限定的気象情報で利用可能な空間リスク評価手法とニントゥアン原発ゾーンプラニングへの応用

国立大学法人長岡技術科学大

A novel ontology framework supporting model-based tourism recommender

In this paper, we present a tourism recommender framework based on the cooperation of ontological knowledge base and supervised learning models. Specifically, a new tourism ontology, which not only captures domain knowledge but also specifies knowledge entities in numerical vector space, is presented. The recommendation making process enables machine learning models to work directly with the ontological knowledge base from training step to deployment step. This knowledge base can work well with classification models (e.g., k-nearest neighbours, support vector machines, or naıve bayes). A prototype of the framework is developed and experimental results confirm the feasibility of the proposed framework. © 2021, Institute of Advanced Engineering and Science. All rights reserved

Wearable devices for remote monitoring of hospitalized patients with COVID-19 in Vietnam

Patients with severe COVID-19 disease require monitoring with pulse oximetry as a minimal requirement. In many low- and middle- income countries, this has been challenging due to lack of staff and equipment. Wearable pulse oximeters potentially offer an attractive means to address this need, due to their low cost, battery operability and capacity for remote monitoring. Between July and October 2021, Ho Chi Minh City experienced its first major wave of SARS-CoV-2 infection, leading to an unprecedented demand for monitoring in hospitalized patients. We assess the feasibility of a continuous remote monitoring system for patients with COVID-19 under these circumstances as we implemented 2 different systems using wearable pulse oximeter devices in a stepwise manner across 4 departments

A Multi-Center Randomised Controlled Trial of Gatifloxacin versus Azithromycin for the Treatment of Uncomplicated Typhoid Fever in Children and Adults in Vietnam

BACKGROUND: Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotics, including the older generation fluoroquinolones, ciprofloxacin and ofloxacin, are failing. OBJECTIVES: We performed a randomised controlled trial to compare the efficacy and safety of gatifloxacin (10 mg/kg/day) versus azithromycin (20 mg/kg/day) as a once daily oral dose for 7 days for the treatment of uncomplicated typhoid fever in children and adults in Vietnam. METHODS: An open-label multi-centre randomised trial with pre-specified per protocol analysis and intention to treat analysis was conducted. The primary outcome was fever clearance time, the secondary outcome was overall treatment failure (clinical or microbiological failure, development of typhoid fever-related complications, relapse or faecal carriage of S. typhi). PRINCIPAL FINDINGS: We enrolled 358 children and adults with suspected typhoid fever. There was no death in the study. 287 patients had blood culture confirmed typhoid fever, 145 patients received gatifloxacin and 142 patients received azithromycin. The median FCT was 106 hours in both treatment arms (95% Confidence Interval [CI]; 94-118 hours for gatifloxacin versus 88-112 hours for azithromycin), (logrank test p = 0.984, HR [95% CI] = 1.0 [0.80-1.26]). Overall treatment failure occurred in 13/145 (9%) patients in the gatifloxacin group and 13/140 (9.3%) patients in the azithromycin group, (logrank test p = 0.854, HR [95% CI] = 0.93 [0.43-2.0]). 96% (254/263) of the Salmonella enterica serovar Typhi isolates were resistant to nalidixic acid and 58% (153/263) were multidrug resistant. CONCLUSIONS: Both antibiotics showed an excellent efficacy and safety profile. Both gatifloxacin and azithromycin can be recommended for the treatment of typhoid fever particularly in regions with high rates of multidrug and nalidixic acid resistance. The cost of a 7-day treatment course of gatifloxacin is approximately one third of the cost of azithromycin in Vietnam. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN67946944

Urinary catecholamine excretion, cardiovascular variability, and outcomes in tetanus

Severe tetanus is characterized by muscle spasm and cardiovascular system disturbance. The pathophysiology of muscle spasm is relatively well understood and involves inhibition of central inhibitory synapses by tetanus toxin. That of cardiovascular disturbance is less clear, but is believed to relate to disinhibition of the autonomic nervous system. The clinical syndrome of autonomic nervous system dysfunction (ANSD) seen in severe tetanus is characterized principally by changes in heart rate and blood pressure which have been linked to increased circulating catecholamines. Previous studies have described varying relationships between catecholamines and signs of ANSD in tetanus, but are limited by confounders and assays used. In this study, we aimed to perform detailed characterization of the relationship between catecholamines (adrenaline and noradrenaline), cardiovascular parameters (heart rate and blood pressure) and clinical outcomes (ANSD, mechanical ventilation required, and length of intensive care unit stay) in adults with tetanus, as well as examine whether intrathecal antitoxin administration affected subsequent catecholamine excretion. Noradrenaline and adrenaline were measured by ELISA from 24-h urine collections taken on day 5 of hospitalization in 272 patients enrolled in a 2 × 2 factorial-blinded randomized controlled trial in a Vietnamese hospital. Catecholamine results measured from 263 patients were available for analysis. After adjustment for potential confounders (i.e., age, sex, intervention treatment, and medications), there were indications of non-linear relationships between urinary catecholamines and heart rate. Adrenaline and noradrenaline were associated with subsequent development of ANSD, and length of ICU stay

