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The influence of the atmospheric boundary layer on nocturnal layers of noctuids and other moths migrating over southern Britain
Insects migrating at high altitude over southern Britain have been continuously monitored by automatically-operating, vertical-looking radars over a period of several years. During some occasions in the summer months, the migrants were observed to form well-defined layer concentrations, typically at heights of 200-400 m, in the stable night-time atmosphere. Under these conditions, insects are likely to have control over their vertical movements and are selecting flight heights which are favourable for long-range migration. We therefore investigated the factors influencing the formation of these insect layers by comparing radar measurements of the vertical distribution of insect density with meteorological profiles generated by the UK Met. Office’s Unified Model (UM). Radar-derived measurements of mass and displacement speed, along with data from Rothamsted Insect Survey light traps provided information on the identity of the migrants. We present here three case studies where noctuid and pyralid moths contributed substantially to the observed layers. The major meteorological factors influencing the layer concentrations appeared to be: (a) the altitude of the warmest air, (b) heights corresponding to temperature preferences or thresholds for sustained migration and (c), on nights when air temperatures are relatively high, wind-speed maxima associated with the nocturnal jet. Back-trajectories indicated that layer duration may have been determined by the distance to the coast. Overall, the unique combination of meteorological data from the UM and insect data from entomological radar described here show considerable promise for systematic studies of high-altitude insect layering
Evaluation of mHealth strategies to optimize adherence and efficacy of Option B+ prevention of mother-to-child HIV transmission: Rationale, design and methods of a 3-armed randomized controlled trial
Background
Lifelong antiretroviral therapy (ART) (Option B+) is recommended for all HIV-infected pregnant/postpartum women, but high adherence is required to maximize HIV prevention potential and maintain maternal health. Mobile health (mHealth) interventions may provide treatment adherence support for women during, and beyond, the pregnancy and postpartum periods.
Methods and design
We are conducting an unblinded, triple-arm randomized clinical trial (Mobile WACh X) of one-way short message service (SMS) vs. two-way SMS vs. control (no SMS) to improve maternal ART adherence and retention in care by 2 years postpartum. We will enroll 825 women from Nairobi and Western Kenya. Women in the intervention arms receive weekly, semi-automated motivational and educational SMS and visit reminders via an interactive, human-computer hybrid communication system. Participants in the two-way SMS arm are also asked to respond to a question related to the message. SMS are based in behavioral theory, are tailored to participant characteristics through SMS tracks, and are timed along the pregnancy/postpartum continuum. After enrollment, follow-up visits are scheduled at 6 weeks; 6, 12, 18, and 24 months postpartum. The primary outcomes, virological failure (HIV viral load ≥ 1000 copies/mL), maternal retention in care, and infant HIV infection or death, will be compared in an intent to treat analysis. We will also measure ART adherence and drug resistance.
Discussion
Personalized and tailored SMS to support HIV-infected women during and after pregnancy may be an effective strategy to motivate women to adhere to ART and remain in care and improve maternal and infant outcomes
Signatures of granular microstructure in dense shear flows
Granular materials react to shear stresses differently than do ordinary
fluids. Rather than deforming uniformly, materials such as dry sand or
cohesionless powders develop shear bands: narrow zones containing large
relative particle motion leaving adjacent regions essentially rigid[1,2,3,4,5].
