A note on the effect of post-mortem maturation on colour of bovine Longissimus dorsi muscle

peer-reviewedFinancial support to P.G. Dunne was provided under the Walsh Fellowship programme of Teagasc.Fifteen heifers were housed and fed a concentrate diet while 54 counterparts grazed at pasture for 90 days at which stage six heifers from each group were slaughtered. The remaining animals in the pasture group were then housed and offered either: concentrate only; concentrate plus grass silage with silage accounting for either 20% or 50% of the total dry matter offered; or zero-grazed grass plus concentrate with grass accounting for 83% of the dry matter offered. Heifers (3/diet) were slaughtered 28, 56, 91 and 120 days thereafter. Colour characteristics of M. longissimus dorsi (LD) were measured at 48 h post mortem. The LD was then vacuum-packaged and stored at between 0 and 4 °C in darkness for 12 days, when colour characteristics were again measured. Maturation of LD resulted in meat that had higher redness values (‘a’ value; P<0.001) and a more intense red colour (higher ‘C’ value; P<0.001) at 14 days post mortem than at 2 days, regardless of diet/duration of feeding. Maturation also resulted in a brighter colour (higher ‘L’ value; P<0.001) but this difference was greatest when cattle were slaughtered the day-56 time point

Defining Benchmark Status: An Application using Euro-Area Bonds

The introduction of the euro on 1 January 1999 created the conditions for an integrated government bond market in the euro area. Using a unique data set from the electronic trading platform Euro-MTS, we consider what is the benchmark' in this market. We develop and apply two definitions of benchmark status that differ from the conventional view that the benchmark is the security with lowest yield at a given maturity. Using Granger-causality and cointegration methods, we find a complex pattern of benchmark status in euro-area government bonds.

cudaMap: a GPU accelerated program for gene expression connectivity mapping

BACKGROUND: Modern cancer research often involves large datasets and the use of sophisticated statistical techniques. Together these add a heavy computational load to the analysis, which is often coupled with issues surrounding data accessibility. Connectivity mapping is an advanced bioinformatic and computational technique dedicated to therapeutics discovery and drug re-purposing around differential gene expression analysis. On a normal desktop PC, it is common for the connectivity mapping task with a single gene signature to take > 2h to complete using sscMap, a popular Java application that runs on standard CPUs (Central Processing Units). Here, we describe new software, cudaMap, which has been implemented using CUDA C/C++ to harness the computational power of NVIDIA GPUs (Graphics Processing Units) to greatly reduce processing times for connectivity mapping. RESULTS: cudaMap can identify candidate therapeutics from the same signature in just over thirty seconds when using an NVIDIA Tesla C2050 GPU. Results from the analysis of multiple gene signatures, which would previously have taken several days, can now be obtained in as little as 10 minutes, greatly facilitating candidate therapeutics discovery with high throughput. We are able to demonstrate dramatic speed differentials between GPU assisted performance and CPU executions as the computational load increases for high accuracy evaluation of statistical significance. CONCLUSION: Emerging ‘omics’ technologies are constantly increasing the volume of data and information to be processed in all areas of biomedical research. Embracing the multicore functionality of GPUs represents a major avenue of local accelerated computing. cudaMap will make a strong contribution in the discovery of candidate therapeutics by enabling speedy execution of heavy duty connectivity mapping tasks, which are increasingly required in modern cancer research. cudaMap is open source and can be freely downloaded from http://purl.oclc.org/NET/cudaMap

Intrinsic ELMing in ASDEX Upgrade and global control system-plasma self-entrainment

It is well established that edge localized modes can be entrained to the frequency of applied global magnetic perturbations. These perturbations are delivered to the plasma using the vertical control system field coil currents. These field coils are part of an active control system that is required to maintain the plasma in a steady state. We perform time domain timeseries analysis of natural ELMing when there are no applied perturbations in the ASDEX Upgrade tokamak. We find that the plasma can transition into a state in which the control system field coil currents continually oscillate and are synchronized with oscillations in characteristic plasma parameters such as plasma edge position and total MHD energy. These synchronous oscillations have a one-to-one correlation with the naturally occurring ELMs; the ELMs all occur when the control system coil current is around a specific temporal phase. Large and small ELMs may be distinguished by the amplitude of inward movement of the edge following an ELM. Large ELMs are then found to occur preferentially around a specific temporal phase of the vertical position control coil current. Small ELMs are most likely in antiphase to this. The large and small natural ELMs occur at the opposite extrema of the oscillations in the control system vertical position control coil current. The control system coil current phase may thus provide a useful parameter to order the observed ELM dynamics. We have identified a class of natural ELMing which is a self-entrained state, in which there is a continual non-linear feedback between the global plasma dynamics and the active control system that is intrinsic to the cyclic dynamics of naturally occurring ELMs. Control system-plasma feedback thus becomes an essential component for integration into future models of natural ELM dynamics

