Foreign location decisions through an institutional lens:A systematic review and future research agenda

A key strategic decision in international business (IB) is where to locate. While there is general agreement that institutions influence location decisions, less is known about the specific levels and mechanisms of institutional influence. To address these gaps, we systematically review and synthesize 106 articles published in 19 general management and IB journals from 1998 to 2019. We examine institutions at different levels (e.g. regional, national or subnational). We also examine the characteristics and experiences of multinational corporations, as well as the industry conditions that determine the boundaries of institutional influence. Key findings from descriptive and thematic analyses reveal both theoretical tensions and empirical gaps. From our organizing framework, we identify four research avenues that can unify future research

Srebp-controlled glucose metabolism is essential for NK cell functional responses

Activated natural killer (NK) cells engage in a robust metabolic response that is required for normal effector function. Using genetic, pharmacological and metabolic analyses, we demonstrated an essential role for Srebp transcription factors in cytokineinduced metabolic reprogramming of NK cells that was independent of their conventional role in the control of lipid synthesis. Srebp was required for elevated glycolysis and oxidative phosphorylation and promoted a distinct metabolic pathway configuration in which glucose was metabolized to cytosolic citrate via the citrate-malate shuttle. Preventing the activation of Srebp or direct inhibition of the citrate-malate shuttle inhibited production of interferon-gamma and NK cell cytotoxicity. Thus, Srebp controls glucose metabolism in NK cells, and this Srebp-dependent regulation is critical for NK cell effector function