M.
- Xu X. M.
- Xu X. M.
- Xu X. M.
- Xu X. M.
- Yabutani T.
- Yamane T.
- Yang H.
- Yang X.
- Yang X.
- Yu P. L.
- Zalman L. S.
- Zickermann I.
- Zickermann I.
- Zumft W. G.
- Zumft W. G.
- Zumft W. G.
- Zumft W. G.
- Zumft W. G.
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
- Author
- Aceituno A
- Acosta I
- Adams A
- Adatia S
- Aerden Leo A.m.
- Aeron-thomas John
- Aggour Mohamed
- Aghaebrahim A
- Agid R
- Aguettaz Pierre
- Ahle Guido
- Aja L
- Akhtar N
- Al Najjar-carpentier Amen-adam
- Al'boutros S
- Al-ajlan F
- Albers Gregory W
- Albers Gregory W.
- Alexandrou M
- Alhazzaa M
- Ali L
- Allen E
- Almekhlafi M
- Alseraya A
- Aly J
- Amar Arun
- Amaro S
- Amato-marzialli B
- Amerson L
- Amiri H
- Andersen G
- Andersen L
- Anderson A
- Andersson Tommy
- Ang Timothy
- Anton C
- Anxionnat René
- Apoil-brissard Marion
- Aram H
- Arenillas Lara Jf
- Arenillas J
- Ariño H
- Arkin S
- Armbruster K
- Armitage K
- Arquizan C
- Arquizan Caroline
- Arteaga Charles
- Ashforth Ra
- Ashok Vasdev
- Attia John
- Ayrignac X
- Azizi A
- Añon J
- Bach E
- Badve Monica
- Baillot Pierre-alexandre
- Bain M
- Bakchine Serge
- Baker C
- Balasa M
- Balgude A
- Bamford John
- Banaras Azra
- Bang Oh Young
- Bang Oy
- Barber P. Alan
- Barber Pa
- Barbier Charlotte
- Barbieux Marianne
- Barnwell S
- Baronnet-chauvet Flore
- Barral Francis-guy
- Barreau Xavier
- Barros Renan Sales
- Bartolini Mario Bruno
- Barton K
- Barton K
- Bartt R
- Basir G
- Bataille Mathieu
- Bauer A
- Baxendell L
- Baxendell L
- Baxter B
- Baxter Bw
- Beadell N
- Beauchamp B
- Beaujeux Rémy
- Beck C
- Beck P
- Becker M
- Beenen Ludo F.m.
- Bejot Yannick
- Belagaje Sr
- Belden J
- Bellew M
- Bellon R
- Bendszus M
- Bennett Patricia
- Berge Jérôme
- Berhoune Nadia-nawel
- Berkefeld J
- Berkhemer Olvert A
- Berkhemer Olvert A
- Bettinger I
- Beumer Debbie
- Bharatha A
- Bhatt A
- Biberacher V
- Biethahn S
- Billigan J
- Binder A
- Bintner Marc
- Biondi Alessandra
- Birchenall Julia
- Bitner A
- Blacquiere D
- Bladin Christopher F
- Blanc Raphael
- Blasco J
- Blayney S
- Blue-schaller A
- Bodenant Marie
- Bodiguel Eric
- Boeckh Behrens T
- Boers Merel
- Boiten Jelis
- Bonafé Alain
- Bonafé Alain
- Boned S
- Bonnet Anne-laure
- Bonneville Jean-françois
- Bonwit E
- Boo S
- Boodt Nikki
- Borst Jordi
- Bot Joseph C.j.
- Boubagra Kamel
- Bouhour Françoise
- Boulos M
- Boulton M
- Bounolleau Pierre
- Bourcier Romain
- Bourdain Frédéric
- Bourgois Nathalie
- Boutoleau-bretonniere Claire
- Boutwell C
- Boyle K
- Bozorgchami H
- Bracard S
- Bracard Serge
- Brant R
- Braun H
- Brekenfeld C
- Brennan P
- Brewer L
- Brick J
- Brion B
- Brooks C
- Brooks Mark
- Broussalis E
- Brouwer Patrick A.
- Brown B
- Brown Martin M
- Brown Martin M.
