Geometric properties of boundary sections of solutions to the Monge--Amp\`ere equation and applications

In this paper, we establish several geometric properties of boundary sections of convex solutions to the Monge-Amp\`ere equations: the engulfing and separating properties and volume estimates. As applications, we prove a covering lemma of Besicovitch type, a covering theorem and a strong type $p-p$ estimate for the maximal function corresponding to boundary sections. Moreover, we show that the Monge-Amp\`ere setting forms a space of homogeneous type.Comment: 24 page

Each of the Eight Simian Hemorrhagic Fever Virus Minor Structural Proteins is Functionally Important

The simian hemorrhagic fever virus (SHFV) genome differs from those of other members of the family Arterivirus in encoding two adjacent sets of four minor structural protein open reading frames (ORFs). A stable, full-length, infectious SHFV-LVR cDNA clone was constructed. Virus produced from this clone had replication characteristics similar to those of the parental virus. A subgenomic mRNA was identified for the SHFV ORF previously identified as 2b. As an initial means of analyzing the functional relevance of each of the SHFV minor structural proteins, a set of mutant infectious clones was generated, each with the start codon of one minor structural protein ORF mutated. Different phenotypes were observed for each ortholog of the pairs of minor glycoproteins and all of the eight minor structural proteins were required for the production of infectious extracellular virus indicating that the duplicated sets of SHFV minor structural proteins are not functionally redundant

Understanding the consequences of repetitive subconcussive head impacts in sport : brain changes and dampened motor control are seen after boxing practice

LW was supported by FP7 grant number 602150-2 (CENTER-TBI)Objectives: The potential effects of exposure to repetitive subconcussive head impacts through routine participation in sport are not understood. To investigate the effects of repetitive subconcussive head impacts we studied boxers following customary training (sparring) using transcranial magnetic stimulation (TMS), decomposition electromyographic (EMG) and tests of memory. Methods: Twenty amateur boxers performed three 3-min sparring bouts. Parameters of brain function and motor control were assessed prior to sparring and again immediately, 1 h and 24 h post-sparring. Twenty control participants were assessed following mock-sparring. Results: One hour after sparring boxers showed increased corticomotor inhibition, altered motor unit recruitment strategies, and decreased memory performance relative to controls, with values returning to baseline by the 24 h follow up. Conclusion: Repetitive subconcussive head impacts associated with sparring resulted in acute and transient brain changes similar to those previously reported in soccer heading, providing convergent evidence that sport-related head impacts produce a GABAergic response. These acute changes in brain health are reminiscent of effects seen following brain injury, and suggest a potential mechanism underlying the damaging long-term effects of routine repetitive head impacts in sport.Publisher PDFPeer reviewe

Evidence for Acute Electrophysiological and Cognitive Changes Following Routine Soccer Heading

Introduction  There is growing concern around the effects of concussion and sub-concussive impacts in sport. Routine game-play in soccer involves intentional and repeated head impacts through ball heading. Although heading is frequently cited as a risk to brain health, little data exist regarding the consequences of this activity. This study aims to assess the immediate outcomes of routine football heading using direct and sensitive measures of brain function.  Methods  Nineteen amateur football players (5 females; age 22±3 y) headed machine-projected soccer balls at standardized speeds, modelling routine soccer practice. The primary outcome measure of corticomotor inhibition measured using transcranial magnetic stimulation, was assessed prior to heading and repeated immediately, 24 h, 48 h and 2 weeks post-heading. Secondary outcome measures were cortical excitability, postural control, and cognitive function.  Results  Immediately following heading an increase in corticomotor inhibition was detected; further to these electrophysiological alterations, measurable reduction memory function were also found. These acute changes appear transient, with values normalizing 24 h post-heading.  Discussion  Sub-concussive head impacts routine in soccer heading are associated with immediate, measurable electrophysiological and cognitive impairments. Although these changes in brain function were transient, these effects may signal direct consequences of routine soccer heading on (long-term) brain health which requires further study

Evidence for acute electrophysiological and cognitive changes following routine soccer heading

This work was supported by the National Institute for Health Research (NIHR) Brain Injury Healthcare Technology Cooperative. This work was supported by existing funding awarded to L.W. as part of Framework 7 programme of the European Union (CENTER-TBI, Grant number: 602150-2). The work made use of a TMS coil to which the company Smartfish contributed £1500 for purchase of. T.DiV.'s postgraduate study is support by the research office of Stirling University. W.S. is supported by a NHS Research Scotland Career Researcher Fellowship. D.I.D. and M.I. are members of SINAPSE – see www.sinapse.ac.uk.Introduction There is growing concern around the effects of concussion and sub-concussive impacts in sport. Routine game-play in soccer involves intentional and repeated head impacts through ball heading. Although heading is frequently cited as a risk to brain health, little data exist regarding the consequences of this activity. This study aims to assess the immediate outcomes of routine football heading using direct and sensitive measures of brain function. Methods Nineteen amateur football players (5 females; age 22 ± 3 y) headed machine-projected soccer balls at standardized speeds, modelling routine soccer practice. The primary outcome measure of corticomotor inhibition measured using transcranial magnetic stimulation, was assessed prior to heading and repeated immediately, 24 h, 48 h and 2 weeks post-heading. Secondary outcome measures were cortical excitability, postural control, and cognitive function. Results Immediately following heading an increase in corticomotor inhibition was detected; further to these electrophysiological alterations, measurable reduction memory function were also found. These acute changes appear transient, with values normalizing 24 h post-heading. Discussion Sub-concussive head impacts routine in soccer heading are associated with immediate, measurable electrophysiological and cognitive impairments. Although these changes in brain function were transient, these effects may signal direct consequences of routine soccer heading on (long-term) brain health which requires further study.Publisher PDFPeer reviewe

