566 research outputs found
A Culture of Mattering: Building Staff Belonging, Purpose and Meaning at an Indigenous Recovery Centre
The Ngwaagan Gamig Recovery Centre/Rainbow Lodge on the Wikwemikong Unceded Reserve in Ontario, Canada provides culturally-based alcohol and drug addiction treatment. We seek to support the staff’s sense of belonging and mattering, and engagement with their leader’s vision to incorporate positive psychology into the culture of the centre. Indigenous culture is being leveraged to heal from within after a history of oppression and cultural genocide in Canada (TRCC, 2015). Informed by the inherent resilience of the Anishinaabe people and culture, and current psychological science, we propose two positive interventions to cultivate mattering among staff. We recommend a peer support framework to establish a foundation of connection, and accompanying storytelling interventions grounded in Indigenous cultural practices. The literature emphasizes storytelling and cultural identity as essential for building resilience and belonging in Indigenous communities, especially for those dealing with addiction. We build upon current storytelling initiatives at Rainbow Lodge and incorporate Anishinaabe culture. We suggest culturally relevant measurement through talking circles and tools already used by the Rainbow Lodge to measure impact. We believe the proposed applications will enhance among the staff a sense of individual and community belonging, purpose and mattering, resulting in a willingness to participate and contribute to new initiatives, and overall increased well-being
Photorespiration: metabolic pathways and their role in stress protection
Photorespiration results from the oxygenase reaction catalysed by ribulose-1,5-bisphosphate carboxylase/
oxygenase. In this reaction glycollate-2-phosphate is produced and subsequently metabolized in the
photorespiratory pathway to form the Calvin cycle intermediate glycerate-3-phosphate. During this metabolic
process, CO2 and NH3 are produced and ATP and reducing equivalents are consumed, thus
making photorespiration a wasteful process. However, precisely because of this ine¤ciency, photorespiration
could serve as an energy sink preventing the overreduction of the photosynthetic electron transport
chain and photoinhibition, especially under stress conditions that lead to reduced rates of photosynthetic
CO2 assimilation. Furthermore, photorespiration provides metabolites for other metabolic processes, e.g.
glycine for the synthesis of glutathione, which is also involved in stress protection. In this review, we
describe the use of photorespiratory mutants to study the control and regulation of photorespiratory pathways.
In addition, we discuss the possible role of photorespiration under stress conditions, such as
drought, high salt concentrations and high light intensities encountered by alpine plants
Generic flow profiles induced by a beating cilium
We describe a multipole expansion for the low Reynolds number fluid flows
generated by a localized source embedded in a plane with a no-slip boundary
condition. It contains 3 independent terms that fall quadratically with the
distance and 6 terms that fall with the third power. Within this framework we
discuss the flows induced by a beating cilium described in different ways: a
small particle circling on an elliptical trajectory, a thin rod and a general
ciliary beating pattern. We identify the flow modes present based on the
symmetry properties of the ciliary beat.Comment: 12 pages, 6 figures, to appear in EPJ
Temperature regulates NF-κB dynamics and function through timing of A20 transcription
NF-κB signaling plays a pivotal role in control of the inflammatory response. We investigated how the dynamics and function of NF-κB were affected by temperature within the mammalian physiological range (34 °C to 40 °C). An increase in temperature led to an increase in NF-κB nuclear/cytoplasmic oscillation frequency following Tumor Necrosis Factor alpha (TNFα) stimulation. Mathematical modeling suggested that this temperature sensitivity might be due to an A20-dependent mechanism, and A20 silencing removed the sensitivity to increased temperature. The timing of the early response of a key set of NF-κB target genes showed strong temperature dependence. The cytokine-induced expression of many (but not all) later genes was insensitive to temperature change (suggesting that they might be functionally temperature-compensated). Moreover, a set of temperature- and TNFα-regulated genes were implicated in NF-κB cross-talk with key cell-fate–controlling pathways. In conclusion, NF-κB dynamics and target gene expression are modulated by temperature and can accurately transmit multidimensional information to control inflammation
Susceptibility sets and the final outcome of collective Reed–Frost epidemics
This paper is concerned with exact results for the final outcome of stochastic SIR (susceptible → infective → recovered) epidemics among a closed, finite and homogeneously mixing population. The factorial moments of the number of initial susceptibles who ultimately avoid infection by such an epidemic are shown to be intimately related to the concept of a susceptibility set. This connection leads to simple, probabilistically illuminating proofs of exact results concerning the total size and severity of collective Reed–Frost epidemic processes, in terms of Gontcharoff polynomials, first obtained in a series of papers by Claude Lef`evre and Philippe Picard. The proofs extend easily to include general final state random variables defined on SIR epidemics, and also to multitype epidemics
Active Brownian Particles. From Individual to Collective Stochastic Dynamics
We review theoretical models of individual motility as well as collective
dynamics and pattern formation of active particles. We focus on simple models
of active dynamics with a particular emphasis on nonlinear and stochastic
dynamics of such self-propelled entities in the framework of statistical
mechanics. Examples of such active units in complex physico-chemical and
biological systems are chemically powered nano-rods, localized patterns in
reaction-diffusion system, motile cells or macroscopic animals. Based on the
description of individual motion of point-like active particles by stochastic
differential equations, we discuss different velocity-dependent friction
functions, the impact of various types of fluctuations and calculate
characteristic observables such as stationary velocity distributions or
diffusion coefficients. Finally, we consider not only the free and confined
individual active dynamics but also different types of interaction between
active particles. The resulting collective dynamical behavior of large
assemblies and aggregates of active units is discussed and an overview over
some recent results on spatiotemporal pattern formation in such systems is
given.Comment: 161 pages, Review, Eur Phys J Special-Topics, accepte
The relationship between risk factors for falling and the quality of life in older adults
BACKGROUND: Falls are one of the major health problems that effect the quality of life among older adults. The aim of this study was to explore the relationship between quality of life (Short Form-12) and the risk factors of falls (balance, functional mobility, proprioception, muscle strength, flexibility and fear of falling) in older adults. METHODS: One hundred sixteen people aged 65 or older and living in the T.C. Emekli Sandigi Narlidere nursing home participated in the study. Balance (Berg Balance test), functional mobility (Timed Up and Go), proprioception (joint position sense), muscle strength (back/leg dynamometer), flexibility (sit and reach) and fear of falling (Visual Analogue Scale) were assessed as risk factors for falls. The quality of life was measured by Short Form-12 (SF-12). RESULTS: A strong positive correlation was observed between Physical Health Component Summary of SF-12, General Health Perception and balance, muscle strength. Proprioception and flexibility did not correlated with SF-12 (p > 0.05). There was negative correlation between Physical Health Component Summary of SF-12, General Health Perception and fear of falling, functional mobility (p < 0.05). CONCLUSION: We concluded that the risk factors for falls (balance, functional mobility, muscle strength, fear of falling) in older adults are associated with quality of life while flexibility and proprioception are not
DNA methylation in diploid inbred lines of potatoes and its possible role in the regulation of heterosis
Self-incompatible diploid potatoes were altered to self-compatible ones by a function of S-locus inhibitor gene and continued selfing generated highly homozygous inbreds. In this study, this process was investigated for the status of DNA methylation by a simple method using genomic DNA digested by methylation-sensitive restriction enzymes prior to RAPD analysis. We detected 31 methylation-sensitive RAPD bands, of which 11 were newly appeared in the selfed progenies, and 6 of them stably inherited to subsequent generations. Aberrant segregations and paternal- or atavism-like transmission were also found. Segregating methylation-sensitive bands in initial populations became fixed in the advanced selfed progenies by 75.0–93.8%, of which 41.7% were fixed to all present and 58.3% to all absent. Because DNA methylation is generally recognized to suppress gene expression as regulatory factors, homozygosity/heterozygosity of methylated DNA may be involved in inbreeding depression/heterosis
- …