- Brown Scott
- Brunner F
- Buck B
- Budzik R
- Buffon Porcher Frédérique
- Buhk J-h
- Burg K
- Burns Pa
- Burns Paul
- Butcher Ks
- Caceves D
- Cahagne Vincent
- Calderon Arnulphi M
- Calleja Sanz Ai
- Calvert J
- Calvet David
- Campbell Bruce C V
- Campbell Bruce Cv
- Campbell D
- Campbell D
- Campbell N
- Cano L
- Carandang R
- Cardona P
- Carelli Gabriela
- Caroff Jildaz
- Carpenter Jeffrey
- Carpenter Js
- Casaubon Lk
- Castaño C
- Cate C
- Caucheteux Nathalie
- Cayley A
- Celestino Sherisse
- Cerejo R
- Cervera A
- Cha J
- Chabert Emmanuel
- Chabriat Hugues
- Chamorro A
- Chan R
- Chandra Ronil V
- Chang H-w
- Chang I
- Chang V
- Charif M
- Charlin Cyril
- Chassin Olivier
- Chau Yves
- Chavent Adrien
- Chen M
- Cheng Ching E
- Cheng B
- Chiacchierini Richard
- Cho Tae-hee
- Choe H
- Choi P
- Chong Winston
- Churilov Leonid
- Clarencon Frédéric
- Clarençon Frédéric
- Clark D
- Clark W
- Clavelou Pierre
- Clement F
- Clifton Andrew
- Clifton Andy
- Cloud Geoffrey
- Cnyrim C
- Cobo E
- Codas J
- Cogez Julien
- Cognard Christophe
- Cohen David J.
- Collins R
- Connolly Ls
- Coote Skye
- Cordonnier Charlotte
- Cornut-chauvinc Catherine
- Cortes M
- Cortijo Garcia E
- Cortsen M
- Coscojuela P
- Coskun Oguzhan
- Costalat V
- Costalat Vincent
- Cotter P
- Coté Va
- Coughlan T
- Couillard P
- Coulthard Alan
- Coulton Bronwyn
- Courtheoux Patrick
- Coutts Sb
- Cowley Elise
- Crandall S
- Crann S
- Crespo Vallejo E
- Cronquist M
- Cross L
- Crowe M
- Crozier Sophie
- Csizmadia Marloes
- Cuadras P
- Cullen A
- Cunningham James
- Cunningham N
- D'este Cate
- Da Costa L
- Dahlgren R
- Dallinga René J.
- Daly T
- Daly T
- Damgaard D
- Dancer S
- Danch M-j
- Daneault N
- Darcel Françoise
- Das E
- Daumas-duport Benjamin
- Davis Stephen M
- Davis Stephen M
- Davis T
- Day J
- Day Susan
- De Bont-stikkelbroeck José
- De Bruijn Sebastiaan F.
- De Bustos Medeiros Elisabeth
- De Gaalon Solène
- De Kort Paul L.m.
- De La Ossa Natalia Pérez
- De Meris Joke
- De Miquel Ma
- De Ridder Ans
- De Villiers Laetitia
- De Vries Joost
- Debiais Séverine
- Debruxelles Sabrina
- Decesare S
- Decroix Jean Pierre
- Dehkharghani S
- Del Campo Jm
- Dellinger C
- Dellinger C
- Deltour Sandrine
- Demaerschalk B
- Demchuk Am
- Demchuk Andrew M
- Den Hertog Heleen M.
- Denier Christian
- Deplanque Dominique
- Derdeyn C
- Derelle Anne-laure
- Derex Laurent
- Derkinderen Pascal
- Desai J
- Desal Hubert
- Deschaintre Y
- Deshaies E
- Deshmukh V
- Desousa K
- Detante Olivier
- Devlin T
- Devlin T
- Devlin Thomas G
- Dewey Helen M
- Dharia R
- Dharmadhikari S
- Di Maria Federico
- Diener Hans Christoph
- Diepers M
- Dietzold M
- Dippel Diederik W J
- Dippel Diederik W.j.
- Dixit Anand
- Dixit Anand
- Dobbe Roeland
- Dogan A
- Dolan E
- Domico J
- Domigo Valérie
- Dominger C
- Donegan C
- Donnan Geoffrey A
- Donnan Geoffrey A
- Dooley G
- Doppelheuer S
- Dorado L
- Dowlatshahi D
- Dowlatshahi D
- Dowling Richard
- Doyle R
- Drofa A
- Drouineau Jacques
- Drupals E
- Du Mesnil De Rochemont R
- Dubas Frédéric
- Dubuc V
- Duckwiler G
- Ducrocq Xavier
- Ducrocq Xavier
- Ducruet A
- Ducruet A
- Duff S
- Dugay Marie-hélène
- Durocher A
- Dussaule Claire
- Dávalos A
- Dávalos Antoni
- Ecker Rd
- Eesa M
- Eesa M
- Eesa M
- El Zammar Z
- Elamin E
- Elhammady M
- Elnour E
- Emery Dj
- Emmer Bart J.
