10 research outputs found
The acute phase management of spinal cord injury affecting polytrauma patients : the ASAP study
Publisher Copyright: © 2022, The Author(s).Background: Few data on the management of acute phase of traumatic spinal cord injury (tSCI) in patients suffering polytrauma are available. As the therapeutic choices in the first hours may have a deep impact on outcome of tSCI patients, we conducted an international survey investigating this topic. Methods: The survey was composed of 29 items. The main endpoints of the survey were to examine: (1) the hemodynamic and respiratory management, (2) the coagulation management, (3) the timing of magnetic resonance imaging (MRI) and spinal surgery, (4) the use of corticosteroid therapy, (5) the role of intraspinal pressure (ISP)/spinal cord perfusion pressure (SCPP) monitoring and (6) the utilization of therapeutic hypothermia. Results: There were 171 respondents from 139 centers worldwide. A target mean arterial pressure (MAP) target of 80â90 mmHg was chosen in almost half of the cases [n = 84 (49.1%)]. A temporary reduction in the target MAP, for the time strictly necessary to achieve bleeding control in polytrauma, was accepted by most respondents [n = 100 (58.5%)]. Sixty-one respondents (35.7%) considered acceptable a hemoglobin (Hb) level of 7 g/dl in tSCI polytraumatized patients. An arterial partial pressure of oxygen (PaO2) of 80â100 mmHg [n = 94 (55%)] and an arterial partial pressure of carbon dioxide (PaCO2) of 35â40 mmHg [n = 130 (76%)] were chosen in most cases. A little more than half of respondents considered safe a platelet (PLT) count > 100.000/mm3 [n = 99 (57.9%)] and prothrombin time (PT)/activated partial thromboplastin time (aPTT) < 1.5 times the normal control [n = 85 (49.7%)] in patients needing spinal surgery. MRI [n = 160 (93.6%)] and spinal surgery [n = 158 (92.4%)] should be performed after intracranial, hemodynamic, and respiratory stabilization by most respondents. Corticosteroids [n = 103 (60.2%)], ISP/SCPP monitoring [n = 148 (86.5%)], and therapeutic hypothermia [n = 137 (80%)] were not utilized by most respondents. Conclusions: Our survey has shown a great worldwide variability in clinical practices for acute phase management of tSCI patients with polytrauma. These findings can be helpful to define future research in order to optimize the care of patients suffering tSCI.Peer reviewe
Survey of the interventional cardiology procedures in Italy
Interventional cardiology procedures are increasing because they offer many advantages to patients compared with other techniques: therefore the Italian National Institution for Insurance against Accidents at Work decided to start a survey for monitoring the state-of-the-art regarding the professionals involved in those procedures. The survey covered six cardiology and medical physics Italian departments. Each centre was asked to record 10 examinations for five types of procedures: coronary angiography (CA), electrophysiology studies (ES), pacemaker implantation (PI), percutaneous transluminal coronary angioplasty (PTCA) and radiofrequency catheter ablation (RA). For each examination all the centres were requested to fill in a questionnaire containing information regarding the operator performing the examination, the patient and the procedure. A total of 290 examinations were recorded: 103 CA, 14 ES, 68 PI, 79 PTCA and 26 RA. As occupational doses are strongly related to patient doses, both patients and operators radiation dose data are reported. Ratios of maximum to minimum mean patient doses across the hospitals surveyed were 2.0, 3.9, 7.0, 1.8 and 1.4 for CA, ES, PI, PTCA and RA, respectively. The calculated rounded mean dose-area product values across all participating hospitals were comparable with other values reported in the literature. In general, specific radiation protection tools were used by all operators performing different procedures in all hospitals. A major issue in this survey was the absence of information about correlation between staff and patient doses in a single procedure: future studies could be more aimed to prospective goals where occupational exposures per procedure are monitored specifically. © The Author 2012. Published by Oxford University Press. All rights reserved
