Adaptive homodyne measurement of optical phase

We present an experimental demonstration of the power of real-time feedback in quantum metrology, confirming a theoretical prediction by Wiseman regarding the superior performance of an adaptive homodyne technique for single-shot measurement of optical phase. For phase measurements performed on weak coherent states with no prior knowledge of the signal phase, we show that the variance of adaptive homodyne estimation approaches closer to the fundamental quantum uncertainty limit than any previously demonstrated technique. Our results underscore the importance of real-time feedback for reaching quantum performance limits in coherent telecommunication, precision measurement and information processing.Comment: RevTex4, color PDF figures (separate files), submitted to PR

Distribution and incidence of viruses in Irish seed potato crops

peer-reviewedVirus diseases are of key importance in potato production and in particular for the production of disease-free potato seed. However, there is little known about the frequency and distribution of potato virus diseases in Ireland. Despite a large number of samples being tested each year, the data has never been collated either within or across years. Information from all known potato virus testing carried out in the years 2006–2012 by the Department of Agriculture Food and Marine was collated to give an indication of the distribution and incidence of potato virus in Ireland. It was found that there was significant variation between regions, varieties, years and seed classes. A definition of daily weather data suitable for aphid flight was developed, which accounted for a significant proportion of the variation in virus incidence between years. This use of weather data to predict virus risk could be developed to form the basis of an integrated pest management approach for aphid control in Irish potato crops

Ionospheric corrections to precise time transfer using GPS

The free electrons in the earth's ionosphere can retard the time of reception of GPS signals received at a ground station, compared to their time in free space, by many tens of nanoseconds, thus limiting the accuracy of time transfer by GPS. The amount of the ionospheric time delay is proportional to the total number of electrons encountered by the wave on its path from each GPS satellite to a receiver. This integrated number of electrons is called Total Electron Content, or TEC. Dual frequency GPS receivers designed by Allen Osborne Associates, Inc. (AOA) directly measure both the ionospheric differential group delay and the differential carrier phase advance for the two GPS frequencies and derive from this the TEC between the receiver and each GPS satellite in track. The group delay information is mainly used to provide an absolute calibration to the relative differential carrier phase, which is an extremely precise measure of relative TEC. The AOA Mini-Rogue ICS-4Z and the AOA TurboRogue ICS-4000Z receivers normally operate using the GPS P code, when available, and switch to cross-correlation signal processing when the GPS satellites are in the Anti-Spoofing (A-S) mode and the P code is encrypted. An AOA ICS-Z receiver has been operated continuously for over a year at Hanscom AFB, MA to determine the statistics of the variability of the TEC parameter using signals from up to four different directions simultaneously. The 4-channel ICS-4Z and the 8-channel ICS-4000Z, have proven capabilities to make precise, well calibrated, measurements of the ionosphere in several directions simultaneously. In addition to providing ionospheric corrections for precise time transfer via satellite, this dual frequency design allows full code and automatic codeless operation of both the differential group delay and differential carrier phase for numerous ionospheric experiments being conducted. Statistical results of the data collected from the ICS-4Z during the initial year of ionospheric time delay in the northeastern U.S., and initial results with the ICS-4000Z, will be presented

Nuclear electric propulsion: A better, safer, cheaper transportation system for human exploration of Mars

NASA has completed a preliminary mission and systems study of nuclear electric propulsion (NEP) systems for 'split-sprint' human exploration and related robotic cargo missions to Mars. This paper describes the study, the mission architecture selected, the NEP system and technology development needs, proposed development schedules, and estimated development costs. Since current administration policy makers have delayed funding for key technology development activities that could make Mars exploration missions a reality in the near future, NASA will have time to evaluate various alternate mission options, and it appears prudent to ensure that Mars mission plans focus on astronaut and mission safety, while reducing costs to acceptable levels. The split-sprint nuclear electric propulsion system offers trip times comparable to nuclear thermal propulsion (NTP) systems, while providing mission abort opportunities that are not possible with 'reference' mission architectures. Thus, NEP systems offer short transit times for the astronauts, reducing the exposure of the crew to intergalactic cosmic radiation. The high specific impulse of the NEP system, which leads to very low propellant requirements, results in significantly lower 'initial mass in low earth orbit' (IMLEO). Launch vehicle packaging studies show that the NEP system can be launched, assembled, and deployed, with about one less 240-metric-ton heavy lift launch vehicle (HLLV) per mission opportunity - a very Technology development cost of the nuclear reactor for an NEP system would be shared with the proposed nuclear surface power systems, since nuclear systems will be required to provide substantial electrical power on the surface of Mars. The NEP development project plan proposed includes evolutionary technology development for nuclear electric propulsion systems that expands upon SP-100 (Space Power - 100 kw(e)) technology that has been developed for lunar and Mars surface nuclear power, and small NEP systems for interplanetary probes. System upgrades are expected to evolve that will result in even shorter trip times, improved payload capabilities, and enhanced safety and reliability