Since shear bands mark areas of flow, material failure and energy dissipation,
they play a crucial role for many industrial, civil engineering and geophysical
processes[6]. They also appear in related contexts, such as in lubricating
fluids confined to ultra-thin molecular layers[7]. Detailed information on
motion within a shear band in a three-dimensional geometry, including the
degree of particle rotation and inter-particle slip, is lacking. Similarly,
only little is known about how properties of the individual grains - their
microstructure - affect movement in densely packed material[5]. Combining
magnetic resonance imaging, x-ray tomography, and high-speed video particle
tracking, we obtain the local steady-state particle velocity, rotation and
packing density for shear flow in a three-dimensional Couette geometry. We find
that key characteristics of the granular microstructure determine the shape of
the velocity profile.Comment: 5 pages, incl. 4 figure
Supernova 2007bi as a pair-instability explosion
Stars with initial masses 10 M_{solar} < M_{initial} < 100 M_{solar} fuse
progressively heavier elements in their centres, up to inert iron. The core
then gravitationally collapses to a neutron star or a black hole, leading to an
explosion -- an iron-core-collapse supernova (SN). In contrast, extremely
massive stars (M_{initial} > 140 M_{solar}), if such exist, have oxygen cores
which exceed M_{core} = 50 M_{solar}. There, high temperatures are reached at
relatively low densities. Conversion of energetic, pressure-supporting photons
into electron-positron pairs occurs prior to oxygen ignition, and leads to a
violent contraction that triggers a catastrophic nuclear explosion. Tremendous
energies (>~ 10^{52} erg) are released, completely unbinding the star in a
pair-instability SN (PISN), with no compact remnant. Transitional objects with
100 M_{solar} < M_{initial} < 140 M_{solar}, which end up as iron-core-collapse
supernovae following violent mass ejections, perhaps due to short instances of
the pair instability, may have been identified. However, genuine PISNe, perhaps
common in the early Universe, have not been observed to date. Here, we present
our discovery of SN 2007bi, a luminous, slowly evolving supernova located
within a dwarf galaxy (~1% the size of the Milky Way). We measure the exploding
core mass to be likely ~100 M_{solar}, in which case theory unambiguously
predicts a PISN outcome. We show that >3 M_{solar} of radioactive 56Ni were
synthesized, and that our observations are well fit by PISN models. A PISN
explosion in the local Universe indicates that nearby dwarf galaxies probably
host extremely massive stars, above the apparent Galactic limit, perhaps
resulting from star formation processes similar to those that created the first
stars in the Universe.Comment: Accepted version of the paper appearing in Nature, 462, 624 (2009),
including all supplementary informatio
Mycobacterial ESAT-6 and katG are Recognized by Sarcoidosis CD4+ T Cells When Presented by the American Sarcoidosis Susceptibility Allele, DRB1*1101
Do Interventions Designed to Support Shared Decision-Making Reduce Health Inequalities? : A Systematic Review and Meta-Analysis
Copyright: © 2014 Durand et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background: Increasing patient engagement in healthcare has become a health policy priority. However, there has been concern that promoting supported shared decision-making could increase health inequalities. Objective: To evaluate the impact of SDM interventions on disadvantaged groups and health inequalities. Design: Systematic review and meta-analysis of randomised controlled trials and observational studies.Peer reviewe
X-Ray Spectroscopy of Stars
(abridged) Non-degenerate stars of essentially all spectral classes are soft
X-ray sources. Low-mass stars on the cooler part of the main sequence and their
pre-main sequence predecessors define the dominant stellar population in the
galaxy by number. Their X-ray spectra are reminiscent, in the broadest sense,
of X-ray spectra from the solar corona. X-ray emission from cool stars is
indeed ascribed to magnetically trapped hot gas analogous to the solar coronal
plasma. Coronal structure, its thermal stratification and geometric extent can
be interpreted based on various spectral diagnostics. New features have been
identified in pre-main sequence stars; some of these may be related to
accretion shocks on the stellar surface, fluorescence on circumstellar disks
due to X-ray irradiation, or shock heating in stellar outflows. Massive, hot
stars clearly dominate the interaction with the galactic interstellar medium:
they are the main sources of ionizing radiation, mechanical energy and chemical
enrichment in galaxies. High-energy emission permits to probe some of the most
important processes at work in these stars, and put constraints on their most
peculiar feature: the stellar wind. Here, we review recent advances in our
understanding of cool and hot stars through the study of X-ray spectra, in
particular high-resolution spectra now available from XMM-Newton and Chandra.
