Non-vascular interventional procedures: effective dose to patient and equivalent dose to abdominal organs by means of dicom images and Monte Carlo simulation

This study evaluates X-ray exposure in patient undergoing abdominal extra-vascular interventional procedures by means of Digital Imaging and COmmunications in Medicine (DICOM) image headers and Monte Carlo simulation. The main aim was to assess the effective and equivalent doses, under the hypothesis of their correlation with the dose area product (DAP) measured during each examination. This allows to collect dosimetric information about each patient and to evaluate associated risks without resorting to in vivo dosimetry. The dose calculation was performed in 79 procedures through the Monte Carlo simulator PCXMC (A PC-based Monte Carlo program for calculating patient doses in medical X-ray examinations), by using the real geometrical and dosimetric irradiation conditions, automatically extracted from DICOM headers. The DAP measurements were also validated by using thermoluminescent dosimeters on an anthropomorphic phantom. The expected linear correlation between effective doses and DAP was confirmed with an R(2) of 0.974. Moreover, in order to easily calculate patient doses, conversion coefficients that relate equivalent doses to measurable quantities, such as DAP, were obtained

Transient Astrophysics with the Square Kilometre Array

This chapter provides an overview of the possibilities for transient and variable-source astrophysics with the Square Kilometre Array. While subsequent chapters focus on the astrophysics of individual events, we focus on the broader picture, and how to maximise the science coming from the telescope. The SKA as currently designed will be a fantastic and ground-breaking facility for radio transient studies, but the scientifc yield will be dramatically increased by the addition of (i) near-real-time commensal searches of data streams for events, and (ii) on occasion, rapid robotic response to Target-of-Opprtunity style triggers

Possible Detection of Apparent Superluminal inward motion in Markarian 421 after the Giant X-ray flare in February, 2010

We report on the VLBI follow-up observations using the Japanese VLBI Network (JVN) array at 22 GHz for the largest X-ray flare of TeV blazar Mrk 421 that occurred in mid-February, 2010. The total of five epochs of observations were performed at intervals of about 20 days between March 7 and May 31, 2010. No new-born component associated with the flare was seen directly in the total intensity images obtained by our multi-epoch VLBI observations. However, one jet component located at ~1 mas north-west from the core was able to be identified, and its proper motion can be measured as -1.66+/-0.46 mas yr^-1, which corresponds to an apparent velocity of -3.48+/-0.97 c. Here, this negative velocity indicates that the jet component was apparently moving toward the core. As the most plausible explanation, we discuss that the apparent negative velocity was possibly caused by the ejection of a new component, which could not be resolved with our observations. In this case, the obtained Doppler factor of the new component is around 10 to 20, which is consistent with the ones typically estimated by model fittings of spectral energy distribution for this source.Comment: 9 pages, 6 figures, 3 tables, accepted for publication in Ap

Silver nanoparticle-coated polyhydroxyalkanoate based electrospun fibers for wound dressing applications

Wound dressings are high performance and high value products which can improve the regeneration of damaged skin. In these products, bioresorption and biocompatibility play a key role. The aim of this study is to provide progress in this area via nanofabrication and antimicrobial natural materials. Polyhydroxyalkanoates (PHAs) are a bio-based family of polymers that possess high biocompatibility and skin regenerative properties. In this study, a blend of poly(3-hydroxybutyrate) (P(3HB)) and poly(3-hydroxyoctanoate-co-3-hydroxy decanoate) (P(3HO-co-3HD)) was electrospun into P(3HB))/P(3HO-co-3HD) nanofibers to obtain materials with a high surface area and good han-dling performance. The nanofibers were then modified with silver nanoparticles (AgNPs) via the dip-coating method. The silver-containing nanofiber meshes showed good cytocompatibility and interesting immunomodulatory properties in vitro, together with the capability of stimulating the human beta defensin 2 and cytokeratin expression in human keratinocytes (HaCaT cells), which makes them promising materials for wound dressing applications

Understanding Gesture Expressivity through Muscle Sensing

Expressivity is a visceral capacity of the human body. To understand what makes a gesture expressive, we need to consider not only its spatial placement and orientation, but also its dynamics and the mechanisms enacting them. We start by defining gesture and gesture expressivity, and then present fundamental aspects of muscle activity and ways to capture information through electromyography (EMG) and mechanomyography (MMG). We present pilot studies that inspect the ability of users to control spatial and temporal variations of 2D shapes and that use muscle sensing to assess expressive information in gesture execution beyond space and time. This leads us to the design of a study that explores the notion of gesture power in terms of control and sensing. Results give insights to interaction designers to go beyond simplistic gestural interaction, towards the design of interactions that draw upon nuances of expressive gesture

LOFT - a Large Observatory For x-ray Timing

The high time resolution observations of the X-ray sky hold the key to a number of diagnostics of fundamental physics, some of which are unaccessible to other types of investigations, such as those based on imaging and spectroscopy. Revealing strong gravitational field effects, measuring the mass and spin of black holes and the equation of state of ultradense matter are among the goals of such observations. At present prospects for future, non-focused X-ray timing experiments following the exciting age of RXTE/PCA are uncertain. Technological limitations are unavoidably faced in the conception and development of experiments with effective area of several square meters, as needed in order to meet the scientific requirements. We are developing large-area monolithic Silicon Drift Detectors offering high time and energy resolution at room temperature, which require modest resources and operation complexity (e.g., read-out) per unit area. Based on the properties of the detector and read-out electronics that we measured in the lab, we developed a realistic concept for a very large effective area mission devoted to X-ray timing in the 2-30 keV energy range. We show that effective areas in the range of 10-15 square meters are within reach, by using a conventional spacecraft platform and launcher of the small-medium class.Comment: 13 pages, 8 figures, 1 table, Proceedings of SPIE Vol. 7732, Paper No. 7732-66, 201