The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy Indian adolescents

Background: QuantiFERON-TB Gold In-Tube (QFT) is an IFNγ-release assay used in the diagnosis of Mycobacterium tuberculosis (MTB) infection. The risk of TB progression increases with the magnitude of the MTB-specific IFNγ-response. QFT reversion, also associated with low Tuberculin Skin Test responses, may therefore represent a transient immune response with control of M. tuberculosis infection. However, studies at the single cell level have suggested that the quality (polyfunctionality) of the T-cell response is more important than the quantity of cytokines produced. Objective: To explore the quality and/or magnitude of mycobacteria-specific T-cell responses associated with QFT reversion and persistent QFT-positivity. Methods: Multi-color flowcytometry on prospectively collected peripheral blood mononuclear cells was applied to assess mycobacteria-specific T-cell responses in 42 QFT positive Indian adolescents of whom 21 became QFT negative (reverters) within one year. Ten QFT consistent negatives were also included as controls. Results: There was no difference in the qualitative PPD-specific CD4+ T-cell response between QFT consistent positives and reverters. However, compared with QFT consistent positives, reverters displayed lower absolute frequencies of polyfunctional (IFNγ+IL2+TNFα+) CD4+ T-cells at baseline, which were further reduced to the point where they were not different to QFT negative controls one year later. Moreover, absolute frequencies of these cells correlated well with the magnitude of the QFT-response. Conclusion: Whereas specific polyfunctional CD4+ T-cells have been suggested to protect against TB progression, our data do not support that higher relative or absolute frequencies of PPD-specific polyfunctional CD4+ T-cells in peripheral blood can explain the reduced risk of TB progression observed in QFT reverters. On the contrary, absolute frequencies of these cells correlated with the QFT-response, suggesting that this readout reflects antigenic load

Associations between prenatal exposure to phthalates and features of the metabolic syndrome in males from childhood into adulthood

Phthalate metabolites are detectable within the majority of the population. Evidence suggests that a prenatal exposure to phthalates may be associated with the subsequent risks of obesity and elevated blood pressure. We hypothesised that a prenatal exposure to phthalates would lead to an increase in adverse cardiometabolic parameters through childhood and adulthood. The maternal serum phthalate measurements from the stored samples taken from Gen1 mothers at 18 and 34 weeks gestation were examined in relation to the cardiometabolic measures in 387 male offspring from the Raine Study. Data from the Gen2 follow-ups between 3 and 27 years were used. The primary outcomes were analysed longitudinally using linear mixed models for the repeated measures. Non-alcoholic fatty liver disease (NAFLD) was assessed at 17 years using logistic regression. A consistent positive relationship was observed between a prenatal exposure to mono-carboxy-iso-octyl phthalate (MCiOP) through adolescence into adulthood with systolic blood pressure. There were no other consistent cardiovascular associations. Mid-levels of prenatal exposures to Mono-n-butyl phthalate (MnBP) were associated with a greater incidence of NAFLD. Detectable Mono-3-carboxypropyl phthalate (MCPP) was associated with a lower serum HDL-C through late childhood into adulthood, while a higher prenatal exposure to mono-iso-butyl phthalate (MiBP), was associated with a higher LDL-C at 22 years of age. A mid-level prenatal exposure to mono-2-ethylhexyl phthalate (MEHP) metabolites was associated with higher insulin in adulthood, while a higher prenatal exposure to the sum of the Di-(2-ethyl-hexyl) phthalate (DEHP) and Di-iso-nonyl phthalate (DiNP) metabolites was associated with higher fasting serum glucose in adulthood. In conclusion, our study demonstrated that higher prenatal phthalate exposures to some phthalate metabolites was associated with some adverse metabolic profiles through adolescence into adulthood, although the consistent themes were limited to a few metabolites and the outcomes of systolic blood pressure, fasting insulin and glucose

Surface ozone variability and the jet position: Implications for projecting future air quality

