Comparative numerical analysis for cost and embodied carbon optimisation of steel building structures

The study investigates an area of sustainable structural design that is often overlooked in practical engineering applications. Specifically, a novel method to optimise the cost and embodied carbon performance of steel building structures simultaneously is explored in this paper. To achieve this, a parametric design model was developed to rapidly analyse code compliant structural configurations based on project specific constraints and rigorous testing of multiple steel beams (UB sections), floor construction typologies (precast or composite) and column layouts that could not be performed manually by engineering practitioners. Detailed objective functions are embedded in the model to compute the cost and life cycle carbon emissions of different material types used in the structure. Results from a comparative numerical analysis of a real case study illustrate that the proposed optimisation approach could guide structural engineers towards areas of the solution space with realistic design configurations, enabling them to effectively evaluate cost and carbon trade-offs. This significant contribution implies that the optimisation model could reduce the time required for the design and analysis of multiple structural configurations especially during the early stages of a project. Overall, the paper suggests that the deployment of automated design procedures can enhance the quality as well as the efficiency of the optimisation analysis.The research described in this paper was financially supported by Innovate UK through the ‘Innovative engineering approach for material, carbon and cost efficiency of steel buildings’ project with reference number 10247

Options to make steel reuse profitable: An analysis of cost and risk distribution across the UK construction value chain

Although steel reuse has been identified as an effective method to reduce the carbon and energy impact of construction, it is in effect only a marginal practice. A detailed analysis of the costs and risks of reuse in practice in the uk is lacking. We found that although there is a sufficient spread between the price of steel scrap and new steel, this difference cannot be captured by the demolition contractors. Rather, reused steel is somewhat more expensive than new elements, except in certain circumstances such as when the reused elements are available from a nearby site, or when testing elements can be avoided. Further, we show that neither the costs of steel reuse, nor the risks, nor its benefits are spread equitably throughout the construction industry supply chain: most of the substantial and capital-intensive changes required for the widespread adoption of steel reuse are concentrated on steelwork contractors and stockists. Based on this analysis, we suggest helping the emergence of a specialised stockist.This research was supported by Innovate UK, project ‘Supply Chain Integration for structural steel reuse’, ref. 132106; EPSRC Material demand reduction: NMZL/112, RG82144, EPSRC reference: EP/N02351X/1

Real and perceived barriers to steel reuse across the UK construction value chain

© 2017 Elsevier B.V. Although steel reuse has been identified as an effective method to reduce the carbon and energy impact of construction, its occurrence is shrinking in the UK. This can be partly explained by the many barriers which have been identified in the literature, but a detailed analysis of how these barriers affect different parts of the supply chain is still lacking. We show that there is a contrast between perceived higher costs and time required to employ reused steel and the assessments of realised projects. Using a novel ranking method inspired from the field of information retrieval (tf-idf), we have analysed interviews of actors across the supply chain to determine the acuteness of the perception of each barrier. We show that demolition contractors, stockists, and fabricators face specific barriers which each need to be addressed at their level. This is in contrast with more generic barriers present throughout the value chain which we show are probably more perception than reality. Finally, we suggest how supply chain integration could facilitate reuse and make it economically viable at scale

Acetylcholine release and choline uptake by cuttlefish (Sepia officinalis) optic lobe synaptosomes

