Exclusive Preference on Concurrent Schedules in Children with Autism Spectrum Disorder

Treatment programs often utilize positive consequences to establish, increase, or maintain behavior. Recently, Dube and McIlvane (2002) examined the sensitivity of individuals with neurodevelopmental disabilities to differences in the frequency and magnitude of reinforcing consequences. Six individuals were exposed to a concurrent-choice procedure during which each option was associated with a range of schedules differing in reinforcer frequency or magnitude. Data were analyzed in accordance with the generalized matching law (Baum, 1974) and the positive slopes of obtained matching functions indicated sensitivity to the programmed reinforcer disparities. In recent follow-up work, we have been using the methods of Dube and McIlvane (2002) to assess sensitivity to changes in reinforcer frequency in individuals at lower functioning levels. During pretraining, a number of our recent participants developed exclusive or near-exclusive stimulus preferences that have proven difficult to overcome. This “Research in Progress” report is intended to highlight this challenge, describe efforts to overcome it, and to report potentially promising remedial procedures

Assessing Behavioral Momentum in Humans with Mental Retardation and Unstable Baselines

Our laboratory is currently conducting studies of behavioral momentum in humans with mental retardation. A better understanding of momentum effects may contribute to more effective procedures for reducing or eliminating learning problems in this population (e.g., McIlvane & Dube, 2000). In our studies, we have occasionally encountered cases where even liberal baseline stability criteria were not met after a substantial number of sessions, and thus typical procedures for evaluating momentum were not appropriate. This brief report will describe an alternative testing procedure that we are examining for use in these situations

A FORMAÇÃO DE CLASSES DE EQUIVALÊNCIA VIA PAREAMENTO POR IDENTIDADE E DISCRIMINAÇÃO SIMPLES COM CONSEQÜÊNCIAS ESPECÍFICAS PARA AS CLASSES

Human participant performances often show evidence of learning untrained relations when conditional discrimination training between physically dissimilar stimuli is conducted. These emergent relations document equivalence class formation. The current study investigated whether class-specific consequences (i.e. the specific reinforcers used for each potential class during training) also join the equivalence class. Several studies have suggested they do so. However, training in those studies typically included arbitrary matching and identity matching baselines. In the current study, two autistic children were trained on simple discrimination reversals and identity matching with class specific consequences. They were then given arbitrary matching probes. Performances of both children initially showed evidence of class formation on these tests, despite the fact that neither had received training on arbitrary matching. In addition, one of the participants showed evidence of class formation after simple discrimination reversal training alone. These results demonstrate that the reinforcing consequences do in fact become part of the stimulus equivalence class and provide support for the ideas that equivalence (1) arises from reinforcement contingency and (2) is not based upon language skills. Key words: Stimulus equivalence, matching to sample, simple discrimination, outcome-specific reinforcement,differential outcomes effect, mental retardationO desempenho de participantes humanos freqüentemente mostra aprendizagem de relações não diretamente ensinadas após o treino de discriminações condicionais entre estímulos fisicamente diferentes. Essas relações emergentes documentam a formação de classes de equivalência. O presente estudo investigou se conseqüências específicas paras as classes (i.e., reforçadores específicos usados para cada classe potencial durante o treino) também integram as classes de equivalência. Vários estudos anteriores sugeriram que as conseqüências específicas podem integrar as classes, entretanto, o treino nesses estudos inclui pareamento arbitrário e pareamento por identidade. No presente estudo, duas crianças autistas foram submetidas apenas a treino de reversões de discriminações simples e pareamento por identidade com conseqüências específicas paras as classes potenciais. Então, testes de pareamento arbitrário foram conduzidos. O desempenho das crianças evidenciou a formação de classes nestes testes, a despeito de elas não terem experiência de treino de pareamento arbitrário. Adicionalmente, um dos participantes mostrou evidência de formação de classes após treino de reversões de discriminação simples somente. Esses resultados tanto demonstram que as conseqüências reforçadoras de fato se tornam parte das classes de equivalência, quanto dão suporte à idéia de que equivalência surge das contingências de reforçamento e não é baseada em habilidades lingüísticas. Palavras-chave: equivalência de estímulos, pareamento ao modelo, discriminação simples, reforçamento específico, efeito de conseqüência específica, retardo menta