Changes in the variability of surface ozone can affect the incidence of ozone pollution events. Analysis of multi-century simulations from a chemistry climate model shows that present-day summertime variability of surface ozone depends strongly on the jet stream position over eastern North America. This relationship holds on decadal time scales under projected climate change scenarios, in which surface ozone variability follows the robust poleward shift of the jet. The correlation between ozone and co-located temperature over eastern North America is also closely tied to the jet position, implying that local ozone-temperature relationships may change as the circulation changes. Jet position can thus serve as a dynamical predictor of future surface ozone variability over eastern North America and may also modulate ozone variability in other northern midlatitude regions

Glassy Transition and Aging in a Model without Disorder

We study the off-equilibrium relaxational dynamics of the Amit-Roginsky $\phi^3$ field theory, for which the mode coupling approximation is exact. We show that complex phenomena such as aging and ergodicity breaking are present at low temperature, similarly to what is found in long range spin glasses. This is a generalization of mode coupling theory of the structural glass transition to off-equilibrium situations.Comment: 9 pages, 1 uuencoded figure, LaTex, preprint NORDITA 94/3

The first crop plant genetically engineered to release an insect pheromone for defence

Insect pheromones offer potential for managing pests of crop plants. Volatility and instability are problems for deployment in agriculture but could be solved by expressing genes for the biosynthesis of pheromones in the crop plants. This has now been achieved by genetically engineering a hexaploid variety of wheat to release (E)-β-farnesene (Eβf), the alarm pheromone for many pest aphids, using a synthetic gene based on a sequence from peppermint with a plastid targeting amino acid sequence, with or without a gene for biosynthesis of the precursor farnesyl diphosphate. Pure Eβf was produced in stably transformed wheat lines with no other detectable phenotype but requiring targeting of the gene produced to the plastid. In laboratory behavioural assays, three species of cereal aphids were repelled and foraging was increased for a parasitic natural enemy. Although these studies show considerable potential for aphid control, field trials employing the single and double constructs showed no reduction in aphids or increase in parasitism. Insect numbers were low and climatic conditions erratic suggesting the need for further trials or a closer imitation, in the plant, of alarm pheromone release

Design and operation of automated ice-tethered profilers for real-time seawater observations in the polar oceans

An automated, easily-deployed Ice-Tethered Profiler (ITP) has been developed for deployment on perennial sea ice in polar oceans to measure changes in upper ocean temperature and salinity in all seasons. The ITP system consists of three components: a surface instrument that sits atop an ice floe, a weighted, plastic-jacketed wire-rope tether of arbitrary length (up to 800 m) suspended from the surface instrument, and an instrumented underwater unit that profiles up and down the wire tether. The profiling underwater unit is similar in shape and dimension to an ARGO float except that the float's variable-buoyancy system is replaced with a traction drive unit. Deployment of ITPs may be conducted either from ice caps or icebreakers, utilizing a self contained tripod/winch system that requires no power. Careful selection of an appropriate multiyear ice floe is needed to prolong the lifetime of the system (up to 3 years depending on the profiling schedule). Shortly after deployment, each ITP begins profiling the water column at its programmed sampling interval. After each acquired temperature and salinity profile, the underwater unit (PROCON) transfers the data and engineering files using an inductive modem to the surface controller (SURFCON). SURFCON also accumulates battery voltages, buoy temperature, and locations from GPS at specified intervals in status files, and queues that information for transmission at the start of each new day. At frequent intervals, an Iridium satellite transceiver in the surface package calls and transmits queued status and CTD data files onto a WHOI logger computer, which are subsequently processed and displayed in near-real time at http://www.whoi.edu/itp. In 2004 and 2005, three ITP prototypes were deployed in the Arctic Ocean. Each system was programmed with accelerated sampling schedules of multiple one-way traverses per day between 10 and 750-760 m depth in order to quickly evaluate endurance and component fatigue. Two of the ITPs are continuing to function after more than 10 months and 1200 profiles. Larger motor currents are observed at times of fast ice floe motion when larger wire angles develop and drag forces on the profiler are increased. The CTD profile data so far obtained document interesting spatial variations in the major water masses of the Beaufort Gyre, show the double-diffusive thermohaline staircase that lies above the warm, salty Atlantic layer, and many mesoscale eddys. Deployed together with CRREL Ice Mass Balance (IMB) buoys, these ITP systems also operate as part of an Ice Based Observatory (IBO). Data returned from an array of IBOs within an Arctic Observing Network will provide valuable real time observations, support studies of ocean processes, and facilitate numerical model initialization and validation.Funding was provided by the National Science Foundation under Contract Nos. OCE-0324233 and ARC-0519899