Neutral pion emission from accelerated protons in the supernova remnant W44

We present the AGILE gamma-ray observations in the energy range 50 MeV - 10 GeV of the supernova remnant (SNR) W44, one of the most interesting systems for studying cosmic-ray production. W44 is an intermediate-age SNR (20, 000 years) and its ejecta expand in a dense medium as shown by a prominent radio shell, nearby molecular clouds, and bright [SII] emitting regions. We extend our gamma-ray analysis to energies substantially lower than previous measurements which could not conclusively establish the nature of the radiation. We find that gamma-ray emission matches remarkably well both the position and shape of the inner SNR shocked plasma. Furthermore, the gamma-ray spectrum shows a prominent peak near 1 GeV with a clear decrement at energies below a few hundreds of MeV as expected from neutral pion decay. Here we demonstrate that: (1) hadron-dominated models are consistent with all W44 multiwavelength constraints derived from radio, optical, X-ray, and gamma-ray observations; (2) ad hoc lepton-dominated models fail to explain simultaneously the well-constrained gamma-ray and radio spectra, and require a circumstellar density much larger than the value derived from observations; (3) the hadron energy spectrum is well described by a power-law (with index s = 3.0 \pm 0.1) and a low-energy cut-off at Ec = 6 \pm 1 GeV. Direct evidence for pion emission is then established in an SNR for the first time.Comment: accepted for publication on ApJ

Multiwavelength observations of 3C 454.3. III. Eighteen months of AGILE monitoring of the "Crazy Diamond"

We report on 18 months of multiwavelength observations of the blazar 3C 454.3 (Crazy Diamond) carried out in July 2007-January 2009. We show the results of the AGILE campaigns which took place on May-June 2008, July-August 2008, and October 2008-January 2009. During the May 2008-January 2009 period, the source average flux was highly variable, from an average gamma-ray flux F(E>100MeV) > 200E-8 ph/cm2/s in May-June 2008, to F(E>100MeV)~80E-8 ph/cm2/s in October 2008-January 2009. The average gamma-ray spectrum between 100 MeV and 1 GeV can be fit by a simple power law (Gamma_GRID ~ 2.0 to 2.2). Only 3-sigma upper limits can be derived in the 20-60 keV energy band with Super-AGILE. During July-August 2007 and May-June 2008, RXTE measured a flux of F(3-20 keV)= 8.4E-11 erg/cm2/s, and F(3-20 keV)=4.5E-11 erg/cm2/s, respectively and a constant photon index Gamma_PCA=1.65. Swift/XRT observations were carried out during all AGILE campaigns, obtaining a F(2-10 keV)=(0.9-7.5)E-11 erg/cm2/s and a photon index Gamma_XRT=1.33-2.04. BAT measured an average flux of ~5 mCrab. GASP-WEBT monitored 3C 454.3 during the whole 2007-2008 period from the radio to the optical. A correlation analysis between the optical and the gamma-ray fluxes shows a time lag of tau=-0.4 days. An analysis of 15 GHz and 43 GHz VLBI core radio flux observations shows an increasing trend of the core radio flux, anti- correlated with the higher frequency data. The modeling SEDs, and the behavior of the long-term light curves in different energy bands, allow us to compare the jet properties during different emission states, and to study the geometrical properties of the jet on a time-span longer than one year.Comment: Accepted for publication in ApJ. Adapted Abstract. 17 pages, 19 Figures, 5 Table

The K20 survey. VI. The Distribution of the Stellar Masses in Galaxies up to z~2

We present a detailed analysis of the stellar mass content of galaxies up to z=2.5 in the K20 galaxy sample, that has a 92% spectroscopic completeness and a complete $UBVRIzJK_s$ multicolor coverage. We find that the M/L ratio decreases with redshift: in particular, the average M/L ratio of early type galaxies decreases with $z$, with a scatter that is indicative of a range of star--formation time-scales and redshift of formation. More important, the typical M/L of massive early type galaxies is larger than that of less massive ones, suggesting that their stellar population formed at higher z. The final K20 galaxy sample spans a range of stellar masses from M*=10^9Msun to M*=10^12Msun, with massive galaxies ($M*>10^11Msun) detected up to z~2. We compute the Galaxy Stellar Mass Function at various z, of which we observe only a mild evolution (i.e. by 20-30%) up to z~1. At z>1, the evolution of the GSMF appears to be much faster: at z~2, about 35% of the present day stellar mass in objects with M*~10^11Msun appear to have assembled. We also detect a change in the physical nature of the most massive galaxies, since at z>1 a population of massive star--forming galaxies progressively appears. We finally analyze our results in the framework of Lambda-CDM hierarchical models. First, we show that the large number of massive galaxies detected at high z does not violate any fundamental Lambda-CDM constraint based on the number of massive DM halos. Then, we compare our results with the predictions of renditions of both semianalytic and hydro-dynamical models, that range from severe underestimates to slight overestimates of the observed mass density at z<~2. We discuss how the differences among these models are due to the different implementation of the main physical processes. (Abridged)Comment: Accepted for publication on Astronomy & Astrophysic