Equivalence class formation via identity matching to sample and simple discrimination with class-specific consequences

Human participant performances often show evidence of learning untrained relations when conditional discrimination training between physically dissimilar stimuli is conducted. These emergent relations document equivalence class formation. The current study investigated whether class-specific consequences (i.e. the specific reinforcers used for each potential class during training) also join the equivalence class. Several studies have suggested they do so. However, training in those studies typically included arbitrary matching and identity matching baselines. In the current study, two autistic children were trained on simple discrimination reversals and identity matching with class specific consequences. They were then given arbitrary matching probes. Performances of both children initially showed evidence of class formation on these tests, despite the fact that neither had received training on arbitrary matching. In addition, one of the participants showed evidence of class formation after simple discrimination reversal training alone. These results demonstrate that the reinforcing consequences do in fact become part of the stimulus equivalence class and provide support for the ideas that equivalence (1) arises from reinforcement contingency and (2) is not based upon language skills

Studies of Brain Activity Correlates of Behavior in Individuals with and without Developmental Disabilities

There is a rich assortment of brain imaging methodologies that permits evaluation of the covert events that are necessary to complete a comprehensive account of behavior. Among the latter methodologies, our laboratories have begun to explore event-related potential (ERP) research to complement traditional behavior analysis

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.

BACKGROUND: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequencing, we studied the effects of loss-of-function mutations in selected genes. RESULTS: We confirmed previously observed significant associations between coronary artery disease and low-frequency missense variants in the genes LPA and PCSK9. We also found significant associations between coronary artery disease and low-frequency missense variants in the genes SVEP1 (p.D2702G; minor-allele frequency, 3.60%; odds ratio for disease, 1.14; P=4.2×10(-10)) and ANGPTL4 (p.E40K; minor-allele frequency, 2.01%; odds ratio, 0.86; P=4.0×10(-8)), which encodes angiopoietin-like 4. Through sequencing of ANGPTL4, we identified 9 carriers of loss-of-function mutations among 6924 patients with myocardial infarction, as compared with 19 carriers among 6834 controls (odds ratio, 0.47; P=0.04); carriers of ANGPTL4 loss-of-function alleles had triglyceride levels that were 35% lower than the levels among persons who did not carry a loss-of-function allele (P=0.003). ANGPTL4 inhibits lipoprotein lipase; we therefore searched for mutations in LPL and identified a loss-of-function variant that was associated with an increased risk of coronary artery disease (p.D36N; minor-allele frequency, 1.9%; odds ratio, 1.13; P=2.0×10(-4)) and a gain-of-function variant that was associated with protection from coronary artery disease (p.S447*; minor-allele frequency, 9.9%; odds ratio, 0.94; P=2.5×10(-7)). CONCLUSIONS: We found that carriers of loss-of-function mutations in ANGPTL4 had triglyceride levels that were lower than those among noncarriers; these mutations were also associated with protection from coronary artery disease. (Funded by the National Institutes of Health and others.).Supported by a career development award from the National Heart, Lung, and Blood Institute, National Institutes of Health (NIH) (K08HL114642 to Dr. Stitziel) and by the Foundation for Barnes–Jewish Hospital. Dr. Peloso is supported by the National Heart, Lung, and Blood Institute of the NIH (award number K01HL125751). Dr. Kathiresan is supported by a Research Scholar award from the Massachusetts General Hospital, the Donovan Family Foundation, grants from the NIH (R01HL107816 and R01HL127564), a grant from Fondation Leducq, and an investigator-initiated grant from Merck. Dr. Merlini was supported by a grant from the Italian Ministry of Health (RFPS-2007-3-644382). Drs. Ardissino and Marziliano were supported by Regione Emilia Romagna Area 1 Grants. Drs. Farrall and Watkins acknowledge the support of the Wellcome Trust core award (090532/Z/09/Z), the British Heart Foundation (BHF) Centre of Research Excellence. Dr. Schick is supported in part by a grant from the National Cancer Institute (R25CA094880). Dr. Goel acknowledges EU FP7 & Wellcome Trust Institutional strategic support fund. Dr. Deloukas’s work forms part of the research themes contributing to the translational research portfolio of Barts Cardiovascular Biomedical Research Unit, which is supported and funded by the National Institute for Health Research (NIHR). Drs. Webb and Samani are funded by the British Heart Foundation, and Dr. Samani is an NIHR Senior Investigator. Dr. Masca was supported by the NIHR Leicester Cardiovascular Biomedical Research Unit (BRU), and this work forms part of the portfolio of research supported by the BRU. Dr. Won was supported by a postdoctoral award from the American Heart Association (15POST23280019). Dr. McCarthy is a Wellcome Trust Senior Investigator (098381) and an NIHR Senior Investigator. Dr. Danesh is a British Heart Foundation Professor, European Research Council Senior Investigator, and NIHR Senior Investigator. Drs. Erdmann, Webb, Samani, and Schunkert are supported by the FP7 European Union project CVgenes@ target (261123) and the Fondation Leducq (CADgenomics, 12CVD02). Drs. Erdmann and Schunkert are also supported by the German Federal Ministry of Education and Research e:Med program (e:AtheroSysMed and sysINFLAME), and Deutsche Forschungsgemeinschaft cluster of excellence “Inflammation at Interfaces” and SFB 1123. Dr. Kessler received a DZHK Rotation Grant. The analysis was funded, in part, by a Programme Grant from the BHF (RG/14/5/30893 to Dr. Deloukas). Additional funding is listed in the Supplementary Appendix.This is the author accepted manuscript. The final version is available from the Massachusetts Medical Society via http://dx.doi.org/10.1056/NEJMoa150765

