An Update on the CDDIS

The Crustal Dynamics Data Inforn1ation System (CoorS) supports data archiving and distribution activities for the space geodesy and geodynamics community. The main objectives of the system are to store space geodesy and geodynamics related data products in a central data bank, to maintain infom1ation about the archival of these data, and to disseminate these data and information in a timely mam1er to a global scientific research community. The archive consists of GNSS, laser ranging, VLBI, and OORIS data sets and products derived from these data. The coors is one of NASA's Earth Observing System Oata and Infom1ation System (EOSorS) distributed data centers; EOSOIS data centers serve a diverse user community and are tasked to provide facilities to search and access science data and products. The coors data system and its archive have become increasingly important to many national and international science communities, in pal1icular several of the operational services within the International Association of Geodesy (lAG) and its project the Global Geodetic Observing System (GGOS), including the International OORIS Service (IDS), the International GNSS Service (IGS), the International Laser Ranging Service (ILRS), the International VLBI Service for Geodesy and Astrometry (IVS), and the International Earth Rotation Service (IERS). The coors has recently expanded its archive to supp011 the IGS Multi-GNSS Experiment (MGEX). The archive now contains daily and hourly 3D-second and subhourly I-second data from an additional 35+ stations in RINEX V3 fOm1at. The coors will soon install an Ntrip broadcast relay to support the activities of the IGS Real-Time Pilot Project (RTPP) and the future Real-Time IGS Service. The coors has also developed a new web-based application to aid users in data discovery, both within the current community and beyond. To enable this data discovery application, the CDDIS is currently implementing modifications to the metadata extracted from incoming data and product files pushed to its archive. This poster will include background information about the system and its user communities, archive contents and updates, enhancements for data discovery, new system architecture, and future plans

Synchronization modulation increases transepithelial potentials in MDCK monolayers through Na/K pumps

Peer reviewedPublisher PD

Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children

BACKGROUND Typhoid fever caused by multidrug-resistant H58 Salmonella Typhi is an increasing public health threat in sub-Saharan Africa. METHODS We conducted a phase 3, double-blind trial in Blantyre, Malawi, to assess the efficacy of Vi polysaccharide typhoid conjugate vaccine (Vi-TCV). We randomly assigned children who were between 9 months and 12 years of age, in a 1:1 ratio, to receive a single dose of Vi-TCV or meningococcal capsular group A conjugate (MenA) vaccine. The primary outcome was typhoid fever confirmed by blood culture. We report vaccine efficacy and safety outcomes after 18 to 24 months of follow-up. RESULTS The intention-to-treat analysis included 28,130 children, of whom 14,069 were assigned to receive Vi-TCV and 14,061 were assigned to receive the MenA vaccine. Blood culture–confirmed typhoid fever occurred in 12 children in the Vi-TCV group (46.9 cases per 100,000 person-years) and in 62 children in the MenA group (243.2 cases per 100,000 person-years). Overall, the efficacy of Vi-TCV was 80.7% (95% confidence interval [CI], 64.2 to 89.6) in the intention-to-treat analysis and 83.7% (95% CI, 68.1 to 91.6) in the per-protocol analysis. In total, 130 serious adverse events occurred in the first 6 months after vaccination (52 in the Vi-TCV group and 78 in the MenA group), including 6 deaths (all in the MenA group). No serious adverse events were considered by the investigators to be related to vaccination. CONCLUSIONS Among Malawian children 9 months to 12 years of age, administration of Vi-TCV resulted in a lower incidence of blood culture–confirmed typhoid fever than the MenA vaccine. (Funded by the Bill and Melinda Gates Foundation; ClinicalTrials.gov number, NCT03299426

