1,352 research outputs found
Contrast set mining in temporal databases
Understanding the underlying differences between groups or classes in certain contexts can be of the utmost importance. Contrast set mining relies on discovering significant patterns by contrasting two or more groups. A contrast set is a conjunction of attribute–value pairs that differ meaningfully in its distribution across groups. A previously proposed technique is rules for contrast sets, which seeks to express each contrast set found in terms of rules. This work extends rules for contrast sets to a temporal data mining task. We define a set of temporal patterns in order to capture the significant changes in the contrasts discovered along the considered time line. To evaluate the proposal accuracy and ability to discover relevant information, two different real-life data sets were studied using this approach.(undefined
Applicability of Synthetic Aperture Radar Wind Retrievals on Offshore Wind Resources Assessment in Hangzhou Bay, China
In view of the high cost and sparse spatial resolution of offshore meteorological observations, ocean winds retrieved from satellites are valuable in offshore wind resource assessment as a supplement to in situ measurements. This study examines satellite synthetic aperture radar (SAR) images from ENVISAT advanced SAR (ASAR) for mapping wind resources with high spatial resolution. Around 181 collected pairs of wind data from SAR wind maps and from 13 meteorological stations in Hangzhou Bay are compared. The statistical results comparing in situ wind speed and SAR-based wind speed show a standard deviation (SD) of 1.99 m/s and correlation coefficient of R = 0.67. The model wind directions, which are used as input for the SAR wind speed retrieval, show a high correlation coefficient (R = 0.89) but a large standard deviation (SD = 42.3°) compared to in situ observations. The Weibull probability density functions are compared at one meteorological station. The SAR-based results appear not to estimate the mean wind speed, Weibull scale and shape parameters and wind power density from the full in situ data set so well due to the lower number of satellite samples. Distributions calculated from the concurrent 81 SAR and in situ samples agree well
One-step deposition of nano-to-micron-scalable, high-quality digital image correlation patterns for high-strain in-situ multi-microscopy testing
Digital Image Correlation (DIC) is of vital importance in the field of
experimental mechanics, yet, producing suitable DIC patterns for demanding
in-situ mechanical tests remains challenging, especially for ultra-fine
patterns, despite the large number of patterning techniques in the literature.
Therefore, we propose a simple, flexible, one-step technique (only requiring a
conventional deposition machine) to obtain scalable, high-quality, robust DIC
patterns, suitable for a range of microscopic techniques, by deposition of a
low melting temperature solder alloy in so-called 'island growth' mode, without
elevating the substrate temperature. Proof of principle is shown by
(near-)room-temperature deposition of InSn patterns, yielding highly dense,
homogeneous DIC patterns over large areas with a feature size that can be tuned
from as small as 10nm to 2um and with control over the feature shape and
density by changing the deposition parameters. Pattern optimization, in terms
of feature size, density, and contrast, is demonstrated for imaging with atomic
force microscopy, scanning electron microscopy (SEM), optical microscopy and
profilometry. Moreover, the performance of the InSn DIC patterns and their
robustness to large deformations is validated in two challenging case studies
of in-situ micro-mechanical testing: (i) self-adaptive isogeometric digital
height correlation of optical surface height profiles of a coarse, bimodal InSn
pattern providing microscopic 3D deformation fields (illustrated for
delamination of aluminum interconnects on a polyimide substrate) and (ii) DIC
on SEM images of a much finer InSn pattern allowing quantification of high
strains near fracture locations (illustrated for rupture of a Fe foil). As
such, the high controllability, performance and scalability of the DIC patterns
offers a promising step towards more routine DIC-based in-situ micro-mechanical
testing.Comment: Accepted for publication in Strai
Dirac states with knobs on: interplay of external parameters and the surface electronic properties of 3D topological insulators
Topological insulators are a novel materials platform with high applications
potential in fields ranging from spintronics to quantum computation. In the
ongoing scientific effort to demonstrate controlled manipulation of their
electronic structure by external means, stoichiometric variation and surface
decoration are two effective approaches that have been followed. In ARPES
experiments, both approaches are seen to lead to electronic band structure
changes. Such approaches result in variations of the energy position of bulk
and surface-related features and the creation of two-dimensional electron
gases.The data presented here demonstrate that a third manipulation handle is
accessible by utilizing the amount of illumination a topological insulator
surface has been exposed to under typical experimental ARPES conditions. Our
results show that this new, third, knob acts on an equal footing with
stoichiometry and surface decoration as a modifier of the electronic band
structure, and that it is in continuous competition with the latter. The data
clearly point towards surface photovoltage and photo-induced desorption as the
physical phenomena behind modifications of the electronic band structure under
exposure to high-flux photons. We show that the interplay of these phenomena
can minimize and even eliminate the adsorbate-related surface band bending on
typical binary, ternary and quaternary Bi-based topological insulators.
