1,232 research outputs found

    Les cuines del món

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    Treball de l'alumnat del Grau d'Educació Primària de la Facultat d'Educació de la UB. Proposta d'activitat emmarcada al projecte de recerca EDU201S-69332-R "Desarrollo de las competencias para la educación multilingüe". Any: 2017. Tutors: Juli Palou i Margarida CambraMitjançant aquesta proposta, intentem tractar la interculturalitat i la diversitat de llengües que hi ha a la classe. A partir d’una activitat culinària, pretenem que el conjunt de nens i nenes comparteixin els plats més típics del seu país d’origen, per fomentar la incorporació dels alumnes i les seves cultures pertinents

    Changes in Subjective Well‑Being Over Time: Economic and Social Resources do Matter

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    The authors gratefully acknowledge the financial support provided by the Government of Spain through grant ECO2015-63734-P (MINECO/FEDER), the FPU2014/1123 fellowship from the Spanish Ministry of Education and the Fortalecimiento Program of the University of Granada (SEJ-340, SEJ-393). Funding for open access charge: Universidad de Granada/CBUA.This article analyzes the main determinants of changes in subjective well-being over time in Germany distinguishing between long-term and short-term changes. Our findings for the long term indicate that social capital and values and cultural dimensions have the greatest capacity to predict changes in subjective well-being. Likewise, the correlation between economic resources and subjective well-being is weaker due to the small increase registered in household income and because people compare their income with those who are better off and feel envy. In the short term, economic resources have the highest capacity to predict both improvements (ups) and declines (downs) in subjective well-being. Finally, we also suggest that, whenever information is available, personality traits should be taken into account in the analysis of changes in subjective well-being over time in order to achieve more reliable estimates.Government of Spain (MINECO/FEDER) ECO2015-63734-PSpanish Government FPU2014/1123Fortalecimiento Program of the University of Granada SEJ-340 SEJ-393Universidad de Granada/CBU

    Estimating the Maximum Hidden Vertex Set in Polygons

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    It is known that the MAXIMUM HIDDEN VERTEX SET problem on a given simple polygon is NP-hard [11], therefore we focused on the development of approximation algorithms to tackle it. We propose four strategies to solve this problem, the first two (based on greedy constructive search) are designed specifically to solve it, and the other two are based on the general metaheuristics Simulated Annealing and Genetic Algorithms. We conclude, through experimentation, that our best approximate algorithm is the one based on the Simulated Annealing metaheuristic. The solutions obtained with it are very satisfactory in the sense that they are always close to optimal (with an approximation ratio of 1.7, for arbitrary polygons; and with an approximation ratio of 1.5, for orthogonal polygons). We, also, conclude, that on average the maximum number of hidden vertices in a simple polygon (arbitrary or orthogonal) with n vertices is n4

    Minimum Vertex Guard problem for orthogonal polygons: a genetic approach

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    The problem of minimizing the number of guards placed on vertices needed to guard a given simple polygon (MINIMUM VERTEX GUARD problem) is NP-hard. This computational complexity opens two lines of investigation: the development of algorithms that determine approximate solutions and the determination of optimal solutions for special classes of simple polygons. In this paper we follow the first line of investigation proposing an approximation algorithm based on the general met heuristic Genetic Algorithms to solve the MINIMUM VERTEXGUARD problem

    Solving the minimum vertex floodlight problem with hybrid metaheuristics

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    In this paper we propose four approximation algorithms (metaheuristic based), for the Minimum Vertex Floodlight Set problem. Urrutia et al. [9] solved the combinatorial problem, although it is strongly believed that the algorithmic problem is NP-hard. We conclude that, on average, the minimum number of vertex floodlights needed to illuminate a orthogonal polygon with n vertices is n/4,29

    Escondiendo puntos en espirales e histogramas

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    El problema de maximizar el número de vértices que no son visibles dos a dos en un polígono simple P, (MAXIMUN HIDDEN VERTEX SET) es un problema NP-duro [6]. En este trabajo se resuelve el problema para dos tipos de polígonos: espirales e histogramas. Para los primeros se obtiene un algoritmo lineal que resuelve el problema MHVS y cotas para el máximo número h de vértices ocultos, [r2 ]+ 1 ≤ h ≤ r + 1, siendo r el número de vértices cóncavos del polígono espiral. Para polígonos histograma se demuestra que h = r − (p − 1), siendo p el número de lados fondo

    Blocos Provocadores de Diálogo e Interação em Textos-base para Educação a Distância

