The glucose necessary to maintain the glucemia in eviscerated dogs

The study of carbohydrate changes in eviscerated animals as a method for investigating the glucose utilization in the peripheral tissues has been carried out by Soskin (1, 2) on the dog, by Mirsky and Broh-Kahn (3) on the rabbit, and by Russell (4) on the rat. We have carried out a large number of experiments in dogs in order to evaluate this method and to compare the results obtained in normal dogs with those obtained in hypophysectomized, diabetic and thyroidtreated dogs.Fil: Houssay, Bernardo Alberto. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Dosne, Christiane. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Foglia, Virgilio G.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinapapelKofax Power v.3.1Fujitsu ScanSnap SV600Trabajos IBYMEUnidad documental simpleBiblioteca Bernardo A. Houssay-0

Recuerdos de Eugenia Sacerdote de Lustig (1910-2011)

Correspondencia con motivo de la muerte de Eugenia Sacerdote de LustigFil: Dosne de Pasqualini, Christiane.Unidad documental simpl

Diabetes hipofisaria en perros sin suprarrenales

La acción diabetógena de la pars distalis de la hipófisis ha sido comprobada en el sapo hipofisoprivo-pancreatoprivo en ausencia de las suprarrenales (Houssay y Biasotti, 1933-36; Houssay y Leloir, 1935). Ha sido obtenida por Houssay y Biasotti (1938) en perros privados primero de la suprarrenal derecha, luego del páncreas dejando sólo 4 g y por fin de la suprarrenal izquierda; en esas condiciones se les mantuvo con extracto corticosuprarrenal, a dosis no diabetógenas, y luego se les inyectó extracto ánterohipofisario pofisario que provocó la hiperglucemia diabética en 3 sobre 4 perros. Para descartar la posible acción sinérgica del extracto córticoadrenal se realizaron los experimentos descritos en este trabajo, los que han permitido demostrar que el extracto ánterohipofisario produce la acción diabetógena en perros sin suprarrenales, ya sea inyectados con desoxicorticosterona, que no es hiperglucemiante, o bien mantenidos en vida con sólo cloruro de sodio. Estos experimentos fueron realizados en 1940-41-42 y no fueron publicados en detalle, aunque han sido mencionadas sus conclusiones (Houssay, 1942).Fil: Houssay, Bernardo A.. Fundación de Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Foglia, Virgilio G.. Fundación de Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Dosne Pasqualini, Christiane. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación de Instituto de Biología y Medicina Experimental; ArgentinaPresentado a la Sociedad Argentina de Biología el 6 de junio de 1946.papelKofax Power v.3.1Fujitsu ScanSnap SV600Trabajos IBYMEUnidad documental simpleBiblioteca Bernardo A. Houssay-0

Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies.

Background: Sepsis and bacterial meningitis are major causes of mortality and morbidity in neonates and infants. Meropenem, a broad-spectrum antibiotic, is not licensed for use in neonates and infants below 3 months of age and sufficient information on its plasma and CSF disposition and dosing in neonates and infants is lacking. Objectives: To determine plasma and CSF pharmacokinetics of meropenem in neonates and young infants and the link between pharmacokinetics and clinical outcomes in babies with late-onset sepsis (LOS). Methods: Data were collected in two recently conducted studies, i.e. NeoMero-1 (neonatal LOS) and NeoMero-2 (neonatal meningitis). Optimally timed plasma samples (n = 401) from 167 patients and opportunistic CSF samples (n = 78) from 56 patients were analysed. Results: A one-compartment model with allometric scaling and fixed maturation gave adequate fit to both plasma and CSF data; the CL and volume (standardized to 70 kg) were 16.7 (95% CI 14.7, 18.9) L/h and 38.6 (95% CI 34.9, 43.4) L, respectively. CSF penetration was low (8%), but rose with increasing CSF protein, with 40% penetration predicted at a protein concentration of 6 g/L. Increased infusion time improved plasma target attainment, but lowered CSF concentrations. For 24 patients with culture-proven Gram-negative LOS, pharmacodynamic target attainment was similar regardless of the test-of-cure visit outcome. Conclusions: Simulations showed that longer infusions increase plasma PTA but decrease CSF PTA. CSF penetration is worsened with long infusions so increasing dose frequency to achieve therapeutic targets should be considered

artificial intelligence: implications in the customer journey artificial intelligence & chatbots : implications in the customer experience

Artificial Intelligence is humankind's most dominant "weapon" to transform the retail industry. "How AI will shape a new era for seamless customer journeys" defines the critical research question. The rise of digital interfaces enforced by the Covid-19 pandemic, emerging technologies, and the big data revolution represents the preeminent drivers to disrupt AI adoption towards a new era of customer experience in the retail landscape. This work project investigates how AI technologies revolutionize the banking industry impacted by chatbots towards rethought customer engagement among financial services. Further explores the consequences throughout the supply chain workflow and the role of sustainability by shaping the AI future world