Including the influence of the sample temperature, these data set up a
framework for the external control of the electronic band structure in
topological insulator compounds in an ARPES setting. Four external knobs are
available: bulk stoichiometry, surface decoration, temperature and photon
exposure. These knobs can be used in conjunction to tune the band energies near
the surface and consequently influence the topological properties of the
relevant electronic states.Comment: 16 pages, 8 figure
Spectral Correlation in Incommensurate Multi-Walled Carbon Nanotubes
We investigate the energy spectra of clean incommensurate double-walled
carbon nanotubes, and find that the overall spectral properties are described
by the so-called critical statistics of Anderson metal-insulator transition. In
the energy spectra, there exist three different regimes characterized by
Wigner-Dyson, Poisson, and semi-Poisson distributions. This feature implies
that the electron transport in incommensurate multi-walled nanotubes can be
either diffusive, ballistic, or intermediate between them, depending on the
position of the Fermi energy.Comment: final version to appear in Phys. Rev. Let
Study of B -> \rho \pi decays at Belle
This paper describes a study of B meson decays to the pseudoscalar-vector
final state \rho\pi using 31.9\times 10^6 B\bar{B} events collected with the
Belle detector at KEKB. The branching fractions B(B^+ \to \rho^0\pi^+) =
(8.0^{+2.3+0.7}_{-2.0-0.7}) \times 10^{-6} and B(B^0 -> \rho^{+-} \pi^{-+}) =
(20.8^{+6.0+2.8}_{-6.3-3.1}) \times 10^{-6} are obtained. In addition, a 90%
confidence level upper limit of B(B^0 \to \rho^0\pi^0) < 5.3 \times 10^{-6}is
reported.Comment: 14 pages, 3 figures, to be submitted to Phys. Lett.
Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity
Background:
Chronic mTORC1 activation in skeletal muscle is linked with age-associated loss of muscle mass and strength, known as sarcopenia. Genetic activation of mTORC1 by conditionally ablating mTORC1 upstream inhibitor TSC1 in skeletal muscle accelerates sarcopenia development in adult mice. Conversely, genetic suppression of mTORC1 downstream effectors of protein synthesis delays sarcopenia in natural aging mice. mTORC1 promotes protein synthesis by activating ribosomal protein S6 kinases (S6Ks) and inhibiting eIF4E-binding proteins (4EBPs). Whole-body knockout of S6K1 or muscle-specific over-expression of a 4EBP1 mutant transgene (4EBP1mt), which is resistant to mTORC1-mediated inhibition, ameliorates muscle loss with age and preserves muscle function by enhancing mitochondria activities, despite both transgenic mice showing retarded muscle growth at a young age. Why repression of mTORC1-mediated protein synthesis can mitigate progressive muscle atrophy and dysfunction with age remains unclear.
Methods:
Mice with myofiber-specific knockout of TSC1 (TSC1mKO), in which mTORC1 is hyperactivated in fully differentiated myofibers, were used as a mouse model of sarcopenia. To elucidate the role of mTORC1-mediated protein synthesis in regulating muscle mass and physiology, we bred the 4EBP1mt transgene or S6k1 floxed mice into the TSC1mKO mouse background to generate 4EBP1mt-TSC1mKO or S6K1-TSC1mKO mice, respectively. Functional and molecular analyses were performed to assess their role in sarcopenia development.