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    Apresenta-se, neste trabalho, o uso de um texto-base no contexto de um curso de Educação a Distância Online. No texto-base foram usados blocos provocadores de diálogo e interação. Os alunos das quatro turmas da disciplina Tópicos Especiais em Sistemas de Informação do curso de sistemas de informação (UAB/UFAL) usaram o texto-base com os blocos provocadores de diálogo e interação para estudar e realizar as atividades de cada unidade dessa disciplina. Objetivando verificar a compreensão dos alunos foram utilizados mapas conceituais. Os resultados foram positivos, todos os alunos gostaram, argumentando que o texto-base tinha aparência de conversação e que propiciava a participação deles. No final, 93,55% dos alunos foram aprovados nas quatro turmas

    Late-onset thymidine kinase 2 deficiency: a review of 18 cases

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    BACKGROUND: TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the 'myopathic form' of the mitochondrial depletion/multiple deletions syndrome, with a wide spectrum of severity. METHODS: We describe 18 patients with mitochondrial myopathy due to mutations in the TK2 gene with absence of clinical symptoms until the age of 12. RESULTS: The mean age of onset was 31 years. The first symptom was muscle limb weakness in 10/18, eyelid ptosis in 6/18, and respiratory insufficiency in 2/18. All patients developed variable muscle weakness during the evolution of the disease. Half of patients presented difficulty in swallowing. All patients showed evidence of respiratory muscle weakness, with need for non-invasive Mechanical Ventilation in 12/18. Four patients had deceased, all of them due to respiratory insufficiency. We identified common radiological features in muscle magnetic resonance, where the most severely affected muscles were the gluteus maximus, semitendinosus and sartorius. On muscle biopsies typical signs of mitochondrial dysfunction were associated with dystrophic changes. All mutations identified were previously reported, being the most frequent the in-frame deletion p.Lys202del. All cases showed multiple mtDNA deletions but mtDNA depletion was present only in two patients. CONCLUSIONS: The late-onset is the less frequent form of presentation of the TK2 deficiency and its natural history is not well known. Patients with late onset TK2 deficiency have a consistent and recognizable clinical phenotype and a poor prognosis, due to the high risk of early and progressive respiratory insufficiency.Instituto de Salud Carlos III PI16-01843 PI16/00579 CP09/00011Subdirección General de Evaluación y Fomento de la Investigación Sanitaria PI16-01843 PI16/00579 CP09/00011 PI 15/00431 PMP15/0002

    Porous Titanium surfaces to control bacteria growth: mechanical properties and sulfonated polyetheretherketone coating as antibiofounling approaches

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    Here, titanium porous substrates were fabricated by a space holder technique. The relationship between microstructural characteristics (pore equivalent diameter, mean free-path between pores, roughness and contact surface), mechanical properties (Young’s modulus, yield strength and dynamic micro-hardness) and bacterial behavior are discussed. The bacterial strains evaluated are often found on dental implants: Methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. The colony-forming units increased with the size of the spacer for both types of studied strains. An antibiofouling synthetic coating based on a sulfonated polyetheretherketone polymer revealed an effective chemical surface modification for inhibiting MRSA adhesion and growth. These findings collectively suggest that porous titanium implants designed with a pore size of 100–200 µm can be considered most suitable, assuring the best biomechanical and bifunctional anti-bacterial properties.University of Seville VI Plan Propio de Investigación y Transferencia—US 2018, I.3A

    Balancing porosity and mechanical properties of titanium samples to favor cellular growth against bacteria

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    Two main problems limit the success of titanium implants: bacterial infection, which restricts their osseointegration capacity; and the stiffness mismatch between the implant and the host cortical bone, which promotes bone resorption and risk of fracture. Porosity incorporation may reduce this difference in stiffness but compromise biomechanical behavior. In this work, the relationship between the microstructure (content, size, and shape of pores) and the antibacterial and cellular behavior of samples fabricated by the space-holder technique (50 vol % NH4HCO3 and three ranges of particle sizes) is established. Results are discussed in terms of the best biomechanical properties and biofunctional activity balance (cell biocompatibility and antibacterial behavior). All substrates achieved suitable cell biocompatibility of premioblast and osteoblast in adhesion and proliferation processes. It is worth to highlighting that samples fabricated with the 100–200 μm space-holder present better mechanical behavior—in terms of stiffness, microhardness, and yield strength—which make them a very suitable material to replace cortical bone tissues. Those results exposed the relationship between the surface properties and the race of bacteria and mammalian cells for the surface with the aim to promote cellular growth over bacteria.University of Seville (Spain) VI Plan Propio de Investigación y Transferencia—US 2018, I.3A
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