Acetylcholine (ACh), which is synthesized from choline (Ch), is believed to hold a central place in signaling mechanisms within the central nervous system (CNS) of cuttlefish (Sepia officinalis) and other coleoid cephalopods. Although the main elements required for cholinergic function have been identified in cephalopods, the transmembrane translocation events promoting the release of ACh and the uptake of Ch remain largely unsolved. The ACh release and Ch uptake were quantitatively studied through the use of in vitro chemiluminescence and isotopic methods on a subcellular fraction enriched in synaptic nerve endings (synaptosomes) isolated from cuttlefish optic lobe. The ACh release evoked by K+ depolarization was found to be very high (0.04 pmol ACh.s-(1).mg(-1) protein). In response to stimulation by veratridine, a secretagogue (a substance that induces secretion) that targets voltage-gated Na+ channels, the release rate and the total amount of ACh released were significantly lower, by 10-fold, than the response induced by KCl. The high-affinity uptake of choline was also very high (31 pmol Ch.min(-1).mg(-1) protein). The observed ACh release and Ch uptake patterns are in good agreement with published data on preparations characterized by high levels of ACh metabolism, adding further evidence that ACh acts as a neurotransmitter in cuttlefish optic lobe.FCTPOCTI/BSE/46721/2002SFRH/BPD/14677/2003SFRH/BD/1079/2000SFRH/BD/6403/2001SFRH/BD/18101/2004EC (to Y.D.) - LIPIDIET - QLK1-CT-2002-0017

Regularity and optimisation practice in steel structural frames in real design cases

Large amounts of energy and carbon are embodied in the frames of buildings, making efficient structural design a key aspect of reducing the carbon footprint of buildings. Similarly to a previous study which analysed real structures had observed that the unused mass of steel framed building could amount to nearly 46 % of the total mass due to over-specification of the sections, we find a value of 36 %. We observe that this value correlates with the design method, with software-aided design bringing significant improvements and with the design stage, where most of the optimisation seem to occur between the preliminary and tender stage. We find that neither the regularity of the structure nor the cost, independent of the measure used, correlate with the mean utilisation ratio (ur). Conversely, we observe an apparent reluctance to design beams above a 0.8 capacity ur. This reluctance explains most of the unused mass in buildings. The rest of unused mass consists in cores, trimmers and ties (6 %), some of which bear loads not captured in this analysis but are otherwise necessary for stability reasons, and in edge secondary beams (3 %) which design is constrained, and should not necessarily be considered as ‘unused’ mass

CDK6 levels regulate quiescence exit in human hematopoietic stem cells.

Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanisms underlying this variability in HSC division kinetics are unknown. We report here that quiescence exit kinetics are differentially regulated within human HSC subsets through the expression level of CDK6. LT-HSCs lack CDK6 protein. Short-term (ST)-HSCs are also quiescent but contain high CDK6 protein levels that permit rapid cell cycle entry upon mitogenic stimulation. Enforced CDK6 expression in LT-HSCs shortens quiescence exit and confers competitive advantage without impacting function. Computational modeling suggests that this independent control of quiescence exit kinetics inherently limits LT-HSC divisions and preserves the HSC pool to ensure lifelong hematopoiesis. Thus, differential expression of CDK6 underlies heterogeneity in stem cell quiescence states that functionally regulates this highly regenerative system.This work was supported by the Swiss National Science Foundation (E.L.), Roche (E.L.), the Fondation Suisse pour les Bourses en Me´ decine et Biologie (E.L.), the Swedish Research Council (S.Z.); and a Canadian Institutes of Health Research (CIHR) fellowship in partnership with the Aplastic Anemia and Myelodysplasia Association of Canada (S.Z.). Work in J.E.D.’s laboratory is supported by grants from the CIHR, Canadian Cancer Society, Terry Fox Foundation, Genome Canada through the Ontario Genomics Institute, Ontario Institute for Cancer Research with funds from the province of Ontario, a Canada Research Chair, the Princess Margaret Hospital foundation, and the Ontario Ministry of Health and Long Term Care (OMOHLTC). Research in E.L.’s laboratory is currently supported by a recruitment support from the Wellcome Trust and a core support grant from the Wellcome Trust and MRC to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute.This is the final published version. It first appeared at http://www.cell.com/cell-stem-cell/abstract/S1934-5909%2815%2900018-1

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny.