Mode regularization of the susy sphaleron and kink: zero modes and discrete gauge symmetry

To obtain the one-loop corrections to the mass of a kink by mode regularization, one may take one-half the result for the mass of a widely separated kink-antikink (or sphaleron) system, where the two bosonic zero modes count as two degrees of freedom, but the two fermionic zero modes as only one degree of freedom in the sums over modes. For a single kink, there is one bosonic zero mode degree of freedom, but it is necessary to average over four sets of fermionic boundary conditions in order (i) to preserve the fermionic Z$_2$ gauge invariance $\psi \to -\psi$, (ii) to satisfy the basic principle of mode regularization that the boundary conditions in the trivial and the kink sector should be the same, (iii) in order that the energy stored at the boundaries cancels and (iv) to avoid obtaining a finite, uniformly distributed energy which would violate cluster decomposition. The average number of fermionic zero-energy degrees of freedom in the presence of the kink is then indeed 1/2. For boundary conditions leading to only one fermionic zero-energy solution, the Z$_2$ gauge invariance identifies two seemingly distinct `vacua' as the same physical ground state, and the single fermionic zero-energy solution does not correspond to a degree of freedom. Other boundary conditions lead to two spatially separated $\omega \sim 0$ solutions, corresponding to one (spatially delocalized) degree of freedom. This nonlocality is consistent with the principle of cluster decomposition for correlators of observables.Comment: 32 pages, 5 figure

Laplace Operators on Fractals and Related Functional Equations

We give an overview over the application of functional equations, namely the classical Poincar\'e and renewal equations, to the study of the spectrum of Laplace operators on self-similar fractals. We compare the techniques used to those used in the euclidean situation. Furthermore, we use the obtained information on the spectral zeta function to define the Casimir energy of fractals. We give numerical values for this energy for the Sierpi\'nski gasket

The relative ineffectiveness of bibliographic search engines

Author Posting. © American Institute of Biological Sciences, 2005. This article is posted here by permission of American Institute of Biological Sciences for personal use, not for redistribution. The definitive version was published in Bioscience 55 (2005): 688–692, doi:10.1641/0006-3568(2005)055[0688:TRIOBS]2.0.CO;2.The increasing number of scientific publications has made bibliographic search engines essential tools in all disciplines. These software-based devices, however, are far from perfect. Comparisons of software-based bibliographic search engines with complete lists of three authors' publications showed that reference citations were not generally available before 1970, and that the effectiveness of recovery was improving but was quite variable, yielding on average 36 percent of the publications. There was marked year-to-year inconsistency in the recovery of titles. The inconsistency could not be explained by differences in indexing due to journal reputation: there was no evident relationship between search effectiveness and journal impact factor, but the percentage of recovered citations was higher for indexed journals. Search engines are widely used in bibliographic searches performed for evaluating researchers, awarding promotions, or assessing journal performance. Given the ineffectiveness of search engines, their use in making such important personal and institutional decisions needs careful consideration

Beliefs, barriers and preferences of European overweight women to adopt a healthier lifestyle in pregnancy to minimize risk of developing gestational diabetes mellitus: an explorative study

Introduction: Overweight and obese women are at high risk of developing gestational diabetes mellitus (GDM). Lifestyle programs might help curb the GDM risk. We explored beliefs, perceived barriers and preferences regarding lifestyle changes among overweight European pregnant women to help inform the development of future high quality lifestyle interventions. Methods: An explorative mixed methods, two-staged study was conducted to gather information from pregnant European women (BMI≥25kg/m2). In three European countries (Belgium, Netherlands, United Kingdom) interviews were conducted, followed by questionnaires in six other European countries (Austria, Denmark, Ireland, Italy, Poland, Spain). Content analysis, descriptive and chi square statistics were applied (p&#60;0.05). Results: Women preferred to obtain detailed information about their personal risk. The health of their baby was major motivating factor. Perceived barriers for physical activity included pregnancy-specific issues such as tiredness and experiencing physical complaints. Insufficient time was a barrier more frequently reported by women with children. Abstaining from snacking was identified as a challenge for the majority of women, especially for those without children. Women preferred to obtain support from their partner, as well as health professionals and valued flexible lifestyle programs. Conclusions: Healthcare professionals need to inform overweight pregnant women about their personal risk, discuss lifestyle modification and assist in weight management. Lifestyle programs should be tailored to the individual, taking into account barriers experienced by overweight first-time mothers and multipara women