- Epstein Jonathan
- Erkmen K
- Eshghi Omid
- Esperon C
- Estrade Laurent
- Eubank G
- Evain Sarah
- Evrard Serge
- Ezzeddine M
- Faivre Anthony
- Fallon C
- Fanale C
- Farb R
- Farid H
- Faro S
- Farrag A
- Farrow Schmidt A
- Faugeras Frederic
- Faulder Kenneth
- Favre Wiki Isabelle
- Felix Sandra
- Ferre Jean-christophe
- Ferrier Anna
- Field Deborah
- Field Ts
- Fields J
- Fitzsimmons B-fm
- Flach Zwenneke
- Fleitour Nadine
- Fleming L
- Fleury Olivier
- Flores A
- Flynn P
- Foerch C
- Ford Gary
- Ford Gary A
- Ford Ian
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- Wardlaw Joanna
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- Wermer Marieke Jh
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- Yavagal D
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- Zaidat O
- Zaidi S
- Zavanone Chiara
- Zech M
- Zegarac V
- Zerlauth Jean-baptiste
- Zimmel L
- Zuniga Paolo
- Zurasky J
- Publication venue
- 'Elsevier BV'
- Publication date
- 16/12/2017
- Field of study
Background:
General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard care.
Methods:
For this meta-analysis, patient-level data were pooled from all patients included in randomised trials in PuMed published between Jan 1, 2010, and May 31, 2017, that compared endovascular thrombectomy predominantly done with stent retrievers with standard care in anterior circulation ischaemic stroke patients (HERMES Collaboration). The primary outcome was functional outcome assessed by ordinal analysis of the modified Rankin scale (mRS) at 90 days in the GA and non-GA subgroups of patients treated with endovascular therapy versus those patients treated with standard care, adjusted for baseline prognostic variables. To account for between-trial variance we used mixed-effects modelling with a random effect for trials incorporated in all models. Bias was assessed using the Cochrane method. The meta-analysis was prospectively designed, but not registered.
Findings:
Seven trials were identified by our search; of 1764 patients included in these trials, 871 were allocated to endovascular thrombectomy and 893 were assigned standard care. After exclusion of 74 patients (72 did not undergo the procedure and two had missing data on anaesthetic strategy), 236 (30%) of 797 patients who had endovascular procedures were treated under GA. At baseline, patients receiving GA were younger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatment clinical severity compared with patients who did not have GA. Endovascular thrombectomy improved functional outcome at 3 months both in patients who had GA (adjusted common odds ratio (cOR) 1·52, 95% CI 1·09–2·11, p=0·014) and in those who did not have GA (adjusted cOR 2·33, 95% CI 1·75–3·10, p<0·0001) versus standard care. However, outcomes were significantly better for patients who did not receive GA versus those who received GA (covariate-adjusted cOR 1·53, 95% CI 1·14–2·04, p=0·0044). The risk of bias and variability between studies was assessed to be low.
Interpretation:
Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons
Clinical and genetic characteristics of late-onset Huntington's disease
- Author
- Aanonsen Nils Olaf
- Aaserud Olaf
- Abbruzzese Giovanni
- Acera Gil Maria Angeles
- Ackermann Oda
- Adarmes Astrid
- Agarwal Veena
- Agosti Chiara
- Akhtar Shahbana
- Alaerts Nick
- Alarcón María Dolores
- Albanese Alberto (ORCID:0000-0002-5864-0006)
- Allain Philippe
- Almagro Carmen Antúnez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrews Thomasin
- Andrich Jürgen
- Anheim Mathieu
- Anjum Uruj
- Anna Bryl Jacek Anioła
- Annic Agnès
- Antczak Jakub
- Antequera Torres María Martirio
- Antonova Victoria
- Arbelo José Matías
- Arkuszewski Michał
- Armstrong Richard
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-Lévi Anne-Catherine
- Bachoud-Lévi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandettini di Poggio Monica
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barlati Sergio
- Barral Verónica Mañanes
- Barrero Francisco
- Barrett Wendy
- Barth Katrin
- Barth Katrin
- Barthélémy Recka
- Bartoli Caterina
- Barun Nadia
- Bas Jordi
- Bascuñana Mónica
- Becanovic Kristina
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benaminov Stanislav
- Benito Dolors Moragues
- Bentivoglio Anna Rita (ORCID:0000-0002-9663-095X)
- Bentivoglio Anna-Rita
- Berglund Maria
- Berglund Måns
- Berglund Peter
- Bergmann Ulrike
- Bernal-Escudero Maravilla
- Bernard Tomáš
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bezdíček Ondřej
- Bijlsma Emilia K.
- Bioux Sandrine
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- Björnsson Elisabeth
- Bjørgo Kathrine
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- Boelmans Kai
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- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- Borgerød Nancy
- Bos Reineke
- Bos Reineke
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- Burgunder Jean-Marc
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- Busquets Núria
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- Caldentey Juan García
- Caldentey Juan García
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- Callaghan Jenny
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- Clenaghan Catherine
- Cleret de Langavant Laurent
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- Come Adrien
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- Cosgrove Jeremy
- Costa Andreia
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- Coulthard Elizabeth
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- Cubillo Patricia Trigo
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- D'Alessio Barbara
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- De Bruycker Christelle
- de Die-Smulders Christine EM.