Results:
Here, we show that 4EBP1mt-TSC1mKO, but not S6K1-TSC1mKO, preserved muscle mass (36.7% increase compared with TSC1mKO, P < 0.001) and strength (36.8% increase compared with TSC1mKO, P < 0.01) at the level of control mice. Mechanistically, 4EBP1 activation suppressed aberrant protein synthesis (two-fold reduction compared with TSC1mKO, P < 0.05) and restored autophagy flux without relieving mTORC1-mediated inhibition of ULK1, an upstream activator of autophagosome initiation. We discovered a previously unidentified phenotype of lysosomal failure in TSC1mKO mouse muscle, in which the lysosomal defect was also conserved in the naturally aged mouse muscle, whereas 4EBP1 activation enhanced lysosomal protease activities to compensate for impaired autophagy induced by mTORC1 hyperactivity. Consequently, 4EBP1 activation relieved oxidative stress to prevent toxic aggregate accumulation (0.5-fold reduction compared with TSC1mKO, P < 0.05) in muscle and restored mitochondrial homeostasis and function.
Conclusions:
We identify 4EBP1 as a communication hub coordinating protein synthesis and degradation to protect proteostasis, revealing therapeutic potential for activating lysosomal degradation to mitigate sarcopenia
Measurement of K^+K^- production in two-photon collisions in the resonant-mass region
K^+K^- production in two-photon collisions has been studied using a large
data sample of 67 fb^{-1} accumulated with the Belle detector at the KEKB
asymmetric e^+e^- collider. We have measured the cross section for the process
gamma gamma -> K^+ K^- for center-of-mass energies between 1.4 and 2.4 GeV, and
found three new resonant structures in the energy region between 1.6 and 2.4
GeV. The angular differential cross sections have also been measured.Comment: 24 pages, 8 figures, to appear in Euro. Phys. Jour.
Observation of Radiative Decay
We report the observation of the decay with a
statistical significance of in 78.1 \ifb of data collected by the
Belle experiment at the KEKB collider. This is the first observation
of a flavor-changing radiative decay of a charmed meson. The Cabibbo- and
color-suppressed decays , are also observed for
the first time. We measure branching fractions \br(D^{0} \to \phi \gamma)
= [ 2.60^{+0.70}_{-0.61} \stat {}^{+0.15}_{-0.17} \syst ] \times 10^{-5},
\br(D^{0} \to \phi \pi^{0})
= [ 8.01 \pm 0.26 \stat \pm 0.47 \syst ] \times 10^{-4}, and \br(D^{0} \to
\phi \eta) = [ 1.48 \pm 0.47 \stat \pm 0.09 \syst ] \times 10^{-4}.Comment: 9 pages, 4 figures, Belle Preprint 2003-24, KEK Preprint 2003-75,
updated version of BELLE-CONF-0346 (contributed paper to the XXI
International Symposium on Lepton and Photon Interactions at High
Energies,Fermilab Aug 11-16,2003). to appear in Phys. Rev. Let
An inclusive measurement of the photon energy spectrum in b->s gamma decays
We report a fully inclusive measurement of the flavour changing neutral
current decay b->s gamma in the energy range 1.8 GeV < E* < 2.8 GeV, covering
95% of the total spectrum. Using 140 fb^-1 we obtain BF(b->s gamma)= 3.55 +/-
0.32 +0.30-0.31 +0.11-0.07, where the errors are statistical, systematic and
from theory corrections. We also measure the first and second moments of the
photon energy spectrum above 1.8 GeV and obtain = 2.292 +/- 0.026 +/- 0.034
GeV and -^2 = 0.0305 +/- 0.0074 +/- 0.0063 GeV^2, where the errors are
statistical and systematic.Comment: RevTex4, 6 pages, Submitted to Phys.Rev.Lett. Replaced: added table
of systematic errors. New results take into account radiative J/Psi decay
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