Some comments on the high energy emission from regions of star formation beyond the galaxy

Regions that currently are or have been subject to a strong process of star formation are good candidates to be intense gamma-ray and neutrino emitters. They may even perhaps be sites where ultra high energy cosmic rays are produced. Outside the Galaxy, the more powerful sites of star formation are found within very active galaxies such as starbursts (SGs) and Luminous or Ultra-Luminous Infrared Galaxies (LIRGs or ULIRGs). Some general characteristic of these objects are herein reviewed from the point of view of their possible status as high energy emitters. Revised estimations of the high energy gamma-ray yield of Arp 220 are presented.Comment: 17 pages, 6 figures. Solicited Brief Review prepared for Modern Physics Letters

Impact of hospitalization on nutritional status in persons aged 65 years and over (NUTRIFRAG Study): Protocol for a prospective observational study

[ES] Background Malnutrition is a recurring problem that has become more relevant in recent years. The aim of this study is to assess the risk of malnutrition and nutritional status on admission and its evolution until discharge in patients aged 65 and over admitted to medical and surgical hospitalization units in hospitals of the Spanish National Health System. Methods Prospective observational study to be carried out in the medical-surgical hospitalization units of 9 public hospitals between 01/09/2022 and 31/12/2024. Using consecutive sampling, a total of 4077 patients will be included (453 in each hospital). Variables included are related to the care process, functionality, cognition and comorbidity, risk profile, nutritional status and dysphagia; as well as frailty, dietary quality and contextual variables. The incidence of risk of malnutrition, undernutrition and dysphagia during the care process and at discharge will be calculated. The association with risk factors will be studied with logistic regression models and multivariate Cox regression models. In addition, an analysis of participants’ satisfaction with food services will be carried out. The study was approved by the Ethics and Research Committee on 30/09/2020, approved for funding on 02/12/2021 and with registration number RBR-5jnbyhk in the Brazilian clinical trials database (ReBEC) for observational studies. Discussion Some studies address nutritional status or dysphagia in older people in various care settings. However, there is a lack of large sample studies including both processes of the impact of hospitalization. The results of the project will provide information on the incidence and prevalence of both pathologies in the study subjects, their associated factors and their relationship with the average length of stay, mortality and early readmission. In addition, early detection of a problem such as malnutrition related to the disease and/or dysphagia during a hospital stay will favor the action of professionals to resolve both pathologies and improve the health status of patients.This study has been funded by Instituto de Salud Carlos III (ISCIII) through the Project "PI21/00738" and co-funded by the European Union. The funders did not and will not have a role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Impact of hospitalization on nutritional status in persons aged 65 years and over (NUTRIFRAG Study): Protocol for a prospective observational study

Background: Malnutrition is a recurring problem that has become more relevant in recent years. The aim of this study is to assess the risk of malnutrition and nutritional status on admission and its evolution until discharge in patients aged 65 and over admitted to medical and surgical hospitalization units in hospitals of the Spanish National Health System. Methods: Prospective observational study to be carried out in the medical-surgical hospitalization units of 9 public hospitals between 01/09/2022 and 31/12/2024. Using consecutive sampling, a total of 4077 patients will be included (453 in each hospital). Variables included are related to the care process, functionality, cognition and comorbidity, risk profile, nutritional status and dysphagia; as well as frailty, dietary quality and contextual variables. The incidence of risk of malnutrition, undernutrition and dysphagia during the care process and at discharge will be calculated. The association with risk factors will be studied with logistic regression models and multivariate Cox regression models. In addition, an analysis of participants' satisfaction with food services will be carried out. The study was approved by the Ethics and Research Committee on 30/09/2020, approved for funding on 02/12/2021 and with registration number RBR-5jnbyhk in the Brazilian clinical trials database (ReBEC) for observational studies. Discussion: Some studies address nutritional status or dysphagia in older people in various care settings. However, there is a lack of large sample studies including both processes of the impact of hospitalization. The results of the project will provide information on the incidence and prevalence of both pathologies in the study subjects, their associated factors and their relationship with the average length of stay, mortality and early readmission. In addition, early detection of a problem such as malnutrition related to the disease and/or dysphagia during a hospital stay will favor the action of professionals to resolve both pathologies and improve the health status of patients.This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project "PI21/00738" and co-funded by the European Union. The funders did not and will not have a role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.S

Innovaciones y mejoras en el proyecto tutoría entre compañeros. Curso 2015-2016

Memoria ID-0137. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2015-2016

[Gamma]-ray emission form regions of star formation : theory and observations with the MAGIC telescope /