- De Gregorio Francesca
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- Dedichá Nadia Rodríguez
- Defebvre Luc
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- Di Bella Daniela
- Di Donato Stefano
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- Dose Matthias
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- Ferreira Joaquim J.
- Ferreira Joaquim J.
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- Fullam Ruth
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- Ganos Christos
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- García Moreno José Manuel
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- Gogol (formerly Kalbarczyk) Anna
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- Gomez Esteban Juan Carlos
- González Amaia
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- Haig-Brown Diane
- Hallam Caroline
- Hamer Stephanie
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Handley Olivia J.
- Hannequin Didier
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- Held Christine
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- Holl (formerly Hödl) Anna
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- Jacek (formerly Rödig
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- Landwehrmeyer G. Bernhard
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- Léonard Marie-Claude
- López del Val Javier
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- López Rosa Guerrero
- López-Sendón Moreno José Luis
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- Martinez-Horta Saul
- Martinez-Horta Saul
- Martinez-Jaurrieta Maria Dolores
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- Middleton Julia
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- Nanetti Lorenzo
- Narożańska Ewa
- Neleborn-Lingefjärd Liselotte
- Nemeth Andrea H.
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- Neutel Dulce
- Nevitt Louise
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- Nielsen Jørgen
- Nielsen Jørgen E.
- Niemelä Valter
- Niess Anke
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- Oosterloo Mayke
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- Orth Michael
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- Painold Annamaria
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- Peter Mireille
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- Peña José Chacón
- Phillipps Clélie
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- Prieto Marta Para
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- Quarrell Oliver
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- Rakowicz Maryla
- Raman Ashok
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- Ramos-Arroyo Maria
- Ramos-Arroyo Maria Antonia
- Redondo Luis
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- Regeur Lisbeth
- Reilmann Ralf
- Reimer Jan
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- Reiter Eva-Magdalena
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- Romano Silvia
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- Romero Lemos María Dolores
- Romero Irene
- Romero Sandra Gutierrez
- Romoli Anna Maria
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- Roos Raymund A. C.
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- Rose Sarah
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- Rowett Liz
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- Schüpbach Michael
- Sciruicchio Vittorio
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- Sebastián Ana Rojo
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- Seliverstov Yury
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- Seppi Klaus
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- Simpson Sheila A.
- Simpson Steve
- Simpson Steve
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- Szinwelski Michal
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- t Hart Ellen P.
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
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- Taroni Franco
- Tartari Díaz-Zorita Juan Pablo
- Tataru Alina
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- Tedroff Joakim
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- Ulla Miguel
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- Ullah Jasmin
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- Valentine Ruth
- van de Wyngaerde Françoise
- van den Bogaard Simon J. A.
- van Hout Monique S. E.
- van Kuijk Sander MJ.
- van Oostrom Joost
- Van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen
- van Walsem Marleen R.
- Vandenberghe Wim
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- Vangsted-Hansen Christina
- Vargas-González Laura
- Vaughan Vivien
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- Verena Baake
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- Verny Christophe
- Verstappen Carla
- Verstraelen (formerly Ritchie) Nichola
- Verstraelen (Ritchie) Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Vieira da Silva Wildson
- Viladrich Cèlia Mareca
- Vilaplana Carmen Peiró
- Villa Carolina
- Villanueva Clara
- Villanueva Marina Ávila
- Vingerhoets Francois
- Vinther-Jensen Tua
- Vivancos Laura
- Vogel Melanie
- Vuillaume Isabelle
- Waber Mirella
- Wagner Caroline
- Wahlström+ Jan
- Wahlström+ Jan
- Wallden Tina
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Weckx Petra
- Weekes Rebecca
- Weekes Rebecca
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wermuth Lene
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Wider+ Christian
- Widner Håkan
- Wiklund Leif
- Wikström Birgitta
- Wild Edward
- Wild Sue
- Williams Josh
- Winkelmann Juliane
- Winkler Jürgen
- Winnberg Elisabeth
- Witjes-Ané Marie-Noelle
- Witjes-Ané Marie-Noëlle
- Witkowski Grzegorz
- Witkowski Grzegorz
- Wiśniewski Bartłomiej
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wood Sue
- Wright Abigail
- Wright Abigail
- Wright Jan
- Wójcik Magdalena
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Yudina Elizaveta
- Yudina Elizaveta
- Zalyalova Zuleykha
- Zaremba
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Zea Sevilla Maria Ascension
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zouitina Yassine
- Zucker Birgit
- Åman Jaana
- Østern Rune
- Šašinková Pavla
- Šenkárová Zuzana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients