2,594 research outputs found
Energy storage mechanisms in vacancy-ordered Wadsley-Roth layered niobates
Wadsley–Roth (WR) crystallographic shear structures demonstrate high energy and power densities as Li-ion battery anode materials. We report the (de)lithiation behavior of two WR-derived layered niobates: NaNb_{3}O_{8} and KNb_{3}O_{8}. Both demonstrate multi-electron (Nb5+/Nb3+) redox on the first discharge, reacting with ≈5 mol Li per mol ANb_{3}O_{8}. Li intercalation in NaNb_{3}O_{8} is dominated by Li-diffusion kinetics and evolution of the interlayer structure, with Li initially filling octahedral sites near the interlayer space to draw the layers together to form a (2 × 2)_{∞} WR structure. This average structure change pushes Na ions into the square channels, blocking fast Li diffusion down the square channels that provide the fast Li-ion conduction in most WR materials. Upon charge, Li ions incorporated into the octahedral WR sites (ordered vacancies in the layered structure) are extracted, revealing a new, reversible Li site for additional capacity in WR-like materials. The behavior of KNb_{3}O_{8} is similar, but has additional hysteresis associated with its larger counter-cation. While neither layered niobate matches the demonstrated performance of WR materials, by studying them, we identify a route for increased capacity in WR-like frameworks. Additionally, we identify the important role of Li diffusion kinetics and counter-cations in the cycling behavior of WR-derived structures
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris
CITATION: Visser, M. J. E.; Kell, D. B. & Pretorius, E. 2019. Bacterial dysbiosis and translocation in psoriasis vulgaris. Frontiers in Cellular and Infection Microbiology, 9:7. doi:10.3389/fcimb.2019.00007The original publication is available at https://www.frontiersin.org/journals/cellular-and-infection-microbiology#Psoriasis vulgaris is a chronic inflammatory skin condition, associated with both a
physical and a psychological burden. Our understanding of the etiology of this disease
remains incomplete. Conventionally, psoriasis has been viewed as a condition that
manifests solely in the skin. However, the systemic inflammatory nature of this disease
has been confirmed by the presence of a wide array of dysregulated cytokines and
inflammatory markers in the serum of these patients. Both dysregulated gut and skin
microbiomes have been found in association with psoriasis. An evident association
also exists between inflammatory bowel disease and this condition. Regarding the skin
microbiome, changes have been observed in the relative abundance of Firmicutes,
Actinobacteria, and Proteobacteria. Additionally, Staphylococcus and Streptococcus
spp. were detected more frequently in lesional skin. Alterations in the gut microbiome
have been characterized by a decrease in the Bacteroidetes phylum and an increase in
the Faecalibacterium genus. We suggest that dysbiosis of the skin and gut microbiota
may contribute to psoriasis, by promoting the translocation of microbes from these sites
into the bloodstream. Consistent with the Iron Dysregulation and Dormant Microbes
hypothesis, these microorganisms are in a physiologically dormant state, but may be
awakened periodically and shed their cell wall components, such as lipopolysaccharide
and lipoteichoic acid. Both of these inflammagens may contribute significantly to
maintaining a chronic inflammatory state in the host, such as is seen in individuals
diagnosed with psoriasis.https://www.frontiersin.org/articles/10.3389/fcimb.2019.00007/fullPublisher’s versio
Cost-effectiveness of child caries management: a randomised controlled trial (FiCTION trial)
Background: A three-arm parallel group, randomised controlled trial set in general dental practices in England, Scotland, and Wales was undertaken to evaluate three strategies to manage dental caries in primary teeth. Children, with at least one primary molar with caries into dentine, were randomised to receive Conventional with best practice prevention (C + P), Biological with best practice prevention (B + P), or best practice Prevention Alone (PA). Methods: Data on costs were collected via case report forms completed by clinical staff at every visit. The coprimary outcomes were incidence of, and number of episodes of, dental pain and/or infection avoided. The three strategies were