Positive Organisational Psychology 2.0: Embracing The Technological Revolution

Positive Organisational Psychology (POP) has experienced significant growth in the past two decades, contributing to our understanding of work-related well-being and performance. However, the discipline is now on the cusp of a new wave of research and innovation that may reshape its discourse. This paper introduces the concept of ‘Positive Organisational Psychology 2.0’ (POP 2.0) as an evidence-based, data-driven field that utilizes technological advancements and human-centred design to understand and enhance positive characteristics of individuals, organisations, and society for optimal psychological functioning, wellbeing, and performance. The paper begins with an overview of POP’s emergence, highlighting its key characteristics and exploring the factors behind its rapid growth and declining relevance. We then conceptualize POP 2.0, outline its defining features, and advocate for a broader scope, expanded focal audience, enhanced methodologies, and transformative role shifts for practitioners. We conclude by outlining opportunities, challenges and perspectives for the next wave of innovative research

The use of biofluid markers to evaluate the consequences of sport-related subconcussive head impact exposure : a scoping review

This review was supported by the University of Stirling (no grant number applies). L.W. also received support as part of Framework 7 programme of the European Union (CENTER-TBI, Grant number: 602150–2). S.M. received research support from the Italian Ministry of Health (GR-2013–02354960).Background Amidst growing concern about the safety of sport-related repetitive subconcussive head impacts (RSHI), biofluid markers may provide sensitive, informative, and practical assessment of the effects of RSHI exposure. Objective This scoping review aimed to systematically examine the extent, nature, and quality of available evidence from studies investigating the effects of RSHI on biofluid markers, to identify gaps and to formulate guidelines to inform future research. Methods PRISMA extension for Scoping Reviews guidelines were adhered to. The protocol was pre-registered through publication. MEDLINE, Scopus, SPORTDiscus, CINAHL, PsycINFO, Cochrane Library, OpenGrey, and two clinical trial registries were searched (until March 30, 2022) using descriptors for subconcussive head impacts, biomarkers, and contact sports. Included studies were assessed for risk of bias and quality. Results Seventy-nine research publications were included in the review. Forty-nine studies assessed the acute effects, 23 semi-acute and 26 long-term effects of RSHI exposure. The most studied sports were American football, boxing, and soccer, and the most investigated markers were (in descending order): S100 calcium-binding protein beta (S100B), tau, neurofilament light (NfL), glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), phosphorylated tau (p-tau), ubiquitin C-terminal hydrolase L1 (UCH-L1), and hormones. High or moderate bias was found in most studies, and marker-specific conclusions were subject to heterogeneous and limited evidence. Although the evidence is weak, some biofluid markers—such as NfL—appeared to show promise. More markedly, S100B was found to be problematic when evaluating the effects of RSHI in sport. Conclusion Considering the limitations of the evidence base revealed by this first review dedicated to systematically scoping the evidence of biofluid marker levels following RSHI exposure, the field is evidently still in its infancy. As a result, any recommendation and application is premature. Although some markers show promise for the assessment of brain health following RSHI exposure, future large standardized and better-controlled studies are needed to determine biofluid markers’ utility.Publisher PDFPeer reviewe

The Use of Biofluid Markers to Evaluate the Consequences of Sport-Related Subconcussive Head Impact Exposure : A Scoping Review

Funding Information: This review was supported by the University of Stirling (no grant number applies). L.W. also received support as part of Framework 7 programme of the European Union (CENTER-TBI, Grant number: 602150–2). S.M. received research support from the Italian Ministry of Health (GR-2013–02354960).Peer reviewe

N=4 Versus N=2 Phases, Hyperk\"Ahler Quotients and the 2D Topological Twist

We consider N=2 and N=4 supersymmetric gauge theories in two-dimensions, coupled to matter multiplets. In analogy with the N=2 case also in the N=4 case one can introduce Fayet-Iliopoulos terms.The associated three-parameters have the meaning of momentum-map levels in a HyperK\"ahler quotient construction. Differently from the N=2 case, however, the N=4 has a single phase corresponding to an effective $\sigma$-model. There is no Landau-Ginzburg phase. The main possible application of our N=4 model is to an effective Lagrangian construction of a $\sigma$-model on ALE-manifolds. We discuss the A and B topological twists of these models clarifying some issues not yet discussed in the literature, in particular the identification of the topological systems emerging from the twist. Applying our results to the case of ALE-manifolds we indicate how one can use the topologically twisted theories to study the K\"ahler class and complex structure deformations of these gravitational instantons.Comment: plain Latex, 77 pages, SISSA/151/93/E

Global Aspects of Abelian and Center Projections in SU(2) Gauge Theory

We show that the global aspects of Abelian and center projection of a SU(2) gauge theory on an arbitrary manifold are naturally described in terms of smooth Deligne cohomology. This is achieved through the introduction of a novel type of differential topological structure, called Cho structure. Half integral monopole charges appear naturally in this framework.Comment: 43 pages, no figures, requires AMS font files AMSSYM.DEF and amssym.tex. Completely rewritten, corrected and streamlined versio