The DORIS Data Center at the CDDIS

The DORIS system (Doppler Orbitography and Radio positioning Integrated by Satellite) was designed and developed by CNES, the National Geographic Institute, IGN (Institut G6ographique National), and the Space Geodesy Research Group, GRGS (Groupe de Recherches de Geodesie Spatiale - CNES/CNRS/Universite Paul Sabatier) to meet new needs for the precise determination of satellite positions on their orbits and for precise positioning of terrestrial beacons. This system has been carried since 1990 on the French SPOT 2 satellite, since 1992 on the French/American satellite TOPEX/POSEIDON, and since 1998 on the French SPOT 4 satellite. It will be part of the JASON (CNES/NASA) and ENVISAT (ESA) altimetric missions and also the SPOT follow-on Earth observation missions. DORIS is a radio-electrical system which takes Doppler measurements between a satellite in low orbit and a permanent global network for the purpose, on the one hand, of determining the satellite's position in orbit, and on the other hand, of locating ground beacons with a high degree of precision

MEASUREMENT OF NATURAL IRRADIANCE IN GREENHOUSES : THE EFFECT OF AVERAGING PERIOD AND NUMBER OF SENSORS ON MEASUREMENT RELIABILITY

Measurements of natural photosynthetic photon flux (PPF) at 1m above the floor in glass and polyethylene greenhouses obtained using a mobile sampling system are compared to data obtained by 6 stationary sensors at the same height. Analysis of the data shows that the use of multiple stationary sensors does not lead to an accurate value of the spatial average irradiance under sunny conditions in either glass or polyethylene greenhouses when integration times are short (1 to 3h). With longer integration times (up to 10h), these inaccuracies are insignificant under glass. Under polyethylene, systematic differences in PPF occur across the greenhouse. In our region, calculations using data from this experiment indicate that average differences in total radiation accumulations during February can be as large as those induced in typical supplemental irradiation experiments. These systematic gradients should be taken into account in experiments where the parameters being studied may be sensitive to radiation integrals

MEASUREMENT OF NATURAL IRRADIANCE IN GREENHOUSES : THE EFFECT OF AVERAGING PERIOD AND NUMBER OF SENSORS ON MEASUREMENT RELIABILITY

Measurements of natural photosynthetic photon flux (PPF) at 1m above the floor in glass and polyethylene greenhouses obtained using a mobile sampling system are compared to data obtained by 6 stationary sensors at the same height. Analysis of the data shows that the use of multiple stationary sensors does not lead to an accurate value of the spatial average irradiance under sunny conditions in either glass or polyethylene greenhouses when integration times are short (1 to 3h). With longer integration times (up to 10h), these inaccuracies are insignificant under glass. Under polyethylene, systematic differences in PPF occur across the greenhouse. In our region, calculations using data from this experiment indicate that average differences in total radiation accumulations during February can be as large as those induced in typical supplemental irradiation experiments. These systematic gradients should be taken into account in experiments where the parameters being studied may be sensitive to radiation integrals

Submission of the first fullscale prototype chip for upgraded ATLAS pixel detector at LHC, FE-I4A

A new ATLAS pixel chip FE-I4 is being developed for use in upgraded LHC luminosity environments, including the near-term Insertable B-Layer (IBL) upgrade. FE-I4 is designed in a 130 nm CMOS technology, presenting advantages in terms of radiation tolerance and digital logic density compared to the View the MathML source0.25μm CMOS technology used for the current ATLAS pixel IC, FE-I3. The FE-I4 architecture is based on an array of 80×336 pixels, each View the MathML source50×250μm2, consisting of analog and digital sections. In the summer 2010, a first full scale prototype FE-I4A was submitted for an engineering run. This IC features the full scale pixel array as well as the complex periphery of the future full-size FE-I4. The FE-I4A contains also various extra test features which should prove very useful for the chip characterization, but deviate from the needs for standard operation of the final FE-I4 for IBL. In this paper, focus will be brought to the various features implemented in the FE-I4A submission, while also underlining the main differences between the FE-I4A IC and the final FE-I4 as envisioned for IBL