In Healthy Subjects Nasal Nitric Oxide Does Not Correlate with Olfactory Sensitivity, Trigeminal Sensitivity, and Nasal Airflow

Objective: The aim of the study was to determine the relationship between nasal nitric oxide (nNO) and olfactory sensitivity, trigeminal sensitivity and nasal airflow in healthy subjects. Study design: This is a correlational study. Setting: This study was carried out in a tertiary referral centre. Participants: Forty healthy participants were recruited. Main outcome measures: nNO was measured using a chemiluminescence analyser (Niox Vero® , Circassia AB, Uppsala, Sweden), olfactory sensitivity was determined using phenyl ethyl alcohol odour thresholds using the 'Sniffin' Sticks', trigeminal sensitivity was assessed with carbon dioxide delivered by an automated device, and nasal airflow was measured using the peak nasal inspiratory flow (PNIF). Results: The median nNO was 518 ppb (IQR =333) in the right nostril, and it was 567 ppb (IQR = 314) in the left nostril. The median odour threshold was 7.1 (IQR = 4.4), the median CO2 threshold was 919 ms (IQR = 1297) and the mean PNIF was 108 L/min (SEM = 4.9). nNO did not correlate significantly with odour threshold, CO2 threshold or PNIF (Spearman's |ρ| .18). Conclusion: In healthy subjects, nNO does not appear to be associated with olfactory sensitivity, trigeminal sensitivity and PNIF.info:eu-repo/semantics/publishedVersio

Determination of audit activity in modern conditions

The task of compulsory audit of financial statements is the provision of reasonable assurance that is accepted and performed by the entity in accordance with the requirements of this Law and international standards of audit by checking the financial statements or consolidated financial statements in order to express an independent opinion of the auditor on its compliance with all significant aspects and compliance with the requirements of international financial reporting standards or national accounting (statutory) standards and laws of Ukraine

The European Climate Research Alliance (ECRA): collaboration from bottom-up

The European Climate Research Alliance (ECRA) is an association of leading European research institutions in the field of climate research (http://www.ecra-climate.eu/, last access: 6 December 2018). ECRA is a bottom-up initiative and helps to facilitate the development of climate change research, combining the capacities of national research institutions, and inducing closer ties between existing national research initiatives, projects and infrastructures. ECRA works as an open platform to bring together climate researchers, providing excellent scientific expertise for policy makers and of societal relevance. The ECRA Board consists of representatives of ECRA partners and decides on governance, scientific priorities, and organisational matters. Currently organized into four Collaborative Programmes, climate scientists share their knowledge, experience and expertise to identify the most important research requirements for the future, thus developing a foresight approach. The CPs cover the topics: (1) Arctic variability and change, (2) Sea level changes and coastal impacts, (3) Changes in the hydrological cycle and (4) High impact events. The CP activities are planned in workshops and participation is open to all interested scientists from the relevant research fields. In particular, young researchers are actively encouraged to join the network. Each CP develops its joint research priorities for shaping European research into the future. Because scientific themes are interconnected, the four Collaborative Programmes interact with each other, e.g. through the organization of common workshops or joint applications. In addition, the Collaborative Programme leads attend the Board meetings. The different formats of ECRA meetings range from scientific workshops to briefing events and side events at conferences to involve different groups of interests. This facilitates the interaction of scientists, various stakeholder groups and politicians. A biennial open ECRA General Assembly that is organised in Brussels represents an umbrella event and acts as a platform for discussion and contact with stakeholders. This event is an excellent opportunity to jointly discuss research priorities of high societal relevance

Time-resolved spectroscopy of the primary photosynthetic processes of membrane-bound reaction centers from an antenna-deficient mutant of Rhodobacter capsulatus

The primary photosynthetic reactions in whole membranes of the antenna-deficient mutant strain U43 (pTXA6–10) of Rhodobacter capsulatus are studied by transient absorption and emission spectroscopy with subpicosecond time resolution. Extensive similarities between the transient absorption data on whole membranes and on isolated reaction centers support the idea that the primary processes in isolated reaction centers are not modified by the isolation procedure

Optimal interpolation of satellite and ground data for irradiance nowcasting at city scales

We use a Bayesian method, optimal interpolation, to improve satellite derived irradiance estimates at city-scales using ground sensor data. Optimal interpolation requires error covariances in the satellite estimates and ground data, which define how information from the sensor locations is distributed across a large area. We describe three methods to choose such covariances, including a covariance parameterization that depends on the relative cloudiness between locations. Results are computed with ground data from 22 sensors over a 75×80 km area centered on Tucson, AZ, using two satellite derived irradiance models. The improvements in standard error metrics for both satellite models indicate that our approach is applicable to additional satellite derived irradiance models. We also show that optimal interpolation can nearly eliminate mean bias error and improve the root mean squared error by 50%

Designing an effective climate-policy mix: accounting for instrument synergy

We assess evidence from theoretical-modelling, empirical and experimental studies on how interactions between instruments of climate policy affect overall emissions reduction. Such interactions take the form of negative, zero or positive synergistic effects. The considered instruments comprise performance and technical standards, carbon pricing, adoption subsidies, innovation support, and information provision. Based on the findings, we formulate climate-policy packages that avoid negative and employ positive synergies, and compare their strengths and weaknesses on other criteria. We note that the international context of climate policy has been neglected in assessments of policy mixes, and argue that transparency and harmonization of national policies may be key to a politically feasible path to meet global emission targets. This suggests limiting the complexity of climate-policy packages

The optimal form of the scanning near-field optical microscopy probe

A theoretical approach to determine the optimal form of the near-field optical microscope probe is proposed. An analytical expression of the optimal probe form with subwavelength aperture has been obtained. The advantages of the probe with the optimal form are illustrated using numerical calculations. The conducted calculations show 10 times greater light throughput and the reception possibility of the more compactly localized light at the output probe aperture which could indicate better spatial resolution of the optical images in near-field optical technique using optimal probe.Comment: 12 pages, 6 figure

Identification of the mitochondrial MSRB2 as a binding partner of LG72

Genetic studies have linked the evolutionary novel, anthropoid primate-specific gene locus G72/G30 in the etiology of schizophrenia and other psychiatric disorders. However, the function of the protein encoded by this locus, LG72, is currently controversially discussed. Some studies have suggested that LG72 binds to and regulates the activity of the peroxisomal enzyme D-amino-acid-oxidase, while others proposed an alternative role of this protein due to its mitochondrial location in vitro. Studies with transgenic mice expressing LG72 further suggested that high levels of LG72 lead to an impairment of mitochondrial functions with a concomitant increase in reactive oxygen species production. In the present study, we now performed extensive interaction analyses and identified the mitochondrial methionine-R-sulfoxide reductase B2 (MSRB2) as a specific interaction partner of LG72. MSRB2 belongs to the MSR protein family and functions in mitochondrial oxidative stress defense. Based on our results, we propose that LG72 is involved in the regulation of mitochondrial oxidative stress