Consultable des del TDXTítol obtingut de la portada digitalitzadaEs el propósito de esta tesis estudiar la posibilidad de que regiones con importante actividad en formación estelar sean fuentes de rayos gamma para los actuales y futuros detectores, ya sean detectores de rayos gamma con base en satélites como telescopios Cherenkov situados en la superficie terrestre. Tras una evaluación fenomenológica positiva de que la emisión de rayos gamma procedente de galaxias con elevada actividad en formación estelar (como las llamadas starburst o las galaxias ultra luminosas en el infrarrojo) esté cerca de la sensibilidad de los actuales detectores de rayos gamma, se han desarrollado y presentado modelos detallados de la emisión difusa multifrecuencia procedente de los dos mejores candidatos, NGC 253 y Arp 220. Se predice que ambas galaxias serán detectables para GLAST, el próximo satélite de rayos gamma con una sensibilidad sin precedentes, y por HESS y MAGIC, los actuales telescopios Cherenkov con mayor sensibilidad, en caso de que éstos dediquen suficiente tiempo de observación a estas galaxias. En la parte teórica de la tesis se describe también un modelo que propone la emisión de importantes flujos de rayos gamma en regiones de formación estelar dentro de nuestra Galaxia, como serían las asociaciones de estrellas jóvenes del tipo OB. El modelo considera la emisión de rayos gamma a energías cercanas a los TeV mediante interacciones hadrónicas en el sí de vientos estelares de algunas de las estrellas de la asociación, prediciendo a la vez que la emisión a bajas energías está sustancialmente suprimida debido al efecto de modulación que la población de rayos cósmicos primarios sufre al penetrar en el viento estelar. Se discuten brevemente los mejores candidatos entre las asociaciones OB galácticas conocidas. Finalmente, la tesis recoge un primer análisis de los datos tomados por el Telescopio MAGIC durante la observación de dos regiones de formación estelar. Por una parte, la galaxia ultra luminosa en el infrarrojo más cercana, Arp 220. Por otra parte, TeV J2032+4130, que aún hoy en día sigue siendo una fuente no identificada, y cuyo origen se ha relacionado con la poderosa asociación estelar Cygnus OB2 en repetidas ocasiones. Ninguna de las observaciones ha implicado detección, en consecuencia, se han impuesto límites superiores al flujo de rayos gamma procedente de las fuentes observadas. Sin embargo, a pesar de las pocas horas de observación incluidas en el presente análisis, los límites superiores impuestos por el Telescopio MAGIC para la fuente TeV J2032+4130 están prácticamente al nivel del flujo que el experimento HEGRA detectó para dicha fuente, de manera que un análisis extendido al conjunto completo de datos disponibles, así como futuras observaciones de más larga exposición con el Telescopio MAGIC, podrían proveer resultados interesantes.Was the aim of this thesis to study the possibility that regions with important activity in star formation may appear as sources of gamma-rays for the current and near future gamma-ray detectors, both ground and space-satellite based. After a phenomenological positive evaluation of the fact that the gamma-ray emission from galaxies prone of star formation processes (as starburst or ultra luminous infrared galaxies) may be close to the flux sensitivities of the current gamma-ray telescopes, detailed models of the multiwavelength diffuse emission from the two best candidates, NGC 253 and Arp 220, have been presented. It is predicted that they will be detectable by GLAST, the next largest gamma-ray satellite, and by HESS and MAGIC, the current more sensitive Cherenkov Telescopes, in case enough observation time is devoted. On the other hand, within this thesis it is described a model which proposes the emission of important fluxes of gamma-rays from regions of star formation within our Galaxy, as the stellar association of young OB stars. The model considers the emission of gamma-rays close to TeV energies by hadronic interactions within the stellar winds of some of the stars of the association, predicting at the same time that the emission at lower energies is substantially suppressed due to the modulation effects that the incoming population of primary cosmic rays suffers when penetrating the winds. The best candidates among the galactic OB associations are briefly discussed. Finally, a first analysis of the data taken by the MAGIC Telescope when observing two of these regions of star formation is described. On one hand, the closest ultra luminous infrared galaxy, Arp 220. On the other, TeV J2032+4130, which is still an unidentified source whose origin has been several times related to the powerful stellar OB association Cygnus OB2. Any of both observations has implied detection, and upper limits to the gamma-ray flux have been imposed. However, although the few hours of observation included in the present analysis, the MAGIC upper limits for TeV J2032+4130 are nearly at the level of the flux detected by the HEGRA experiment, so an analysis extended to the complete set of data available as well as deeper observations of this source with the MAGIC Telescope can provide promising results

Diversity of Saccharomyces cerevisiae yeasts associated to spontaneous and inoculated fermenting grapes from Spanish vineyards

The use of commercial yeast strains is a common practice in winemaking leading to a predictable quality in wine production, avoiding stuck or sluggish fermentations. However, the use of commercial yeasts leads to a consequent reduction in autochthonous microbial diversity. In this study, 1047 isolates from three Spanish appellations of origin were checked for fingerprinting on interdelta polymorphisms and the strain composition and diversity analysed using an extensible open-source platform for processing and analysis of an in-house polymorphism database developed for this study. Ancient vineyards managed with organic practices showed intermediate to low levels of strains diversity indicating the existence of stable populations of Saccharomyces cerevisiae strains. A drastic reduction in the number of different S. cerevisiae strains was observed in vineyards with cellars using a selected autochthonous S. cerevisiae strain for winemaking. Contrary, the use of allochthonous commercial strains in wineries did not seem to affect the native S. cerevisiae strain composition and diversity. SIGNIFICANCE AND IMPACT OF THE STUDY: The aim of this study was to compare different viticulture and oenological practices to determine their influence on the composition and diversity of Saccharomyces cerevisiae strains in wine fermentations. The study shows that the use of autochthonous strains of S. cerevisiae as starters for wine fermentation could have an important incidence on S. cerevisiae strains diversity in surrounding vineyards. The use of autochthonous strains of S. cerevisiae reduced the detected number of S. cerevisiae strains, a fact that was not observed when allochthonous commercial strains were used. Furthermore, vineyards managed with organic practices showed intermediate to low levels of S. cerevisiae strain diversity, whereas conventional practices showed higher levels