ranked in order of mean cost and a more costly strategy was compared with a less costly strategy in terms of incremental cost-effectiveness. Costs and outcomes were discounted at 3.5%. Results: A total of 1144 children were randomised with data on 1058 children (C + P n = 352, B + P n = 352, PA n = 354) used in the analysis. On average, it costs £230 to manage dental caries in primary teeth over a period of up to 36 months. Managing children in PA was, on average, £19 (97.5% CI: -£18 to £55) less costly than managing those in B + P. In terms of effectiveness, on average, there were fewer incidences of, (− 0.06; 97.5% CI: − 0.14 to 0.02) and fewer episodes of dental pain and/or infection (− 0.14; 97.5% CI: − 0.29 to 0.71) in B + P compared to PA. C + P was unlikely to be considered cost-effective, as it was more costly and less effective than B + P. Conclusions: The mean cost of a child avoiding any dental pain and/or infection (incidence) was £330 and the mean cost per episode of dental pain and/or infection avoided was £130. At these thresholds B + P has the highest probability of being considered cost-effective. Over the willingness to pay thresholds considered, the probability of B + P being considered cost-effective never exceeded 75%. Trial registration: The trial was prospectively registered with the ISRCTN (reference number ISRCTN77044005) on the 26th January 2009 and East of Scotland Research Ethics Committee provided ethical approved (REC reference: 12/ES/0047)
Dynamic Limits on Planar Libration-Orbit Coupling Around an Oblate Primary
This paper explores the dynamic properties of the planar system of an
ellipsoidal satellite in an equatorial orbit about an oblate primary. In
particular, we investigate the conditions for which the satellite is bound in
librational motion or when the satellite will circulate with respect to the
primary. We find the existence of stable equilibrium points about which the
satellite can librate, and explore both the linearized and non-linear dynamics
around these points. Absolute bounds are placed on the phase space of the
libration-orbit coupling through the use of zero-velocity curves that exist in
the system. These zero-velocity curves are used to derive a sufficient
condition for when the satellite's libration is bound to less than 90 degrees.
When this condition is not satisfied so that circulation of the satellite is
possible, the initial conditions at zero libration angle are determined which
lead to circulation of the satellite. Exact analytical conditions for
circulation and the maximum libration angle are derived for the case of a small
satellite in orbits of any eccentricity.Comment: Submitted to Celestial Mechanics and Dynamical Astronom
Effect of nickel on the microstructure and mechanical property of die-cast Al–Mg–Si–Mn alloy
The effect of nickel on the microstructure and mechanical properties of a die-cast Al–Mg–Si–Mn alloy has been investigated. The results show that the presence of Ni in the alloy promotes the formation of Ni-rich intermetallics. These occur consistently during solidification in the die-cast Al–Mg–Si–Mn alloy across different levels of Ni content. The Ni-rich intermetallics exhibit dendritic morphology during the primary solidification and lamellar morphology during the eutectic solidification stage. Ni was found to be always associated with iron forming AlFeMnSiNi intermetallics, and no Al3Ni intermetallic was observed when Ni concentrations were up to 2.06 wt% in the alloy. Although with different morphologies, the Ni-rich intermetallics were identified as the same AlFeMnSiNi phase bearing a typical composition of Al[100–140](Fe,Mn)[2–7]SiNi[4–9]. With increasing Ni content, the spacing of the α-Al–Mg2Si eutectic phase was enlarged in the Al–Mg–Si–Mn alloy. The addition of Ni to the alloy resulted in a slight increase in the yield strength, but a significant decrease in the elongation. The ultimate tensile strength (UTS) increased slightly from 300 to 320 MPa when a small amount (e.g. 0.16 wt%) of Ni was added to the alloy, but further increase of the Ni content resulted in a decrease of the UTS.The Engineering and Physical Sciences Research Council (EPSRC), Technology Strategy Board (TSB) and Jaguar Land Rover (JLR) in the United Kingdom