We address issues related to coronal structure, flares, the composition of
coronal plasma, X-ray production in accretion streams and outflows, X-rays from
single OB-type stars, massive binaries, magnetic hot objects and evolved WR
stars.Comment: accepted for Astron. Astrophys. Rev., 98 journal pages, 30 figures
(partly multiple); some corrections made after proof stag
Non-thermal emission processes in massive binaries
In this paper, I present a general discussion of several astrophysical
processes likely to play a role in the production of non-thermal emission in
massive stars, with emphasis on massive binaries. Even though the discussion
will start in the radio domain where the non-thermal emission was first
detected, the census of physical processes involved in the non-thermal emission
from massive stars shows that many spectral domains are concerned, from the
radio to the very high energies.
First, the theoretical aspects of the non-thermal emission from early-type
stars will be addressed. The main topics that will be discussed are
respectively the physics of individual stellar winds and their interaction in
binary systems, the acceleration of relativistic electrons, the magnetic field
of massive stars, and finally the non-thermal emission processes relevant to
the case of massive stars. Second, this general qualitative discussion will be
followed by a more quantitative one, devoted to the most probable scenario
where non-thermal radio emitters are massive binaries. I will show how several
stellar, wind and orbital parameters can be combined in order to make some
semi-quantitative predictions on the high-energy counterpart to the non-thermal
emission detected in the radio domain.
These theoretical considerations will be followed by a census of results
obtained so far, and related to this topic... (see paper for full abstract)Comment: 47 pages, 5 postscript figures, accepted for publication in Astronomy
and Astrophysics Review. Astronomy and Astrophysics Review, in pres
Prioritising surveillance for alien organisms transported as stowaways on ships travelling to South Africa
The global shipping network facilitates the transportation and introduction of marine and terrestrial organisms to regions where they are not native, and some of these organisms become invasive. South Africa was used as a case study to evaluate the potential for shipping to contribute to the introduction and establishment of marine and terrestrial alien species (i.e. establishment debt) and to assess how this varies across shipping routes and seasons. As a proxy for the number of species introduced (i.e. 'colonisation pressure') shipping movement data were used to determine, for each season, the number of ships that visited South African ports from foreign ports and the number of days travelled between ports. Seasonal marine and terrestrial environmental similarity between South African and foreign ports was then used to estimate the likelihood that introduced species would establish. These data were used to determine the seasonal relative contribution of shipping routes to South Africa's marine and terrestrial establishment debt. Additionally, distribution data were used to identify marine and terrestrial species that are known to be invasive elsewhere and which might be introduced to each South African port through shipping routes that have a high relative contribution to establishment debt. Shipping routes from Asian ports, especially Singapore, have a particularly high relative contribution to South Africa's establishment debt, while among South African ports, Durban has the highest risk of being invaded. There was seasonal variation in the shipping routes that have a high relative contribution to the establishment debt of the South African ports. The presented method provides a simple way to prioritise surveillance effort and our results indicate that, for South Africa, port-specific prevention strategies should be developed, a large portion of the available resources should be allocated to Durban, and seasonal variations and their consequences for prevention strategies should be explored further. (Résumé d'auteur
Astrobiological Complexity with Probabilistic Cellular Automata
Search for extraterrestrial life and intelligence constitutes one of the
major endeavors in science, but has yet been quantitatively modeled only rarely
and in a cursory and superficial fashion. We argue that probabilistic cellular
automata (PCA) represent the best quantitative framework for modeling
astrobiological history of the Milky Way and its Galactic Habitable Zone. The
relevant astrobiological parameters are to be modeled as the elements of the
input probability matrix for the PCA kernel. With the underlying simplicity of
the cellular automata constructs, this approach enables a quick analysis of
large and ambiguous input parameters' space. We perform a simple clustering
analysis of typical astrobiological histories and discuss the relevant boundary
conditions of practical importance for planning and guiding actual empirical
astrobiological and SETI projects. In addition to showing how the present
framework is adaptable to more complex situations and updated observational
databases from current and near-future space missions, we demonstrate how
numerical results could offer a cautious rationale for continuation of
practical SETI searches.Comment: 37 pages, 11 figures, 2 tables; added journal reference belo
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