A prototype for the AMS-RICH experiment

The AMS spectrometer will be installed on the International Space Station in 2005. Among other improvements over the first version of the instrument, a ring imaging Cherenkov detector (RICH) will be added and should open a new window for cosmic-ray physics, allowing isotope separation up to A = 25 between 1 and 10 GeV/c and element identification up to Z = 25 between threshold and 1 TeV/c/nucleon. It should also contribute to the high level of redundancy required for AMS and reject efficiency albedo particles. A second generation prototype has been operated for a few months : the architecture and the first results are presented.Comment: Proceedings of the 3rd International Conference on "New developments in photodetection" (Beaune - France

On the reliability of electrical drives for safety-critical applications

The aim of this work is to present some issues related to fault tolerant electric drives,which are able to overcome different types of faults occurring in the sensors, in thepower converter and in the electrical machine, without compromising the overallfunctionality of the system. These features are of utmost importance in safety-criticalapplications. In this paper, the reliability of both commercial and innovative driveconfigurations, which use redundant hardware and suitable control algorithms, will beinvestigated for the most common types of fault: besides standard three phase motordrives, also multiphase topologies, open-end winding solutions, multi-machineconfigurations will be analyzed, applied to various electric motor technologies. Thecomplexity of hardware and control strategies will also be compared in this paper, sincethis has a tremendous impact on the investment costs

Criteria for Bayesian model choice with application to variable selection

In objective Bayesian model selection, no single criterion has emerged as dominant in defining objective prior distributions. Indeed, many criteria have been separately proposed and utilized to propose differing prior choices. We first formalize the most general and compelling of the various criteria that have been suggested, together with a new criterion. We then illustrate the potential of these criteria in determining objective model selection priors by considering their application to the problem of variable selection in normal linear models. This results in a new model selection objective prior with a number of compelling properties.Comment: Published in at http://dx.doi.org/10.1214/12-AOS1013 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

Constraints on WIMP Dark Matter from the High Energy PAMELA pˉ/p\bar{p}/p data

A new calculation of the $\bar{p}/p$ ratio in cosmic rays is compared to the recent PAMELA data. The good match up to 100 GeV allows to set constraints on exotic contributions from thermal WIMP dark matter candidates. We derive stringent limits on possible enhancements of the WIMP \pbar flux: a $m_{\rm WIMP}$=100 GeV (1 TeV) signal cannot be increased by more than a factor 6 (40) without overrunning PAMELA data. Annihilation through the $W^+W^-$ channel is also inspected and cross-checked with $e^+/(e^-+e^+)$ data. This scenario is strongly disfavored as it fails to simultaneously reproduce positron and antiproton measurements.Comment: 5 pages, 5 figures, the bibliography has been updated, minor modifications have been made in the tex

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases

Oxidative stress is generally considered as the consequence of an imbalance between pro- and antioxidants species, which often results into indiscriminate and global damage at the organismal level. Elderly people are more susceptible to oxidative stress and this depends, almost in part, from a decreased performance of their endogenous antioxidant system. As many studies reported an inverse correlation between systemic levels of antioxidants and several diseases, primarily cardiovascular diseases, but also diabetes and neurological disorders, antioxidant supplementation has been foreseen as an effective preventive and therapeutic intervention for aging-associated pathologies. However, the expectations of this therapeutic approach have often been partially disappointed by clinical trials. The interplay of both endogenous and exogenous antioxidants with the systemic redox system is very complex and represents an issue that is still under debate. In this review a selection of recent clinical studies concerning antioxidants supplementation and the evaluation of their influence in aging-related diseases is analyzed. The controversial outcomes of antioxidants supplementation therapies, which might partially depend from an underestimation of the patient specific metabolic demand and genetic background, are presented

Sb-SnO2-Nanosized-Based Resistive Sensors for NO2 Detection

A study over Sb-promoted tin oxide nanopowders for sensing applications is reported. nanopowders pure and promoted with 5 wt% of antimony were prepared by wet chemical methods and widely characterized by TEM, XRD, and XPS techniques. Thick film resistive sensors were fabricated by depositing the synthesized nanopowders by drop-coating on interdigited alumina substrates. The sensing characteristics of the pure and Sb-promoted sensors for the monitoring of trace level of were studied. The response of the sensors to water vapor was also investigated, revealing that Sb acts favorably eliminating the interference of humidity

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a major clinical feature of cachexia, leading to weight loss, dampening patients' quality of life, and reducing patients' response to anticancer therapy. RAGE (receptor for advanced glycation end-products) is a multiligand receptor of the immunoglobulin superfamily and a mediator of muscle regeneration, inflammation, and cancer. Methods: By using murine models consisting in the injection of colon 26 murine adenocarcinoma (C26-ADK) or Lewis lung carcinoma (LLC) cells in BALB/c and C57BL/6 or Ager−/− (RAGE-null) mice, respectively, we investigated the involvement of RAGE signalling in the main features of cancer cachexia, including the inflammatory state. In vitro experiments were performed using myotubes derived from C2C12 myoblasts or primary myoblasts isolated from C57BL/6 wild type and Ager−/− mice treated with the RAGE ligand, S100B (S100 calcium-binding protein B), TNF (tumor necrosis factor)α±IFN (interferon) γ, and tumour cell- or masses-conditioned media to analyse hallmarks of muscle atrophy. Finally, muscles of wild type and Ager−/− mice were injected with TNFα/IFNγ or S100B in a tumour-free environment. Results: We demonstrate that RAGE is determinant to activate signalling pathways leading to muscle protein degradation in the presence of proinflammatory cytokines and/or tumour-derived cachexia-inducing factors. We identify the RAGE ligand, S100B, as a novel factor able to induce muscle atrophy per se via a p38 MAPK (p38 mitogen-activated protein kinase)/myogenin axis and STAT3 (signal transducer and activator of transcription 3)-dependent MyoD (myoblast determination protein 1) degradation. Lastly, we found that in cancer conditions, an increase in serum levels of tumour-derived S100B and HMGB1 (high mobility group box 1) occurs leading to chronic activation/overexpression of RAGE, which induces hallmarks of cancer cachexia (i.e. muscle wasting, systemic inflammation, and release of tumour-derived pro-cachectic factors). Absence of RAGE in mice translates into reduced serum levels of cachexia-inducing factors, delayed loss of muscle mass and strength, reduced tumour progression, and increased survival. Conclusions: RAGE is a molecular determinant in inducing the hallmarks of cancer cachexia, and molecular targeting of RAGE might represent a therapeutic strategy to prevent or counteract the cachectic syndrome

A constant dark matter halo surface density in galaxies

We confirm and extend the recent finding that the central surface density r_0*rho_0 galaxy dark matter halos, where r_0 and rho_0 are the halo core radius and central density, is nearly constant and independent of galaxy luminosity. Based on the co-added rotation curves of about 1000 spiral galaxies, mass models of individual dwarf irregular and spiral galaxies of late and early types with high-quality rotation curves and, galaxy-galaxy weak lensing signals from a sample of spiral and elliptical galaxies, we find that log(r_0*rho_0) = 2.15 +- 0.2, in units of log(Msol/pc^2). We also show that the observed kinematics of Local Group dwarf spheroidal galaxies are consistent with this value. Our results are obtained for galactic systems spanning over 14 magnitudes, belonging to different Hubble Types, and whose mass profiles have been determined by several independent methods. In the same objects, the approximate constancy of rho_0*r_0 is in sharp contrast to the systematical variations, by several orders of magnitude, of galaxy properties, including rho_0 and central stellar surface density.Comment: Accepted for publication in MNRAS. 9 pages, 4 figure