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016

The UN’s Sustainable Development Goals (SDGs) are grounded in the global ambition of “leaving no one behind”. Understanding today’s gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicators over the period 1990–2016 for 188 countries, and then on the basis of these past trends, we projected indicators to 2030

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI). METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE differed from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate. FINDINGS: The highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years (1·61-1·93) for males and 1·96 years (1·69-2·13) for females. Total global DALYs remained largely unchanged from 1990 to 2016 (-2·3% [-5·9 to 0·9]), with decreases in communicable, maternal, neonatal, and nutritional (CMNN) disease DALYs offset by increased DALYs due to non-communicable diseases (NCDs). The exemplars, calculated as the five lowest ratios of observed to expected age-standardised DALY rates in 2016, were Nicaragua, Costa Rica, the Maldives, Peru, and Israel. The leading three causes of DALYs globally were ischaemic heart disease, cerebrovascular disease, and lower respiratory infections, comprising 16·1% of all DALYs. Total DALYs and age-standardised DALY rates due to most CMNN causes decreased from 1990 to 2016. Conversely, the total DALY burden rose for most NCDs; however, age-standardised DALY rates due to NCDs declined globally. INTERPRETATION: At a global level, DALYs and HALE continue to show improvements. At the same time, we observe that many populations are facing growing functional health loss. Rising SDI was associated with increases in cumulative years of life lived with disability and decreases in CMNN DALYs offset by increased NCD DALYs. Relative compression of morbidity highlights the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning. The analysis of DALYs and HALE and their relationship to SDI represents a robust framework with which to benchmark location-specific health performance. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform health policies, health system improvement initiatives, targeted prevention efforts, and development assistance for health, including financial and research investments for all countries, regardless of their level of sociodemographic development. The presence of countries that substantially outperform others suggests the need for increased scrutiny for proven examples of best practices, which can help to extend gains, whereas the presence of underperforming countries suggests the need for devotion of extra attention to health systems that need more robust support. FUNDING: Bill & Melinda Gates Foundation