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1
The production of red blood cells follows the sequential formation of proerythroblasts and basophilic, polychromatophilic and orthochromatic erythroblasts, and is promoted by the hormone erythropoietin (Epo) in response to tissue hypoxia. However, little is known about the negative regulation of this process. Death receptors are a family of surface molecules that trigger caspase activation and apoptosis in a variety of cell types. Here we show that immature erythroid cells express several death receptors whose ligands are produced by mature erythroblasts. Exposure of erythroid progenitors to mature erythroblasts or death-receptor ligands resulted in caspase-mediated degradation of the transcription factor GATA-1, which is associated with impaired erythroblast development. Expression of a caspase- resistant GATA-1 mutant, but not of the wild-type gene, completely restored erythroid expansion and differentiation following the triggering of death receptors, indicating that there is regulatory feedback between mature and immature erythroblasts through caspase-mediated cleavage of GATA-1. Similarly, erythropoiesis blockade following Epo deprivation was largely prevented by the expression of caspase-inhibitory proteins or caspase- resistant GATA-1 in erythroid progenitors. Caspase-mediated cleavage of GATA- 1 may therefore represent an important negative control mechanism in erythropoiesis
ââThe Battle for Conradâ inside and outside Italian academia in the years 1924-1960â.
SĂŹ canta lâempiaâŠ: Rinascimento e Opera. Seminari « LâOpĂ©ra narrateur » 2013-2014 (Saint-Denis, UniversitĂ© Paris 8-Paris, Institut National dâHistoire de lâArt)
International audienceCe volume inclut vingt-deux essais sur les sources Renaissance dans le livret d'opĂ©ra. StructurĂ© en quatre parties, il recueille des Ă©tudes sur les adaptations opĂ©ratiques du Roland Furieux («LâArioste et le Furieux»), de La JĂ©rusalem DĂ©livrĂ©e («Le Tasso et Armide») et de leurs «Epigones» (CervantĂšs, MĂ©tastase), en plus d'une section consacrĂ©e Ă la rĂ©ception lyrique des personnages de la Renaissance (Mona Lisa, les MĂ©dicis, Christophe Colomb, Pier Luigi Farnese, Beatrice Cenci, Torquato Tasso lui-mĂȘme). Il rend publics les rĂ©sultats de la troisiĂšme phase des sĂ©minaires consacrĂ©s à «LâOpĂ©ra narrateur», Renaissance et OpĂ©ra (2013â2014) qui se sont tenus dans le cadre du Laboratoire dâĂtudes Romanes de lâUniversitĂ© Paris 8. Il analyse la maniĂšre dont la scĂšne musicale a su intĂ©grer Ă ses propres fins les poĂšmes chevaleresques et privilĂ©gie le lien entre modĂšle littĂ©raire et Ă©criture pour le thĂ©Ăątre en musique, sans toutefois nĂ©gliger les questions de mise en scĂšne, de scĂ©nographie et de chorĂ©graphie.Il presente volume include ventidue saggi sulle fonti rinascimentali nella librettistica. Strutturato in quattro parti, raccoglie studi sugli adattamenti operistici dellâOrlando furioso («LâAriosto e il Furioso»), de La Gerusalemme liberata («Il Tasso e Armida») e dei loro «Epigoni» (Cervantes, Metastasio), oltre a una sezione dedicata alle recezione lirica dei personaggi del Rinascimento (Monna Lisa, i Medici, Cristoforo Colombo, Pier Luigi Farnese, Beatrice Cenci, lo stesso Torquato Tasso). Rende pubblici i risultati della terza fase dei seminari dedicati a «LâOpĂ©ra narrateur», Rinascimento e Opera (2013â2014), tenutisi nellâambito del Laboratoire dâĂtudes Romanes dellâUniversitĂ Paris 8. Analizza il modo in cui la scena musicale ha saputo interpretare ai propri fini i poemi cavallereschi, privilegiando il nesso tra modello letterario e scrittura per il teatro in musica, pur senza trascurare le questioni inerenti alla messinscena, alla scenografia e alla coreografia
Tradizione, Traduzione, Trasformazione
Il volume offre un punto di sintesi sulla teoria e pratica della traduzione letteraria tra il Giappone e le lingue europee, proponendo un percorso transdisciplinare di traduzione tra lingue, usi antropologici e codici culturali
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The acute phase management of spinal cord injury affecting polytrauma patients: the ASAP study.