In a classical view of hematopoiesis, the various blood cell lineages arise via a hierarchical scheme starting with multipotent stem cells that become increasingly restricted in their differentiation potential through oligopotent and then unipotent progenitors. We developed a cell-sorting scheme to resolve myeloid (My), erythroid (Er), and megakaryocytic (Mk) fates from single CD34(+) cells and then mapped the progenitor hierarchy across human development. Fetal liver contained large numbers of distinct oligopotent progenitors with intermingled My, Er, and Mk fates. However, few oligopotent progenitor intermediates were present in the adult bone marrow. Instead, only two progenitor classes predominate, multipotent and unipotent, with Er-Mk lineages emerging from multipotent cells. The developmental shift to an adult "two-tier" hierarchy challenges current dogma and provides a revised framework to understand normal and disease states of human hematopoiesis.This work was supported by Postdoctoral Fellowship Awards from Canadian Institute of Health Research (CIHR) to FN and SZ. SZ is supported by (Aplastic Anemia). FN is a recipient of a scholar’s research award from the Ontario Institute of Cancer Research (OICR), through generous support from the Ontario Ministry of Research and Innovation. Research in EL laboratory is supported by a Wellcome Trust Sir Henry Dale Fellowship and core support grant from the Wellcome Trust and MRC to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute. Work in the Dick laboratory is supported by grants from the CIHR, Canadian Cancer Society, Terry Fox Foundation, Genome Canada through the Ontario Genomics Institute, OICR with funds from the province of Ontario, a Canada Research Chair and the Ontario Ministry of Health and Long Term Care (OMOHLTC).This is the author accepted manuscript. The final version is available from AAAS via http://dx.doi.org/10.1126/science.aab211

Numerical benchmark campaign of cost action tu1404 – microstructural modelling

This paper presents the results of the numerical benchmark campaign on modelling of hydration and microstructure development of cementitious materials. This numerical benchmark was performed in the scope of COST Action TU1404 “Towards the next generation of standards for service life of cement-based materials and structures”. Seven modelling groups took part in the campaign applying different models for prediction of mechanical properties (elastic moduli or compressive strength) in cement pastes and mortars. The simulations were based on published experimental data. The experimental data (both input and results used for validation) were open to the participants. The purpose of the benchmark campaign was to identify the needs of different models in terms of input experimental data, verify predictive potential of the models and finally to provide reference cases for new models in the future. The results of the benchmark show that a relatively high scatter in the predictions can arise between different models, in particular at early ages (e.g. elastic Young’s modulus predicted at 1 d in the range 6-20 GPa), while it reduces at later age, providing relatively good agreement with experimental data. Even though the input data was based on a single experimental dataset, the large differences between the results of the different models were found to be caused by distinct assumed properties for the individual phases at the microstructural level, mainly because of the scatter in the nanoindentation-derived properties of the C-S-H phase.</jats:p

National-Scale Rainfall-Triggered Landslide Susceptibility and Exposure in Nepal

Nepal is one of the most landslide-prone countries in the world, with year-on-year impacts resulting in loss of life and imposing a chronic impediment to sustainable livelihoods. Living with landslides is a daily reality for an increasing number of people, so establishing the nature of landslide hazard and risk is essential. Here we develop a model of landslide susceptibility for Nepal and use this to generate a nationwide geographical profile of exposure to rainfall-triggered landslides. We model landslide susceptibility using a fuzzy overlay approach based on freely-available topographic data, trained on an inventory of mapped landslides, and combine this with high resolution population and building data to describe the spatial distribution of exposure to landslides. We find that whilst landslide susceptibility is highest in the High Himalaya, exposure is highest within the Middle Hills, but this is highly spatially variable and skewed to on average relatively low values. Around 4 × 106 Nepalis (∼15\% of the population) live in areas considered to be at moderate or higher degree of exposure to landsliding (>0.25 of the maximum), and critically this number is highly sensitive to even small variations in landslide susceptibility. Our results show a complex relationship between landslides and buildings, that implies wider complexity in the association between physical exposure to landslides and poverty. This analysis for the first time brings into focus the geography of the landslide exposure and risk case load in Nepal, and demonstrates limitations of assessing future risk based on limited records of previous events