Children and parents’ perspectives on the acceptability of three management strategies for dental caries in primary teeth within the ‘Filling Children’s Teeth: Indicated Or Not’ Randomised Controlled Trial – a qualitative study
de Branges-Rovnyak spaces: basics and theory
For a contractive analytic operator-valued function on the unit disk
, de Branges and Rovnyak associate a Hilbert space of analytic
functions and related extension space
consisting of pairs of analytic functions on the unit disk . This
survey describes three equivalent formulations (the original geometric de
Branges-Rovnyak definition, the Toeplitz operator characterization, and the
characterization as a reproducing kernel Hilbert space) of the de
Branges-Rovnyak space , as well as its role as the underlying
Hilbert space for the modeling of completely non-isometric Hilbert-space
contraction operators. Also examined is the extension of these ideas to handle
the modeling of the more general class of completely nonunitary contraction
operators, where the more general two-component de Branges-Rovnyak model space
and associated overlapping spaces play key roles. Connections
with other function theory problems and applications are also discussed. More
recent applications to a variety of subsequent applications are given in a
companion survey article
Presynaptic actions of 4-Aminopyridine and γ-aminobutyric acid on rat sympathetic ganglia in vitro
Responses to bath-applications of 4-aminopyridine (4-AP) and -aminobutyric acid (GABA) were recorded intracellularly from neurones in the rat isolated superior cervical ganglion.
4-aminopyridine (0.1–1.0 mmol/l) usually induced spontaneous action potentials and excitatory postsynaptic potentials (EPSPs), which were blocked by hexamethonium. Membrane potential was unchanged; spike duration was slightly increased. Vagus nerve B-and C-fibre potentials were prolonged.
In 4-AP solution (0.1–0.3 mmol/l), GABA (0.1 mmol/l), 3-aminopropanesulphonic acid or muscimol evoked bursts of spikes and EPSPs in addition to a neuronal depolarization. These bursts, which were not elicited by glycine, glutamate, taurine or (±)-baclofen, were completely antagonised by hexamethonium, tetrodotoxin or bicuculline methochloride.
It is concluded that: (a) 4-AP has a potent presynaptic action on sympathetic ganglia; (b) presynaptic actions of GABA can be recorded postsynaptically in the presence of 4-AP; and (c) the presynaptic GABA-receptors revealed in this condition are similar to those on the postsynaptic membrane
"I am your mother and your father!": In vitro derived gametes and the ethics of solo reproduction
In this paper, we will discuss the prospect of human reproduction achieved with gametes originating from only one person. According to statements by a minority of scientists working on the generation of gametes in vitro, it may become possible to create eggs from men’s non-reproductive cells and sperm from women’s. This would enable, at least in principle, the creation of an embryo from cells obtained from only one individual: ‘solo reproduction’. We will consider what might motivate people to reproduce in this way, and the implications that solo reproduction might have for ethics and policy. We suggest that such an innovation is unlikely to revolutionise reproduction and parenting. Indeed, in some respects it is less revolutionary than in vitro fertilisation as a whole. Furthermore, we show that solo reproduction with in vitro created gametes is not necessarily any more ethically problematic than gamete donation—and probably less so. Where appropriate, we draw parallels with the debate surrounding reproductive cloning. We note that solo reproduction may serve to perpetuate reductive geneticised accounts of reproduction, and that this may indeed be ethically questionable. However, in this it is not unique among other technologies of assisted reproduction, many of which focus on genetic transmission. It is for this reason that a ban on solo reproduction might be inconsistent with continuing to permit other kinds of reproduction that also bear the potential to strengthen attachment to a geneticised account of reproduction. Our claim is that there are at least as good reasons to pursue research towards enabling solo reproduction, and eventually to introduce solo reproduction as an option for fertility treatment, as there are to do so for other infertility related purposes
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