BACKGROUND: Few data on the management of acute phase of traumatic spinal cord injury (tSCI) in patients suffering polytrauma are available. As the therapeutic choices in the first hours may have a deep impact on outcome of tSCI patients, we conducted an international survey investigating this topic. METHODS: The survey was composed of 29 items. The main endpoints of the survey were to examine: (1) the hemodynamic and respiratory management, (2) the coagulation management, (3) the timing of magnetic resonance imaging (MRI) and spinal surgery, (4) the use of corticosteroid therapy, (5) the role of intraspinal pressure (ISP)/spinal cord perfusion pressure (SCPP) monitoring and (6) the utilization of therapeutic hypothermia. RESULTS: There were 171 respondents from 139 centers worldwide. A target mean arterial pressure (MAP) target of 80-90 mmHg was chosen in almost half of the cases [nâ=â84 (49.1%)]. A temporary reduction in the target MAP, for the time strictly necessary to achieve bleeding control in polytrauma, was accepted by most respondents [nâ=â100 (58.5%)]. Sixty-one respondents (35.7%) considered acceptable a hemoglobin (Hb) level of 7 g/dl in tSCI polytraumatized patients. An arterial partial pressure of oxygen (PaO2) of 80-100 mmHg [nâ=â94 (55%)] and an arterial partial pressure of carbon dioxide (PaCO2) of 35-40 mmHg [nâ=â130 (76%)] were chosen in most cases. A little more than half of respondents considered safe a platelet (PLT) countâ>â100.000/mm3 [nâ=â99 (57.9%)] and prothrombin time (PT)/activated partial thromboplastin time (aPTT)â<â1.5 times the normal control [nâ=â85 (49.7%)] in patients needing spinal surgery. MRI [nâ=â160 (93.6%)] and spinal surgery [nâ=â158 (92.4%)] should be performed after intracranial, hemodynamic, and respiratory stabilization by most respondents. Corticosteroids [nâ=â103 (60.2%)], ISP/SCPP monitoring [nâ=â148 (86.5%)], and therapeutic hypothermia [nâ=â137 (80%)] were not utilized by most respondents. CONCLUSIONS: Our survey has shown a great worldwide variability in clinical practices for acute phase management of tSCI patients with polytrauma. These findings can be helpful to define future research in order to optimize the care of patients suffering tSCI
: Verdi narratore. Atti del convegno internazionale (Saint-Denis, UniversitĂ© Paris 8-Parigi, Institut National dâHistoire de lâArt, 23-26 ottobre 2013)
International audienceLa vera storia ci narra racchiude trentaquattro saggi di musicologi, studiosi di storia della musica, del teatro e del cinema, letterati, biografi, specialisti dei media contemporanei, direttori dâorchestra, registi e cantanti lirici. E' suddiviso in quattro sezioni: «Il tempo della narrazione», «La costruzione dellâopera», «La narrazione scenica e cinematografica», «Verdi narrato».La vera storia ci narra recueille trente-quatre essais de musicologues, d'historiens de la musique, du thĂ©Ăątre et du cinĂ©ma, de littĂ©raires, de biographes, de spĂ©cialistes des mĂ©dias contemporains, de chefs d'orchestre, de metteurs en scĂšne et de chanteurs d'opĂ©ra. Il s'articule en quatre sections : «Le temps de la narration », «La construction de lâoeuvre », «La narration scĂ©nique et cinĂ©matographique », «Verdi narrĂ© »