The holonomy of the supercovariant connection and Killing spinors

We show that the holonomy of the supercovariant connection for M-theory backgrounds with $N$ Killing spinors reduces to a subgroup of SL(32-N,\bR)\st (\oplus^N \bR^{32-N}). We use this to give the necessary and sufficient conditions for a background to admit $N$ Killing spinors. We show that there is no topological obstruction for the existence of up to 22 Killing spinors in eleven-dimensional spacetime. We investigate the symmetry superalgebras of supersymmetric backgrounds and find that their structure constants are determined by an antisymmetric matrix. The Lie subalgebra of bosonic generators is related to a real form of a symplectic group. We show that there is a one-one correspondence between certain bases of the Cartan subalgebra of sl(32, \bR) and supersymmetric planar probe M-brane configurations. A supersymmetric probe configuration can involve up to 31 linearly independent planar branes and preserves one supersymmetry. The space of supersymmetric planar probe M-brane configurations is preserved by an SO(32,\bR) subgroup of SL(32, \bR).Comment: 27 pages, a key reference was added. v3: minor change

Chiral spinors and gauge fields in noncommutative curved space-time

The fundamental concepts of Riemannian geometry, such as differential forms, vielbein, metric, connection, torsion and curvature, are generalized in the context of non-commutative geometry. This allows us to construct the Einstein-Hilbert-Cartan terms, in addition to the bosonic and fermionic ones in the Lagrangian of an action functional on non-commutative spaces. As an example, and also as a prelude to the Standard Model that includes gravitational interactions, we present a model of chiral spinor fields on a curved two-sheeted space-time with two distinct abelian gauge fields. In this model, the full spectrum of the generalized metric consists of pairs of tensor, vector and scalar fields. They are coupled to the chiral fermions and the gauge fields leading to possible parity violation effects triggered by gravity.Comment: 50 pages LaTeX, minor corrections and references adde

Surface Terms as Counterterms in the AdS/CFT Correspondence

We examine the recently proposed technique of adding boundary counterterms to the gravitational action for spacetimes which are locally asymptotic to anti-de Sitter. In particular, we explicitly identify higher order counterterms, which allow us to consider spacetimes of dimensions d<=7. As the counterterms eliminate the need of ``background subtraction'' in calculating the action, we apply this technique to study examples where the appropriate background was ambiguous or unknown: topological black holes, Taub-NUT-AdS and Taub-Bolt-AdS. We also identify certain cases where the covariant counterterms fail to render the action finite, and we comment on the dual field theory interpretation of this result. In some examples, the case of vanishing cosmological constant may be recovered in a limit, which allows us to check results and resolve ambiguities in certain asymptotically flat spacetime computations in the literature.Comment: Revtex, 18 pages. References updated and few typo's fixed. Final versio

Dimensionless cosmology

Although it is well known that any consideration of the variations of fundamental constants should be restricted to their dimensionless combinations, the literature on variations of the gravitational constant $G$ is entirely dimensionful. To illustrate applications of this to cosmology, we explicitly give a dimensionless version of the parameters of the standard cosmological model, and describe the physics of Big Bang Neucleosynthesis and recombination in a dimensionless manner. The issue that appears to have been missed in many studies is that in cosmology the strength of gravity is bound up in the cosmological equations, and the epoch at which we live is a crucial part of the model. We argue that it is useful to consider the hypothetical situation of communicating with another civilization (with entirely different units), comparing only dimensionless constants, in order to decide if we live in a Universe governed by precisely the same physical laws. In this thought experiment, we would also have to compare epochs, which can be defined by giving the value of any {\it one} of the evolving cosmological parameters. By setting things up carefully in this way one can avoid inconsistent results when considering variable constants, caused by effectively fixing more than one parameter today. We show examples of this effect by considering microwave background anisotropies, being careful to maintain dimensionlessness throughout. We present Fisher matrix calculations to estimate how well the fine structure constants for electromagnetism and gravity can be determined with future microwave background experiments. We highlight how one can be misled by simply adding $G$ to the usual cosmological parameter set

Quantifying atherogenic lipoproteins for lipid-lowering strategies : Consensus-based recommendations from EAS and EFLM

The joint consensus panel of the European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) recently addressed present and future challenges in the laboratory diagnostics of atherogenic lipoproteins. Total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, and calculated non-HDL cholesterol (= total - HDL cholesterol) constitute the primary lipid panel for estimating risk of atherosclerotic cardiovascular disease (ASCVD) and can be measured in the nonfasting state. LDL cholesterol is the primary target of lipid-lowering therapies. For on-treatment follow-up, LDL cholesterol shall be measured or calculated by the same method to attenuate errors in treatment decisions due to marked between-method variations. Lipoprotein(a)-cholesterol is part of measured or calculated LDL cholesterol and should be estimated at least once in all patients at risk of ASCVD, especially in those whose LDL cholesterol decline poorly upon statin treatment. Residual risk of ASCVD even under optimal LDL-lowering treatment should be also assessed by non-HDL cholesterol or apolipoprotein B, especially in patients with mild-to-moderate hypertriglyceridemia (2-10 mmol/L). Non-HDL cholesterol includes the assessment of remnant lipoprotein cholesterol and shall be reported in all standard lipid panels. Additional apolipoprotein B measurement can detect elevated LDL particle numbers often unidentified on the basis of LDL cholesterol alone. Reference intervals of lipids, lipoproteins, and apolipoproteins are reported for European men and women aged 20-100 years. However, laboratories shall flag abnormal lipid values with reference to therapeutic decision thresholds.Peer reviewe

