3,034 research outputs found
Welcome to ICCF-18!
PresentationThese slides support the oral presentation, "Welcome to ICCF-18!" by Robert V. Duncan, Ph.D
Welcome message from General Chair Dr. Robert V. Duncan
The welcome message from the ICCF18 general chair, Dr. Robert V. Duncan
Methodological Issues in Multistage Genome-Wide Association Studies
Because of the high cost of commercial genotyping chip technologies, many
investigations have used a two-stage design for genome-wide association
studies, using part of the sample for an initial discovery of ``promising''
SNPs at a less stringent significance level and the remainder in a joint
analysis of just these SNPs using custom genotyping. Typical cost savings of
about 50% are possible with this design to obtain comparable levels of overall
type I error and power by using about half the sample for stage I and carrying
about 0.1% of SNPs forward to the second stage, the optimal design depending
primarily upon the ratio of costs per genotype for stages I and II. However,
with the rapidly declining costs of the commercial panels, the generally low
observed ORs of current studies, and many studies aiming to test multiple
hypotheses and multiple endpoints, many investigators are abandoning the
two-stage design in favor of simply genotyping all available subjects using a
standard high-density panel. Concern is sometimes raised about the absence of a
``replication'' panel in this approach, as required by some high-profile
journals, but it must be appreciated that the two-stage design is not a
discovery/replication design but simply a more efficient design for discovery
using a joint analysis of the data from both stages. Once a subset of
highly-significant associations has been discovered, a truly independent
``exact replication'' study is needed in a similar population of the same
promising SNPs using similar methods.Comment: Published in at http://dx.doi.org/10.1214/09-STS288 the Statistical
Science (http://www.imstat.org/sts/) by the Institute of Mathematical
Statistics (http://www.imstat.org
Robust Statistical Detection of Power-Law Cross-Correlation
We show that widely used approaches in statistical physics incorrectly
indicate the existence of power-law cross-correlations between financial stock
market fluctuations measured over several years and the neuronal activity of
the human brain lasting for only a few minutes. While such cross-correlations
are nonsensical, no current methodology allows them to be reliably discarded,
leaving researchers at greater risk when the spurious nature of cross-
correlations is not clear from the unrelated origin of the time series and
rather requires careful statistical estimation. Here we propose a theory and
method (PLCC-test) which allows us to rigorously and robustly test for power-
law cross-correlations, correctly detecting genuine and discarding spurious
cross-correlations, thus establishing meaningful relationships between
processes in complex physical systems. Our method reveals for the first time
the presence of power-law cross-correlations between amplitudes of the alpha
and beta frequency ranges of the human electroencephalogram
One-electron atomic-molecular ions containing Lithium in a strong magnetic field
The one-electron Li-containing Coulomb systems of atomic type and
molecular type , and are studied in
the presence of a strong magnetic field a.u. in the
non-relativistic framework. They are considered at the Born-Oppenheimer
approximation of zero order (infinitely massive centers) within the parallel
configuration (molecular axis parallel to the magnetic field). The variational
and Lagrange-mesh methods are employed in complement to each other. It is
demonstrated that the molecular systems , and
can exist for sufficiently strong magnetic fields a.u. and that can even be stable at
magnetic fields typical of magnetars.Comment: 22 pages, 9 figures, 4 table
Amphiphilic drug interactions with model cellular membranes are influenced by lipid chain-melting temperature.
Small-molecule amphiphilic species such as many drug molecules frequently exhibit low-to-negligible aqueous solubility, and generally have no identified transport proteins assisting their distribution, yet are able to rapidly penetrate significant distances into patient tissue and even cross the blood-brain barrier. Previous work has identified a mechanism of translocation driven by acid-catalysed lipid hydrolysis of biological membranes, a process which is catalysed by the presence of cationic amphiphilic drug molecules. In this study, the interactions of raclopride, a model amphiphilic drug, were investigated with mixtures of biologically relevant lipids across a range of compositions, revealing the influence of the chain-melting temperature of the lipids upon the rate of acyl hydrolysis
A tropospheric ozone maximum over the Middle East
The GEOS-CHEM global 3-D model of tropospheric chemistry predicts a summertime O3 maximum over the Middle East, with mean mixing ratios in the middle and upper troposphere in excess of 80 ppbv. This model feature is consistent with the few observations from commercial aircraft in the region. Its origin in the model reflects a complex interplay of dynamical and chemical factors, and of anthropogenic and natural influences. The anticyclonic circulation in the middle and upper troposphere over the Middle East funnels northern midlatitude pollution transported in the westerly subtropical jet as well as lightning outflow from the Indian monsoon and pollution from eastern Asia transported in an easterly tropical jet. Large-scale subsidence over the region takes place with continued net production of O3 and little mid-level outflow. Transport from the stratosphere does not contribute significantly to the O3 maximum. Sensitivity simulations with anthropogenic or lightning emissions shut off indicate decreases of 20â30% and 10â15% respectively in the tropospheric O3 column over the Middle East. More observations in this region are needed to confirm the presence of the O3 maximum
Spitzer measurements of atomic and molecular abundances in the Type IIP SN 2005af
We present results based on Spitzer Space Telescope mid-infrared (3.6-30
micron) observations of the nearby IIP supernova 2005af. We report the first
ever detection of the SiO molecule in a Type IIP supernova. Together with the
detection of the CO fundamental, this is an exciting finding as it may signal
the onset of dust condensation in the ejecta. From a wealth of fine-structure
lines we provide abundance estimates for stable Ni, Ar, and Ne which, via
spectral synthesis, may be used to constrain nucleosynthesis models.Comment: ApJ Letters (accepted
A simple, low-cost conductive composite material for 3D printing of electronic sensors
3D printing technology can produce complex objects directly from computer aided digital designs. The technology has traditionally been used by large companies to produce fit and form concept prototypes (ârapid prototypingâ) before production. In recent years however there has been a move to adopt the technology as full-scale manufacturing solution. The advent of low-cost, desktop 3D printers such as the RepRap and Fab@Home has meant a wider user base are now able to have access to desktop manufacturing platforms enabling them to produce highly customised products for personal use and sale. This uptake in usage has been coupled with a demand for printing technology and materials able to print functional elements such as electronic sensors. Here we present formulation of a simple conductive thermoplastic composite we term âcarbomorphâ and demonstrate how it can be used in an unmodified low-cost 3D printer to print electronic sensors able to sense mechanical flexing and capacitance changes. We show how this capability can be used to produce custom sensing devices and user interface devices along with printed objects with embedded sensing capability. This advance in low-cost 3D printing with offer a new paradigm in the 3D printing field with printed sensors and electronics embedded inside 3D printed objects in a single build process without requiring complex or expensive materials incorporating additives such as carbon nanotubes
- âŠ