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

THE INFLUENCE OF HOTEL CHARACTERISTICS ON ROOM RATES: A CASE OF VIETNAM

The effect of hotel characteristics on hotel room rates has not been adequately studied in the extant literature. The purpose of this study was to use the hedonic pricing method to measure and compare how different factors of hotels affect room rates. After collecting the data on hotel features that consumers use to make lodging decisions on the TripAdvisor website, a hedonic price model with Box-Cox transformations was built with 23 hotel characteristics. The findings indicate that hotel managers can devise strategies to improve the hotel's attractiveness, service quality, and to change and optimize hotel room rates.Các đặc điểm của khách sạn ảnh hưởng đến giá phòng khách sạn đã được thực hiện qua nhiều nghiên cứu tuy nhiên vẫn chưa đầy đủ. Nghiên cứu này đã tìm cách áp dụng phương pháp định giá hưởng thụ để đo lường và so sánh mức độ ảnh hưởng của giá phòng bởi các yếu tố khác biệt đối với các khách sạn. Sau khi thu thập gần như tất cả dữ liệu liên quan đến các đặc điểm của khách sạn mà người tiêu dùng có thể sử dụng để đưa ra lựa chọn về chỗ ở trên trang web TripAdvisor, một mô hình định giá hưởng thụ với các phép biến đổi Box-Cox được thiết lập với 23 yếu tố là đặc điểm của khách sạn. Kết quả cho thấy các nhà quản lý khách sạn có thể đưa ra các chiến lược để nâng cao sức hấp dẫn của khách sạn, nâng cao chất lượng dịch vụ, thay đổi và tối ưu hóa giá phòng của khách sạn

Asia’s four regionalisms (Southeast Asia, South Asia, Central Asia and East Asia): a view from multilateral treaties of the United Nations

Abstract This study presents a quantitative framework to analyze the engagement of four Asian sub-regions with global issues through their participation in multilateral treaties across various policy areas. The research addresses key questions regarding the speed of Asian states’ involvement in multilateral treaties and their adaptation to these treaties within the United Nations system over time. The approach combines empirical data and conceptualization to ensure a robust evidentiary basis. A dataset comprising 600 major multilateral treaties deposited in the United Nations system, covering diverse global issues, was collected. Additionally, ratification actions from twenty-eight Asian countries were categorized into four sub-regions: East Asia, South Asia, Southeast Asia, and Central Asia. To quantitatively measure states’ engagement with multilateral treaties, the study developed and calculated the Treaty Participation Index for each Asian country and sub-group. In an area predominantly characterized by qualitative research, this paper contributes to the existing literature by providing quantitative and metric findings for comparative analyses of multilateral treaty participation among the four Asian sub-regions, as well as comparisons between Asia and the rest of the world. By analyzing the results, the paper offers an evidence-based assessment of the feasibility of these four regionalisms in Asia, particularly in the context of the transition from international politics to the paradigm of global politics

Understanding the startup’s intention of digital marketing’s learners: An application of the theory of planned behavior (TPB) and technology acceptance method (TAM)

AbstractDue to its low entry barrier, minimal overhead, and high return on investment, digital marketing has become more popular among startups, small and medium-sized enterprises as well as all businesses. There is a high need for workers skilled in Digital Marketing, so it is no surprise that schools are vying for students with an interest in this area. In this study, we will look at how students of digital marketing feel about the goals of startups, using data from recent studies to help us draw conclusions. The findings indicate that there is a strong positive relationship between startups’ propensity to use digital marketing tools and their intended behavior, which has a positive effect on their intention to launch a business. The results also support the theoretical hypotheses of the Technology Acceptance Model (TAM), as entrepreneurs’ propensity to use digital marketing tools has a direct impact on their intention to launch a business. Consistent with recent research, these findings indicate that the level of adoption of technological innovations can predict people’s intent to act in particular ways. This study offers insights for entrepreneurs and policymakers seeking to promote entrepreneurship by maximizing the potential of digital marketing tools.Based on theory of planned behavior (TPB) and the technology acceptance model (TAM), this research has also helped bring to light the role of normative influence and behavioral control in shaping entrepreneurs’ intention