The Life and Death of Barn Beetles: Faunas from Manure and Stored Hay inside Farm Buildings in Northern Iceland

This research was funded by the Commonwealth Scholarship Commission and received support from the Research Budget of the Department of Archaeology at the University of Aberdeen. This project was undertaken as part of doctoral studies supervised by Dr Karen Milek, to whom V.F. is especially grateful for her support and advice. Thomas Birch, Sigrún Inga Garðarsdóttir, and Paul Ledger provided invaluable assistance during fieldwork. V.F. would like to dedicate this paper to Tom and Sía, who met during this fieldwork and are getting married this year. Many people from Fornleifastofnun Íslands – Garðar Guðmundsson, Ólöf Þorsteinsdóttir, Þóra Pétursdóttir, Adolf Friðriksson and Uggi Ævarsson – as well as Unnstein Ingason, Ágústa Edwald, and Mark Young, helped with fieldwork logistics. Special thanks are due to all the Icelandic farmers and their families who kindly allowed us to collect insects on their farms and provided help when needed: Hermann Aðalsteinsson, Hermína Fjóla Ingólfsdóttir, Guðmundur Skúlason, Sigrún Á. Franzdóttir, Dúna Magnúsdóttir, Sverrir Steinbergsson, Valgeir Þorvaldsson, Reynir Sveinsson, Jónas Þór Ingólfsson, and Ívar Ólafsson. Eva Panagiotakopulu, Jan Klimaszewski, Ales Smetana, Georges Pelletier, Gabor Pozsgai, and Jenni Stockham helped with some of the beetle identifications. A.J.D. acknowledges the support of National Science Foundation through ARC 1202692. Consultation of the BugsCEP database (Buckland & Buckland, 2006) aided the redaction of this paper. The authors would like to thank David Smith and two anonymous reviewers for insightful comments that helped improve the quality of this paper.Peer reviewedPostprin

On the Holographic RG-flow and the Low-energy, Strong Coupling, Large N Limit

From the AdS/CFT correspondence, we learn that the classical evolution of supergravity in the bulk can be reduced to a RG-flow equation for the dual low-energy, strongly coupled and large N gauge theory on the boundary. This result has been used to obtain interesting relations between the various terms in the gravitational part of the boundary effective action, in particular the term that affect the cosmological constant. It is found that once the cosmological constant is cancelled in the UV theory, the RG-flow symmetry of the boundary effective action automatically implies the existence of zero cosmological constant solutions that extend all the way into the IR. Given the standard (and well founded) contradiction between the RG-flow idea and the observational evidence of a small cosmological constant, this is considered to be an important progress, albeit incomplete, towards the final solution. Motivated by this success, it would be interesting to see whether this RG-stability extends outside the scope of strong 't Hooft coupling and large N regime that are implicitly assumed in the de Boer-Verlinde-Verlinde Hamilton-Jacobi formulation of the holographic RG-flow equations of the boundary theory. In this paper, we address this question. Taking into account the leading order corrections in the 1/N and $\alpha'/{R^2}$ parameters, we derive new bulk/boundary relations, from which one can read all the local terms in the boundary effective action. Next, we use the resulting constraints, to examine whether the RG-stability of the cosmological constant extends to the new coupling regime. It would be also interesting to use these constraints to study the Randall-Sundrum scenario in this case.Comment: 27 pages, LateX, no figures, minor changes, typos corrected and added more reference

Quantifying atherogenic lipoproteins for lipid-lowering strategies: consensus-based recommendations from EAS and EFLM

The joint consensus panel of the European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) recently addressed present and future challenges in the laboratory diagnostics of atherogenic lipoproteins. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), LDL cholesterol (LDLC), and calculated non-HDLC (=total - HDLC) constitute the primary lipid panel for estimating risk of atherosclerotic cardiovascular disease (ASCVD) and can be measured in the nonfasting state. LDLC is the primary target of lipid-lowering therapies. For on-treatment follow-up, I.DLC shall be measured or calculated by the same method to attenuate errors in treatment decisions due to marked between-method variations. Lipoprotein(a) [Lp(a)]-cholesterol is part of measured or calculated LDLC and should be estimated at least once in all patients at risk of ASCVD, especially in those whose LDLC declines poorly upon statin treatment. Residual risk of ASCVD even under optimal LDL-lowering treatment should be also assessed by non-HDLC or apolipoprotein B (apoB), especially in patients with mild-to-moderate hypertriglyceridemia (2-10 mmol/L). Non-HDLC includes the assessment of remnant lipoprotein cholesterol and shall be reported in all standard lipid panels. Additional apoB measurement can detect elevated LDL particle (LDLP) numbers often unidentified on the basis of LDLC alone. Reference intervals of lipids, lipoproteins, and apolipoproteins are reported for European men and women aged 20-100 years. How-ever, laboratories shall flag abnormal lipid values with reference to therapeutic decision thresholds.Afdeling Klinische Chemie en Laboratoriumgeneeskunde (AKCL

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely