Solar astronomy

An overview is given of modern solar physics. Topics covered include the solar interior, the solar surface, the solar atmosphere, the Large Earth-based Solar Telescope (LEST), the Orbiting Solar Laboratory, the High Energy Solar Physics mission, the Space Exploration Initiative, solar-terrestrial physics, and adaptive optics. Policy and related programmatic recommendations are given for university research and education, facilitating solar research, and integrated support for solar research

Influence of neighbourhood‐level crowding on sleep‐disordered breathing severity: mediation by body size

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/113768/1/jsr12305.pd

Gray Dasar-Dasar Anatomi (Bab 3 dan Bab 4)

Cavitas thoracis adalah suatu ruangan berbentuk silinder tak beraturan dengan lubang/bukaan superior (apertura thoracica superior) yang sempit dan lubang/ Bukaan inferior (apertura thoracici inferior)yang relatif lebih lebar. Cavitas thoracis terdiri dari dinding,2 cavitas pleuralis,pulmo dan mediastinum. Cavitas thoracis: mewadahi dan melindungi cor, pulmo, dan pembuluh-pembuluh darah besar,bertindak sebagai saluran untuk struktur-struktur yang lewat antara regiones cervicales dan abdomen. berperan penting saat bernafas, dan berperan sebagai penyangga untuk extremitas superior. Cavitas thoracis juga berperan sebagai penyangga extremitas superior. Musculi yang melekat pada dinding anterior thorax berperan menyediakan sebagai penyangga ini, dan bersama-sama dengan jaringan ikat. nervus, dan pembuluh darah di sekitarnya, serta kulit penutup, dan fascia superficialisnya. kesemuanya membentuk regiones pectorales

Correlative Gene Expression to Protective Seroconversion in Rift Valley Fever Vaccinates

Rift Valley fever Virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease, Rift Valley fever (RVF). In both humans and livestock, protective immunity can be achieved through vaccination. Earlier and more recent vaccine trials in cattle and sheep demonstrated a strong neutralizing antibody and total IgG response induced by the RVF vaccine, authentic recombinant MP-12 (arMP-12). From previous work, protective immunity in sheep and cattle vaccinates normally occurs from 7 to 21 days after inoculation with arMP-12. While the serology and protective response induced by arMP-12 has been studied, little attention has been paid to the underlying molecular and genetic events occurring prior to the serologic immune response. To address this, we isolated RNA from whole blood of vaccinated calves over a time course of 21 days before and after vaccination with arMP-12. The time course RNAs were sequenced by RNASeq and bioinformatically analyzed. Our results revealed time-dependent activation or repression of numerous gene ontologies and pathways related to the vaccine induced immune response and its regulation. Additional bioinformatic analyses identified a correlative relationship between specific host immune response genes and protective immunity prior to the detection of protective serum neutralizing antibody responses. These results contribute an important proof of concept for identifying molecular and genetic components underlying the immune response to RVF vaccination and protection prior to serologic detection.The open access fee for this work was funded through the Texas A&M University Open Access to Knowledge (OAK) Fund

Long‐lived Snell dwarf mice display increased proteostatic mechanisms that are not dependent on decreased mTORC1 activity

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111144/1/acel12329.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/111144/2/acel12329-sup-0001-SuppInfo.pd

Preliminary Results on HAT-P-4, TrES-3, XO-2, and GJ 436 from the NASA EPOXI Mission

EPOXI (EPOCh + DIXI) is a NASA Discovery Program Mission of Opportunity using the Deep Impact flyby spacecraft. The EPOCh (Extrasolar Planet Observation and Characterization) Science Investigation will gather photometric time series of known transiting exoplanet systems from January through August 2008. Here we describe the steps in the photometric extraction of the time series and present preliminary results of the first four EPOCh targets.Comment: 4 pages, 2 figures. To appear in the Proceedings of the 253rd IAU Symposium: "Transiting Planets", May 2008, Cambridge, M

Novel Role for the Golgi Membrane Protein TMEM165 in Control of Migration and Invasion for Breast Carcinoma

The TMEM165 gene encodes for a multiple pass membrane protein localized in the Golgi that has been linked to congenital disorders of glycosylation. The TMEM165 protein is a putative ion transporter that regulates H+/Ca++/Mn++ homeostasis and pH in the Golgi. Previously, we identified TMEM165 as a potential biomarker for breast carcinoma in a glycoproteomic study using late stage invasive ductal carcinoma tissues with patient-matched adjacent normal tissues. The TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry. Our hypothesis is that the TMEM165 protein confers a growth advantage to breast cancer. In this preliminary study we have investigated the expression of TMEM165 in earlier stage invasive ductal carcinoma and ductal carcinoma in situ cases. We created a CRISPR/Cas9 knockout of TMEM165 in the human invasive breast cancer cell line MDAMB231. Our results indicate that removal of TMEM165 in these cells results in a significant reduction of cell migration, tumor growth, and tumor vascularization in vivo. Furthermore, we find that TMEM165 expression alters the glycosylation of breast cancer cells and these changes promote the invasion and growth of breast cancer by altering the expression levels of key glycoproteins involved in regulation of the epithelial to mesenchymal transition such as E-cadherin. These studies illustrate new potential functions for this Golgi membrane protein in the control of breast cancer growth and invasion

Mars Aeronomy Observer: Report of the Science Working Team

The Mars Aeronomy Observer (MAO) is a candidate follow-on mission to Mars Observer (MO) in the Planetary Observer Program. The four Mariner and two Viking spacecraft sent to Mars between 1965 and 1976 have provided a wealth of information concerning Martian planetology. The Mars Observer, to be launched in 1990, will build on their results by further examining the elemental and mineralogical composition of the surface, the strength and multipolar composition of the planetary magnetic field, the gravitational field and topography, and the circulation of the lower atmosphere. The Mars Aeronomy Observer is intended to address the last major aspects of Martian environment which have yet to be investigated: the upper atmosphere, the ionsphere, and the solar wind interaction region

Formal analytical solutions for the Gross-Pitaevskii equation

Considering the Gross-Pitaevskii integral equation we are able to formally obtain an analytical solution for the order parameter $\Phi (x)$ and for the chemical potential $\mu$ as a function of a unique dimensionless non-linear parameter $\Lambda$. We report solutions for different range of values for the repulsive and the attractive non-linear interactions in the condensate. Also, we study a bright soliton-like variational solution for the order parameter for positive and negative values of $\Lambda$. Introducing an accumulated error function we have performed a quantitative analysis with other well-established methods as: the perturbation theory, the Thomas-Fermi approximation, and the numerical solution. This study gives a very useful result establishing the universal range of the $\Lambda$-values where each solution can be easily implemented. In particular we showed that for $\Lambda <-9$, the bright soliton function reproduces the exact solution of GPE wave function.Comment: 8 figure